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Microplastic and Nanoplastic Detoxification and Turmeric-Boswellia C

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DOCTORS' RESEARCH, INC.

Microplastic and Nanoplastic Detoxification and Turmeric-Boswellia C

Executive summary: There are major concerns about microplastics and nanoplastics that enter into the human body orally and/or through breathing. Although there is no universally accepted way to detoxify the body of all of them, there are foods such as acerola cherries, fenugreek, ginger, boswellia, turmeric, and others that have been shown to support the reduction of inflammation and may support physiological defenses against oxidative or inflammatory stress associated with microplastic exposure. This is because of their:

  1. Nutrient components (vitamin C, quercetin, saponins),
  2. Containing of amphiphilic compounds that may form micelle-like structures during digestion,
  3. Ability to support bile metabolism,
  4. Ability to support liver and lymphatic detoxification, and
  5. Ability to prevent and/or remove oxidative damage (which can be an indirect result of plastic ingestion).

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Turmeric Boswellia C contains a combination of foods with those properties. While precise mechanisms for removal of plastics in the human body are not fully understood, studies support the view that the combining of these foods is synergistically beneficial for detoxification and human health.

  • Supports healthy joints
  • Natural antioxidant
  • Synergystic herbal blend
  • Supports healthy blood sugar levels

Turmeric-Boswellia C™ supplies herbs which have traditionally been used to support joint health and comfort. Some of the herbs also can support healthy blood sugar levels. 

Turmeric-Boswellia C™ is a synergistic blend of herbs which also supplies 100% Food vitamin C. These foods can aid in reducing inflammation and free radical damaged caused by enivronmental, microplastic, and other toxins.

Plastic Issues and Remedies

“Nanoplastics (NPs) as contaminants in food and water have drawn increasing public attention … NPs reduce brain function” [1]. Microplastics and nanoplastics are being implicated in neurological degeneration, negative effects of aging, and other matters. Animal studies have shown these plastics can trigger inflammatory responses [1,2].

Avoidance of all such plastics is basically impossible in the 21st century, but people would be wise to reduce exposure.

Beyond that, while there is no accepted ‘treatment’ for all ingested microplastics or nanoplastics, that does not mean that foods and nutrients from foods cannot be helpful in their removal or with any inflammation they may cause.

Consider that many foods and herbs have historically been used to assist with inflammation [1]. The combination of anti-inflammatory foods found in Turmeric- Boswellia C is something to consider.

Understand that plastics are composed of hydrophobic molecules [3]. It has been shown that amphiphilic block copolymers self-assemble into micelles with a hydrophobic core that can solubilize/encapsulate hydrophobic molecules such as those found in plastics [3].

A micelle is a supramolecular structure formed by amphiphilic molecules — compounds with both a hydrophobic (nonpolar) part and a hydrophilic (polar) part. They spontaneously form spherical (or sometimes cylindrical) aggregates in aqueous solution, with the hydrophobic tails inward and the hydrophilic heads outward. Classic examples include detergents, bile salts, phospholipids, and saponins.

While no foods literally contain amphiphilic micelles in the same structured form found in lab surfactant systems, many foods naturally form micelles during digestion, or contain molecules capable of forming micelles once mixed with bile or water–fat interfaces.

Foods such acerola cherries, fenugreek, ginger, boswellia, and turmeric have often been found to work better together than separately. Furthermore, they do contain molecules that can act amphiphilically and may form micelle-like or colloidal aggregates under certain conditions (especially in water or oil-water mixtures). So, while they don’t contain pre-formed micelles in the same sense as soap or bile, extracts from these plants can self-assemble into micelle-like colloids because of their natural amphiphilic compounds. This may account for the finding that some substances contained within them, like saponins which are in all of them (though most abundant in fenugreek), may influence microplastic aggregation, adsorption, and elimination [4].

Saponins are textbook amphiphilic molecules and form micelles that can encapsulate hydrophobic substances [5,6]—microplastics are hydrophobic substances. Although many microplastic particles are too large to be encapsulated in micelles, nanoplastics certainly can be. Other effects from saponins on larger microplastic particles would likely relate to surface adsorption or changes in aggregation, as opposed to true micelle entrapment.

Although many plastics/polymers are electrically neutral, their surface reactivity and leached chemicals can provoke oxidative stress. Thus, their presence in living organisms can result in oxidative damage [7]. Therefore, antioxidant containing foods (like acerola cherries) can help reduce, as well as “clean up,” some of that damage.

Acerola Cherries

Acerola cherries (Malpighia emarginata DC) are one of the richest natural sources of vitamin C and contain phytonutrients like carotenoids phenolics, anthocyanins, and flavonoids [8]. “The vitamin C produced by acerola is better absorbed by the human organism than synthetic ascorbic acid” [9]. The presence of functional phytochemicals in acerola has been shown to influence the intestinal epithelial cells to increase the cellular uptake of vitamin C as opposed to vitamin C alone [10]. “Acerola…contains bioflavonoids” [11], anthocyanins, and quercetin [12]. An animal study found that “acerola juice reduces low-grade inflammation” [13]. Vitamin C “occurs in the body in the form of ascorbate, known for its strong antioxidant and anti-inflammatory properties” [14]. Not only does vitamin C have free radical scavenging abilities, it also has been shown to increase the antioxidant abilities of some other foods [6]. Vitamin C has been shown to “reduce stress markers and inflammation by neutralizing harmful molecules, activating protective pathways, and regulating autophagy, providing potential protection” associated with microplastics [4]. Curcumin, which is a component of turmeric, tends to improve the anti-inflammatory traits of vitamin C [15]. Studies show that vitamin C can reduce toxicities [16]. Acerola cherries contain both vitamin C and bioflavonoids which work synergistically, whereas one study showed that vitamin C “acts synergistically to protect cutaneous tissue cells in culture against oxidative damage” [16].

An in vitro study performed at Doctors’ Research with a digital ORP meter demonstrated that a citrus food vitamin C has negative ORP, but that ascorbic acid had positive ORP [17]. It is negative ORP which better helps clean up oxidative damage [18]. Since ascorbic acid has positive ORP (as well as positive redox potential [19]), it can never replace food vitamin C. Thus, high vitamin C foods, such as acerola cherries, should be considered when plastic ingestion contributes to free radical damage.

Boswellia Gum

Boswellia Gum (Boswellia Serrata), also known as frankincense, has been shown to have anti-inflammatory and anti-oxidant properties [20,21]. An animal study it helpful against the effect of toxicants [22]. Boswellia’s anti-inflammatory and anti-oxidant properties may account for its protection against induced toxins [23]. “The gum exudate obtained from the bark of the tree B. serrata, also called Indian olibanum, has been … widely used in various formulations for the treatment of inflammation” [24]. Boswellia contains triterpenoids. Triterpenoids, although themselves highly hydrophobic, can form colloids in the presence of other amphiphilic compounds (e.g., phospholipids or surfactants in extracts) [25]. “For several thousand years (~4000) Boswellia serrata and Curcuma longa have been used in Aryuvedic medicine for treatment of various illnesses … which are mediated through pathways associated with inflammation … The anti-inflammatory effects of boswellic acids and curcumin have translated to … the improvement … as shown in numerous clinical trials” [26]. Other studies have also pointed to the synergistic benefit of combining boswellia and turmeric together [27]. Another paper concluded that boswellia and fenugreek worked well together [28].

Fenugreek

“Fenugreek (Trigonella foenum graecum L.) (FG) is a plant … with … anti-inflammatory, anti-oxidant, … effects … evidence supports a role for fenugreek in protecting against … inflammation” [29]. It is approved by German Commission E for inflammation of the skin [20]. It has also been found to be helpful for dealing with toxins and inflammation of the lungs [30]. Fenugreek gum and Boswellia gum have been found to work synergistically [31]. Fenugreek contains quercetin [32]. Fenugreek also contains saponins [20]. Saponins in fenugreek can influence bile acid metabolism and lipid emulsification, which may aid in the detoxification of nanoplastics [33]. Fenugreek saponins, “After oral administration, with gentle stirring in the gastrointestinal fluids, they form micro- or nanoemulsions” [34]. Thus, that could also be why fenugreek can be helpful in detoxifying from nanoparticles substances like plastics.

Ginger Rhizome

Ginger Rhizome Zingiber officinale has anti-inflammatory effects [20]. “Scientific evidence supports the beneficial properties of ginger, including antioxidant and anti-inflammatory capacities” [35]. “Ginger, a well-known natural product, has been demonstrated to possess antioxidant, anti-inflammatory, … properties” and supports “healthy aging” [36]. “Overall, eight RCTs reported the anti-inflammatory effect of ginger supplementation” [37]. On a totally different note, a randomized double-blind study found health benefits when fenugreek, ginger, and turmeric were combined [38]. An animal study found that ginger looked to help protect against toxic changes caused by a type of plastic [39]. Ginger aids with bile metabolism [40]. Since in vitro research suggests that bile salts potentially appear to assist in aggregation of micro and nano plastics [41], this may represent one pathway by which ginger could influence the processing or aggregation of plastic particles, and thus may be a way ginger assists in the removal of plastics in the body.

Turmeric

“Turmeric (Curcuma longa) is a type of herb belonging to ginger family … Turmeric’s effects on health are generally centered upon an orange-yellow colored, lipophilic polyphenol substance called “curcumin,” which is acquired from the rhizomes of the herb. Curcumin is known to have antioxidant, anti-inflammatory, … effects [42]. “Turmeric has antihepatotoxic … and anti-inflammatory effects“ [20]. Curcuma longa (syn. C. domestica Valeton and C. brog Valeton) is also known as “turmeric” worldwide [43]. “In general, curcumin is beneficial to human health, demonstrating pharmacological activities of anti-inflammation and antioxidation” [44]. Curcumin in combination with boswellic acid is more effective “presumably due to synergistic effects of curcumin and boswellic acid” [45]. Turmeric compounds support “healthy aging” as they have helped prevent cellular damage [46] and may offer protective antioxidant activity against microplastic-induced stress [4]. A study including turmeric, ginger root, vitamin C, and boswellia extracts concluded there was efficacy of the blend [47]. Curcumin can form nanosized colloidal aggregates in aqueous media and in the presence of natural emulsifiers [48], hence that may explain turmeric’s aiding in the expulsion of microplastics.

