Nutritional Musculoskeletal Support

Nutritional Musculoskeletal Support

The human body has a system of support for what is contained in it, including bones, cartilage, tendons, and ligaments.

CARTILAGE
Cartilage is a firm, but flexible tissue, that cushions joints and provides structural support. It covers the ends of bones in joints (like the knee) to reduce friction and absorb shock. There are different types, including hyaline cartilage (in joints and the nose), elastic cartilage (in the ear), and fibrocartilage (in intervertebral discs). Cartilage is primarily made of chondrocytes (cartilage cells) embedded in a gel-like extracellular matrix. The matrix consists of collagen fibers, proteoglycans, and water, which give cartilage its flexibility and cushioning ability. Cartilage is avascular (lacks blood vessels), meaning it relies on diffusion for nutrient exchange.

LIGAMENTS
Ligaments are strong, fibrous bands of tissue that connect bone to bone and stabilize joints. They also help prevent excessive movement that could lead to injury. For example, the ACL (anterior cruciate ligament) helps to stabilize the knee. Ligaments are made mostly of dense regular connective tissue, rich in collagen fibers (mostly Type I collagen). The collagen fibers are arranged in the body in a slightly wavy pattern, allowing for some elasticity but mainly providing strong, stable connections between bones. Ligaments have some blood supply, but healing can still be slow due to limited circulation.

TENDONS
Tendons are tough, rope-like structures that connect muscle to bone. They transmit the force generated by muscles to move the bones. The Achilles tendon, for instance, connects the calf muscles to the heel bone. Tendons are composed of dense regular connective tissue, with parallel bundles of Type I collagen fibers that make them incredibly strong. Tendons have tenocytes (specialized tendon cells) that help maintain the structure. Tendons contain less elastin than ligaments, making them more rigid, which is necessary for efficiently transmitting force from muscle to bone. They have a better blood supply than cartilage but less than muscles, meaning healing is slow but not as slow as cartilage.


Cartilage, ligaments, and tendons are mainly composed of collagen. In addition to various proteins, various nutrients are involved in its production. For example, vitamin C functions as a cofactor for enzymes (prolyl and lysyl hydroxylase) that help stabilize collagen structure. Silicon is essential for the production of collagen and glycosaminoglycans (GAGs), which form the extracellular matrix of cartilage, as it helps in the cross-linking of collagen fibers, making them stronger and more stable. Omega 3 fatty acids can help reduce inflammation, which can degrade collagen over time.

Below are 100% FOOD Supplements intended for Nutritional Musculoskeletal Support

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Diabetes: Types I and II

In the United States, the incidence of diabetes in adults rose by 33% from 1990 to 1998 and still appears to be on the rise.  Obesity is considered one of the major risk factors for diabetes, but that may be more due to dietary choices.

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Simply Female Article

Simply Female™

100% Food supplement that is intended to supply nutrients needed to maintain and support female health. In addition to supporting the hypothalamic-pituitary-adrenal axis, this plural glandular supplement contains specific female reproductive gland peptides, enzymes and hormone precursors.

Women have unique organs and require special care. Simply FemaleTM was developed to help naturally nourish and support a woman’s organs by providing 100% glandular support. 

The consumption of glandulars provides nutritional support to the corresponding gland in the human body [e.g. 1]. Glandular organs contain vitamins, minerals, and nutritional peptides, without sugar [2]. They also supply enzymes, and substances believed to be hormone precursors. Freeze drying results in a glandular that is the closest to ‘whole food’ [3].

Unlike plants, glands have most of the same biological materials (like enzymes and other peptides) that humans do [4]. It is now believed that there are as many as 75,000 different enzymes in the human body [5]. Consuming glandulars helps directly supply enzymes. Enzymes are biological catalysts that encourage metabolic, catabolic, and digestive processes in the body. They help rebuild and detoxify. Enzymes tend to be specific, such as thyroid enzymes tend to help the thyroid, but are ignored in the ear. Enzymes help the respective organs they are involved with function better.

Simply FemaleTM is intended to support the Hypothalamic-Pituitary-Adrenal (HPA) Axis as well as other systems in the female body. The HPA Axis is your body’s main way of responding to stress. It consists of three organs that each release hormones to eventually raise cortisol level in your body. The HPA Axis is a communication system between three organs, it is crucial for your body’s stress management [6]. These endocrine system organs create a feedback loop of hormones to enact and regulate your body’s stress reaction.

