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Nutri-West (*) Food Research International Food Research Int’l Vegetarian
Adreno-Lyph-160 Simply Adrenal Vegetarian Adrenal
Adreno-Lyph-Para High Stress Adrenal Vegetarian Adrenal
Adreno-Lyph-Sym Anxie-Tone Vegetarian Adrenal
Allerhale Aller-Lung Support Aller-Lung Support
Amino All Intracellular Cough Vitamin-Mineral Shake
Anxiolix Anxie-Tone Vegetarian Tryptophan
Aspartic Chrom Gluco-Sugar-Balance Gluco-Sugar-Balance
Aspartic Mag Magnesium Complex Magnesium Complex
Aspartic Multi-Min Vitamin-Mineral Vitamin-Mineral
B Complex B Stress Complex B Stress Complex
Beta-C-TR C Complex C Complex
Biostress-B Anxie-Tone B Stress Complex
Black Currant Seed Oil Le Feminine Advantage Wheat Germ Oil E
Black Walnut Para-Dysbio-Zyme Para-Dysbio-Zyme
Brain Plus Serious Brain Enhancer Vegetarian Tyrosine
C-1000-TR C Complex C Complex
CAL-MAG 1:1 Calcium Complex and Magnesium Complex Calcium Complex and Magnesium Complex
Calcium Lactate Cal-Mag Complex Cal-Mag Complex
Cand-Ex Probio-Zyme-Yst Probio-Zyme-Yst
Carbo-Met Gluco-Sugar-Balance Gluco-Sugar-Balance
Cardioplex Cardio-Power CoQ10-Cardio
Chewable C-500 C Complex C Complex
China West #6 Xanthium Formula Vira-Chron Vira-Chron
Chloroplex Green Vegetable Alkalizer Green Vegetable Alkalizer
CLM-NRV Anxie-Tone Vegetarian Tryptophan
Con-Lyph Conga-Immune Vira-Bac-Yst
Co Q 10-Plus CoQ10-Cardio CoQ10-Cardio
Complete Brain Charge Serious Brain Enhancer Vegetarian Tyrosine
Complete Child DHA/EPA Omega 3 EPA/DHA Wheat Germ Oil E
Complete Neuro Anxie-Tone Vegetarian Tryptophan
Core Level Adrenal High Stress Adrenal Vegetarian Adrenal
Core Level Bile GB Support Pro-Enzymes
Core Level Bone Matrix Cal-Mag Complex Cal-Mag Complex
Core Level C-TR Herbal Antioxidant C Complex
Core Level D-Tox Detox-N-Cleanse Detox-N-Cleanse
Core Level Health Reserve Vitamin-Mineral Vitamin-Mineral
Core Level Heart Cardio-Power CoQ10-Cardio
Core Level Kidney. Uro-Kid Support Green Vegetable Alkalizer
Core Level Liver Liva-Detox & Support Detox-N-Cleanse
Core Level Lung Simply Lung, plus Aller-Lung Support Aller-Lung Support
Core Level Magnesium Magnesium Complex Magnesium Complex
Core Level Manganese Cal-Mag Complex Cal-Mag Complex
Core Level Orchic Prosta-Power or Simply Orchic Libida-Life, plus Zinc Complex
Core Level Ovary Le Feminine Advantage or Simply Ovary Libida-Life
Core Level Pancreas Digesti-Pan or Simply Pancreas Pro-Enzymes
Core Level Pituitary Migratrol Vegetarian Thyro
Core Level Potassium Uro-Kid Support or Green Vegetable Alkalizer Green Vegetable Alkalizer
Core Level Prostate Prosta-Power Libida-Life, plus Zinc Complex
Core Level RNA Serious Brain Enhancer Vegetarian Tryptophan
Core Level Thymus Thymo-Immune Vira-Bac-Yst
Core Level Thyro Metabolic Thyro or Vegetarian Thyro Vegetarian Thyro
Core Level Uterus Le Feminine Advantage or Simply Uterus Libida-Life
Core Level Zinc Herbal Antioxidant or Zinc Complex Herbal Antioxidant or Zinc Complex
DHEA-25 High Stress Adrenal or Simply Adrenal Vegetarian Adrenal
Digest Plus Digesti-Pan Pro-Enzymes
Disc-Zyme Inflam-Enzymes Inflam-Enzymes
DIU-Plus Arginase Bladder or Uro-Kid Support Green Vegetable Alkalizer
DSF Formula Anxie-Tone Vegetarian Adrenal
E-Tocotrienols Selenium E Selenium E
Echinacea Conga-Immune Vira-Bac-Yst and Zinc Complex
Enzyme Forte Simply Pancreas Pro-Enzymes
Exspore Probio-Zyme-Yst Probio-Zyme-Yst
Eyebright Plus Complete Eye Health Herbal Antioxidant
F-Complex Omega 3 EPA/DHA Wheat Germ Oil E
Fem-Plus Le Feminine Advantage Libida-Life
Ferrous-Fumaro Hematic Formula Hematic Formula
Flualgia Thymo-Immune Vira-Bac-Yst
#3 GB-LIV GB Support Pro-Enzymes
GB-Plus GB Support Pro-Enzymes
GH-Choline Choline Complex Choline Complex
Glan-Plus-F Le Feminine Advantage Libida-Life
Glyco-Lyph Gluco-Sugar-Balance Gluco-Sugar-Balance
Greens Renew Powder Vitamin-Mineral Shake Vitamin-Mineral Shake
Hemo-Lyph Hematic Formula Hematic Formula
Homocysteine Redux Vitamin B-6, B-12, & Folate Vitamin B-6, B-12, & Folate
HPZ Vira-Chron Vira-Chron
Hyper-D Pro-Enzymes, plus Simply Pancreas Pro-Enzymes
Hypo-D Digesti-Pan Pro-Enzymes
Immu-Bac Thymo-Immune Vira-Bac-Yst
Immuno-Plus Thymo-Immune Vira-Bac-Yst
Iodine Rescue Vegetarian Thyro Vegetarian Thyro
ISB Formula Thymo-Immune or Intracellular Cough Vira-Bac-Yst, plus Vitamin-Mineral
Liga-PN Inflam-Enzymes or Advanced Joint Complex Inflam-Enzymes or Cal-Mag Complex
Lipotrophic Plus Cholester-Right Cholester-Right
Liva-Lyph Simply Liver Pro-Enzymes
LNG RESP Simply Lung, plus Aller-Lung Support Aller-Lung Support
LIV-GB Plus GB Support Pro-Enzymes
L-Tyrosine-S Vegetarian Tyrosine Vegetarian Tyrosine
Lyso-Lyph-Forte Inflam-Enzymes Inflam-Enzymes
Magnesium Chelate Magnesium Complex Magnesium Complex
Menopause Le Feminine Advantage Libida-Life
Multibalance Vitamin-Mineral Vitamin-Mineral
Multi-Gland Complex Intracellular Cough Vitamin-Mineral Shake
Ovary-Lyph-F Simply Ovary Libida-Life
Pan-Lyph Simply Pancreas Pro-Enzymes
Pan-Lyph Chelate Simply Pancreas, plus Zinc Complex Pro-Enzymes
Parazym-A Para-Dysbio-Zyme Para-Dysbio-Zyme
Parotid-Lyph Complete Smell & Taste Zinc Complex, plus Magnesium Complex
Pineal Lyph Restful Mind Support Vegetarian Tryptophan
Pit-Lyph-Anterior Migratrol Vegetarian Thyro
Pit-Lyph-Whole Migratrol Vegetarian Thyro
Pre/Post Natal Vitamin-Mineral Vitamin-Mineral
Pro-Cortisol Balance Anxie-Tone or Restful Mind Support Vegetarian Tryptophan
Prosta-Plus Prosta-Power Libida-Life, plus Zinc Complex
Prostate Support Prosta-Power Libida-Life, plus Zinc Complex
RNA-DNA-Plus Serious Brain Enhancer Vegetarian Tryptophan, plus Selenium E
Rutin Plus Herbal Antioxidant or Vira-Bac-Yst Herbal Antioxidant or Vira-Bac-Yst
Sago-C-500 C Complex C Complex
Selenium Chelate Selenium E Selenium E
Sino-Lung Formula Vira-Bac-Yst or Aller-Lung Support Vira-Bac-Yst or Aller-Lung Support
Spleeno-Lyph Simply Spleen Detox-N-Cleanse
T-Lyph Simply Thyroid Vegetarian Thyro
Thymo-Lyph Simply Thymus Vira-Bac-Yst
Thyro-Plus Vegetarian Thyro Vegetarian Thyro
Tillandsia B12 Complete Ear Health Vitamin B-6, B-12, & Folate
Total 5-HTP Restful Mind Support Vegetarian Tryptophan
Total Enzymes Pro-Enzyme Pro-Enzymes
Total Eyebright C Complete Ear Health Herbal Antioxidant
Total Eyebright M Complete Eye Health Herbal Antioxidant
Total Fem-Bal Le Feminine Advantage Libida-Life
Total Flu-Cdl #1 Thymo-Immune Vira-Bac-Yst
Total Green Green Vegetable Alkalizer or Vitamin-Mineral Shake Green Vegetable Alkalizer or Vitamin-Mineral Shake
Total Heart Cardio-Power CoQ10-Cardio
Total Leaky Gut Probio-Zyme-Yst Probio-Zyme-Yst
Total Lipotrophic Cholester-Right Cholester-Right
Total Liver D-Tox Liva-Detox & Support Detox-N-Cleanse
Total Male Prosta-Power Libida-Life, plus Zinc Complex
Total Multimmune Thymo-Immune Vira-Bac-Yst
Total Probiotics Probio-Zyme-Yst Probio-Zyme-Yst
Total Systemic D-tox Detox-N-Cleanse Detox-N-Cleanse
Total Thyroid #2 Metabolic Thyro Vegetarian Thyro
Total VR-X Vira-Chron Vira-Chron
Total Yst Redux Probio-Zyme-Yst Probio-Zyme-Yst
Trace Min Plus Vitamin-Mineral Vitamin-Mineral
#12 UR-Kid Arginase Bladder Green Vegetable Alkalizer
Uro-Bac Uro-Kid Support Green Vegetable Alkalizer
Vana-Chrom Gluco-Sugar-Balance Gluco-Sugar-Balance
Vermafuge-AG Para-Dysbio-Zyme Para-Dysbio-Zyme
Virex Vira-Chron Vira-Chron
Vitamin D3-400 D Complex D Complex
Whole System Fem-H Le Feminine Advantage Libida-Life
Whole System Histo-Zym Aller-Lung Support Aller-Lung Support
Whole System Intra-Bac Intracellular Cough Vira-Bac-Yst
Whole System Kidney Uro-Kid Support Green Vegetable Alkalizer
Whole System Liver Liva-Detox & Support Detox-N-Cleanse
Whole System Thymus Complex Thymo-Immune Vira-Bac-Yst
Whole System Yst GB Support Probio-Zyme-Yst
Yst-Dysbio-Cleans Probio-Zyme-Yst Probio-Zyme-Yst
Zinc Chelate Zinc Complex Zinc Complex
Medi-Herb (*) Food Research International Food Research Int’l Vegetarian
Adrenal Complex Vegetarian Adrenal Vegetarian Adrenal
Albizia Complex Aller-Lung Support Aller-Lung Support
Bacopa Complex Serious Brain Enhancer Vegetarian Tyrosine
Bilberry Complete Eye Health Herbal Antioxidant
Bone Complex Cal-Mag Complex Cal-Mag Complex
Boswellia Complex Uro-Kid Support Herbal Antioxidant
Broncafect Intracellular Cough Aller-Lung Support
Broncafect Phytosynergist Intracellular Cough Aller-Lung Support
Burdock Complex Para-Dysbio-Zyme Para-Dysbio-Zyme
Capsella Complex Phytosynergist Vegetarian Thyro and Simply Uterus Vegetarian Thyro and Magnesium Complex
Cat’s Claw Forte Aller-Lung Support Aller-Lung Support or Green Vegetable Alkalizer
Chaste Tree Le Feminine Advantage Vegetarian Thyro
ChelaCo Detox-N-Cleanse Detox-N-Cleanse
Colax GB Support Green Vegetable Alkalizer
Coleus Forte Metabolic Thyro Vegetarian Thyro
Cramplex Simply Thyroid Magnesium Complex
Cranberry Complex Arginase Bladder Vira-Bac-Yst
DermaCo Liva-DeTox & Support Detox-N-Cleanse
DiGest Digesti-Pan Pro-Enzymes
DiGest Phytosynergist Digesti-Pan Pro-Enzymes
Echinacea Premium Conga-Immune Vira-Bac-Yst and Zinc Complex
Eleuthero Anxie-Tone Vegetarian Tryptophan
Euphrasia Complex Thymo-Immune or Complete Eye Health Aller-Lung Support
Evening Primrose Oil Le Feminine Advantage Wheat Germ Oil E
Fe-Max Iron Tonic Phytosyn. Hematic Formula Hematic Formula
FemCo Le Feminine Advantage Libida-Life
Ganoderma & Shiitake Conga-Immune Vira-Bac-Yst and Zinc Complex
Garlic Forte Cholester-Right Cholester-Right
Ginkgo Forte Serious Brain Enhancer Vegetarian Tyrosine
Golden Seal Thymo-Immune Aller-Lung Support
Gotu Kola Complex Advanced Joint Complex Libida-Life
Gut Flora Complex Probio-Zyme-Yst Probio-Zyme-Yst
Gymnema Gluco-Sugar-Balance Gluco-Sugar-Balance
Hawthorn Co-Q10 Cardio Co-Q10 Cardio
Herbal Throat Spray Phytosyn. Conga-Immune Aller-Lung Support and Zinc Complex
HerbaVital Herbal Antioxidant or Libida-Life Herbal Antioxidant or Libida-Life
HiPep Digesti-Pan Pro-Enzymes