Scientific research has concluded that the combinations of antioxidants such as vitamin C (which is in acerola cherries), quercetin (which is in acerola cherries and fenugreek) and curcumin (which is in turmeric) have been found to “reduce stress markers and inflammation by neutralizing harmful molecules, activating protective pathways, and regulating autophagy, providing potential protection” associated with microplastics [4].

Based on current scientific literature, ingredients such as turmeric, boswellia, fenugreek, ginger, black pepper, and acerola cherries provide synergistic antioxidant and anti-inflammatory support that may help mitigate some biological effects associated with microplastic exposure.

Adjunctive Products:

Liva-DeTox & Support, Herbal Antioxidant and Intestinal Support

Dr. Mercola has written, “The liver also plays an essential role in clearing microplastics from the bloodstream — Specialized immune cells in the liver, known as Kupffer cells, help trap these foreign particles and route them into bile for elimination via the intestines.” [49]. “The basic functions of the liver can be divided into (1) its vascular functions for storage and filtration of the blood, (2), its metabolic functions concerned with the majority of the metabolic systems of the body, (3) its secretory and excretory functions…About 1100 milliliters of bloods flows from the portal vein and into the liver sinusoids each minute, and about an additional 350 milliliters flows into the sinusoids from the hepatic artery” [50]. The liver thus partially detoxifies the equivalent of all the blood in the body several times per hour. The liver contains Kupffer cells, which are large macrophages that can efficiently cleanse the blood [50]. Liva-DeTox & Support which contains bovine liver tissue provides nutrients traditionally associated with liver support [51]. Liva-DeTox & Support contains milk thistle which is a source of silymarin. Silymarin appears to be helpful as an adjunctive for inflammation and oxidative stress management, which may be relevant to microplastic exposure for potential plastic detoxification [52]. Liva-DeTox & Support also supplies beets and garlic. Garlic has anti-inflammatory uses, whereas beets are said “to have antihepatoxic effects…probably due to the herb’s concentration of betaine” [20].

For additional antioxidant and detoxification support, consider Herbal Antioxidant. Herbal Antioxidant synergistically combines 12 antioxidant containing foods, including acerola cherries, ginger, milk thistle (silymarin source), and turmeric (curcumin source).

Also consider Intestinal Support, which includes bovine intestinal, lymphatic, and pancreatic tissue as well as collinsonia. An in vitro study involving rat derived intestinal epithelial tissue found that those tissues did uptake microplastics [53]. This lends support to the view that ingestion of bovine intestinal tissue may do the same thing, and as it would tend to be excreted, this could result in less microplastics remaining in the human body. Bovine pancreatic tissues naturally contain digestive enzymes. Lymphatic tissue contains macrophages [50]. Macrophages in the lymph nodes act as “clean-up” cells as they engulf and digest foreign particles that enter the lymph through lymphatic vessels. As oral consumption of bovine glands have long been considered by proponents to assist the organ they are related to in the human body [e.g. 54-56], it may be concluded that providing intestinal, lymphatic, and pancreatic tissue may help the excretion processes of intestines in humans. Collinsonia root (also known as stone root) which has long been used as an intestinal tonic and to aid against inflammation [20].

Yes, there is scientific evidence that ingredients in products such as Turmeric-Boswellia C, Liva-DeTox & Support, Herbal Antioxidant, and Intestinal Support should be considered to aid individuals who are concerned about ingested microplastics and nanoplastics.

 

Liva-DeTox & Support™

  • Supports a healthy liver
  • Helps deal with pollutants
  • Detoxifier
  • Supports healthy lymphatic system

Liva-DeTox & Support™ is a 100% Food supplement that is intended to supply nutrients, glandulars, and herbs needed to maintain and support optimal liver health. It supports detoxification from environmental and other toxins.

Liva-DeTox & Support™ naturally contains carbohydrates, lipids, and proteins (including all ten essential amino acids), and protein chaperones as found in the listed foods.

Herbal Antioxidant™

  • Provides 12 real antioxidant foods
  • Supplies 12 free-radical fighting foods
  • Superior source of antioxidants

Herbal Antioxidants™ is a 100% vegan Food supplement that is intended to supply real antioxidant nutrients needed to maintain and support optimal health and protection from free radicals (including some caused by micro/nano plastic reactions).

Each of the antioxidant nutrients are 100% whole food and synergistically protect against a wide range of free radicals. Antioxidants are believed to help address the effects of aging, support healthy brain tissue, maintain capillary integrity, restore collagen strength, supports healthy skin, and maintain a healthy cardiovascular system.

Intestinal Support™

  • Supports healthy intestinal tissue
  • Promotes proper digestion
  • Emulsifies fat
  • Tonifies gastro-intestinal system

Intestinal Support™ is a 100% Food supplement containing herbs and other glandulars to support intestinal and digestive health.

Intestines are involved in the digestion and absorption of nutrients as well as the excretion of waste. When they are not functioning well there can be digestive problems. If they are weak, hernias and/or colorectal issues sometimes develop. Bovine intestinal tissue provides peptides and enzymes to nutritionally support the intestines.

References

[1] Yang Q, et al. Oral feeding of nanoplastics affects brain function of mice by inducing macrophage IL-1 signal in the intestine. Cell Reports, Volume 42, Issue 4, 25 April 2023, 112346
[2] Bianchi M, et al. Biological Effects of Micro-/Nano-Plastics in Macrophages. Nanomaterials 2025, 15(5), 394; https://doi.org/10.3390/nano15050394
[3] Wang D, et al. Polymeric Micelles for the Delivery of Poorly Soluble Drugs: from Nanoformulation to Clinical Approval. Adv Drug Deliv Rev. 2020 Sep 24;156:80–118. doi: 10.1016/j.addr.2020.09.009
[4] Wang Z, et al. Antioxidant Intervention Against Microplastic Hazards. Antioxidants 2025, 14(7), 797
[5] Kim AV, et al. Mechanism of the enhancing effect of glycyrrhizin on nifedipine penetration through a lipid membrane. J Mol Liq. 2021 Dec 15:344:117759. doi: 10.1016/j.molliq.2021.117759
[6] Zhang J, et al. Saponin-Based Near-Infrared Nanoparticles with Aggregation-Induced Emission Behavior: Enhancing Cell Compatibility and Permeability. ACS Appl Bio Mater. 2019 Feb 18;2(2):943-951. doi: 10.1021/acsabm.8b00812
[7] Rui J. Exposure to Polypropylene Microplastics via Oral Ingestion Induces Colonic Apoptosis and Intestinal Barrier Damage through Oxidative Stress and Inflammation in Mice. Toxics. 2023 Jan 28;11(2):127. doi: 10.3390/toxics11020127
[8] Prakesh A, Baskaran R. Acerola, an untapped functional superfruit: a review on latest frontiers. J Food Sci Technol. 2018 Sep; 55(9): 3373–3384
[9] Assis SAD, Fernandes FP, Martins ABG, Oliveira OMMDF. Acerola: importance, culture conditions, production and biochemical aspects. Fruits. 2008;63(2):93–101; also published by Cambridge Press
[10] Takino Y, et al. Acerola (Malpighia emarginata DC.) Promotes Ascorbic Acid Uptake into Human Intestinal Caco-2 Cells via Enhancing the Gene Expression of Sodium-Dependent Vitamin C Transporter 1. J Nutr Sci Vitaminol (Tokyo). 2020;66(4):296-299