The HPA Axis is comprised of three glands:

  Hypothalamus: The hypothalamus is a structure deep within your brain. The hypothalamus keeps your body in a balanced state (homeostasis). The hormones [it produces] can control body temperature, water balance, appetite, gastric activity, and the fear and rage emotions [7]. The hypothalamus can also increase feelings of tranquility [8].

  Pituitary: The pituitary gland is a small endocrine gland located at the base of the brain below the hypothalamus. It makes several essential hormones and regulates other endocrine glands management [6]. The pituitary gland secretes human growth hormone, adrenocorticotrophin, thyroid-stimulating hormone, follicle-stimulating hormone, luteinizing hormone, antidiuretic hormone (also called vasopressin), and oxytocin [8]. Beef pituitary glandulars have been recommended for fatigue, stress intolerance, digestive complaints, metabolic disorders, headaches, obesity, delayed healing response, and nervous manifestations [9]. Some have also recommended it to help with sleep as well as seasonal affective disorders.

  Adrenal: The adrenal glands secrete androgens, which in a woman’s body can be converted into estrogen, along with cortisol (which controls aspects of metabolism) and aldosterone. They also produce mineralocorticoids (involved in electrolyte balance) and glucocorticoids (involved in blood sugar regulation). Adrenal glands secrete epinephrine and norepinephrine in response to sympathetic stimulation. “More than 30 steroids have been isolated from the adrenal cortex” [8]. Adrenal glandular support is often used by people who are under stress, fatigued, having difficulty getting up in the morning, who have adrenal stress headaches, or have an abnormal craving for salts [10].

In addition to supporting the HPA Axis, women may benefit from additional bovine glandular support of the reproductive organs. 

Simply FemaleTM contains glandular support for the ovaries, fallopian tubes, uterus and cervix. 

  Ovary: While ovaries are involved in reproduction and hormone production, bovine ovarian tissue has been advised to help women sleep at night, reduce the production of acne, improve mood, sometimes aid in menopausal issues and for some women, increase fertility [11].

  Fallopian tubes: are a pair of hollow, muscular ducts located between the ovaries and uterus. Each Fallopian tube is a channel between the ovaries which are involved with reproduction and menstruation [8]. Estrogen causes the ciliated epithelial cells that line the fallopian tubes to increase [8].

  Bovine uterus extracts have long been used for women with leucorrhea, uterine cysts, fibroids, uterine displacement, excessive or scanty mense, some types of sterility, menstruation cramps, prolapse uterus [7, 12]. Some practitioners have found uterine glandulars to be helpful for female moods.

  The cervix is the lower, narrow canal part of the uterus, connecting it to the vagina. It plays a vital role in menstruation, fertility, pregnancy, and childbirth [13]. The cervix allows fluids to leave and enter the uterus.

Simply FemaleTM also contains bovine thyroid tissue (note: bovine thyroid glands are thyroxine-free, thus do not result in a shutting down of the thyroid gland when taken). Thyroid tissue is used by people with symptoms associated with low thyroid such as afternoon tiredness, poor circulation, poor temperature tolerance, headaches, low metabolism, diminished female libido, weight concerns, and sometimes dry skin [14]. After a short adjustment period many people will find that they crave less junk food, caffeine, and similar items less but instead carve more water, fruits, and even vegetables.

Bovine animal glands have been consumed since the beginning of history [15], and glandulars have been part of the human diet for thousands of years. They were used for medicinal purposes in the USA in the 1800s [16] and were mentioned in Merck’s 1905 Manual of Materia Medica [17]. Their long-term use in nutritional supplements began over a century ago [18].

Various studies and reports involving glandulars have been published [e.g. 19-26]. Interestingly, a study of Australian aborigines found that those that had obesity and diabetes who left Western diets and returned to a native diet that included consuming animal glands found that those diseases reversed [26]. Glandulars are “generally recognized as safe” [27]

New Zealand, Australian, and Argentinean farmers tend to raise their cattle more naturally than those raised in places that use a lot of genetically-modified grains like the USA. Cows in New Zealand, Australia, and Argentina are almost exclusively raised on unfertilized natural grasses which are found in the pastures of those lands. Neither New Zealand nor Australia, nor Argentina has ever had a case of BSE (bovine spongiform encephalopathy) nor scrapie, a similar disease found in sheep [28-30]. Simply FemaleTM only provides glands from those southern hemisphere nations.