Horsechestnut Complex Metabolic Thyro Herbal Antioxidant
Kava Forte Restful Mind Support Vegetarian Tryptophan
LivCo Liva-DeTox & Support Pro-Enzymes, plus Green Vegetable Alkalizer
Livton Complex Liva-DeTox & Support Pro-Enzymes, plus Green Vegetable Alkalizer
Nervagenic Anxie-Tone or Restful Mind Support Vegetarian Tryptophan
Nevaton Anxie-Tone or Restful Mind Support Vegetarian Tryptophan
ProstaCo Prosta-Power Libida-Life
PulmaCo Aller-Lung Support or Simply Lung Aller-Lung Support
ResCo Intracellular Cough or Aller-Lung Sup. Aller-Lung Support
ResCo Phytosynergist Intracellular Cough or Aller-Lung Sup. Aller-Lung Support
Rhodiola & Ginseng Complex High Stress Adrenal Vegetarian Adrenal
Saligesic Inflam-Enzymes Inflam-Enzymes
Silymarin Liva-Detox & Support Herbal Antioxidant or Detox-N-Cleanse
St. John’s Wort Serious Brain Enhancer Vegetarian Tyrosine and/or Vegetarian Tryptophan
Thyroid Complex Metabolic Thyro or Migratrol Vegetarian Thyro
Tribulus Prosta-Power or Simply Ovary Libida-Life
UriCo Phytosynergist Arginase Bladder Vira-Bac-Yst
Valerian Complex Anxie-Tone or Restful Mind Support Vegetarian Tryptophan
Vitanox Herbal Antioxidant Herbal Antioxidant
Wild Yam Complex Le Feminine Advantage Libida-Life
Withania Complex Anxie-Tone or Restful Mind Support Vegetarian Tryptophan
Wormwood Complex Para-Dysbio-Zyme Para-Dysbio-Zyme
(*) Most of the product names are trademarks of the respective companies. ** Product contains 4x more wheat germ oil per capsule than SP’s version.
Standard Process (*) Food Research International Food Research Int’l Vegetarian
AC Carbamide Uro-Kid Support Green Vegetable Alkalizer
Adrenal, Desiccated Simply Adrenal Vegetarian Adrenal
AF Betafood Beetafood, GB Support Pro-Enzymes
Albaplex Uro-Kid Support Green Vegetable Alkalizer
Allerplex Aller-Lung Support Aller-Lung Support
Antronex Aller-Lung Support, Simply Liver Aller-Lung Support
Arginex Arginase Bladder Green Vegetable Alkalizer
B-6 - Niacinamide B Stress Complex B Stress Complex
Betacol GB Support Pro-Enzymes
Betaine Hydrochloride Digesti-Pan Pro-Enzymes
Biodent 1Cal-Mag Complex Cal-Mag Complex
Biost 1Cal-Mag Complex, Conga-Immune Cal-Mag Complex
Calcifood 2Cal-Mag Complex Cal-Mag Complex
Calcium Lactate 3Calcium Complex Calcium Complex
Cal-Ma Plus Parathyroid Plus Cal-Mag Complex
Calsol Cal-Mag Complex Cal-Mag Complex
Cardio-Plus Cardio-Power CoQ10-Cardio
Cardiotrophin PMG Simply Cardio CoQ10-Cardio
Catalyn Catalyst Complex or Vitamin-Mineral  Vitamin-Mineral 
Catalyn Chewable Vitamin-Mineral Shake Vitamin-Mineral Shake
Cataplex A-C-P A-C-P Complex C Complex, plus Vira-Bac-YST
Cataplex B Complex B B Stress Complex
Cataplex B-12 Vitamin B-6, B-12 & Folate Vitamin B-6, B-12 & Folate
Cataplex C C Complex C Complex
Cataplex D D Complex D Complex
Cataplex E Selenium E, plus Simply Liver Selenium E
Cataplex E2 Selenium E, plus Simply Liver Selenium E
Cataplex F Omega 3/EPA/DHA Wheat Germ Oil E
Cataplex G G Complex B Stress Complex
Cataplex GTF Gluco-Sugar-Balance Gluco-Sugar-Balance
Cayenne Pepper Advanced Joint Complex Detox-N-Cleanse
Chezyn Zinc Complex, plus Simply Liver Zinc Complex
Chlorophyl Complex Green Vegetable Alkalizer Green Vegetable Alkalizer
Cholachol GB Support Pro-Enzymes
Cholachol II GB Support, plus Aller-Lung Support Pro-Enzymes, plus Aller-Lung Support
Cholaplex GB Support or Nattokinase Cholester-Right or Nattokinase
Choline Choline Complex Choline Complex
Circuplex Anxie-Tone Vegetarian Adrenal
Congaplex Conga-Immune Vira-Chron, plus C Complex
Collagen C C Complex, plus Advanced Joint Complex C Complex
Collinsonia Root GB Support Pro-Enzymes, plus Magnesium Complex
Cruciferous Complete Green Vegetable Alkalizer Green Vegetable Alkalizer
Cyrofood Simply Liver, plus Vitamin-Mineral Shake Vitamin-Mineral Shake
Cyro-Yeast Probio-Zyme-YST Probio-Zyme-YST
Cyruta Vira-Bac-YST, plus Nattokinase Vira-Bac-YST, plus Nattokinase
Cyruta Plus Vira-Bac-YST Vira-Bac-YST
Dermatrophin PMG Advanced Joint Complex Herbal Antioxidant
Diaplex Digesti-Pan plus Gluco-Sugar-Balance Pro-Enzymes plus Gluco-Sugar-Balance
Disodium Phosphate GB Support Pro-Enzymes plus Gluco-Sugar-Balance
Drenamin High Stress Adrenal Vegetarian Adrenal
Drenatropin PMG Simply Adrenal Vegetarian Adrenal
Echinacea-C Thymo-Immune C Complex, plus Vira-Bac-YST
e-Manganese Migratrol plus Selenium E Vegetarian Thyro
Emphaplex Intracellular Cough plus Simply Lung Aller-Lung Support
e-Poise Vitamin-Mineral Shake Vitamin-Mineral Shake
Fen-Cho GB Support Pro-Enzymes
Fen-Gre Aller-Lung Support Aller-Lung Support
Ferrofood Hematic Formula Hematic Formula
Folic Acid B12 Vitamin B-6, B-12, & Folate Vitamin B-6, B-12, & Folate
For-Til B12 Complete Ear Health Vitamin B-6, B-12, & Folate
Garlic Cholester-Right Cholester-Right
Gastrex Digesti-Pan Pro-Enzymes
Ginko Synergy Serious Brain Enhancer Vegetarian Tyrosine plus Herbal Antioxidant
Glucosamine Synergy Advanced Joint Complex Inflam-Enzymes
Hepatrophin PMG Simply Liver Pro-Enzyme plus Green Vegetable Alkalizer
Hypothalamus PMG Hypothalamus EMG or Simply Hypothalamus B Stress Complex plus Vegetarian Adrenal
Hypothalamex Restful Mind Support Vegetarian Tryptophan, B Stress Complex
Immuplex Thymo-Immune Vira-Chron
Inositol Inositol Complex Inositol Complex
Iodomere Metabolic Thyro Vegetarian Thyro
Iplex Complete Eye Health Herbal Antioxidant, Vitamin-Mineral
Lact-Enz Probio-Zyme-Yst Probio-Zyme-Yst or Pro-Enzymes (vegan)
Lactic Acid Yeast Probio-Zyme-Yst Probio-Zyme-Yst or Pro-Enzymes (vegan)
Ligaplex I Cal-Mag Complex plus Inflam-Enzymes Cal-Mag Complex plus Inflam-Enzymes
Ligaplex II Advanced Joint Complex, plus Inflam-Enzymes Inflam-Enzymes
Linum B-6 Omega 3/EPA/DHA, plus Vitamin B-6, B-12, & Folate Wheat Germ Oil E, plus Vitamin B-6, B-12, & Folate
Livaplex Liva DeTox & Support Detox-N-Cleanse
Magnesium Lactate Magnesium Complex Magnesium Complex
Mammary PMG Simply Mammary Libida-Life
Manganese B-12 Cal-Mag Complex plus Vitamin B6, B-12 & Folate Cal-Mag Complex plus Vitamin B6, B-12 & Folate
Min-Chex Nerve Chex Cal-Mag Complex plus Vegetarian Thyro
Min-Tran Mineral Tran Cal-Mag Complex plus Vitamin B-6, B-12, & Folate and Vegetarian Tryptophan
Multi-Zyme Digesti-Pan Pro-Enzymes plus Para-Dysbio-Zyme
Myo-Plus Cardio-Power Co-Q10 Cardio
Myotrophin PMG Simply Cardio Co-Q10 Cardio
Neuroplex Serious Brain Enhancer Vegetarian Tyrosine, Vegetarian Adrenal
Neurotrophin PMG Serious Brain Enhancer Vegetarian Tryptophan, Vegetarian Adrenal
Niacinamide B-6 B Stress Complex B Stress Complex
Nutrimere Metabolic Thyro Vegetarian Thyro
Oculotrophin PMG Complete Eye Health Herbal Antioxidant
Okra Pepsin Digesti-Pan Pro-Enzymes
OPC Synergy Herbal Antioxidant Herbal Antioxidant
Orchex Simply Orchic Libida-Life
Orchic PMG Simply Orchic Libida-Life
Organically Bound Minerals Land and Sea Minerals Vitamin-Mineral Shake
Organic Iodine Vegetarian Thyro Vegetarian Thyro
Ostarplex Cal-Mag Complex Cal-Mag Complex
Ostrophin PMG Cal-Mag Complex Cal-Mag Complex
Ovatrophin PMG Simply Ovary or Le Feminine Advantage Libida-Life
Ovex or Ovex-P Simply Ovary or Le Feminine Advantage Libida-Life
Palmettoplex Prosta-Power Libida-Life
Pancreatrophin PMG Simply Pancreas Pro-Enzymes
Paraplex Simply Pancreas plus Migratrol Pro-Enzymes plus Magnesium Complex
Parotid PMG Complete Smell & Taste Zinc Complex plus Magnesium Complex
Phytolyn Green Vegetable Alkalizer Green Vegetable Alkalizer
Pituitrophin PGM Pituitary EMG Vegetarian Thyro
Pneumotrophin PMG Simply Lung Aller-Lung Support
Prolamine Iodine Vegetarian Thyro Vegetarian Thyro
Prost-X Prosta-Power Libida-Life plus Zinc Complex
Prostate PMG Prosta-Power Libida-Life plus Zinc Complex
Proteofood Digesti-Pan plus Para-Dysbio-Zyme Pro-Enzymes plus Para-Dysbio-Zyme
Renafood Arginase Bladder Vegetarian Adrenal plus Vitamin-Mineral Shake
Renatrophin PMG Uro-Kid Support Vegetarian Adrenal plus Vitamin-Mineral Shake
Ribonucleic Acid Serious Brain Enhancer Vegetarian Tyrosine, Vegetarian Adrenal
Rumaplex Advanced Joint Complex Cal-Mag Complex
Senaplex Restful Mind Support plus Vitamin-Mineral Vegetarian Tryptophan plus Vitamin-Mineral
Sesame Seed Oil Omega 3/EPA/DHA plus Green Vegetable Alkalizer Green Vegetable Alkalizer plus Wheat Germ Oil E
SP Cleanse Detox- N-Cleanse Detox- N-Cleanse
SP Complete Vitamin-Mineral Shake Vitamin-Mineral Shake
SP Green Food Green Vegetable Alkalizer or Vitamin-Mineral Shake Green Vegetable Alkalizer or Vitamin-Mineral Shake
Spanish Black Radish GB Support Probio-Zyme-Yst
Spleen Desiccated Simply Spleen Detox-N-Cleanse
Spleen PMG Spleen EMG Detox-N-Cleanse
St. John's Wort Anxie-Tone or Serious Brain Enhancer Vegetarian Tryptophan
Super EFF Omega 3/EPA/DHA Wheat Germ Oil E
Symplex F Le Feminine Advantage Libida-Life
Symplex M Prosta-Power Libida-Life
Thymex Simply Thymus Vira-Bac-YST
Thymus PMG Thymus EMG Vira-Bac-YST
Thytrophin PMG Thymus EMG Vegetarian Thyro
Trace Minerals- B12 Vitamin-Mineral Shake or Land and Sea Minerals Vitamin-Mineral Shake or Land and Sea Minerals
Tuna Omega-3 Oil Omega 3/EPA/DHA Wheat Germ Oil E
Utrophin PMG Simply Uterus Libida-Life
Vasculin Cardio-Power Vitamin B-6, B12, & Folate, plus Co-Q10 Cardio
Wheat Germ Oil Wheat Germ Oil Wheat Germ Oil
Wheat Germ Oil Fortified Wheat Germ Oil ** Wheat Germ Oil
Whey Pro-Complete Vitamin-Mineral Shake Vitamin-Mineral Shake
Whole Food Fiber Vitamin-Mineral Shake Vitamin-Mineral Shake
Zinc Liver Chelate Simply Liver plus Zinc Complex Zinc Complex plus Pro-Enzymes
Zymex Probio-Zyme-Yst Probio-Zyme-Yst
Zymex II Para-Dysbio-Zyme Para-Dysbio-Zyme
Zypan Digesti-Pan Pro-Enzymes
1 Dento-Gums is more equivalent. 2 Calci-Chew is more equivalent. 3 Calcium Lactate + is more equivalent. All of these are available from Bioscience Formulas. (*) Most of the product names are trademarks of the respective companies. ** Product contains 4x more wheat germ oil per capsule than SP’s version.