[11] Hwang J, Hodis HN, Sevanian A.  Soy and alfalfa phytoestrogen extracts become potent low-density lipoprotein antioxidants in the presence of acerola cherry extract. J Agric Food Chem. 2001;49(1):308-314
[12] Hanamura T, Mayama C, Aoki H, Hirayama Y, Shimizu M.  Antihyperglycemic effect of polyphenols from Acerola (Malpighia emarginata DC.) fruit.  Biosci Biotechnol Biochem. 2006 Aug;70(8):1813-20
[13] Dias FM, et al. Acerola (Malpighia emarginata DC.) juice intake protects against alterations to proteins involved in inflammatory and lipolysis pathways in the adipose tissue of obese mice fed a cafeteria diet. Lipids Health Dis. 2014; 13: 24
[14] Gegotek G, Skrzydlewska E.Antioxidative and Anti-Inflammatory Activity of Ascorbic Acid. Antioxidants (Basel). 2022 Oct; 11(10): 1993
[15] Chen L, et al. A Novel Combination of Vitamin C, Curcumin and Glycyrrhizic Acid Potentially Regulates Immune and Inflammatory Response Associated with Coronavirus Infections: A Perspective from System Biology Analysis. Nutrients. 2020 Apr; 12(4): 1193
[16] Hendler SS, Rorvik D. Pdr for Nutritional Supplementd, 2nd edition. Thomson Reuters, 2008
[17] Thiel R.  ORP Study on Food Vitamin C for Food Research LLC.  Doctors’ Research Inc., Arroyo Grande (CA), February 17, 2006
[18] Fowkes SW.  Antioxidants & reduction.  Smart Life News, 2000;7(9):6-8
[19] Budvari S, et al editors. The Merck Index: An encyclopedia of Chemicals, Drugs, and Biologicals, 12th ed.  Merck Research Laboratories, Whitehouse Station (NJ), 1996
[20] Gruenwald J, Brendler T, Jaenicke C, editors. PDR for Herbal Medicines, 4th ed.  Thomson, Montvale (NJ), 2007
[21] Beghelli D, et al. Antioxidant and Ex Vivo Immune System Regulatory Properties of Boswellia serrata Extracts. Oxid Med Cell Longev. 2017; 2017: 7468064
[22] Alyahya A, Asad M. Repeated 28-DAY oral dose study on Boswellia sacra oleo gum resin extract for testicular toxicity in rats. J Ethnopharmacol. 2020 Aug 10:258:112890. doi: 10.1016/j.jep.2020.112890
[23] Rahimi VB, et al. Boswellia serrata inhibits LPS-induced cardiotoxicity in H9c2 cells: Investigating role of anti-inflammatory and antioxidant effects. Toxicon. 2023 Jun 15:229:107132. doi: 10.1016/j.toxicon.2023.107132
[24] Almeida-da-Silva CL, et al. Effects of Frankincense Compounds on Infection, Inflammation, and Oral Health. Molecules. 2022 Jul; 27(13): 4174
[25] Cometa S, et al. Effectiveness of gellan gum scaffolds loaded with Boswellia serrata extract for in-situ modulation of pro-inflammatory pathways affecting cartilage healing. Int J Biol Macromol. 2024 Oct;277(Pt 1):134079. doi: 10.1016/j.ijbiomac.2024.134079
[26] Septhi V. Potential complementary and/or synergistic effects of curcumin and boswellic acids for management of osteoarthritis. Ther Adv Musculoskelet Dis. 2022; 14
[27] Bannuru RR, et al. Efficacy of Curcumin and Boswellia for Knee Osteoarthritis: Systematic Review and Meta-Analysis. Semin Arthritis Rheum. 2018 Dec; 48(3): 416–429
[28] Chattopadhyay K, et al. Effectiveness and Safety of Ayurvedic Medicines in Type 2 Diabetes Mellitus Management: A Systematic Review and Meta-Analysis. Front Pharmacol. 2022 Jun 8;13:821810
[29] Knott EJ, et al. Fenugreek supplementation during high-fat feeding improves specific markers of metabolic health. Sci Rep. 2017; 7: 12770
[30] Abdrabouh A. Inflammatory and proapoptotic effects of inhaling gasoline fumes on the lung and ameliorative effects of fenugreek seeds. Sci Rep. 2022; 12: 14446
[31] Kumar RV, Sinha VR. A novel synergistic galactomannan-based unit dosage form for sustained release of acarbose. AAPS PharmSciTech . 2012 Mar;13(1):262-75
[32] Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006.2025 Jul 15
[33] Shao Z, et al. Aggregation kinetics of polystyrene nanoplastics in gastric environments: Effects of plastic properties, solution conditions, and gastric constituents. Environment International, Volume 170, December 2022, 107628
[34] Sinka D, et al. Formulation, Characterization and Permeability Studies of Fenugreek (Trigonella foenum-graecum) Containing Self-Emulsifying Drug Delivery System (SEDDS). Molecules. 2022 Apr 29;27(9):2846. doi: 10.3390/molecules27092846
[35] Ballester P, et al. Effect of Ginger on Inflammatory Diseases. Molecules. 2022 Nov; 27(21): 7223
[36] Ozkur M. Ginger for Healthy Ageing: A Systematic Review on Current Evidence of Its Antioxidant, Anti-Inflammatory, and Anticancer Properties.Oxid Med Cell Longev. 2022; 2022: 4748447
[37] Anh NH, et al. Ginger on Human Health: A Comprehensive Systematic Review of 109 Randomized Controlled Trials. Nutrients. 2020 Jan; 12(1): 157
[38] Bumrungpert A, et al. Effects of Fenugreek, Ginger, and Turmeric Supplementation on Human Milk Volume and Nutrient Content in Breastfeeding Mothers: A Randomized Double-Blind Controlled Trial. Breastfeed Med. 2018 Nov 9. doi: 10.1089
[39] Denwer S, et. al. The possible protective effect of ginger extract on toxic changes induced by bisphenol A on the thyroid gland of adult male albino rats: light and electron microscopic study. Ultrastruct Pathol. 2024 Nov;48(6):445-475. doi: 10.1080/01913123.2024.2395849
[40] Yu Y, et al. Dry ginger and Schisandra chinensis modulate intestinal flora and bile acid metabolism to treatment asthma. Front Microbiol. 2025 Mar 27:16:1541335. doi: 10.3389/fmicb.2025.1541335
[41] Shao Z, et al. Aggregation kinetics of polystyrene nanoplastics in gastric environments: Effects of plastic properties, solution conditions, and gastric constituents. Environment International, Volume 170, December 2022, 107628
[42] Kocaadam B, Şanlier N. Curcumin, an active component of turmeric (Curcuma longa), and its effects on health. Crit Rev Food Sci Nutr. 2017 Sep 2;57(13):2889-2895
[43] Dosoky NS, Setzer W. Chemical Composition and Biological Activities of Essential Oils of Curcuma Species. Nutrients. 2018 Sep; 10(9): 1196
[44] Liu S, et al. A Comprehensive Review on the Benefits and Problems of Curcumin with Respect to Human Health. Molecules. 2022 Jul; 27(14): 4400
[45] Haroyan A, et al. Efficacy and safety of curcumin and its combination with boswellic acid in osteoarthritis: a comparative, randomized, double-blind, placebo-controlled study. BMC Complement Altern Med. 2018; 18: 7
[46] Rahman M, et al. Curcuma longa L. Prevents the Loss of β-Tubulin in the Brain and Maintains Healthy Aging in Drosophila melanogaster. Mol Neurobiol. 2022; 59(3): 1819–1835
[47] Bharat TB, et al. Ingredients of a Natural Oral Nutritional Supplement and Their Role in the Treatment of Osteoarthritis. Clin Med Insights Arthritis Musculoskelet Disord. 2022 Mar 25;15:11795441211063365
[48] Moutas S, et al. Curcumin-decorated nanoliposomes with very high affinity for amyloid-β1-42 peptide. Biomaterials. 2011 Feb;32(6):1635-45. doi: 10.1016/j.biomaterials.2010.10.027
[49] Mercola J. Study Finds Widespread Microplastics in Reproductive Fluids, What It Means for Fertility. Mercola.com, September 29, 2025
[50] Guyton AC, Hall JE. Textbook of Medical Physiology, 9th ed. WB Saunders, Phil., 1996
[51] Profiles in Nutritional Progress.  Rubicon Productions, Bakersfield, 1993
[52] Elsheikh A, et al. Polystyrene microplastic particles induced hepatotoxic injury via pyroptosis, oxidative stress, and fibrotic changes in adult male albino rats; the therapeutic role of silymarin. Toxicol Mech Methods. 2023 Nov;33(6):512-528. doi: 10.1080/15376516.2023.2191270
[53] Sofield CE, et al. Digestion of microplastics with simulated gastrointestinal conditions mitigates uptake by intestinal epithelial cells: Quantified by imaging flow cytometry. Journal of Hazardous Materials Volume 498, 15 October 2025, 139816
[54] Burns D. Accumulating scientific evidence supports glandular therapy.  The Digest of Chiropractic Economics, Nov/Dec 1987: 74-79
[55] Schwartz EF. Glandular therapy.  The American Chiropractor, January/February 1983:14-18
[56] Profiles in Nutritional Progress.  Rubicon Productions, Bakersfield, 1993

This document is intended solely for the use of health care professionals. It has not been evaluated by the US FDA or any other governmental authority. Scientists can, and do, often come to differing conclusions when looking at data and reports.

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Adenine – Sometimes Called Vitamin B-4

FOOD RESEARCH Products are "100% FOOD Nutrients"

Nutrition from FOOD, What a concept!™

DOCTORS' RESEARCH, INC.

Adenine, Sometimes Called Vitamin B-4

Most Food Research products contain what is called Vitamin B-4, Adenine. Adenine is considered by some health care professionals to be essential for heart health.

Published scientific evidence looks to support this (e.g. Yu F, et al. Nicotinamide Adenine Dinucleotide Supplementation to Alleviate Heart Failure: A Mitochondrial Dysfunction Perspective. Nutrients. 2025 May 29;17(11):1855; Tannus C, et al. Nicotinamide Riboside Supplementation Restores Myocardial Nicotinamide Adenine Dinucleotide Levels, Improves Survival, and Promotes Protective Environment Post Myocardial Infarction. Cardiovasc Drugs Ther. 2024 Dec;38(6):1385-1396; Leu JG, et al. The Cell Protective Effect of Adenine on Hypoxia–Reoxygenation Injury through PPAR Delta Activation. Life 2021, 11(12), 1408).

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Over the years, adenine has been referred to as vitamin B-4, though it is not officially considered to be an “essential” nutrient.

Additionally, it is known that adenine has a central role in cellular respiration. It is part of adenosine triphosphate which provides the energy that drives and supports most activities in living cells, such as protein synthesis, chemical synthesis, muscle contraction, and nerve impulse propagation. In respiration it also participates as part of the cofactors nicotinamide adenine dinucleotide, flavin adenine dinucleotide, and Coenzyme A (Amjad J, et al. Role of NAD+ in regulating cellular and metabolic signaling pathways. Mol Metab. 2021 Feb 17;49: 101195).

Do Food Research Supplements Contain Adenine?

Some have wondered if Food Research supplements contain adenine. The fact is that pretty much all of them do!

Two ingredients that are in many Food Research supplements are Saccharomyces cerevisiae and organic brown rice, both of which contain adenine.

Published research clearly supports this view. Let’s look at Saccharomyces cerevisiae:

Saccharomyces cerevisiae. The adenine content of individual yeast extract powders was examined in relation to the cell mass (dry cell weight, DCW) achieved in culture media formulated with these powders. A general increase in DCW was observed with increasing adenine concentration in the yeast extract. … A minimum requirement for cell growth is at least as low as 12.5 mg of adenine/g of cells. (VanDousin W, et al. Adenine quantitation in yeast extracts and fermentation media and its relationship to protein expression and cell growth in adenine auxotrophs of Saccharomyces cerevisiae. Biotechnol Prog. 1997 Jan-Feb;13(1):1-7)

Here is some of why Saccharomyces cerevisiae contains adenine:

Saccharomyces cerevisiae (baker’s or brewer’s yeast) contains adenine for the same fundamental reason every living cell does: adenine is a core building block of many essential molecules. Here’s how it functions in yeast:

  1. Nucleic acid synthesis
  • Adenine is one of the four nucleotide bases in DNA (A–T pairing) and RNA (A–U pairing).
  • Without adenine, the yeast could not replicate its genome or transcribe genes.
  1. Energy and metabolism
  • Adenine is part of adenosine triphosphate (ATP), the cell’s main energy currency.
  • It is also found in ADP, AMP, and in cofactors like NAD⁺/NADH and FAD (via adenine-containing adenosine moieties).
  1. Signaling and regulation
  • Cyclic AMP (cAMP), a derivative of adenine, is a key second messenger in yeast nutrient sensing and stress responses.
  1. Biosynthetic context
  • Yeast cells synthesize adenine de novo through the purine biosynthetic pathway, starting from simple precursors (like amino acids and ribose-5-phosphate).
  • Many lab strains have mutations in this pathway (e.g., ADE2, ADE8), which is why researchers often supplement growth media with adenine to prevent red pigment accumulation or growth defects.