In summary, Simply FemaleTM supports the HPA Axis, the reproductive organs and the thyroid gland. Simply Female offers complete glandular support for the neuroendocrine system, the endocrine system and the reproductive system.  

Women seeking relief from hormonal imbalances, as well as those ending hormone replacement therapy, can nourish and help stabilize their endocrine systems with glandular support, such as in Simply FemaleTM [31].

Some of these studies (or citations) may not conform to peer review standards, therefore, the results are not conclusive. Professionals can, and often do, come to different conclusions when reviewing scientific data. None of these statements have been reviewed by the FDA. All products distributed by Doctors’ Research, Inc. are nutritional and are not intended for the treatment or prevention of any medical conditions.

Simply FemaleTM is intended to support the Hypothalamic-Pituitary-Adrenal (HPA) Axis as well as other systems in the female body. The HPA Axis is your body’s main way of responding to stress. It consists of three organs that each release hormones to eventually raise cortisol level in your body.

The HPA Axis is a communication system between three organs, it is crucial for your body’s stress management [6]. These endocrine system organs create a feedback loop of hormones to enact and regulate your body’s stress reaction.

References

[1] Burns D. Accumulating scientific evidence supports glandular therapy.  The Digest of Chiropractic Economics, Nov/Dec 1987: 74-79
[2] Basic Report: 13318, Beef, variety meats and by-products, brain, raw. National Nutrient Database for Standard Reference Legacy Release, April, 2019; Basic Report: 13325, Beef, variety meats and by-products, liver, raw. National Nutrient Database for Standard Reference Legacy Release, April, 2018
[3] The Difference Between Freeze-Dried, Dehydrated and Raw Foods. Trail Blazers Pets, December 13, 2017
[4] Hulsey MG, Martin, RJ.  The role of animals in nutritional research.  Nutr Today,1993;28 (5):1993
[5] The Handy Answer Book Series, 2nd edition. Visible Ink Press, 2014
[6] Hypothalamic-Pituitary-Adrenal (HPA) Axis, Cleveland Clinic, https://my.clevelandclinic.org/health/body/hypothalamic-pituitary-adrenal-hpa-axis, accessed 08/05/2025
[7] Profiles in Nutritional Progress.  Rubicon Productions, Bakersfield, 1993
[8] Guyton AC, Hall JE.  Textbook of Medical Physiology, 9th ed. WB Saunders, 1996
[9] Lee R. Pituitary Cytotrophin. Product Bulletins, circa 1950
[10] Lee R. Adrenamin.  In Product Bulletins, circa 1950
[11] Lee R. Ovary Cytotrophin.  In Product Bulletins, circa 1950
[12] Lee R. Uterus Cytotrophin.  In Product Bulletins, circa 1950
[13] Prendiville W, Sankaranarayanan R. Anatomy of the uterine cervix and the transformation zone. Colposcopy and Treatment of Cervical Precancer, International Agency for Research on Cancer, 2017
[14] Neumann C. Serious Nutrition: Incorporating Clinically Effective Nutrition Into Your Practice.  Source Graphics, Kelowna (B.C.), 2005
[15] Dunbar R.  Foraging for nature’s balanced diet.  New Scientist August 31, 1991:25-28
[16] Isaacs LL. A Brief History of Glandular Therapy: More Than Just Thyroid. Integr Med (Encinitas). 2023 May;22(2):26-31
[17] Merck’s 1905 Manual of the Materia Medica: A Ready-reference Pocket Book for the Physician and Surgeon Containing Names of the Chemicals and Drugs, 3rd ed. Merck & Co, 1905, p. 114
[18] Harrower H.  Practical Organotherapy.  3rd ed.  W.B.  Conkey Co.: Hammond (Indiana): 31-36, 1921
[19] Shamberger RC, Hendron WH, Leictner AM.  Long-term nutritional and metabolic consequences of pancreaticoduodenectomy in children.  Surgery, 1994;115(3): 382-388
[20] Thiel R., Fowkes S.W.  Down syndrome and thyroid dysfunction: Should nutritional support be the first-line treatment? Medical Hypotheses, 2007; 69:809-815
[21] Thiel R. Might disorders of calcium cause or contribute to myoclonic seizures?  Medical Hypotheses, 2006; 66(5):969-974
[22] Thiel R. Thiel R. CHARGE (Hall-Hittner) Syndrome and Nutrition: A novel case report, 2006
[23] Thiel R.  Might disorders of calcium cause or contribute to myoclonic seizures?  Med Hypo. 2006; 66(5):969-974
[24] DeCava JA.  Glandular supplements.  Nutrition News and Views 1997; 1(3):1-10
[25] Thiel R. Efficacy of Glandulars and Herbs: The Result of 945 Cases. The Original Internist, Volume 19 (1), March 2012, 7-11
[26] O’Dea K. Traditional diet and food preferences of Australian aboriginal hunter-gatherers. Philos Trans R Soc Lond B Biol Sci. 1991 Nov 29;334(1270):233-240; discussion 240-241
[27] Generally Recognized as Safe (GRAS). USFDA, https://www.fda.gov/food/food-ingredients-packaging/generally-recognized-safe-gras accessed 02/07/20
[28] JOINT STATEMENT FROM THE NEW ZEALAND FOOD SAFETY AUTHORITY AND MINISTRY OF AGRICULTURE AND FORESTRY. BSE in the US has no food safety impact in New Zealand or threat to our animal health status. 24 December 2003
[29] New Zealand’s Scrapie Freedom.  New Zealand Food Safety Authority.  Nzfsa.gov 2/16/06
[30] Scudel A.A, et al.  Analysis of risk factos and active surveillance for BSE in Argentina.  Siiap.sagyp.mecon.ar 02/16/06
[31] Clinical Reference Guide, Revised April 2018