Nutri-West (*) Food Research International Food Research Int’l Vegetarian
Adreno-Lyph-160 Simply Adrenal Vegetarian Adrenal
Adreno-Lyph-Para High Stress Adrenal Vegetarian Adrenal
Adreno-Lyph-Sym Anxie-Tone Vegetarian Adrenal
Allerhale Aller-Lung Support Aller-Lung Support
Amino All Intracellular Cough Vitamin-Mineral Shake
Anxiolix Anxie-Tone Vegetarian Tryptophan
Aspartic Chrom Gluco-Sugar-Balance Gluco-Sugar-Balance
Aspartic Mag Magnesium Complex Magnesium Complex
Aspartic Multi-Min Vitamin-Mineral Vitamin-Mineral
B Complex B Stress Complex B Stress Complex
Beta-C-TR C Complex C Complex
Biostress-B Anxie-Tone B Stress Complex
Black Currant Seed Oil Le Feminine Advantage Wheat Germ Oil E
Black Walnut Para-Dysbio-Zyme Para-Dysbio-Zyme
Brain Plus Serious Brain Enhancer Vegetarian Tyrosine
C-1000-TR C Complex C Complex
CAL-MAG 1:1 Calcium Complex and Magnesium Complex Calcium Complex and Magnesium Complex
Calcium Lactate Cal-Mag Complex Cal-Mag Complex
Cand-Ex Probio-Zyme-Yst Probio-Zyme-Yst
Carbo-Met Gluco-Sugar-Balance Gluco-Sugar-Balance
Cardioplex Cardio-Power CoQ10-Cardio
Chewable C-500 C Complex C Complex
China West #6 Xanthium Formula Vira-Chron Vira-Chron
Chloroplex Green Vegetable Alkalizer Green Vegetable Alkalizer
CLM-NRV Anxie-Tone Vegetarian Tryptophan
Con-Lyph Conga-Immune Vira-Bac-Yst
Co Q 10-Plus CoQ10-Cardio CoQ10-Cardio
Complete Brain Charge Serious Brain Enhancer Vegetarian Tyrosine
Complete Child DHA/EPA Omega 3 EPA/DHA Wheat Germ Oil E
Complete Neuro Anxie-Tone Vegetarian Tryptophan
Core Level Adrenal High Stress Adrenal Vegetarian Adrenal
Core Level Bile GB Support Pro-Enzymes
Core Level Bone Matrix Cal-Mag Complex Cal-Mag Complex
Core Level C-TR Herbal Antioxidant C Complex
Core Level D-Tox Detox-N-Cleanse Detox-N-Cleanse
Core Level Health Reserve Vitamin-Mineral Vitamin-Mineral
Core Level Heart Cardio-Power CoQ10-Cardio
Core Level Kidney. Uro-Kid Support Green Vegetable Alkalizer
Core Level Liver Liva-Detox & Support Detox-N-Cleanse
Core Level Lung Simply Lung, plus Aller-Lung Support Aller-Lung Support
Core Level Magnesium Magnesium Complex Magnesium Complex
Core Level Manganese Cal-Mag Complex Cal-Mag Complex
Core Level Orchic Prosta-Power or Simply Orchic Libida-Life, plus Zinc Complex
Core Level Ovary Le Feminine Advantage or Simply Ovary Libida-Life
Core Level Pancreas Digesti-Pan or Simply Pancreas Pro-Enzymes
Core Level Pituitary Migratrol Vegetarian Thyro
Core Level Potassium Uro-Kid Support or Green Vegetable Alkalizer Green Vegetable Alkalizer
Core Level Prostate Prosta-Power Libida-Life, plus Zinc Complex
Core Level RNA Serious Brain Enhancer Vegetarian Tryptophan
Core Level Thymus Thymo-Immune Vira-Bac-Yst
Core Level Thyro Metabolic Thyro or Vegetarian Thyro Vegetarian Thyro
Core Level Uterus Le Feminine Advantage or Simply Uterus Libida-Life
Core Level Zinc Herbal Antioxidant or Zinc Complex Herbal Antioxidant or Zinc Complex
DHEA-25 High Stress Adrenal or Simply Adrenal Vegetarian Adrenal
Digest Plus Digesti-Pan Pro-Enzymes
Disc-Zyme Inflam-Enzymes Inflam-Enzymes
DIU-Plus Arginase Bladder or Uro-Kid Support Green Vegetable Alkalizer
DSF Formula Anxie-Tone Vegetarian Adrenal
E-Tocotrienols Selenium E Selenium E
Echinacea Conga-Immune Vira-Bac-Yst and Zinc Complex
Enzyme Forte Simply Pancreas Pro-Enzymes
Exspore Probio-Zyme-Yst Probio-Zyme-Yst
Eyebright Plus Complete Eye Health Herbal Antioxidant
F-Complex Omega 3 EPA/DHA Wheat Germ Oil E
Fem-Plus Le Feminine Advantage Libida-Life
Ferrous-Fumaro Hematic Formula Hematic Formula
Flualgia Thymo-Immune Vira-Bac-Yst
#3 GB-LIV GB Support Pro-Enzymes
GB-Plus GB Support Pro-Enzymes
GH-Choline Choline Complex Choline Complex
Glan-Plus-F Le Feminine Advantage Libida-Life
Glyco-Lyph Gluco-Sugar-Balance Gluco-Sugar-Balance
Greens Renew Powder Vitamin-Mineral Shake Vitamin-Mineral Shake
Hemo-Lyph Hematic Formula Hematic Formula
Homocysteine Redux Vitamin B-6, B-12, & Folate Vitamin B-6, B-12, & Folate
HPZ Vira-Chron Vira-Chron
Hyper-D Pro-Enzymes, plus Simply Pancreas Pro-Enzymes
Hypo-D Digesti-Pan Pro-Enzymes
Immu-Bac Thymo-Immune Vira-Bac-Yst
Immuno-Plus Thymo-Immune Vira-Bac-Yst
Iodine Rescue Vegetarian Thyro Vegetarian Thyro
ISB Formula Thymo-Immune or Intracellular Cough Vira-Bac-Yst, plus Vitamin-Mineral
Liga-PN Inflam-Enzymes or Advanced Joint Complex Inflam-Enzymes or Cal-Mag Complex
Lipotrophic Plus Cholester-Right Cholester-Right
Liva-Lyph Simply Liver Pro-Enzymes
LNG RESP Simply Lung, plus Aller-Lung Support Aller-Lung Support
LIV-GB Plus GB Support Pro-Enzymes
L-Tyrosine-S Vegetarian Tyrosine Vegetarian Tyrosine
Lyso-Lyph-Forte Inflam-Enzymes Inflam-Enzymes
Magnesium Chelate Magnesium Complex Magnesium Complex
Menopause Le Feminine Advantage Libida-Life
Multibalance Vitamin-Mineral Vitamin-Mineral
Multi-Gland Complex Intracellular Cough Vitamin-Mineral Shake
Ovary-Lyph-F Simply Ovary Libida-Life
Pan-Lyph Simply Pancreas Pro-Enzymes
Pan-Lyph Chelate Simply Pancreas, plus Zinc Complex Pro-Enzymes
Parazym-A Para-Dysbio-Zyme Para-Dysbio-Zyme
Parotid-Lyph Complete Smell & Taste Zinc Complex, plus Magnesium Complex
Pineal Lyph Restful Mind Support Vegetarian Tryptophan
Pit-Lyph-Anterior Migratrol Vegetarian Thyro
Pit-Lyph-Whole Migratrol Vegetarian Thyro
Pre/Post Natal Vitamin-Mineral Vitamin-Mineral
Pro-Cortisol Balance Anxie-Tone or Restful Mind Support Vegetarian Tryptophan
Prosta-Plus Prosta-Power Libida-Life, plus Zinc Complex
Prostate Support Prosta-Power Libida-Life, plus Zinc Complex
RNA-DNA-Plus Serious Brain Enhancer Vegetarian Tryptophan, plus Selenium E
Rutin Plus Herbal Antioxidant or Vira-Bac-Yst Herbal Antioxidant or Vira-Bac-Yst
Sago-C-500 C Complex C Complex
Selenium Chelate Selenium E Selenium E
Sino-Lung Formula Vira-Bac-Yst or Aller-Lung Support Vira-Bac-Yst or Aller-Lung Support
Spleeno-Lyph Simply Spleen Detox-N-Cleanse
T-Lyph Simply Thyroid Vegetarian Thyro
Thymo-Lyph Simply Thymus Vira-Bac-Yst
Thyro-Plus Vegetarian Thyro Vegetarian Thyro
Tillandsia B12 Complete Ear Health Vitamin B-6, B-12, & Folate
Total 5-HTP Restful Mind Support Vegetarian Tryptophan
Total Enzymes Pro-Enzyme Pro-Enzymes
Total Eyebright C Complete Ear Health Herbal Antioxidant
Total Eyebright M Complete Eye Health Herbal Antioxidant
Total Fem-Bal Le Feminine Advantage Libida-Life
Total Flu-Cdl #1 Thymo-Immune Vira-Bac-Yst
Total Green Green Vegetable Alkalizer or Vitamin-Mineral Shake Green Vegetable Alkalizer or Vitamin-Mineral Shake
Total Heart Cardio-Power CoQ10-Cardio
Total Leaky Gut Probio-Zyme-Yst Probio-Zyme-Yst
Total Lipotrophic Cholester-Right Cholester-Right
Total Liver D-Tox Liva-Detox & Support Detox-N-Cleanse
Total Male Prosta-Power Libida-Life, plus Zinc Complex
Total Multimmune Thymo-Immune Vira-Bac-Yst
Total Probiotics Probio-Zyme-Yst Probio-Zyme-Yst
Total Systemic D-tox Detox-N-Cleanse Detox-N-Cleanse
Total Thyroid #2 Metabolic Thyro Vegetarian Thyro
Total VR-X Vira-Chron Vira-Chron
Total Yst Redux Probio-Zyme-Yst Probio-Zyme-Yst
Trace Min Plus Vitamin-Mineral Vitamin-Mineral
#12 UR-Kid Arginase Bladder Green Vegetable Alkalizer
Uro-Bac Uro-Kid Support Green Vegetable Alkalizer
Vana-Chrom Gluco-Sugar-Balance Gluco-Sugar-Balance
Vermafuge-AG Para-Dysbio-Zyme Para-Dysbio-Zyme
Virex Vira-Chron Vira-Chron
Vitamin D3-400 D Complex D Complex
Whole System Fem-H Le Feminine Advantage Libida-Life
Whole System Histo-Zym Aller-Lung Support Aller-Lung Support
Whole System Intra-Bac Intracellular Cough Vira-Bac-Yst
Whole System Kidney Uro-Kid Support Green Vegetable Alkalizer
Whole System Liver Liva-Detox & Support Detox-N-Cleanse
Whole System Thymus Complex Thymo-Immune Vira-Bac-Yst
Whole System Yst GB Support Probio-Zyme-Yst
Yst-Dysbio-Cleans Probio-Zyme-Yst Probio-Zyme-Yst
Zinc Chelate Zinc Complex Zinc Complex
Medi-Herb (*) Food Research International Food Research Int’l Vegetarian
Adrenal Complex Vegetarian Adrenal Vegetarian Adrenal
Albizia Complex Aller-Lung Support Aller-Lung Support
Bacopa Complex Serious Brain Enhancer Vegetarian Tyrosine
Bilberry Complete Eye Health Herbal Antioxidant
Bone Complex Cal-Mag Complex Cal-Mag Complex
Boswellia Complex Uro-Kid Support Herbal Antioxidant
Broncafect Intracellular Cough Aller-Lung Support
Broncafect Phytosynergist Intracellular Cough Aller-Lung Support
Burdock Complex Para-Dysbio-Zyme Para-Dysbio-Zyme
Capsella Complex Phytosynergist Vegetarian Thyro and Simply Uterus Vegetarian Thyro and Magnesium Complex
Cat’s Claw Forte Aller-Lung Support Aller-Lung Support or Green Vegetable Alkalizer
Chaste Tree Le Feminine Advantage Vegetarian Thyro
ChelaCo Detox-N-Cleanse Detox-N-Cleanse
Colax GB Support Green Vegetable Alkalizer
Coleus Forte Metabolic Thyro Vegetarian Thyro
Cramplex Simply Thyroid Magnesium Complex
Cranberry Complex Arginase Bladder Vira-Bac-Yst
DermaCo Liva-DeTox & Support Detox-N-Cleanse
DiGest Digesti-Pan Pro-Enzymes
DiGest Phytosynergist Digesti-Pan Pro-Enzymes
Echinacea Premium Conga-Immune Vira-Bac-Yst and Zinc Complex
Eleuthero Anxie-Tone Vegetarian Tryptophan
Euphrasia Complex Thymo-Immune or Complete Eye Health Aller-Lung Support
Evening Primrose Oil Le Feminine Advantage Wheat Germ Oil E
Fe-Max Iron Tonic Phytosyn. Hematic Formula Hematic Formula
FemCo Le Feminine Advantage Libida-Life
Ganoderma & Shiitake Conga-Immune Vira-Bac-Yst and Zinc Complex
Garlic Forte Cholester-Right Cholester-Right
Ginkgo Forte Serious Brain Enhancer Vegetarian Tyrosine
Golden Seal Thymo-Immune Aller-Lung Support
Gotu Kola Complex Advanced Joint Complex Libida-Life
Gut Flora Complex Probio-Zyme-Yst Probio-Zyme-Yst
Gymnema Gluco-Sugar-Balance Gluco-Sugar-Balance
Hawthorn Co-Q10 Cardio Co-Q10 Cardio
Herbal Throat Spray Phytosyn. Conga-Immune Aller-Lung Support and Zinc Complex
HerbaVital Herbal Antioxidant or Libida-Life Herbal Antioxidant or Libida-Life
HiPep Digesti-Pan Pro-Enzymes