So Saccharomyces cerevisiae doesn’t contain adenine for any special “yeast-only” reason—it’s a universal requirement of cellular life, critical for genetic information, energy transfer, and metabolic regulation.

It should be added that Saccharomyces cerevisiae has a higher concentration of adenine than wheat germ or organic brown rice.

At Doctors’ Research we wondered how much adenine would be in 521 mg of Saccharomyces cerevisiae, which is the minimum amount contained in Food Research’s B Stress Complex.

There isn’t a single fixed number, because the adenine content varies. But we can make a reasonable ball-park estimate from typical yeast composition.

  1. Find nucleic-acid content

Published analyses of dried baker’s yeast report roughly:

  • RNA: 5–10 % of dry weight (yeast is RNA-rich).
  • DNA: ~0.5 % of dry weight.

Let’s take a midrange total nucleic acid content ≈ 7 % of dry mass.

For 521 mg dry weight:

  • Total nucleic acids ≈ 0.07 × 521 mg ≈ 36 mg.
  1. Fraction of adenine bases

In RNA (adenine, cytosine, guanine, uracil) → ~25 % adenine by base count.
In DNA (adenine, thymine, cytosine, guanine) → ~25 % adenine.

So adenine bases ≈ 0.25 × 36 mg ≈ 9 mg (as the free base equivalent).

  1. Add other adenine-containing molecules

Yeast also contains ATP, NAD⁺, FAD, etc., but those pools are small compared with the bulk RNA. That might add perhaps another milligram or two of adenine equivalents.

Estimated range

≈ 8–12 mg of adenine (as free base) in 521 mg dried yeast
—roughly 1.5–2 % of the dry weight.

This is only a biochemical back-of-the-envelope figure.
Different growth phases, extraction methods, or definitions (free vs. bound adenine) can shift the result, but it gives you the right order of magnitude.

So, that is what we came up with independently.

Since the Saccharomyces cerevisiae in B Stress Complex comes from the Grow Company, we asked it for an ingredient by ingredient analysis. For all of the amounts claimed on the label, Grow estimated that there would be between 4.6 to 15.4 mg of adenine per capsule in B Stress Complex (Tical A. Adenine. Calculation Report, September 25, 2025).

However, since Food Research actually puts 10% more Grow nutrients than the B Stress Complex label states (for purposes of supporting the “Best Buy” date), then the range actually would appear to be 5.1 to 16.9 mg per capsule.

So, yes, the fact is that B Stress Complex , as well as many other Food Research supplements, contain a substantial amount of adenine, also sometimes called vitamin B-4.

Do not let anyone try to convince you otherwise.

Some of these studies (or citations) may not conform to peer review standards, therefore, the results are not conclusive. Professionals can, and often do, come to different conclusions when reviewing scientific data. None of these statements have been reviewed by the FDA. All products distributed by Doctors’ Research, Inc. are nutritional and are not intended for the treatment or prevention of any medical conditions.

B Stress Complex™

  • Supports energy metabolism
  • Eases stress
  • Superior source of B vitamins
  • Contains no dangerous synthetics

B Stress Complex™ naturally contains carbohydrates, lipids, proteins (including all ten essential amino acids), and superoxide dismutase as found in specially grown, enzymatically processed Saccharomyces cerevisiae, and organic brown rice. 

Unlike many so-called “natural” formulas, B Stress Complex™  formula contains no synthetic USP nutrients or isolated mineral salts, but only contains foods, food complexes, and food concentrates.

Vitamin B-6, B-12 & Folate™

  • Superior source of folate
  • Superior source of Vitamin B-6
  • Superior source of Vitamin B-12
  • Assists in balancing healthy homocysteine levels

Unlike other so-called “whole food” formulas, Vitamin B-6, B-12 & Folate™does not contain USP folic acid as that form is not what is found in natural foods.  Vitamins B6, B12, and B9 support healthy blood. B12 is essential for myelin synthesis and central nervous system function.

Unlike most so-called “natural” supplements, Vitamin B-6, B-12 & Folate™ does not contain any folic acid, which is a sythetic from of vitamin B-9 and is dangerous (for more details, please check out the article on Folic Acid Dangers)

Vitamin-Mineral™

  • Protective array of carotenoids and anti-aging antioxidants
  • Superior vitamin forms and superior mineral forms
  • Easy to digest & can be taken on an empty stomach without upset

Food  Vitamins and Minerals ARE Better!

Most multi-vitamin formulas are primarily synthetic (e.g. petroleum-derived) vitamins plus crushed industrial rocks, yet even peer reviewed medical research has concluded that food vitamins are superior to synthetics [1].

Numerous scientific papers have concluded that Food vitamins and minerals are better than USP isolated ‘nutrients’ because they contain important enzymes, peptides and phytonutrients which are critical to the utilization of vitamins and minerals and are lacking in isolated USP nutrients [e.g. 1,2].

References

[1] Shils ME, Olson JA, Shike M. Modern Nutrition in Health and Disease, 9th ed. Williams & Wilkins, Balt., 1999
[2] Whitney EN, Hamilton EMN. Understanding Nutrition, 4th ed. West Publishing, NY, 1987
[3] Leklem JE. Vitamin B6. In Modern Nutrition in Health and Disease, 8th ed. Lea & Febiger, Phil.,1994:383-394
[4] Ensminger AH, Ensminger ME, Konlade JE, Robson JRK. Food & Nutrition Encyclopedia, 2nd ed. CRC Press, New York, 1993
[5] Shils ME, et al. Modern Nutrition in Health and Disease, 10th ed. Lipponcott Williams & Wilkins, Balt., 2006
[6] Mervyn L. The B Vitamins. Thorsons, Wellingborough (UK), 1981
[7] Vitamin-Mineral Manufacturing Guide Nutrient Empowerment, volume 1. Nutrition Resource, Lakeport (CA), 1986
[8] Glauser TA, Morita DA. Encephalopathic epilepsy after infancy. In Pediatric Epilepsy, 2nd ed. Demos, New York, 2001:201-218
[9] Hendler SS, Rorvik D, eds. PDR for Nutritional Supplements. Medical Economics, Montvale (NJ), 2001
[10] Shils ME, Olson JA, Shike M. Modern Nutrition in Health and Disease, 8th ed. Lea & Febiger, Phil., 1994
[11] Ishida A, Kanefusa H, Fujita H, Toraya T. Microbiological activities in nucleotide loop-modified analogues of vitamin B12. Arch Microbiol 1994;161(4):293-299
[12] Tandler B, Krhenbul S, Brass EP. Unusual mitochondria in the hepatocytes of rats treated with a vitamin B12 analogue. Anat Rec 1994;231(1):1-6
[13] Moracova M, et al. Biological properties of vitamin B12. Nutr Res Rev. 2025 Jun;38(1):338-370
[14] Mather Y, Hazra AB. Methylations in vitamin B12 biosynthesis and catalysis. Curr Opin Struct Biol. 2022 Dec:77:102490
[15] Verhoef P. Homocysteine metabolism and risk of myocardial infarction: Relation with vitamin B6, B12, and Folate. Am J Epidemiol 1996;143(9):845-859
[16] Brattstrom L. Vitamins as homocysteine-lowering agents: A mini review. Presentation at The Experimental Biology 1995 AIN Colloquium, April 13, 1995, Atlanta Georgia
[17] Lucock M. Is folic acid the ultimate functional food component for disease prevention? BMJ, 2004;328:211-214
[18] Menezo Y. Folic Acid, Folinic Acid, 5 Methyl TetraHydroFolate Supplementation for Mutations That Affect Epigenesis through the Folate and One-Carbon Cycles. Biomolecules. 2022 Jan 24;12(2):197
[19] Macrae R, Robson RK, Sadler MJ. Encyclopedia of Food Science and Nutrition. Academic Press, NY, 1993
[20] Thiel R.  Folic Acid is Hazardous to Your Health.  What About Food Folate?  The Original Internist, 17(2) June 2010, 88-90; Thiel R. Is Folic Acid is Hazardous to Your Health? What About Food Folate? Monitor of Naturopathy, Spring 2025
[21] Gonzalez-Gross M, Marcos A, Pietrzik K. Nutrition and cognitive impairment in the elderly. Br J Nutr 2001;86:313-321
[22] Brown S, et al. High serum homocysteine appear to be a risk factor. Family Practice News May 1, 1995:25
[23] Null G. Superoxide Dismutase. In The Clinician’s Handbook of Natural Healing. Kensington Books, New York, 1997:137-144
[24] Romandini P, Bonotto C, Bertoloni G, Beltramini M, Salvato B. Superoxide dismutase, catalase and cell dimorphism in Candida albicans cells exposed to methanol and different temperature. Comp Biochem Physiol Pharm Toxicol Endocrinol,1994;108(1):53-57 [25] Thompson FE, et al. Sources of fiber and fat in the diets of U.S. women ages 19 to 50: implications for nutritional education and policy. Am J Pub Health 1992, 82(5):695-702
[26] Dietary fiber: importance of function as well as amount. Lancet 1992, 340:1133-1134
[27] Jensen B. The Chemistry of Man. Bernard Jensen, Escondido, 1983
[28] Nielsen FH. Ultratrace minerals. In Modern Nutrition in Health and Disease, 9th ed. Williams and Wilkins, Balt.;1999:283-303

All products distributed by Doctors’ Research, Inc. are nutritional and are not intended for the treatment or prevention of any medical conditions.

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GMOs and Health: Any Risk?

GMOs, or “genetically modified organisms,” are plants or animals that have been genetically engineered with DNA from bacteria, viruses or other plants and animals. These experimental combinations of genes from different species cannot occur in nature or in traditional crossbreeding.

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Nutritional Musculoskeletal Support

FOOD RESEARCH Products are "100% FOOD Nutrients"

Nutrition from FOOD, What a concept!™

DOCTORS' RESEARCH, INC.

Nutritional Musculoskeletal Support

The human body has a system of support for what is contained in it, including bones, cartilage, tendons, and ligaments.

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CARTILAGE
Cartilage is a firm, but flexible tissue, that cushions joints and provides structural support. It covers the ends of bones in joints (like the knee) to reduce friction and absorb shock. There are different types, including hyaline cartilage (in joints and the nose), elastic cartilage (in the ear), and fibrocartilage (in intervertebral discs). Cartilage is primarily made of chondrocytes (cartilage cells) embedded in a gel-like extracellular matrix. The matrix consists of collagen fibers, proteoglycans, and water, which give cartilage its flexibility and cushioning ability. Cartilage is avascular (lacks blood vessels), meaning it relies on diffusion for nutrient exchange.