All products distributed by Doctors’ Research, Inc. are nutritional and are not intended for the treatment or prevention of any medical conditions.

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Vitamin B-6, B-12 & Folate™ Article

Vitamin B-6, B-12, & Folate™

100% Food Vitamin B-6, B-12, & Folate is a natural, vegetarian, Food complex source of vitamin B-6, vitamin B-12, and folate, essential nutrients that support human health, including blood [1,2]. Doctors’ Research has been supplying health care professionals Vitamin B-6, B-12, & Folate since 1998.

Unlike other brands, 100% Food Vitamin B-6, B-12, & Folate contains no USP vitamins or vitamin forms foreign to the human body.

Vitamin B-6:
“An understanding of the various forms and quantities of these forms in foods is important in the evaluation of the bioavailability and metabolism of vitamin B-6”… one of the forms that vitamin B-6 exists is in the form of “5’0-(beta-D-glycopyransosyl) pyridoxine. To date only plant foods have been found to contain this interesting form of vitamin B-6” [3]. Yeast and brown rice contain more natural Food vitamin B-6 than other Foods [4]. Vitamin B-6 was first reported in the 1930s [5]. At least one synthetic vitamin B-6 analogue has been found to inhibit natural vitamin B-6 action [6]. Pyridoxine HCL (hydrochloride) which is found in most non-Food supplements, is made with petroleum ester combined with HCL and processed with formaldehyde [7].

“Disorders treated with (B-6)…include Down’s syndrome, autism, hyperoxaluria, gestational diabetes, carpal tunnel syndrome, depression, and diabetic neuropathy”, but the results are consider by some in the mainstream as having “limited value” [1]. Vitamin B-6 is considered to be a first-line treatment for Lennox-Gastaut and some other seizure disorders [8,9]. Many problems including anemias, premenstrual dysphoric disorder (PMDD), PMS, cardiovascular complaints, confusion, depression, irritability, and certain immune problems have responded to vitamin B-6 [9]. A study of healthy elderly individuals found about 1/3 had marginal vitamin B-6 deficiency [9].