Horsechestnut Complex Metabolic Thyro Herbal Antioxidant
Kava Forte Restful Mind Support Vegetarian Tryptophan
LivCo Liva-DeTox & Support Pro-Enzymes, plus Green Vegetable Alkalizer
Livton Complex Liva-DeTox & Support Pro-Enzymes, plus Green Vegetable Alkalizer
Nervagenic Anxie-Tone or Restful Mind Support Vegetarian Tryptophan
Nevaton Anxie-Tone or Restful Mind Support Vegetarian Tryptophan
ProstaCo Prosta-Power Libida-Life
PulmaCo Aller-Lung Support or Simply Lung Aller-Lung Support
ResCo Intracellular Cough or Aller-Lung Sup. Aller-Lung Support
ResCo Phytosynergist Intracellular Cough or Aller-Lung Sup. Aller-Lung Support
Rhodiola & Ginseng Complex High Stress Adrenal Vegetarian Adrenal
Saligesic Inflam-Enzymes Inflam-Enzymes
Silymarin Liva-Detox & Support Herbal Antioxidant or Detox-N-Cleanse
St. John’s Wort Serious Brain Enhancer Vegetarian Tyrosine and/or Vegetarian Tryptophan
Thyroid Complex Metabolic Thyro or Migratrol Vegetarian Thyro
Tribulus Prosta-Power or Simply Ovary Libida-Life
UriCo Phytosynergist Arginase Bladder Vira-Bac-Yst
Valerian Complex Anxie-Tone or Restful Mind Support Vegetarian Tryptophan
Vitanox Herbal Antioxidant Herbal Antioxidant
Wild Yam Complex Le Feminine Advantage Libida-Life
Withania Complex Anxie-Tone or Restful Mind Support Vegetarian Tryptophan
Wormwood Complex Para-Dysbio-Zyme Para-Dysbio-Zyme
(*) Most of the product names are trademarks of the respective companies. ** Product contains 4x more wheat germ oil per capsule than SP’s version.
Standard Process (*) Food Research International Food Research Int’l Vegetarian
AC Carbamide Uro-Kid Support Green Vegetable Alkalizer
Adrenal, Desiccated Simply Adrenal Vegetarian Adrenal
AF Betafood Beetafood, GB Support Pro-Enzymes
Albaplex Uro-Kid Support Green Vegetable Alkalizer
Allerplex Aller-Lung Support Aller-Lung Support
Antronex Aller-Lung Support, Simply Liver Aller-Lung Support
Arginex Arginase Bladder Green Vegetable Alkalizer
B-6 – Niacinamide B Stress Complex B Stress Complex
Betacol GB Support Pro-Enzymes
Betaine Hydrochloride Digesti-Pan Pro-Enzymes
Biodent 1Cal-Mag Complex Cal-Mag Complex
Biost 1Cal-Mag Complex, Conga-Immune Cal-Mag Complex
Calcifood 2Cal-Mag Complex Cal-Mag Complex
Calcium Lactate 3Calcium Complex Calcium Complex
Cal-Ma Plus Parathyroid Plus Cal-Mag Complex
Calsol Cal-Mag Complex Cal-Mag Complex
Cardio-Plus Cardio-Power CoQ10-Cardio
Cardiotrophin PMG Simply Cardio CoQ10-Cardio
Catalyn Catalyst Complex or Vitamin-Mineral  Vitamin-Mineral 
Catalyn Chewable Vitamin-Mineral Shake Vitamin-Mineral Shake
Cataplex A-C-P A-C-P Complex C Complex, plus Vira-Bac-YST
Cataplex B Complex B B Stress Complex
Cataplex B-12 Vitamin B-6, B-12 & Folate Vitamin B-6, B-12 & Folate
Cataplex C C Complex C Complex
Cataplex D D Complex D Complex
Cataplex E Selenium E, plus Simply Liver Selenium E
Cataplex E2 Selenium E, plus Simply Liver Selenium E
Cataplex F Omega 3/EPA/DHA Wheat Germ Oil E
Cataplex G G Complex B Stress Complex
Cataplex GTF Gluco-Sugar-Balance Gluco-Sugar-Balance
Cayenne Pepper Advanced Joint Complex Detox-N-Cleanse
Chezyn Zinc Complex, plus Simply Liver Zinc Complex
Chlorophyl Complex Green Vegetable Alkalizer Green Vegetable Alkalizer
Cholachol GB Support Pro-Enzymes
Cholachol II GB Support, plus Aller-Lung Support Pro-Enzymes, plus Aller-Lung Support
Cholaplex GB Support or Nattokinase Cholester-Right or Nattokinase
Choline Choline Complex Choline Complex
Circuplex Anxie-Tone Vegetarian Adrenal
Congaplex Conga-Immune Vira-Chron, plus C Complex
Collagen C C Complex, plus Advanced Joint Complex C Complex
Collinsonia Root GB Support Pro-Enzymes, plus Magnesium Complex
Cruciferous Complete Green Vegetable Alkalizer Green Vegetable Alkalizer
Cyrofood Simply Liver, plus Vitamin-Mineral Shake Vitamin-Mineral Shake
Cyro-Yeast Probio-Zyme-YST Probio-Zyme-YST
Cyruta Vira-Bac-YST, plus Nattokinase Vira-Bac-YST, plus Nattokinase
Cyruta Plus Vira-Bac-YST Vira-Bac-YST
Dermatrophin PMG Advanced Joint Complex Herbal Antioxidant
Diaplex Digesti-Pan plus Gluco-Sugar-Balance Pro-Enzymes plus Gluco-Sugar-Balance
Disodium Phosphate GB Support Pro-Enzymes plus Gluco-Sugar-Balance
Drenamin High Stress Adrenal Vegetarian Adrenal
Drenatropin PMG Simply Adrenal Vegetarian Adrenal
Echinacea-C Thymo-Immune C Complex, plus Vira-Bac-YST
e-Manganese Migratrol plus Selenium E Vegetarian Thyro
Emphaplex Intracellular Cough plus Simply Lung Aller-Lung Support
e-Poise Vitamin-Mineral Shake Vitamin-Mineral Shake
Fen-Cho GB Support Pro-Enzymes
Fen-Gre Aller-Lung Support Aller-Lung Support
Ferrofood Hematic Formula Hematic Formula
Folic Acid B12 Vitamin B-6, B-12, & Folate Vitamin B-6, B-12, & Folate
For-Til B12 Complete Ear Health Vitamin B-6, B-12, & Folate
Garlic Cholester-Right Cholester-Right
Gastrex Digesti-Pan Pro-Enzymes
Ginko Synergy Serious Brain Enhancer Vegetarian Tyrosine plus Herbal Antioxidant
Glucosamine Synergy Advanced Joint Complex Inflam-Enzymes
Hepatrophin PMG Simply Liver Pro-Enzyme plus Green Vegetable Alkalizer
Hypothalamus PMG Hypothalamus EMG or Simply Hypothalamus B Stress Complex plus Vegetarian Adrenal
Hypothalamex Restful Mind Support Vegetarian Tryptophan, B Stress Complex
Immuplex Thymo-Immune Vira-Chron
Inositol Inositol Complex Inositol Complex
Iodomere Metabolic Thyro Vegetarian Thyro
Iplex Complete Eye Health Herbal Antioxidant, Vitamin-Mineral
Lact-Enz Probio-Zyme-Yst Probio-Zyme-Yst or Pro-Enzymes (vegan)
Lactic Acid Yeast Probio-Zyme-Yst Probio-Zyme-Yst or Pro-Enzymes (vegan)
Ligaplex I Cal-Mag Complex plus Inflam-Enzymes Cal-Mag Complex plus Inflam-Enzymes
Ligaplex II Advanced Joint Complex, plus Inflam-Enzymes Inflam-Enzymes
Linum B-6 Omega 3/EPA/DHA, plus Vitamin B-6, B-12, & Folate Wheat Germ Oil E, plus Vitamin B-6, B-12, & Folate
Livaplex Liva DeTox & Support Detox-N-Cleanse
Magnesium Lactate Magnesium Complex Magnesium Complex
Mammary PMG Simply Mammary Libida-Life
Manganese B-12 Cal-Mag Complex plus Vitamin B6, B-12 & Folate Cal-Mag Complex plus Vitamin B6, B-12 & Folate
Min-Chex Nerve Chex Cal-Mag Complex plus Vegetarian Thyro
Min-Tran Mineral Tran Cal-Mag Complex plus Vitamin B-6, B-12, & Folate and Vegetarian Tryptophan
Multi-Zyme Digesti-Pan Pro-Enzymes plus Para-Dysbio-Zyme
Myo-Plus Cardio-Power Co-Q10 Cardio
Myotrophin PMG Simply Cardio Co-Q10 Cardio
Neuroplex Serious Brain Enhancer Vegetarian Tyrosine, Vegetarian Adrenal
Neurotrophin PMG Serious Brain Enhancer Vegetarian Tryptophan, Vegetarian Adrenal
Niacinamide B-6 B Stress Complex B Stress Complex
Nutrimere Metabolic Thyro Vegetarian Thyro
Oculotrophin PMG Complete Eye Health Herbal Antioxidant
Okra Pepsin Digesti-Pan Pro-Enzymes
OPC Synergy Herbal Antioxidant Herbal Antioxidant
Orchex Simply Orchic Libida-Life
Orchic PMG Simply Orchic Libida-Life
Organically Bound Minerals Land and Sea Minerals Vitamin-Mineral Shake
Organic Iodine Vegetarian Thyro Vegetarian Thyro
Ostarplex Cal-Mag Complex Cal-Mag Complex
Ostrophin PMG Cal-Mag Complex Cal-Mag Complex
Ovatrophin PMG Simply Ovary or Le Feminine Advantage Libida-Life
Ovex or Ovex-P Simply Ovary or Le Feminine Advantage Libida-Life
Palmettoplex Prosta-Power Libida-Life
Pancreatrophin PMG Simply Pancreas Pro-Enzymes
Paraplex Simply Pancreas plus Migratrol Pro-Enzymes plus Magnesium Complex
Parotid PMG Complete Smell & Taste Zinc Complex plus Magnesium Complex
Phytolyn Green Vegetable Alkalizer Green Vegetable Alkalizer
Pituitrophin PGM Pituitary EMG Vegetarian Thyro
Pneumotrophin PMG Simply Lung Aller-Lung Support
Prolamine Iodine Vegetarian Thyro Vegetarian Thyro
Prost-X Prosta-Power Libida-Life plus Zinc Complex
Prostate PMG Prosta-Power Libida-Life plus Zinc Complex
Proteofood Digesti-Pan plus Para-Dysbio-Zyme Pro-Enzymes plus Para-Dysbio-Zyme
Renafood Arginase Bladder Vegetarian Adrenal plus Vitamin-Mineral Shake
Renatrophin PMG Uro-Kid Support Vegetarian Adrenal plus Vitamin-Mineral Shake
Ribonucleic Acid Serious Brain Enhancer Vegetarian Tyrosine, Vegetarian Adrenal
Rumaplex Advanced Joint Complex Cal-Mag Complex
Senaplex Restful Mind Support plus Vitamin-Mineral Vegetarian Tryptophan plus Vitamin-Mineral
Sesame Seed Oil Omega 3/EPA/DHA plus Green Vegetable Alkalizer Green Vegetable Alkalizer plus Wheat Germ Oil E
SP Cleanse Detox- N-Cleanse Detox- N-Cleanse
SP Complete Vitamin-Mineral Shake Vitamin-Mineral Shake
SP Green Food Green Vegetable Alkalizer or Vitamin-Mineral Shake Green Vegetable Alkalizer or Vitamin-Mineral Shake
Spanish Black Radish GB Support Probio-Zyme-Yst
Spleen Desiccated Simply Spleen Detox-N-Cleanse
Spleen PMG Spleen EMG Detox-N-Cleanse
St. John’s Wort Anxie-Tone or Serious Brain Enhancer Vegetarian Tryptophan
Super EFF Omega 3/EPA/DHA Wheat Germ Oil E
Symplex F Le Feminine Advantage Libida-Life
Symplex M Prosta-Power Libida-Life
Thymex Simply Thymus Vira-Bac-YST
Thymus PMG Thymus EMG Vira-Bac-YST
Thytrophin PMG Thymus EMG Vegetarian Thyro
Trace Minerals- B12 Vitamin-Mineral Shake or Land and Sea Minerals Vitamin-Mineral Shake or Land and Sea Minerals
Tuna Omega-3 Oil Omega 3/EPA/DHA Wheat Germ Oil E
Utrophin PMG Simply Uterus Libida-Life
Vasculin Cardio-Power Vitamin B-6, B12, & Folate, plus Co-Q10 Cardio
Wheat Germ Oil Wheat Germ Oil Wheat Germ Oil
Wheat Germ Oil Fortified Wheat Germ Oil ** Wheat Germ Oil
Whey Pro-Complete Vitamin-Mineral Shake Vitamin-Mineral Shake
Whole Food Fiber Vitamin-Mineral Shake Vitamin-Mineral Shake
Zinc Liver Chelate Simply Liver plus Zinc Complex Zinc Complex plus Pro-Enzymes
Zymex Probio-Zyme-Yst Probio-Zyme-Yst
Zymex II Para-Dysbio-Zyme Para-Dysbio-Zyme
Zypan Digesti-Pan Pro-Enzymes
1 Dento-Gums is more equivalent. 2 Calci-Chew is more equivalent. 3 Calcium Lactate + is more equivalent. All of these are available from Bioscience Formulas. (*) Most of the product names are trademarks of the respective companies. ** Product contains 4x more wheat germ oil per capsule than SP’s version.