LIGAMENTS
Ligaments are strong, fibrous bands of tissue that connect bone to bone and stabilize joints. They also help prevent excessive movement that could lead to injury. For example, the ACL (anterior cruciate ligament) helps to stabilize the knee. Ligaments are made mostly of dense regular connective tissue, rich in collagen fibers (mostly Type I collagen). The collagen fibers are arranged in the body in a slightly wavy pattern, allowing for some elasticity but mainly providing strong, stable connections between bones. Ligaments have some blood supply, but healing can still be slow due to limited circulation.

TENDONS
Tendons are tough, rope-like structures that connect muscle to bone. They transmit the force generated by muscles to move the bones. The Achilles tendon, for instance, connects the calf muscles to the heel bone. Tendons are composed of dense regular connective tissue, with parallel bundles of Type I collagen fibers that make them incredibly strong. Tendons have tenocytes (specialized tendon cells) that help maintain the structure. Tendons contain less elastin than ligaments, making them more rigid, which is necessary for efficiently transmitting force from muscle to bone. They have a better blood supply than cartilage but less than muscles, meaning healing is slow but not as slow as cartilage.


Cartilage, ligaments, and tendons are mainly composed of collagen. In addition to various proteins, various nutrients are involved in its production. For example, vitamin C functions as a cofactor for enzymes (prolyl and lysyl hydroxylase) that help stabilize collagen structure. Silicon is essential for the production of collagen and glycosaminoglycans (GAGs), which form the extracellular matrix of cartilage, as it helps in the cross-linking of collagen fibers, making them stronger and more stable. Omega 3 fatty acids can help reduce inflammation, which can degrade collagen over time.

Below are 100% FOOD Supplements intended for Nutritional Musculoskeletal Support

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Simply Female Article

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Nutrition from FOOD, What a concept!™

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Simply Female™

100% Food supplement that is intended to supply nutrients needed to maintain and support female health. In addition to supporting the hypothalamic-pituitary-adrenal axis, this plural glandular supplement contains specific female reproductive gland peptides, enzymes and hormone precursors.

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Women have unique organs and require special care. Simply FemaleTM was developed to help naturally nourish and support a woman’s organs by providing 100% glandular support. 

The consumption of glandulars provides nutritional support to the corresponding gland in the human body [e.g. 1]. Glandular organs contain vitamins, minerals, and nutritional peptides, without sugar [2]. They also supply enzymes, and substances believed to be hormone precursors. Freeze drying results in a glandular that is the closest to ‘whole food’ [3].

Unlike plants, glands have most of the same biological materials (like enzymes and other peptides) that humans do [4]. It is now believed that there are as many as 75,000 different enzymes in the human body [5]. Consuming glandulars helps directly supply enzymes. Enzymes are biological catalysts that encourage metabolic, catabolic, and digestive processes in the body. They help rebuild and detoxify. Enzymes tend to be specific, such as thyroid enzymes tend to help the thyroid, but are ignored in the ear. Enzymes help the respective organs they are involved with function better.

Simply FemaleTM is intended to support the Hypothalamic-Pituitary-Adrenal (HPA) Axis as well as other systems in the female body. The HPA Axis is your body’s main way of responding to stress. It consists of three organs that each release hormones to eventually raise cortisol level in your body. The HPA Axis is a communication system between three organs, it is crucial for your body’s stress management [6]. These endocrine system organs create a feedback loop of hormones to enact and regulate your body’s stress reaction.

The HPA Axis is comprised of three glands:

  Hypothalamus: The hypothalamus is a structure deep within your brain. The hypothalamus keeps your body in a balanced state (homeostasis). The hormones [it produces] can control body temperature, water balance, appetite, gastric activity, and the fear and rage emotions [7]. The hypothalamus can also increase feelings of tranquility [8].

  Pituitary: The pituitary gland is a small endocrine gland located at the base of the brain below the hypothalamus. It makes several essential hormones and regulates other endocrine glands management [6]. The pituitary gland secretes human growth hormone, adrenocorticotrophin, thyroid-stimulating hormone, follicle-stimulating hormone, luteinizing hormone, antidiuretic hormone (also called vasopressin), and oxytocin [8]. Beef pituitary glandulars have been recommended for fatigue, stress intolerance, digestive complaints, metabolic disorders, headaches, obesity, delayed healing response, and nervous manifestations [9]. Some have also recommended it to help with sleep as well as seasonal affective disorders.

  Adrenal: The adrenal glands secrete androgens, which in a woman’s body can be converted into estrogen, along with cortisol (which controls aspects of metabolism) and aldosterone. They also produce mineralocorticoids (involved in electrolyte balance) and glucocorticoids (involved in blood sugar regulation). Adrenal glands secrete epinephrine and norepinephrine in response to sympathetic stimulation. “More than 30 steroids have been isolated from the adrenal cortex” [8]. Adrenal glandular support is often used by people who are under stress, fatigued, having difficulty getting up in the morning, who have adrenal stress headaches, or have an abnormal craving for salts [10].

In addition to supporting the HPA Axis, women may benefit from additional bovine glandular support of the reproductive organs. 

Simply FemaleTM contains glandular support for the ovaries, fallopian tubes, uterus and cervix. 

  Ovary: While ovaries are involved in reproduction and hormone production, bovine ovarian tissue has been advised to help women sleep at night, reduce the production of acne, improve mood, sometimes aid in menopausal issues and for some women, increase fertility [11].

  Fallopian tubes: are a pair of hollow, muscular ducts located between the ovaries and uterus. Each Fallopian tube is a channel between the ovaries which are involved with reproduction and menstruation [8]. Estrogen causes the ciliated epithelial cells that line the fallopian tubes to increase [8].

  Bovine uterus extracts have long been used for women with leucorrhea, uterine cysts, fibroids, uterine displacement, excessive or scanty mense, some types of sterility, menstruation cramps, prolapse uterus [7, 12]. Some practitioners have found uterine glandulars to be helpful for female moods.

  The cervix is the lower, narrow canal part of the uterus, connecting it to the vagina. It plays a vital role in menstruation, fertility, pregnancy, and childbirth [13]. The cervix allows fluids to leave and enter the uterus.

Simply FemaleTM also contains bovine thyroid tissue (note: bovine thyroid glands are thyroxine-free, thus do not result in a shutting down of the thyroid gland when taken). Thyroid tissue is used by people with symptoms associated with low thyroid such as afternoon tiredness, poor circulation, poor temperature tolerance, headaches, low metabolism, diminished female libido, weight concerns, and sometimes dry skin [14]. After a short adjustment period many people will find that they crave less junk food, caffeine, and similar items less but instead carve more water, fruits, and even vegetables.

Bovine animal glands have been consumed since the beginning of history [15], and glandulars have been part of the human diet for thousands of years. They were used for medicinal purposes in the USA in the 1800s [16] and were mentioned in Merck’s 1905 Manual of Materia Medica [17]. Their long-term use in nutritional supplements began over a century ago [18].

Various studies and reports involving glandulars have been published [e.g. 19-26]. Interestingly, a study of Australian aborigines found that those that had obesity and diabetes who left Western diets and returned to a native diet that included consuming animal glands found that those diseases reversed [26]. Glandulars are “generally recognized as safe” [27]

New Zealand, Australian, and Argentinean farmers tend to raise their cattle more naturally than those raised in places that use a lot of genetically-modified grains like the USA. Cows in New Zealand, Australia, and Argentina are almost exclusively raised on unfertilized natural grasses which are found in the pastures of those lands. Neither New Zealand nor Australia, nor Argentina has ever had a case of BSE (bovine spongiform encephalopathy) nor scrapie, a similar disease found in sheep [28-30]. Simply FemaleTM only provides glands from those southern hemisphere nations.

In summary, Simply FemaleTM supports the HPA Axis, the reproductive organs and the thyroid gland. Simply Female offers complete glandular support for the neuroendocrine system, the endocrine system and the reproductive system.  

Women seeking relief from hormonal imbalances, as well as those ending hormone replacement therapy, can nourish and help stabilize their endocrine systems with glandular support, such as in Simply FemaleTM [31].

Some of these studies (or citations) may not conform to peer review standards, therefore, the results are not conclusive. Professionals can, and often do, come to different conclusions when reviewing scientific data. None of these statements have been reviewed by the FDA. All products distributed by Doctors’ Research, Inc. are nutritional and are not intended for the treatment or prevention of any medical conditions.

Simply Female™

Product #731

  • Supports stress management
  • Enhances mood
  • Supports a healthy reproductive system
  • Supports a healthy endocrine system

Simply FemaleTM is intended to support the Hypothalamic-Pituitary-Adrenal (HPA) Axis as well as other systems in the female body. The HPA Axis is your body’s main way of responding to stress. It consists of three organs that each release hormones to eventually raise cortisol level in your body.

The HPA Axis is a communication system between three organs, it is crucial for your body’s stress management [6]. These endocrine system organs create a feedback loop of hormones to enact and regulate your body’s stress reaction.