Vitamin B-12:
Initially Food vitamin B-12 was given for people with pernicious anemia in the form of raw liver, but due to cost considerations a synthetic USP isolate (cyanocobalamin) was developed [6]. Cyanocobalamin, the common pharmacological (USP) form of vitamin B-12, is essentially cobalamins combined with cyanide! [6]. The only two naturally active forms of vitamin B-12 in the human body are methylcobalamin and deoxyadenosylcobalamin and those are in Food [1]. Vitamin B-12 when ingested in its human-active form is non-toxic [1], yet some researchers have concluded “The efficacy and safety of the vitamin B-12 analogues created by nutrient-nutrient interaction in vitamin-mineral supplements is unknown” [10]; interestingly some synthetic vitamin B-12 analogues seem to be antagonistic to vitamin B-12 activity in the body [11,12]! Insufficient vitamin B-12 results in anemia, degeneration of peripheral nerves, and skin hypersensitivity [1,2].

“Vitamin B12, cobalamin, is indispensable for humans owing to its participation in two biochemical reactions: the conversion of l-methylmalonyl coenzyme A to succinyl coenzyme A, and the formation of methionine by methylation of homocysteine” [13].

100% Food Vitamin B-6, B-12, & Folate contains methylated vitamin B-12, a superior form [14].

Vitamin ‘B-9’, Folate
The vitamin once known as B-9 exists in foods as folate. Initially Food folate was given for people with a pregnancy-related anemia in the form of autolyzed yeast; later a synthetic USP isolate was developed [1]. Pteroylglutamic acid (folic acid), the common pharmacological (USP) form of folate is not found significantly as such in the body [1].

“Folic acid is a synthetic folate form” [9]. Folic acid, such as in most supplements, is not found in Foods, folate is [19]. Insufficient folate can result in fatigue, depression, confusion, anemia, reduced immune function, loss of intestinal villi, and an increase in infections [2]. Folate deficiency is the most important determinant in high homocysteine levels [11], and supplemental folate is effective in reducing homocysteine [15,16]. “The highest concentrations of folate exist in yeast…” [1]. Insufficient folate can result in fatigue, depression, confusion, anemia, reduced immune function, loss of intestinal villi, and an increase in infections [2]. “(C)onsumption of more than 266 mcg of synthetic folic acid (PGA) results in absorption of unreduced PGA, which may interfere with folate metabolism for a period of years” [1].

A 2004 paper from the British Medical Journal confirmed what many natural health professional have known all along: since folic acid is unnatural and the body cannot fully convert large amounts of it into usable folate, this artificial substance can be absorbed and may have unknown negative consequences in the human body [17], folate supplementation obviously should be in Food folate forms and not folic acid!

Many scientists have concerns about folic acid [18]. High consumption of folic acid is dangerous [20].

Vitamins B-6, B-12, and Folate are all important nutrients for healthy blood; the absence of any of them can trigger various forms of anemia (especially pernicious anemia) [1,18]. Subclinical deficiencies in vitamin B-12, vitamin B-6, and folate may impair cognitive function [21].

Homocysteine responds to vitamin B-12 and folate [16]. Dr. Mason of Tufts University School of Medicine reports that a 20% elevation of homocysteine significantly increases the risk of cardiovascular disease [12]. Normal homocysteine level is about 12 umol/L, while cardiovascular risk increases about 14-16 umol/L [22]. In addition, even if blood tests for vitamin B-12 or folate appear to be normal, this may be because results are masked by an elevated level of homocysteine. Homocysteine is highly implicated in vascular diseases (such as cardiovascular and other vascular disorders), and can be reduced with sufficient vitamin B-12 and Folate; with vitamin B-6 sometimes playing a supporting role [16].

Superoxide Dismutase:
“Superoxide dismutase (S.O.D.) is one of the most important enzymes that function as cellular antioxidants…The absence of this enzyme is lethal” [1]. “It protects intracellular components from oxidative damage, converting the superoxide ion to hydrogen peroxide” [1]. S.O.D. is a powerful free radical scavenger which has been clinically shown to protect the brain, heart, liver, lungs, kidneys, skin, muscles, penis, nerves, and spinal cord from ischemic injury [23]. High levels of S.O.D. have been associated with reduced growth of Candida albicans [24]. 100% Food Vitamin B-6, B-12, and Folate naturally contains S.O.D.

Organic Brown Rice also a Food complex source of silicon and B vitamins [2,25-28].