Dr. Fauci Takes Isolated Vitamin D and Synthetic Vitamin C

Dr. Fauci takes isolated vitamin D and synthetic vitamin C

By Dr. Robert Thiel

Dr. Anthony Fauci, who is the director of the National Institute of Allergy and Infectious Diseases and a key member of the Coronavirus Task Force, was interviewed:

September 13, 2020

As the world waits for a coronavirus vaccine, many Americans are taking whatever they can to “boost their immunity” against COVID-19. That’s why two actresses, when they had a chance to interview Dr. Anthony Fauci, the director of the National Institute of Allergy and Infectious Diseases and key member of the Coronavirus Task Force, asked him about just that.

Fauci Takes These Two Vitamins Himself

In an interview that was fairly kid-focused, Jennifer Garner asked Fauci, “Now, should moms be doing something just to boost our kids’ immune system? You know, do you need more vitamin C? Do they need more spinach? Is there anything we should be doing? Elderberry?”

Said Fauci: “The answer is to the dismay of many: No. So if a child is deficient…there are two vitamins that you should consider. For example, if you are deficient in vitamin D, that does have an impact on your susceptibility to infection. So I would not mind recommending, and I do it myself taking vitamin D supplements. The other vitamin that people take is vitamin C because it’s a good antioxidant. So if people want to take a gram or two at the most vitamin C, that would be fine. So vitamin C and vitamin D. Okay. Any of the other concoctions and herbs I would not do.” https://www.yahoo.com/lifestyle/dr-fauci-takes-two-vitamins-105900209.html

Let’s go over some of this.

First, yes, vitamin D can be quite helpful. Notice the following:  Vitamin D deficiency increases a person’s risk for catching COVID-19 by 77% compared to those with sufficient levels of the nutrient, a study published Thursday by JAMA Network Open found. https://www.upi.com/Health_News/2020/09/03/Vitamin-D-deficiency-raises-COVID-19-infection-risk-by-77-study-finds/7001599139929/

The human body, with the aid of sunlight, converts cholesterol into vitamin D. And vitamin D can help the immune system. It also looks to reduce the severity of COVID-19 symptoms in some  (see COVID-19: Ghana pushing exercise, Germany reports about Vitamin D). Isolated vitamin D, such as what Dr. Fauci presumably takes, is not as natural as food source vitamin D, but normally does assist in elevating vitamin D levels.