References

[1] Burns D. Accumulating scientific evidence supports glandular therapy.  The Digest of Chiropractic Economics, Nov/Dec 1987: 74-79
[2] Basic Report: 13318, Beef, variety meats and by-products, brain, raw. National Nutrient Database for Standard Reference Legacy Release, April, 2019; Basic Report: 13325, Beef, variety meats and by-products, liver, raw. National Nutrient Database for Standard Reference Legacy Release, April, 2018
[3] The Difference Between Freeze-Dried, Dehydrated and Raw Foods. Trail Blazers Pets, December 13, 2017
[4] Hulsey MG, Martin, RJ.  The role of animals in nutritional research.  Nutr Today,1993;28 (5):1993
[5] The Handy Answer Book Series, 2nd edition. Visible Ink Press, 2014
[6] Hypothalamic-Pituitary-Adrenal (HPA) Axis, Cleveland Clinic, https://my.clevelandclinic.org/health/body/hypothalamic-pituitary-adrenal-hpa-axis, accessed 08/05/2025
[7] Profiles in Nutritional Progress.  Rubicon Productions, Bakersfield, 1993
[8] Guyton AC, Hall JE.  Textbook of Medical Physiology, 9th ed. WB Saunders, 1996
[9] Lee R. Pituitary Cytotrophin. Product Bulletins, circa 1950
[10] Lee R. Adrenamin.  In Product Bulletins, circa 1950
[11] Lee R. Ovary Cytotrophin.  In Product Bulletins, circa 1950
[12] Lee R. Uterus Cytotrophin.  In Product Bulletins, circa 1950
[13] Prendiville W, Sankaranarayanan R. Anatomy of the uterine cervix and the transformation zone. Colposcopy and Treatment of Cervical Precancer, International Agency for Research on Cancer, 2017
[14] Neumann C. Serious Nutrition: Incorporating Clinically Effective Nutrition Into Your Practice.  Source Graphics, Kelowna (B.C.), 2005
[15] Dunbar R.  Foraging for nature’s balanced diet.  New Scientist August 31, 1991:25-28
[16] Isaacs LL. A Brief History of Glandular Therapy: More Than Just Thyroid. Integr Med (Encinitas). 2023 May;22(2):26-31
[17] Merck’s 1905 Manual of the Materia Medica: A Ready-reference Pocket Book for the Physician and Surgeon Containing Names of the Chemicals and Drugs, 3rd ed. Merck & Co, 1905, p. 114
[18] Harrower H.  Practical Organotherapy.  3rd ed.  W.B.  Conkey Co.: Hammond (Indiana): 31-36, 1921
[19] Shamberger RC, Hendron WH, Leictner AM.  Long-term nutritional and metabolic consequences of pancreaticoduodenectomy in children.  Surgery, 1994;115(3): 382-388
[20] Thiel R., Fowkes S.W.  Down syndrome and thyroid dysfunction: Should nutritional support be the first-line treatment? Medical Hypotheses, 2007; 69:809-815
[21] Thiel R. Might disorders of calcium cause or contribute to myoclonic seizures?  Medical Hypotheses, 2006; 66(5):969-974
[22] Thiel R. Thiel R. CHARGE (Hall-Hittner) Syndrome and Nutrition: A novel case report, 2006
[23] Thiel R.  Might disorders of calcium cause or contribute to myoclonic seizures?  Med Hypo. 2006; 66(5):969-974
[24] DeCava JA.  Glandular supplements.  Nutrition News and Views 1997; 1(3):1-10
[25] Thiel R. Efficacy of Glandulars and Herbs: The Result of 945 Cases. The Original Internist, Volume 19 (1), March 2012, 7-11
[26] O’Dea K. Traditional diet and food preferences of Australian aboriginal hunter-gatherers. Philos Trans R Soc Lond B Biol Sci. 1991 Nov 29;334(1270):233-240; discussion 240-241
[27] Generally Recognized as Safe (GRAS). USFDA, https://www.fda.gov/food/food-ingredients-packaging/generally-recognized-safe-gras accessed 02/07/20
[28] JOINT STATEMENT FROM THE NEW ZEALAND FOOD SAFETY AUTHORITY AND MINISTRY OF AGRICULTURE AND FORESTRY. BSE in the US has no food safety impact in New Zealand or threat to our animal health status. 24 December 2003
[29] New Zealand’s Scrapie Freedom.  New Zealand Food Safety Authority.  Nzfsa.gov 2/16/06
[30] Scudel A.A, et al.  Analysis of risk factos and active surveillance for BSE in Argentina.  Siiap.sagyp.mecon.ar 02/16/06
[31] Clinical Reference Guide, Revised April 2018

All products distributed by Doctors’ Research, Inc. are nutritional and are not intended for the treatment or prevention of any medical conditions.

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Vitamin B-6, B-12 & Folate™ Article

FOOD RESEARCH Products are "100% FOOD Nutrients"

Nutrition from FOOD, What a concept!™

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Vitamin B-6, B-12, & Folate™

100% Food Vitamin B-6, B-12, & Folate is a natural, vegetarian, Food complex source of vitamin B-6, vitamin B-12, and folate, essential nutrients that support human health, including blood [1,2]. Doctors’ Research has been supplying health care professionals Vitamin B-6, B-12, & Folate since 1998.

Unlike other brands, 100% Food Vitamin B-6, B-12, & Folate contains no USP vitamins or vitamin forms foreign to the human body.

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Vitamin B-6:
“An understanding of the various forms and quantities of these forms in foods is important in the evaluation of the bioavailability and metabolism of vitamin B-6”… one of the forms that vitamin B-6 exists is in the form of “5’0-(beta-D-glycopyransosyl) pyridoxine. To date only plant foods have been found to contain this interesting form of vitamin B-6” [3]. Yeast and brown rice contain more natural Food vitamin B-6 than other Foods [4]. Vitamin B-6 was first reported in the 1930s [5]. At least one synthetic vitamin B-6 analogue has been found to inhibit natural vitamin B-6 action [6]. Pyridoxine HCL (hydrochloride) which is found in most non-Food supplements, is made with petroleum ester combined with HCL and processed with formaldehyde [7].

“Disorders treated with (B-6)…include Down’s syndrome, autism, hyperoxaluria, gestational diabetes, carpal tunnel syndrome, depression, and diabetic neuropathy”, but the results are consider by some in the mainstream as having “limited value” [1]. Vitamin B-6 is considered to be a first-line treatment for Lennox-Gastaut and some other seizure disorders [8,9]. Many problems including anemias, premenstrual dysphoric disorder (PMDD), PMS, cardiovascular complaints, confusion, depression, irritability, and certain immune problems have responded to vitamin B-6 [9]. A study of healthy elderly individuals found about 1/3 had marginal vitamin B-6 deficiency [9].

Vitamin B-12:
Initially Food vitamin B-12 was given for people with pernicious anemia in the form of raw liver, but due to cost considerations a synthetic USP isolate (cyanocobalamin) was developed [6]. Cyanocobalamin, the common pharmacological (USP) form of vitamin B-12, is essentially cobalamins combined with cyanide! [6]. The only two naturally active forms of vitamin B-12 in the human body are methylcobalamin and deoxyadenosylcobalamin and those are in Food [1]. Vitamin B-12 when ingested in its human-active form is non-toxic [1], yet some researchers have concluded “The efficacy and safety of the vitamin B-12 analogues created by nutrient-nutrient interaction in vitamin-mineral supplements is unknown” [10]; interestingly some synthetic vitamin B-12 analogues seem to be antagonistic to vitamin B-12 activity in the body [11,12]! Insufficient vitamin B-12 results in anemia, degeneration of peripheral nerves, and skin hypersensitivity [1,2].

“Vitamin B12, cobalamin, is indispensable for humans owing to its participation in two biochemical reactions: the conversion of l-methylmalonyl coenzyme A to succinyl coenzyme A, and the formation of methionine by methylation of homocysteine” [13].

100% Food Vitamin B-6, B-12, & Folate contains methylated vitamin B-12, a superior form [14].

Vitamin ‘B-9’, Folate: 
The vitamin once known as B-9 exists in foods as folate. Initially Food folate was given for people with a pregnancy-related anemia in the form of autolyzed yeast; later a synthetic USP isolate was developed [1]. Pteroylglutamic acid (folic acid), the common pharmacological (USP) form of folate is not found significantly as such in the body [1].

“Folic acid is a synthetic folate form” [9]. Folic acid, such as in most supplements, is not found in Foods, folate is [19]. Insufficient folate can result in fatigue, depression, confusion, anemia, reduced immune function, loss of intestinal villi, and an increase in infections [2]. Folate deficiency is the most important determinant in high homocysteine levels [11], and supplemental folate is effective in reducing homocysteine [15,16]. “The highest concentrations of folate exist in yeast…” [1]. Insufficient folate can result in fatigue, depression, confusion, anemia, reduced immune function, loss of intestinal villi, and an increase in infections [2]. “(C)onsumption of more than 266 mcg of synthetic folic acid (PGA) results in absorption of unreduced PGA, which may interfere with folate metabolism for a period of years” [1].

A 2004 paper from the British Medical Journal confirmed what many natural health professional have known all along: since folic acid is unnatural and the body cannot fully convert large amounts of it into usable folate, this artificial substance can be absorbed and may have unknown negative consequences in the human body [17], folate supplementation obviously should be in Food folate forms and not folic acid!

Many scientists have concerns about folic acid [18]. High consumption of folic acid is dangerous [20].

Vitamins B-6, B-12, and Folate are all important nutrients for healthy blood; the absence of any of them can trigger various forms of anemia (especially pernicious anemia) [1,18]. Subclinical deficiencies in vitamin B-12, vitamin B-6, and folate may impair cognitive function [21].

Homocysteine responds to vitamin B-12 and folate [16]. Dr. Mason of Tufts University School of Medicine reports that a 20% elevation of homocysteine significantly increases the risk of cardiovascular disease [12]. Normal homocysteine level is about 12 umol/L, while cardiovascular risk increases about 14-16 umol/L [22]. In addition, even if blood tests for vitamin B-12 or folate appear to be normal, this may be because results are masked by an elevated level of homocysteine. Homocysteine is highly implicated in vascular diseases (such as cardiovascular and other vascular disorders), and can be reduced with sufficient vitamin B-12 and Folate; with vitamin B-6 sometimes playing a supporting role [16].

Superoxide Dismutase:
“Superoxide dismutase (S.O.D.) is one of the most important enzymes that function as cellular antioxidants…The absence of this enzyme is lethal” [1]. “It protects intracellular components from oxidative damage, converting the superoxide ion to hydrogen peroxide” [1]. S.O.D. is a powerful free radical scavenger which has been clinically shown to protect the brain, heart, liver, lungs, kidneys, skin, muscles, penis, nerves, and spinal cord from ischemic injury [23]. High levels of S.O.D. have been associated with reduced growth of Candida albicans [24]. 100% Food Vitamin B-6, B-12, and Folate naturally contains S.O.D.

Organic Brown Rice also a Food complex source of silicon and B vitamins [2,25-28].

Since Vitamin B-6, B-12, & Folate contains only Foods, unlike other isolated supplements, it also naturally includes vitamin B-1 (thiamin), vitamin B-2 (riboflavin), vitamin B-3 (niacinamide), vitamin B-5 (pantothenate), choline, inositol, and other B vitamin factors which often work with vitamins B-6, B-12, and folate in the body. All these factors make 100% Food Vitamin B-6, B-12, & Folate the choice for doctors interested in truly natural health.