Since Vitamin B-6, B-12& Folate contains only Foods, unlike other isolated supplements, it also naturally includes vitamin B-1 (thiamin), vitamin B-2 (riboflavin)vitamin B-3 (niacinamide), vitamin B-5 (pantothenate), choline, inositol, and other B vitamin factors which often work with vitamins B-6B-12, and folate in the body. All these factors make 100% Food Vitamin B-6, B-12& Folate the choice for doctors interested in truly natural health.

Many females simply take Vitamin B-6, B-12& Folate as a Food supplement to help them feel better.

Some of these studies (or citations) may not conform to peer review standards, therefore, the results are not conclusive. Professionals can, and often do, come to different conclusions when reviewing scientific data. None of these statements have been reviewed by the FDA. All products distributed by Doctors’ Research, Inc. are nutritional and are not intended for the treatment or prevention of any medical conditions.

Vitamin B-6, B-12 & Folate™

Unlike other so-called “whole food” formulas, Vitamin B-6, B-12 & Folate™does not contain USP folic acid as that form is not what is found in natural foods.  Vitamins B6, B12, and B9 support healthy blood. B12 is essential for myelin synthesis and central nervous system function.

Unlike most so-called “natural” supplements, Vitamin B-6, B-12 & Folate™ does not contain any folic acid, which is a sythetic from of vitamin B-9 and is dangerous (for more details, please check out the article on Folic Acid Dangers)

References

[1] Shils ME, Olson JA, Shike M. Modern Nutrition in Health and Disease, 9th ed. Williams & Wilkins, Balt., 1999
[2] Whitney EN, Hamilton EMN. Understanding Nutrition, 4th ed. West Publishing, NY, 1987
[3] Leklem JE. Vitamin B6. In Modern Nutrition in Health and Disease, 8th ed. Lea & Febiger, Phil.,1994:383-394
[4] Ensminger AH, Ensminger ME, Konlade JE, Robson JRK. Food & Nutrition Encyclopedia, 2nd ed. CRC Press, New York, 1993
[5] Shils ME, et al. Modern Nutrition in Health and Disease, 10th ed. Lipponcott Williams & Wilkins, Balt., 2006
[6] Mervyn L. The B Vitamins. Thorsons, Wellingborough (UK), 1981
[7] Vitamin-Mineral Manufacturing Guide Nutrient Empowerment, volume 1. Nutrition Resource, Lakeport (CA), 1986
[8] Glauser TA, Morita DA. Encephalopathic epilepsy after infancy. In Pediatric Epilepsy, 2nd ed. Demos, New York, 2001:201-218
[9] Hendler SS, Rorvik D, eds. PDR for Nutritional Supplements. Medical Economics, Montvale (NJ), 2001
[10] Shils ME, Olson JA, Shike M. Modern Nutrition in Health and Disease, 8th ed. Lea & Febiger, Phil., 1994
[11] Ishida A, Kanefusa H, Fujita H, Toraya T. Microbiological activities in nucleotide loop-modified analogues of vitamin B12. Arch Microbiol 1994;161(4):293-299
[12] Tandler B, Krhenbul S, Brass EP. Unusual mitochondria in the hepatocytes of rats treated with a vitamin B12 analogue. Anat Rec 1994;231(1):1-6
[13] Moracova M, et al. Biological properties of vitamin B12. Nutr Res Rev. 2025 Jun;38(1):338-370
[14] Mather Y, Hazra AB. Methylations in vitamin B12 biosynthesis and catalysis. Curr Opin Struct Biol. 2022 Dec:77:102490
[15] Verhoef P. Homocysteine metabolism and risk of myocardial infarction: Relation with vitamin B6, B12, and Folate. Am J Epidemiol 1996;143(9):845-859
[16] Brattstrom L. Vitamins as homocysteine-lowering agents: A mini review. Presentation at The Experimental Biology 1995 AIN Colloquium, April 13, 1995, Atlanta Georgia
[17] Lucock M. Is folic acid the ultimate functional food component for disease prevention? BMJ, 2004;328:211-214
[18] Menezo Y. Folic Acid, Folinic Acid, 5 Methyl TetraHydroFolate Supplementation for Mutations That Affect Epigenesis through the Folate and One-Carbon Cycles. Biomolecules. 2022 Jan 24;12(2):197
[19] Macrae R, Robson RK, Sadler MJ. Encyclopedia of Food Science and Nutrition. Academic Press, NY, 1993
[20] Thiel R.  Folic Acid is Hazardous to Your Health.  What About Food Folate?  The Original Internist, 17(2) June 2010, 88-90; Thiel R. Is Folic Acid is Hazardous to Your Health? What About Food Folate? Monitor of Naturopathy, Spring 2025
[21] Gonzalez-Gross M, Marcos A, Pietrzik K. Nutrition and cognitive impairment in the elderly. Br J Nutr 2001;86:313-321
[22] Brown S, et al. High serum homocysteine appear to be a risk factor. Family Practice News May 1, 1995:25
[23] Null G. Superoxide Dismutase. In The Clinician’s Handbook of Natural Healing. Kensington Books, New York, 1997:137-144
[24] Romandini P, Bonotto C, Bertoloni G, Beltramini M, Salvato B. Superoxide dismutase, catalase and cell dimorphism in Candida albicans cells exposed to methanol and different temperature. Comp Biochem Physiol Pharm Toxicol Endocrinol,1994;108(1):53-57 [25] Thompson FE, et al. Sources of fiber and fat in the diets of U.S. women ages 19 to 50: implications for nutritional education and policy. Am J Pub Health 1992, 82(5):695-702
[26] Dietary fiber: importance of function as well as amount. Lancet 1992, 340:1133-1134
[27] Jensen B. The Chemistry of Man. Bernard Jensen, Escondido, 1983
[28] Nielsen FH. Ultratrace minerals. In Modern Nutrition in Health and Disease, 9th ed. Williams and Wilkins, Balt.;1999:283-303