Second, yes, vitamin C can be helpful. But, Dr. Fauci is not an expert on nutrition or natural interventions for COVID-19. Synthetic vitamin C, normally listed as ascorbic acid, is NOT “a good antioxidant” for human beings as Dr. Fauci claimed. At best, ascorbic acid is a “weak antioxidant” in vivo (in the human body). Here is some information from my book The Truth About Vitamins and Minerals in Supplements:

Vitamin C 

Ascorbic acid (AA) is not a synonym for vitamin C, though it certainly has vitamin C (antiscorbutic) properties; dehydroascorbic acid, DHAA, is the other biologically active form [1-3].  As will be shown later in this chapter, this does not mean that isolated ascorbic acid has the same beneficial properties that vitamin C has in food. Foods generally contain two biologically active forms of vitamin C [1,4,5], yet most synthetic vitamin C only contains isolated ascorbic acid [6,7].  In foods that contain ascorbate, it never exists as an isolate [1,4]. In foods, vitamin C is complexed with carbohydrates, proteins, lipids, and other components of food [1,4].

Ascorbate complexed in food is not the same as isolated ascorbic acid [8]. Under an electron microscope ascorbic acid appears to be crystalline, whereas vitamin C complexed in food appears rounded [9]. The body does not retain isolated ascorbic acid as well as vitamin C from foods [10-12]; this is probably why many who advocate isolated ascorbic acid tell people they need to take it throughout the day.

It is of interest to note that even Albert Szent Gyorgyi, while accepting the Nobel prize for isolating ascorbic acid, told scientists that isolated ascorbic acid did not work by itself, that vitamin C worked best with the factors that are naturally found with it in foods such as citrus.  It has been correctly written that “it was not honest to use the term ‘vitamin C’ for ascorbic acid.  That term should be reserved for the vitamin C COMPLEX.”  “As recently as 1993, to differentiate articles sold as drugs from nutritional supplements, the US Pharmacopoeia referred to ‘ascorbic acid’ as a recognized drug name and ‘vitamin C’ as a recognized food name” [11].   That is a good way even today to think of the difference: Food vitamin C is a real food, while regular ‘natural’ ascorbic acid is pharmaceutically manufactured.   JUST BECAUSE A LABEL CLAIMS THAT IT IS NATURAL, IT DOES NOT MEAN THAT IT DOES NOT CONTAIN AN UNNATURAL SUBSTANCE SUCH AS ISOLATED ASCORBIC ACID, WHICH IS ALWAYS SYNTHETICALLY PRODUCED.

In a limited sense, isolated ascorbic acid is natural.  It originates from corn, but by the time it is processed and sold it bears no resemblance to any natural food [11].  Specifically, non-food, ‘natural’ ascorbic acid is made by fermenting corn sugar into sorbitol, then hydrogenating it until it turns into sorbose.  Then acetone is added to break the molecular bonds, which creates isolated, crystalline, ascorbic acid.  Ascorbic acid does not contain both forms of vitamin C nor bioflavonoids, thus is too incomplete to properly be called vitamin C.  Isolated ascorbic acid is not considered to be natural vitamin C and should not be called vitamin C.

Also, the various patented ‘vitamin C’ compounds that are touted as less acidic than ascorbic acid also are not food.  It is not possible to get a US patent on naturally occurring vitamins as found in food.  For the record, it should be noted that Food vitamin C (as found in tablets) is about ten times less acidic than ascorbic acid.

Bioavailability of Vitamin C

Jacob has written, “The bioavailability of vitamin C in food and ‘natural form’ supplements is not significantly different from that of pure synthetic AA” [4].  For proof he cites two papers.  The first citation is a paper by Mangels (et al) [7]. It is a study that concludes since serum ascorbic acid levels were at similar levels after various vitamin C containing foods and synthetic ascorbic acid were consumed, that the bioavailability is similar.  The study itself appears to be an excellent one, but its conclusions ignore the fact that it may be possible that DHAA or other food constituents associated with natural vitamin C may have positive effects other than raising serum ascorbate levels.  The second citation is a study done by Johnson and Luo [13].  This particular study should not have been cited as it never compared vitamin C as complexed in food versus synthetic ascorbic acid.  It is an excellent paper which compared synthetic ascorbic acid to Ester-C (a commercial blend of ascorbic acid and select metabolites) and to synthetic ascorbic acid mixed with some bioflavonoids.  The data in this study showed that absorption was minimally better with the product with added bioflavonoids, though the authors concluded the differences were not significant [13].

Also Levine (et al) has written, that “There are no data for true bioavailability of vitamin C administered with foods or with compounds in foods,” yet the same chapter also states, “Diets with high vitamin C content from fruits and vegetables are associated with lower cancer risk, especially for cancers of the oral cavity, esophagus, stomach, colon, and lung.  In contrast, consumption of vitamin C as a supplement in experimental trials had no effect on development of colorectal adenoma and stomach cancer” [2]. In other words, whether it is vitamin C or other components of food, foods which are naturally high in vitamin C are better than isolated ascorbic acid.

Although “the bioavailability of vitamin C in humans and… our current understanding of that process and factors that influence it are incomplete” [14], it appears that slower disintegration times improve the bioavailability of vitamin C [15], and that is what foods have.

Other reports seem to give a reasonable hint about the comparison of vitamin C in foods compared to isolated ascorbic acid [11,16-23]; they suggest that foods are superior.

A human study found that a food complex containing 500mg of vitamin C was 2.16 times more effective in reducing sorbitol in diabetics than was isolated ascorbic acid [24]. One study by Vinson and Howard showed an average decrease of 46.8% in protein glycation after four weeks using 1000mg per day of vitamin C complexed in food [25], while a study by Davie, Gould, and Yudkin only had a 33% reduction in three months using 1000mg of isolated ascorbic acid per day [22]. An animal study found that after one month of feeding, vitamin C complexed with food (it was not a simple mixture) induced a significant reduction of 77%, 66%, and 40% in plasma total cholesterol, LDL + VLDL, and triglycerides respectively and that USP ascorbic acid or bioflavonoids alone were ineffective (though isolated USP ascorbic acid did raise HDL); this same study also found that the natural food complex vitamin C strongly inhibited atherosclerosis [26]. Another animal study found that vitamin C complexed in food was 41% more effective than isolated ascorbic acid in decreasing galactitol when cataracts were present [27]. These studies suggest that there may be multiple benefits associated with natural vitamin C that are not always apparent when only serum ascorbic acid levels are measured. Some studies have found much more vitamin C in the blood after 4 hours after ingesting a food vs. a non-food form [e.g. 28-29]. That could be almost infinitely better, depending on what is going on in the body at that time or have basically no benefit at all. It would seem that the body having sufficient vitamin C to deal with free radicals, support the immune system, etc. than to possibly have less than an optimal amount is not the best.

Antioxidant Properties 

Although ascorbic acid is a powerful antioxidant in vitro, it does not have proven significant antioxidant effects in vivo.  How substances react in biological systems and in tests tubes is not always the same. “Despite epidemiological and some experimental studies, it has not been possible to show conclusively that higher than anti-scorbutic intake of” ascorbic acid  “has antioxidant clinical benefit” as ascorbic acid “may be a weak antioxidant in vivo, or its antioxidant actions may have no physiological role, or its role may be small.  The oxidative hypothesis is unproven” [30].  On the other hand, high vitamin C containing foods do have proven in vitro and in vivo antioxidant effects [31].

De-emphasizing vitamin C containing foods by attempting to consume higher quantities of isolated ascorbic acid simply will not have the effects on plasma vitamin C levels, ORP, ORAC, or other health aspects that many consumers of isolated ascorbic acid hope it will.

Oxidative Redux Potential

An in vitro study (see Table 1) found that Food vitamin C tablets have negative ORP (oxidative reductive potential), yet the Merck Index shows that so-called ‘natural’ ascorbic acid has positive ORP.  Negative ORP is much better as it helps ‘clean up’ oxidative damage whereas items with positive ORP do not.  Since it takes negative ORP to clean up oxidative damage, it is logical that only vitamin C in food would be chosen by any interested in dealing with the consequences of free radical damage.

Table 1

USP Ascorbic Acid vs. Food Vitamin C

Nutrient                                                                        pH       Oxidative Reduction Potential 

USP ascorbic acid                                                       3.3                              129 mV

Buffered USP ascorbic acid                                    4.8                                27  mV

Food vitamin C                                                            4.8                              -78  mV

While this study was done in vitro, since Food vitamin C has proven antioxidant effects in vivo [30] and isolated ascorbic acid does not [23], it seems reasonable to conclude that food vitamin C both prevents oxidative damage and ‘cleans up’ damage much better than isolated ascorbic acid.

ORAC

ORAC is an abbreviation for oxygen radical absorbance capacity and is considered one of the best current ways to determine the free-radical fighting abilities of foods/nutrients.

One study found that a specially-grown orange C complex was proven to have 492 micro moles per gram T.E. (Trolox equivalents) of hydrophilic ORAC [19]—ORAC is essentially a measurement of the ability to quench free radicals (antioxidant ability)—while blueberries (one of the highest ORAC sources [20]) only had 195 micro moles per gram T.E. [19]—thus specially-grown orange C complex has 2.52 times the ORAC ability of blueberries.  Vitamin C containing food has over 15.6 times the ORAC of isolated ascorbic acid [20].

Bioflavonoids

Bioflavonoids are normally yellowish substances that are derivatives of flavones. Some have called them vitamin H. They help to maintain capillary walls, which helps to prevent the likelihood of hemorrhaging and bruising. They are also believed to enhance the effectiveness of vitamin C. And while some ascorbic acid formulas contain some bioflavonoids, they normally do not have the full complement of them that nature provides.  Citrus fruits, for example, contain a variety of truly organic bioflavonoids including flavanone glycosides, naringin, neorioctrin, neohesperidin, hesperiden, flavone glycosides, rhoifolin, luteolin, neodiosnin, flavon aglycones, tetra-o-methylisoscutellaren, sinensetin, isosinensetin, tangeretin, nobiletin, 5-0-desmethyl-nobiletin.

Conclusions

The Recommended Daily Allowance (RDA) for vitamin C is currently 60mg per day.  Many feel that the RDA for vitamin C should be 200mg per day [2]. Consuming five servings of fruits and vegetables per day will result in an intake of least 210mg per day of natural vitamin C [2]. There may be more in fresh organic produce; a recent study found that organically grown tomatoes have more vitamin C than “conventionally” grown ones [31].  Although there have been many studies involving isolated ascorbic acid that show it has benefits to human health, studies that have compared it to vitamin C complexed in food tend to show more benefits for the vitamin C in food.