Many females simply take Vitamin B-6, B-12, & Folate as a Food supplement to help them feel better.

Some of these studies (or citations) may not conform to peer review standards, therefore, the results are not conclusive. Professionals can, and often do, come to different conclusions when reviewing scientific data. None of these statements have been reviewed by the FDA. All products distributed by Doctors’ Research, Inc. are nutritional and are not intended for the treatment or prevention of any medical conditions.

Vitamin B-6, B-12 & Folate™

  • Superior source of folate
  • Superior source of Vitamin B-6
  • Superior source of Vitamin B-12
  • Assists in balancing healthy homocysteine levels

Unlike other so-called “whole food” formulas, Vitamin B-6, B-12 & Folate™does not contain USP folic acid as that form is not what is found in natural foods.  Vitamins B6, B12, and B9 support healthy blood. B12 is essential for myelin synthesis and central nervous system function.

Unlike most so-called “natural” supplements, Vitamin B-6, B-12 & Folate™ does not contain any folic acid, which is a sythetic from of vitamin B-9 and is dangerous (for more details, please check out the article on Folic Acid Dangers)

References

[1] Shils ME, Olson JA, Shike M. Modern Nutrition in Health and Disease, 9th ed. Williams & Wilkins, Balt., 1999
[2] Whitney EN, Hamilton EMN. Understanding Nutrition, 4th ed. West Publishing, NY, 1987
[3] Leklem JE. Vitamin B6. In Modern Nutrition in Health and Disease, 8th ed. Lea & Febiger, Phil.,1994:383-394
[4] Ensminger AH, Ensminger ME, Konlade JE, Robson JRK. Food & Nutrition Encyclopedia, 2nd ed. CRC Press, New York, 1993
[5] Shils ME, et al. Modern Nutrition in Health and Disease, 10th ed. Lipponcott Williams & Wilkins, Balt., 2006
[6] Mervyn L. The B Vitamins. Thorsons, Wellingborough (UK), 1981
[7] Vitamin-Mineral Manufacturing Guide Nutrient Empowerment, volume 1. Nutrition Resource, Lakeport (CA), 1986
[8] Glauser TA, Morita DA. Encephalopathic epilepsy after infancy. In Pediatric Epilepsy, 2nd ed. Demos, New York, 2001:201-218
[9] Hendler SS, Rorvik D, eds. PDR for Nutritional Supplements. Medical Economics, Montvale (NJ), 2001
[10] Shils ME, Olson JA, Shike M. Modern Nutrition in Health and Disease, 8th ed. Lea & Febiger, Phil., 1994
[11] Ishida A, Kanefusa H, Fujita H, Toraya T. Microbiological activities in nucleotide loop-modified analogues of vitamin B12. Arch Microbiol 1994;161(4):293-299
[12] Tandler B, Krhenbul S, Brass EP. Unusual mitochondria in the hepatocytes of rats treated with a vitamin B12 analogue. Anat Rec 1994;231(1):1-6
[13] Moracova M, et al. Biological properties of vitamin B12. Nutr Res Rev. 2025 Jun;38(1):338-370
[14] Mather Y, Hazra AB. Methylations in vitamin B12 biosynthesis and catalysis. Curr Opin Struct Biol. 2022 Dec:77:102490
[15] Verhoef P. Homocysteine metabolism and risk of myocardial infarction: Relation with vitamin B6, B12, and Folate. Am J Epidemiol 1996;143(9):845-859
[16] Brattstrom L. Vitamins as homocysteine-lowering agents: A mini review. Presentation at The Experimental Biology 1995 AIN Colloquium, April 13, 1995, Atlanta Georgia
[17] Lucock M. Is folic acid the ultimate functional food component for disease prevention? BMJ, 2004;328:211-214
[18] Menezo Y. Folic Acid, Folinic Acid, 5 Methyl TetraHydroFolate Supplementation for Mutations That Affect Epigenesis through the Folate and One-Carbon Cycles. Biomolecules. 2022 Jan 24;12(2):197
[19] Macrae R, Robson RK, Sadler MJ. Encyclopedia of Food Science and Nutrition. Academic Press, NY, 1993
[20] Thiel R.  Folic Acid is Hazardous to Your Health.  What About Food Folate?  The Original Internist, 17(2) June 2010, 88-90; Thiel R. Is Folic Acid is Hazardous to Your Health? What About Food Folate? Monitor of Naturopathy, Spring 2025
[21] Gonzalez-Gross M, Marcos A, Pietrzik K. Nutrition and cognitive impairment in the elderly. Br J Nutr 2001;86:313-321
[22] Brown S, et al. High serum homocysteine appear to be a risk factor. Family Practice News May 1, 1995:25
[23] Null G. Superoxide Dismutase. In The Clinician’s Handbook of Natural Healing. Kensington Books, New York, 1997:137-144
[24] Romandini P, Bonotto C, Bertoloni G, Beltramini M, Salvato B. Superoxide dismutase, catalase and cell dimorphism in Candida albicans cells exposed to methanol and different temperature. Comp Biochem Physiol Pharm Toxicol Endocrinol,1994;108(1):53-57 [25] Thompson FE, et al. Sources of fiber and fat in the diets of U.S. women ages 19 to 50: implications for nutritional education and policy. Am J Pub Health 1992, 82(5):695-702
[26] Dietary fiber: importance of function as well as amount. Lancet 1992, 340:1133-1134
[27] Jensen B. The Chemistry of Man. Bernard Jensen, Escondido, 1983
[28] Nielsen FH. Ultratrace minerals. In Modern Nutrition in Health and Disease, 9th ed. Williams and Wilkins, Balt.;1999:283-303

All products distributed by Doctors’ Research, Inc. are nutritional and are not intended for the treatment or prevention of any medical conditions.

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Simply Female

FOOD RESEARCH Products are "100% FOOD Nutrients"

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Product #731

Simply Female™

Simply Female™ is a 100% Food supplement that is intended to supply nutrients needed to maintain and support healthy reproductive and endocrine system

90 Capsules   •   $54.00

Gluten-Free

Halal and
Biblically Kosher Compliant.

Have questions? Call by tapping below

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Product Details

Simply FemaleTM is intended to support the Hypothalamic-Pituitary-Adrenal (HPA) Axis as well as other systems in the female body. The HPA Axis is your body’s main way of responding to stress. It consists of three organs that each release hormones to eventually raise cortisol level in your body.

The HPA Axis is a communication system between three organs, it is crucial for your body’s stress management [6]. These endocrine system organs create a feedback loop of hormones to enact and regulate your body’s stress reaction.

Click here and Learn more about Simply Female™

[6] Hypothalamic-Pituitary-Adrenal (HPA) Axis, Cleveland Clinic, https://my.clevelandclinic.org/health/body/hypothalamic-pituitary-adrenal-hpa-axis, accessed 08/05/2025

Other ingredients: Non-GMO Elaeis Guineensis Extract, Organic Brown Rice Flour, Vegetarian (HPMC) Capsule.

Suggested use: Serving size or as recommended by your health care professional. Adjust usage according to nutritional lifestyle requirements.

No Synthetic Nutrients • No Dairy • No Preservatives

* This is a nutritional product and not a medication intended to prevent, treat, or cure any illness. None of these statements has been approved by the US FDA or similar agencies. Not all citations meet peer-reviewed status so the statements are not conclusive. Professionals can, and do, disagree, regarding efficacy of ingredients in nutritional formulas.

Disclaimer: Some of these studies (or citations) may not confom to peer review standards. Therefore, the results are not conclusive. Profressionals can, and often do, come to different conclusions when reviewing scientific data. None of these statements have been reviewed by the FDA.

Click to View the "Complete Lists of our Products"

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Food Research products are distributed exclusively
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Adenine

Most Food Research products contain what is called Vitamin B-4, Adenine. Adenine is considered by some health care professionals to be essential for heart health. 

Learn More

Nutritional Musculoskeletal Support

The human body has a system of support for what is contained in it, including bones, cartilage, tendons, and ligaments.

Click image for more information.

Simply Female

Simply Female™ is intended to support the Hypothalamic-Pituitary-Adrenal (HPA) Axis as well as other systems in the female body. The HPA Axis is your body’s main way of responding to stress. 

Click image for more information.

Vitamin B6, B12 & Folate

100% Food Vitamin B-6, B-12, & Folate is a natural, vegetarian, Food complex source of vitamin B-6, vitamin B-12, and folate, essential nutrients that support human health, including blood.

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  • Supports female reproductive health
  • Supports proper female functions
  • Promotes positive mood

Product Details

Ovaries are female reproductive glands that produce hormones and reproductive cells.

Ovaries are involved with various female hormones. Historically, bovine ovary tissue has been used by women interested in supporting healthy ovarian function. As it has effects that differ from thyroid support, it is often advised to take ovarian tissue before bed.

Bovine ovarian tissue is sometimes advised to help some woman sleep at night, reduce the production of acne, improve mood, sometimes aid in menopausal issues, and for some women, increase fertility [11]. As it has effects that differ from thyroid support, it is often advised to take ovarian tissue before bed.

Click here for further information regarding The TRUTH About GLANDULARS
In Nutritional Supplements

Other ingredients: Organic Brown Rice, Vegetarian (HPMC) Capsule.

Suggested use: Serving size or as recommended by your health care professional. Adjust usage according to nutritional lifestyle requirements.

Posted on

Masculine Advantage™

FOOD RESEARCH Products are "100% FOOD Nutrients"

Nutrition from FOOD, What a concept!™

DOCTORS' RESEARCH, INC.

Product #569

Masculine Advantage™

( Previously known as Prosta-Power™ )

Masculine Advantage™, previously known as Prosta-Power™ is a 100% Food supplement that is intended to supply nutrients, glandulars, and herbs needed to maintain and support optimal prostate and male health.

90 Capsules   •   $31.00

Gluten-Free

Halal and
Biblically Kosher Compliant.

Have questions? Call by tapping below

(805) 489-7185
  • Supports prostate health
  • Mood enhancer
  • Supports sperm health
  • Supports male reproductive health

Product Details

Unlike many so-called “natural” formulas, Masculine Advantage™ is comprised of only food, no synthetic USP nutrients or isolated mineral salts, but only foods, food complexes, and food concentrates.

Masculine Advantage™ also naturally contains carbohydrates, lipids, proteins (including all ten essential amino acids), and truly organic bioflavonoids as found in specially grown, enzymatically processed Saccharomyces cerevisiae.