All products distributed by Doctors’ Research, Inc. are nutritional and are not intended for the treatment or prevention of any medical conditions.

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or Email Us at doctorsfoodresearch@gmail.com for more info.

The TRUTH About GLANDULARS In Nutritional Supplements

Some natural health products contain glandular ingredients and many doctors have used glandulars for years with great success.  Glandular organs, such as heart, aorta, and liver, have been a food source in the human diet for centuries. The consumption of glandulars is believed to provide nutritional support to the corresponding gland in the human body. Glandular organs contain food vitamins and minerals and were often used in the past to supply various nutrients.

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Arginase Bladder™– Nutritional Support for Urine Metabolism and Bladder

Urination is something many people think little about unless something goes wrong.  From excessive urination to nocturnal enuresis to urinary tract infections to urinary incontinence, urinary issues are problems for many.

Most people do not realize that in order to produce urine, the body processes liquids into an intermediate stage which is high in the amino acid called arginine. Normally the liver produces enough of the enzyme arginase to convert and concentrate this liquid into urea (urine) [1]. When it does not, however, in some people this seems to cause the body to try to expel this high arginine liquid excessively, both day and night.

Decades ago a nutrition-based biological process was developed to assist the body with this aspect of urine metabolism . And now, there is actually one and only one 100% food product that utilizes this special biological process without any USP “nutrients” called Arginase Bladder. Arginase bladder is a 100% Food supplement that is intended to supply nutrients to support healthy kidney and bladder function. The kidneys process proteins and liquids and are the primary organs involved in eliminating metabolic waste products from the blood. Arginase Bladder is intended to support the cleansing ability of the kidneys.  It has been written that this type of product is indicated sometimes when there is “[p]ain in area of kidneys or bladder (may radiate through dorsal region to liver area) burning on urination; uremia, uriniferous odor of breath, itching of skin from “salty” (residue) perspiration; edema; ascites, dropsy, etc.; toxemia, body odor, pasty skin, biliousness; liver disease, enlargement, diminished urination, veinous congestion, etc”.a valuable adjunct in all problems involving the liver and kidneys, particularly where this is evidenced by systemic manifestations involving the detoxification mechanisms and fluid balance” [2].

It is a scientific fact that, “Arginase hydrolyzes arginine to urea”. In addition to raising serum arginine levels, arginase deficiency can lead to raised ammonia levels [3]. Arginase is produced in the liver [1,3].

Arginase Bladder contains ingredients which have been used to nutritionally support the bladder and various aspects of urine metabolism. 