REFERENCES

[1] Ross AC, et al, editors. Modern Nutrition in Health & Disease, 11th ed. Lippincott Williams & Wilkins, Balt., 2014
[2] Levine, M, et al.  Vitamin C.  In Present Knowledge in Nutrition, 7th ed.  ILSI Press, Washington, 1996:146-159
[3] Burr-Madsen A.  Gateways College of Natural Health, Module 1.  Gateways College, Shingle Springs (CA), 1996
[4] Jacob RA. Vitamin C. In Modern Nutrition in Health and Disease, 9th ed.  William & Wilkins, Balt.,1999:467-483
[5] Vanderslice JT, Higgs DJ.  Vitamin C content of foods: sample variability.  Am J Clin Nutr, 1991;54(Supp 6):1323S-1327S
[6] The United States Pharmacopeial Convention.  USAN and USP Dictionary of Drug Names.  Mack Printing, Easton (PA), 1986
[7] Mangels AR, et al.  The bioavailability to humans of ascorbic acid from oranges, orange juice and cooked broccoli is similar to that of synthetic ascorbic acid.  J Nutr, 1993;123(6):1054-1061
[8] Turner G.  Spectral Data Services, Tests conducted Feb. 1993
[9]  Thiel R.  Vitamins are naturally found in food complexes.  ANMA Monitor, 1999; 3(1):5-9
[10] Curto TM, Giovannucci EL, McKinlay JB, Maserejian NN. Associations between supplemental or dietary intake of vitamin C and severity of lower urinary tract symptoms. BJU Int. 2015 Jan;115(1):134-42
[11] DeCava J.  Of foods and supplements.  Nutrition News and Views, 1999;3(3):1-10
[12] Summary of bioavailability study results.  Technical Bulletin #s-13.  IntraCell Nutrition, Fort Lee (NJ), 1993
[13] Johnson C, Luo B.  Comparison of the absorption and excretion of three commercially available sources of vitamin C.  J Am Diet Assoc, 1994;94:779-781
[14] Mayersohn M.  Vitamin C bioavailability.  J Nutr Sci Vitaminol,1992;Spec:446-449
[15] Bhagavan HN, Wolkoff BI.  Correlation between the disintegration time and the bioavailability of vitamin C tablets. Pharm Res,1993;10(2):239-242
[16] Mack A.  All vitamin supplements not created equal.  Med Trib, May 21, 1998:17
[17] Thiel R.J, Fowkes S.W.  Can cognitive deterioration associated with Down syndrome be reduced?  Med Hypo. 2005; 64(3):524-532
[18] Thiel R.J.  Natural vitamins may be superior to synthetic ones.  Med Hypo. 2000; 55(6):461-469
[19] ORAC Test by Brunswick Laboratories, Wareham (MA), February 2006
[20] Williams D. ORAC values for fruits and vegetables. Alternatives, 1999;7(22):171
[21] Weisburger JH.  Vitamin C and disease prevention.  J Am Coll Nutr, 1995;14(2):109-111
[22] Davie SJ, Gould BJ, Yudkin JS.  Effect of vitamin C on glycation of proteins.  Diabetes, 1992;41:161-173 D.C.,1995
[23] Sebastian J, et al. Vitamin C as an antioxidant: evaluation of its role in disease prevention. J Am Coll Nutr. 2003;22(1):18-35
[24] Vinson JA, et al. In vitro and in vivo reduction of erythrocyte sorbitol by ascorbic acid. Diabetes, 1989;38:1036-1041
[25] Vinson JA, Howard TB. Inhibition of protein glycation and advanced glycation end products by ascorbic acid and other vitamins and nutrients. Nutr Bioch, 1996;7:659-663
[26] Vinson JA, Hu S, Jung S. A citrus extract plus ascorbic acid decreases lipids, lipid peroxides, lipoprotein oxidative susceptibility, and atherosclerosis in hypercholesterolemic hamsters. J Agric Food Chem, 1998;46:1453-1469
[27] Vinson JA, Courey JM, Maro NP. Comparison of two forms of vitamin C on galactose cataracts. In Nutrition Research, Vol 12. Pergamon Press, 1992:915-922
[28] Vinson JA, Bose P. Comparative bioavailabililty of humans to ascorbic acid alone or in a citrus extract. Am J Clin Nutr, 1988;48:601-406
[29] Vinson JA, Bose P. Bioavailability of synthetic ascorbic acid and a citrus extract. Ann NY Acad Sci, 1987, vol. 498: 525-526
[30] Proteggente AR, et al. The antioxidant effect activity of regularly consumed fruit and vegetables reflect their phenolic and vitamin C composition. Free Radic Res. 2002;36(2):217-233
[31] Organic tomatoes, vitamin C, and calcium.  Nutr Week, 1998;45(1):7

Not only does Dr. Fauci not understand the truth about ascorbic acid supplements (which he and most others take as “vitamin C” supplements), he also is not an expert when it comes to herbal interventions to support the immune systems of those with COVIV-19.  I have successfully treated four people with medical tests that stated that they had COVID-19 using nutrients and herbs–all did well. Public health officials, like Dr. Fauci, do not normally get trained in the clinical use of herbs and normally have no experience treating patients with them clinically. Thus, I do not consider most public health to be experts on most clinical issues.  While government actions have been focused on masks, social distancing, and quarantining those not known to have COVID, a personally helpful approach would be encouraging people to:

        1. Avoid biblically unclean meats,
        2. Eat more fruits and vegetables high in vitamin C,
        3. Fast regularly for those who can,
        4. Consume foods high in zinc like pumpkin seeds or 100% food nutrient supplements which provide Zinc,
        5. Get proper sunlight exposure for vitamin D,
        6. Exercise regularly, and
        7. Lose weight for those who are overweight.

All the above help support one’s innate immune system, which helps the body fight many types of pathogens–not just one.

Instead of doing the above, in places like the USA, more junk food has been consumed, many gyms have been shut down, many beaches and parks have been closed or limited, and many have gained weight during the lockdowns.

The idea of ‘herd immunity’ presumes that the ‘herd’ will have many with strong immune systems–something that mask-wearing does not truly promote, but that healthy living does.

We all should take care to attempt to improve our health during a time with multiple strains of the coronavirus is something all should do.

But, it is best to use real vitamin C in foods or in supplements whose nutrients are 100% food.

This site provides information for doctors and health care professionals and is not intended for use by consumer. 

•  Photos and Images are all used by permission from Pixabay.com & Pexels.com except for those that are Owned and Copyrighted by Doctors Research, Inc.

Catalyn VS Vitamin-Mineral

Catalyn®

Standard Process Laboratories produces a popular product called Catalyn®. Catalyn® Contains Six Chemical Vitamin Additives and Three Processed Rocks (Catalyn®, Product Bulletins, 1953) and three processed rocks (mineral salts).

Standard Process claims in their catalog that Catalyn® “Supplies multiple vitamins and minerals for complete, complex nutritional supplementation.”

A careful reading of the label shows that Catalyn® contains vitamin isolates as the primary source of each of the claimed nutrients.

While Catalyn® does contain carrots, that is not the source of the 1200 IU of vitamin A. The label shows that Catalyn® contains the USP isolate vitamin A palmitate, which is presumably where most, if not all, the 1200 of vitamin A comes from (carrots provide betacarotene, not palmitate).

Catalyn® contains USP ascorbic acid, which is presumably the source of the 4 mg of vitamin C. It may be of interest to note that the original founder of Standard Process, Dr. Royal Lee, did not want people to call ascorbic acid vitamin C:

Dr. Lee felt it was not honest to use the name ‘vitamin C’ for ascorbic acid. That term ‘should be reserved for the vitamin C COMPLEX’ (DeCava, J. The Lee Philosophy-Part II. Nutrition News and Views 2003;7(1):1-6).

Catalyn® contains USP cholocaliferol which is presumably the source of its vitamin D. Dr. Royal Lee once opined:

“The synthetic forms of vitamin D have been found to be toxic” (Lee R. Vitamin D Complex. Lee Foundation for Nutritional Research, Milwaukee, circa 1950).

Catalyn® contains USP thiamine hydrochloride which is presumably the source of its thiamine.

This seems strange as Dr. Royal Lee specifically wrote against isolated and synthetic forms of vitamins, but they are in Catalyn® (Lee R. How and Why are Synthetic Poisons Sold as Iimitations of Natural Foods and Drugs, 1948).

Thiamine hydrochloride is not what is naturally found in food and it is not a food, but a USP isolate.

Thiamine hydrochloride in products like Catalyn®, is a crystalline salt:

Thiamine in food products, like Vitamin-Mineral™ looks like the following:

(Note: Both photos were made using electro microscopy at the same magnification.)

Catalyn® contains riboflavin as an isolated ingredient. Riboflavin does not exist in foods so isolated.

Catalyn® contains USP pyridoxine hydrochloride which is presumably the source of its vitamin B6. Pyridoxine hydrochloride is crystalline in structure and is generally made from petroleum and hydrochloric acid and processed with formaldehyde (Hui JH. Encyclopedia of Food Science and Technology. John Wiley, New York, 1992).

ALL THE CLAIMED NUTRITIONAL SUPPLEMENT FACTS FOR CATALYN® ARE FOR ISOLATED SUBSTANCES THAT HUMANS WOULD NOT NATURALLY EAT.

Now, while it is claimed that Catalyn® is a source of minerals, no mineral claims are on the Supplement Facts section of its label. Hence, we would not categorize it as a complete source of minerals. And since it only lists six vitamins, we would not categorize it as a complete source of vitamins. Catalyn®’s supplement label simply does not have all the vitamins or all the minerals that are essential for human beings.

As far as minerals go, further research on the label reveals that it contains magnesium citrate, which is, in essence, an industrially-processed rock mineral salt. It is therapeutically used as a cathartic (The Merck Index, 12th edition, 1996, p, 5707). A cathartic is a purgative substance.

Catalyn® also contains calcium lactate, which is also used as “a preservative in foods” (The Merck Index, 12th edition, 1996, p, 1716).

Food nutrients, such as are in Vitamin-Mineral™ are superior.

* Standard Process and Catalyn are registered trademarks of Standard Process Laboratories.

Vitamin-Mineral™

Food Research produces Vitamin-Mineral™ which we believe is superior to Catalyn®.

Vitamin-Mineral™ contains nutrients and foods, no chemical additives and no rocks. Food Research claims in their catalog that Vitamin-Mineral™ “is a 100% vegetarian Food supplement that is the best multi-vitamin, multi-mineral product available anywhere.” Vitamin-Mineral™ is qualitatively and quantitatively superior;

1) Vitamin-Mineral™ is much more complete as it contains all vitamins considered essential for humans and is a source of 11 essential minerals.

2) All Vitamin-Mineral™ nutrients are in the same chemical forms as food which makes them better absorbed, utilized and retained by the human body (Medical Hypotheses, 2000; 55(6):461-469).

3) Vitamin-Mineral™ is not a combination of foods and USP isolates, as in Catalyn®.

* These studies may not conform to peer review standards. Therefore the results are not conclusive. Published research has concluded that food vitamins are superior to USP ones.

Vitamin-Mineral™ is superior to Catalyn®.

While Catalyn® is a fine product for those who want what looks like USP isolates mixed in with foods, for optimal health, we recommend Vitamin-Mineral™.

Discerning health care professionals across the USA carry Vitamin-Mineral™ and other 100% food nutrient supplements. If you are a health care professional interested in food nutrients, call 1-805-489-7185 for more information.

If you are not a health care professional, please share this article with yours. If he or she is interested in 100% food nutrient supplements, we would be happy to provide them.

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The immune system is quite complex, but when it reacts to normally harmless foods and pollens allergies, sinus complaints, and/or asthma can result. Throughout the past couple of centuries, many Foods have been consumed to help reduce the histamine-type reactions that allergies tend to produce.

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Vegetarian Thyro™ – 100% Vegan Food Thyroid Support

Many people have joint complaints including various forms of arthritis, rheumatism, lupus, fibromyalgia, multiple sclerosis, and other disorders. At Doctors” Research we believe that nutritional supplementation should be Food, or as close to Food as possible, which is why we came up with 100% Food Advanced Joint Complex.

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Advanced Joint Complex™ for Optimal Joint Health

Many people have joint complaints including various forms of arthritis, rheumatism, lupus, fibromyalgia, multiple sclerosis, and other disorders. At Doctors” Research we believe that nutritional supplementation should be Food, or as close to Food as possible, which is why we came up with 100% Food Advanced Joint Complex.