Masculine Advantage™ was not designed to be a prostate-cancer fighter. It is intended to provide nutritional support for men interested in natural ways that may improve the health of their prostate and sexual organs.

Prostate tissue helps maintain the prostate gland in a good state of repair to support prostate health. Saw palmetto helps support prostate health.

The prostate secretes seminal fluid that helps enhance the fertility and motility of sperm.  

Other ingredients: Enzymatically processed Saccharomyces Cerevisiae, Organic Brown Rice, Vegetarian (HPMC) Capsule.

Suggested use: Serving size or as recommended by your health care professional. Adjust usage according to nutritional lifestyle requirements.

No Synthetic Nutrients • No Dairy • No Preservatives

* This is a nutritional product and not a medication intended to prevent, treat, or cure any illness. None of these statements has been approved by the US FDA or similar agencies. Not all citations meet peer-reviewed status so the statements are not conclusive. Professionals can, and do, disagree, regarding efficacy of ingredients in nutritional formulas.

Disclaimer: Some of these studies (or citations) may not confom to peer review standards. Therefore, the results are not conclusive. Profressionals can, and often do, come to different conclusions when reviewing scientific data. None of these statements have been reviewed by the FDA.

Click to View the "Complete Lists of our Products"

FOOD RESEARCH
also has a list of Product Equivalents​

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Food Research products are distributed exclusively
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To Apply for Wholesale Account

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Product Information Sheets

Adenine

Most Food Research products contain what is called Vitamin B-4, Adenine. Adenine is considered by some health care professionals to be essential for heart health. 

Learn More

Nutritional Musculoskeletal Support

The human body has a system of support for what is contained in it, including bones, cartilage, tendons, and ligaments.

Click image for more information.

Simply Female

Simply Female™ is intended to support the Hypothalamic-Pituitary-Adrenal (HPA) Axis as well as other systems in the female body. The HPA Axis is your body’s main way of responding to stress. 

Click image for more information.

Vitamin B6, B12 & Folate

100% Food Vitamin B-6, B-12, & Folate is a natural, vegetarian, Food complex source of vitamin B-6, vitamin B-12, and folate, essential nutrients that support human health, including blood.

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Dual Vitality™

FOOD RESEARCH Products are "100% FOOD Nutrients"

Nutrition from FOOD, What a concept!™

DOCTORS' RESEARCH, INC.

New!

Product #297

Dual Vitality™

Dual  Vitality™ is a 100% vegan Food  dual support for Energy, Vitality, and a Healthy Immune System. 

90 Capsules   •   $49.00

Vegetarian Formula

Gluten-Free

Halal and
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  • Energy and vitality support
  • Supports endurance
  • Contains 150 mg of Beta-glucans from fruiting bodies
  • Supports healthy mood and nervous system

Product Details

Cordyceps are a type of mushroom which has immunomodulatory, antioxidant, and cellular improving vitality properties. The cordyceps in Dual Vitality™ are provided by Nammex, the company considered to be the top of the line for supplying the best quality mushroom products to health professionals.

“The roots of American ginseng (Panax quinquefolius), contain steroidal saponins called ginsenosides that are purported to be adaptogens (i.e., to increase endurance and improve memory).” Ginseng can protect DNA and help mood.

Other ingredients:Vegetarian (HPMC) Capsule.

Suggested use: Serving size or as recommended by your health care professional. Adjust usage according to nutritional lifestyle requirements.

No Synthetic Nutrients • No Dairy • No Preservatives

* This is a nutritional product and not a medication intended to prevent, treat, or cure any illness. None of these statements has been approved by the US FDA or similar agencies. Not all citations meet peer-reviewed status so the statements are not conclusive. Professionals can, and do, disagree, regarding efficacy of ingredients in nutritional formulas.

Disclaimer: Some of these studies (or citations) may not confom to peer review standards. Therefore, the results are not conclusive. Profressionals can, and often do, come to different conclusions when reviewing scientific data. None of these statements have been reviewed by the FDA.

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Food Research products are distributed exclusively
in the USA by Doctors’ Research, Inc.

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Adenine

Most Food Research products contain what is called Vitamin B-4, Adenine. Adenine is considered by some health care professionals to be essential for heart health. 

Learn More

Nutritional Musculoskeletal Support

The human body has a system of support for what is contained in it, including bones, cartilage, tendons, and ligaments.

Click image for more information.

Simply Female

Simply Female™ is intended to support the Hypothalamic-Pituitary-Adrenal (HPA) Axis as well as other systems in the female body. The HPA Axis is your body’s main way of responding to stress. 

Click image for more information.

Vitamin B6, B12 & Folate

100% Food Vitamin B-6, B-12, & Folate is a natural, vegetarian, Food complex source of vitamin B-6, vitamin B-12, and folate, essential nutrients that support human health, including blood.

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Organic Mushrooms™

FOOD RESEARCH Products are "100% FOOD Nutrients"

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Product #610

Organic Mushrooms™

Organic Mushrooms™ is a 100% vegan Food supplement that is intended to supply nutrients needed to maintain and support a healthy immune system.

90 Capsules   •   $39.00

Vegetarian Formula

Gluten-Free

Halal and
Biblically Kosher Compliant.

Have questions? Call by tapping below

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  • Supports a healthy immune system
  • Provides mood support
  • Contains 100 mg of beta glucans per capsule
  • Supports a healthy cardiovascular system

Product Details

Organic Mushrooms™ supplies a healthy immune supporting blend of Organic Chaga (Inonotus Obliquus), Organic Cordyceps (Cordyceps Militaris), Organic Lion’s Mane (Hericium Erinaceus, Organic Reishi (Ganoderma Lucidum), Organic Shiitake Lentinula edodes), and Organic Turkey Tail (Trametes Versicolor) which naturally provides beta glucans.

Other ingredients:Vegetarian (HPMC) Capsule.

Suggested use: Serving size or as recommended by your health care professional. Adjust usage according to nutritional lifestyle requirements.

No Synthetic Nutrients • No Dairy • No Preservatives

* This is a nutritional product and not a medication intended to prevent, treat, or cure any illness. None of these statements has been approved by the US FDA or similar agencies. Not all citations meet peer-reviewed status so the statements are not conclusive. Professionals can, and do, disagree, regarding efficacy of ingredients in nutritional formulas.

Disclaimer: Some of these studies (or citations) may not confom to peer review standards. Therefore, the results are not conclusive. Profressionals can, and often do, come to different conclusions when reviewing scientific data. None of these statements have been reviewed by the FDA.

Click to View the "Complete Lists of our Products"

FOOD RESEARCH
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Food Research products are distributed exclusively
in the USA by Doctors’ Research, Inc.

To Apply for Wholesale Account

See the MAP of DOCTORS' RESEARCH Regional Sales Representatives

Product Information Sheets

Adenine

Most Food Research products contain what is called Vitamin B-4, Adenine. Adenine is considered by some health care professionals to be essential for heart health. 

Learn More

Nutritional Musculoskeletal Support

The human body has a system of support for what is contained in it, including bones, cartilage, tendons, and ligaments.

Click image for more information.

Simply Female

Simply Female™ is intended to support the Hypothalamic-Pituitary-Adrenal (HPA) Axis as well as other systems in the female body. The HPA Axis is your body’s main way of responding to stress. 

Click image for more information.

Vitamin B6, B12 & Folate

100% Food Vitamin B-6, B-12, & Folate is a natural, vegetarian, Food complex source of vitamin B-6, vitamin B-12, and folate, essential nutrients that support human health, including blood.

Click image for more information.

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Simply Parotid™

FOOD RESEARCH Products are "100% FOOD Nutrients"

Nutrition from FOOD, What a concept!™

DOCTORS' RESEARCH, INC.

Product #738

Simply Parotid™

Simply Parotid™ is a 100% Food supplement that is a 100% Food supplement that is intended to support healthy parotid glands. 

90 Capsules   •   $34.00

Gluten-Free

Halal and
Biblically Kosher Compliant.

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  • Supports healthy parotid glands
  • Supports proper moisture secretion
  • Historically used to support healthy iodine and thyroid metabolism

Product Details

 The late Dr. Royal Lee also recommended parotid gland extracts for those undescended testicles.

Some people have also found parotid glandulars helpful for detoxification. 

Click here for further information regarding The TRUTH About GLANDULARS
In Nutritional Supplements

Other ingredients: Organic Brown Rice, Vegetarian (HPMC) Capsule.

Suggested use: Serving size or as recommended by your health care professional. Adjust usage according to nutritional lifestyle requirements.

No Synthetic Nutrients • No Dairy • No Preservatives

* This is a nutritional product and not a medication intended to prevent, treat, or cure any illness. None of these statements has been approved by the US FDA or similar agencies. Not all citations meet peer-reviewed status so the statements are not conclusive. Professionals can, and do, disagree, regarding efficacy of ingredients in nutritional formulas.

Disclaimer: Some of these studies (or citations) may not confom to peer review standards. Therefore, the results are not conclusive. Profressionals can, and often do, come to different conclusions when reviewing scientific data. None of these statements have been reviewed by the FDA.

Click to View the "Complete Lists of our Products"

FOOD RESEARCH
also has a list of Product Equivalents​

Download PDF Here

FOOD RESEARCH
Product Catalog

Download Here

Food Research products are distributed exclusively
in the USA by Doctors’ Research, Inc.

To Apply for Wholesale Account

See the MAP of DOCTORS' RESEARCH Regional Sales Representatives

Product Information Sheets

Adenine

Most Food Research products contain what is called Vitamin B-4, Adenine. Adenine is considered by some health care professionals to be essential for heart health. 

Learn More

Nutritional Musculoskeletal Support

The human body has a system of support for what is contained in it, including bones, cartilage, tendons, and ligaments.

Click image for more information.

Simply Female

Simply Female™ is intended to support the Hypothalamic-Pituitary-Adrenal (HPA) Axis as well as other systems in the female body. The HPA Axis is your body’s main way of responding to stress. 

Click image for more information.

Vitamin B6, B12 & Folate

100% Food Vitamin B-6, B-12, & Folate is a natural, vegetarian, Food complex source of vitamin B-6, vitamin B-12, and folate, essential nutrients that support human health, including blood.

Click image for more information.

Online Store for Healthcare Professionals

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VITAMINS & MINERALS