Acerola Cherry is one of the most vitamin C dense foods [4]. Arginase is activated by vitamin C [5]. One study found that vitamin C taken prophylactically by pregnant and nursing mothers could reduce the incidence of urinary tract infections [6]. 

Beet and rice specially processed with Rhizopus oryzae and Tillandsia usneoides has long been used to support, “Intermediate processes involving urea metabolism which support liver and kidney function where toxic overload places stress on these organs” [2]. Many decades ago, Royal Lee, Bill Hansen, and David Roderick worked together. A special type of biological process for urinary support was developed around that time that David”s son Steven Roderick uses for Arginase Bladder. Beets themselves have long been used for kidney and bladder disorders [7].

Bovine kidney supplies kidney tissue. Kidney tissue naturally contains kidney enzymes, proteins, and other peptides needed for proper renal function. “The kidneys perform their most important functions by filtering the plasma and removing substances from the filtrate at a variable rate, depending upon the needs of the body. Ultimately, the kidneys “clear” unwanted substances from the filtrate (and therefore from the blood) by excreting them in the urine while returning substances that are needed back to the blood”Urine formation begins with filtration of large amounts of fluid through the glomerular capillaries into Bowman”s capsule”The kidney conserves water by excreting a concentrated urine” [8]. Helping concentrate urine also reduces the possibility of urinary tract infections, and reduces extra trips to the restroom. Kidney tissue is recommended for urinary tract infections and to strengthen the kidneys [9]. 

Bovine liver supplies liver tissue. Bovine liver tissue contains the substances naturally found in the liver, like arginase [1]. In order to convert the high arginine intermediate substrate into urea and orthinine, the body uses the enzyme arginase. “The liver has the greatest amount of this enzyme, and accounts for the majority of urea synthesis”[a] small amount is carried out by the kidney and brain”the hydrolysis of arginine to urea and orthinine makes possible the urea cycle” [1]. An excess accumulation of arginine (due to insufficient arginase) contributes to excessively frequent urination (as the body tries to flush this diluted semi-urine out) and increases in urinary tract infections (as this less concentrated semi-urine is a less hostile environment for pathogens than concentrated urine is). “The liver is well known for its ability to detoxify or excrete”many drugs”hormones” and other substances” [8]. The liver tissue found in Uro-Kid Supportis from New Zealand.

Buckwheat juice and seed has long been used as part of nutrition to support the intermediate processes involving urea metabolism and “support liver and kidney function where toxic overload places stress on these organs” [2]. “A 20% drop in systolic level is not unusual in the initial stages, progressively lowering under long term use. Importance of protracted treatment should be stressed” [10]. Though most often recommended for capillary and venous health (i.e. bruising, varicose veins) [10,11], naturopaths, chiropractors, and holistic doctors have long recommended its leaves or its immune supporting components in products to fight viral and bacterial infections [9,12,13]. In addition to containing chlorophyll, presumably active components include rutin, quercitin, and hyperoside [11] (it also contains other semi-unique Food substances that may be actively needed). It should be noted that, despite its name, buckwheat is not taxonomically related to wheat, and is often used in gluten-free, wheat-free diets [14]. 

Carrots are probably the highest concentrated Food source of the vitamin A precursor beta carotene. “Scientists in India have discovered that carrots afford significant protection for the liver” as carrots contain substances which “increase the activity of several enzymes that speed up detoxification of the liver and other organs” [15]. Carrots appear to have some bladder protection benefits [16].

Goat bladder supplies bladder tissue. Bladder tissue naturally contains the peptides and enzymes that the bladder needs for nutritional support. “The urinary bladder”is a smooth muscle chamber composed of two main parts: (1) the body, which is the major part of the bladder in which urine collects, and (2) the neck, which is a funnel-shaped extension of the body”connecting with the urethra”sensory fibers detect the degree of stretch in the bladder wall. Stretch signals from the posterior urethra are especially strong and are mainly responsible for bladder emptying” [8]. 

Peas have been shown to contain a substance that has “arginine decarboxylase (ADC) activity” [17]. This means that it can help break carbon away from arginine [1,8]. Peas have long been part of arginase related products [i.e. 2]. 

People simply take 100% Food Arginase Bladder to feel better.