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GMOs and Health: Any Risk?

GMOs, or “genetically modified organisms,” are plants or animals that have been genetically engineered with DNA from bacteria, viruses or other plants and animals. These experimental combinations of genes from different species cannot occur in nature or in traditional crossbreeding.

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This site provides information for doctors and health care professionals and is not intended for use by consumer. 

•  Photos and Images are all used by permission from Pixabay.com & Pexels.com except for those that are Owned and Copyrighted by Doctors Research, Inc.

Diabetes: Types I and II

In the United States, the incidence of diabetes in adults rose by 33% from 1990 to 1998 [1] and still appears to be on the rise.  Obesity is considered one of the major risk factors for diabetes [2-4], but that may be more due to dietary choices, including quantity of food, and lack of exercise than weight itself.  Proper food nutrition can play an important role in this disorder.

Diabetes mellitus is a “syndrome characterized by hyperglycemia resulting from absolute or relative impairment in insulin secretion and/or insulin action…Patients with type I diabetes mellitus (DM), also known as insulin-dependent or juvenile onset diabetes, may develop diabetic ketoacidosis.  Patients with type II DM, also known as non-insulin-dependent DM may develop non-ketotic hyperglyemic-hyperosmolar coma.  Common late microvascular complications include retinopathy, nephropathy, and peripheral and autonomic neuropathies.  Macrovascular complications include atherosclerotic coronary and peripheral arterial disease” [3].  Type I DM typically occurs in those less than 30 years of age, while type II usually occurs in those above age 30.  Type I is normally due to low insulin production due to the destruction of pancreatic beta cells [4].  Type II is normally due to insulin resistance (diminished tissue sensitivity to insulin) and impaired beta cell functioning [4].  Obesity is more common in type II [2,3].  Other types include gestational diabetes, malnutrition-related diabetes mellitus, impaired glucose tolerance, as well as some due to genetics, medications, and hormones [4].  It is estimated that 7,000,000 Americans with type II are undiagnosed [4].

Nutrition can affect those with type of diabetes.  The human brain primarily runs on glucose [5].  Nearly all calories, be they from bananas, steak, or candy bars, are converted by the body into glucose (blood sugar).  If the amount of glucose converted is excessive, this will trigger the body’s need to secrete insulin.  But just because nearly all calories in foods are converted to glucose, does not make all foods equal; some foods take longer to be converted.  Those that take longer to convert are known as foods with a lower glycemic effect, whereas those that convert quickly are known to have a higher glycemic effect.  Those foods with a low enough glycemic effect do not cause the body to need to secrete insulin because they provide glucose at such a rate that it is consumed rather than accumulated.

Excessive glucose causes the accumulation of glycogen in non-insulin dependent tissues [4].  Glycoxidation is “a process that occurs with elevated blood glucose levels.  Another pathway that results in the modification of LDL proteins involves the formation of Amadori products.  An adequate amount of antioxidants from the diet or supplements may help prevent or delay the occurrence of diabetic late syndrome” [6].  The formation of Amadori products is a type of nonenzymatic glycosylation [4], and is reversible.  Price et al have stated, “The Maillard or browning reaction between sugars and proteins leads to the formation of chemical modifications and cross-links in proteins, known as advanced glycation end-products (AGEs).  These products contribute to the age-dependent chemical modification of long lived proteins, and accelerated formation of AGEs during hyperglycemia is implicated in the development of diabetic complications” [7] as “sugars react with amino groups in proteins, lipids, and nucleic acids to produce advanced glycation end products” [8].

Diet and Lifestyle Factors

As glycation end products tend to accumulate as the result of disorders of sugar metabolism such as diabetes, it is generally believed that a diet low in refined carbohydrates is a logical choice for those with diabetes.  Diets naturally high in vitamin C have been shown to result in reduced protein glycation [9].  Though this would not stop all glycation end products from forming and accumulating, it may reduce their formation and possibly delay the onset of some of the complications associated with diabetes.

The average adult who develops diabetes consumes less fruits and vegetables than those who do not [10].  Interestingly, one study found that dietary carotenoid intake was inversely related to fasting plasma glucose concentrations; that plasma beta-carotene concentrations were inversely associated with insulin resistance; and that dietary lycopene was directly related to baseline serum concentrations of nonesterified fatty acids [11].  Dietary carotenoids primarily come from vegetables and to a lesser degree from fruits.  It should be noted that a large study that tested isolated betacarotene found that it did not help prevent diabetes [12].

Reducing weight, increasing consumption of fiber, exercise, and reducing the intake of saturated fats also reduce the risk of developing diabetes, even for those with impaired glucose tolerance [13].  Consumption of whole grains is also associated with reduced risk of developing diabetes [14]; this could be due to the natural B vitamins, lower glycemic effect, or simply the fiber of whole grains compared to refined grains.  Similarly, nut consumption has been found to be inversely associated with the risk of type II DM [15].

One risk factor for type I DM is early exposure to cow’s milk, especially if a sibling has sensitivity to milk [16,17].  It has been reported that wheat, soy, and perhaps other foods can provoke pancreatic beta cell destruction through immunological mechanisms in some [18].  In type I diabetes mellitus, hyperglycemia results in the intracellular accumulation of the sugar alcohol sorbitol by the action of aldose reductase on glucose [19].  Based on this evidence, sorbitol and similar alcohol sugars should probably be avoided.  It has been proposed that insulin dependent diabetes may be started by an immunization from environmental proteins such as a virus with molecular mimicry with the islet cell enzyme glutamic acid dehydrogenase, initiating the process [20].  In the islets, GABA inhibits glucagon secretion.  In susceptible individuals the anti-enzyme glutamic acid dehydrogenase immune response may be sufficient to initiate islet cell autoimmunity and damage.  Autoantibodies to insulin and islet cell cytoplasmic glycolipid antigens result and beta cells are lost.  Officially, type I DM occurs only after destruction of the bulk of the insulin-secreting beta cells.  The entire process usually takes years to complete but is faster in young children than adults.  Quite recently a Finnish study found that enterovirus strains were present in 11 of 12 children considered to be pre-type I diabetic [21].

The probable factors predisposing one towards type II DM include obesity, genetics, poor diet, and hypoglycemia [1,2,10,18].  Furthermore, over-consumption of high glycemic foods is probably the factor that has lead to increases in diabetes throughout the world [2], specifically, items such as refined carbohydrates, sugar, sugar-substitutes, soft drinks, white pasta, white rice, white flour, alcohol, and combinations of those substances.  Lower glycemic foods generally include those high in fats, proteins, fiber, and complex carbohydrates; however those at risk for diabetic nephropathy should at least moderately-restrict proteins [4,18].  Eating frequent small meals can also be helpful in keeping blood glucose levels in more desired ranges [18].

Low intensity exercise, such as walking, has been found to significantly reduce blood-glucose levels in type II DM [22].  Caloric restriction and exercise are among the best ways to reduce insulin resistance [23].  Additionally, “high carbohydrate, high fiber diets increase insulin sensitivity and decrease insulin requirements” [4] while caffeine may decrease it [24].  Thus caffeine itself is not advised for diabetics.

Although alcohol itself does raise blood sugar, one large study found that men who drink alcohol moderately have a lower risk of contracting diabetes compared with those who drink heavily or those who drink very little [26].

Raised plasma nonesterified fatty acids are a risk factor for the deterioration of glucose tolerance from normal to impaired, and from impaired to type II DM.  Circulating concentrations of nonesterified fatty acids are elevated in obesity, Type II diabetes and in uncontrolled Type I diabetes or insulin deficiency [25].

Whether it has to do with increased walking, caloric restriction, increased consumption of wild plants, and/or increased consumption of animal glands, Australian Aborigines who forsake the Western lifestyle for a native one have been able to dramatically reverse complications associated with type II diabetes (18,27).

Beneficial Food Nutrients

Many nutrients have been found to be of benefit to people with diabetes.  B vitamins are involved in the production of energy as well as other metabolic processes [23].  B complex vitamins, potassium, and trace minerals are often recommended for diabetics, particularly for the prevention and reversal of oxidative-dysoxygenative insulin dysfunction [28].  Many food nutrients have been reported to have prevent the accumulation of advanced protein glycation end-products [29], which can be a major problem for diabetics.

Thiamin (vitamin B-1) may be helpful for some with diabetic retinopathy [18].  Benfotiamine, a lipid soluble derivative of thiamin, found in leeks, onions, garlic, and shallots can be helpful for many diabetics.

While niacinamide, which can be found in food, has been shown to be helpful for insulin-dependent diabetics (type I DM), niacin, which seldom exists in any substantial quantity in food [23]), tends to worsen (increase) glucose concentrations for those non-insulin dependent diabetics (type II DM) [18].  Niacinamide can also inhibit glycation.

In non-diabetics, a subclinical deficiency of vitamin B-6 can cause insulin resistance [18].  Both type I and type II DM sometimes have marginal B-6 levels [18].  Vitamin B-6 deficiency has been associated with impairments in gluconeogenesis and abnormal glucose intolerance.  Vitamin B-6 has been recommended to help deal with glycation [30].  Furthermore, it or its derivatives have been shown to have anti-glycation effects [7].

One study found that serum levels of females with type I DM tended to be low in folate and high in homocysteine [31].  Folate is the form found in food, and has less affinity for serum folate-binding proteins than folic acid, the form most commonly found in nutritional supplements [16].  Thus folate may be the preferred from.

It should be noted that it has been shown that up to 2,000 mg per day of metformin (Glucophage) can increase total homocysteine levels and decrease vitamin B-12 and folate levels [32].  Thus it is logical that diabetics on that medication consider taking food vitamin B-12 and food folate.  Furthermore it has been found that methylcobalamin, the type of vitamin B-12 found in food [23], may ameliorate the development of diabetic neuropathy [18].

Increasing plasma vitamin C through dietary means has been suggested as an important way for the public to reduce the prevalence of diabetes mellitus [33].  Diabetics have vitamin C levels 30% (or more) lower than non-diabetics and part of this may be due to increased urinary excretion [18].  Vitamin C containing food has over 15.6 times the ORAC of isolated ascorbic acid [34].  Since food vitamin C has proven antioxidant effects in vivo [35] and isolated ascorbic acid does not [36], it seems reasonable to conclude that food vitamin C both prevents oxidative damage and ‘cleans up’ damage much better than isolated ascorbic acid.

Activated vitamin D is required by the islet cell to be able to secrete insulin normally.  One study found that vitamin D status related directly to the capacity to secrete insulin and inversely to glucose tolerance [37].

A double-blind study found that vitamin E improves endothilial vasodilator function in type 1 diabetics [38].  High vitamin E vegetable oil has been found to have significant anti-glycation effects [19].  Consumption of vitamin C and vitamin E prior to a high fat meal has been found to reduce the production of meal-induced C-reactive protein in diabetics [39].  One study found there is an increase in lipid peroxidation after the correction of diabetic ketoacidosis, and administration of antioxidant vitamins, like vitamin E, during the treatment of diabetic ketoacidosis may be of benefit in minimizing oxidative stress and possibly preventing complications of type II diabetes mellitus [40].  Consumption of vitamin E in foods was recently found to reduce the incidence of type II DM [41].

One study found that 30% of those with type II DM in its study were deficient in zinc, and that supplementation with zinc alone, chromium alone, and zinc with chromium resulted in significant reduction of plasma thiobarbituric acid reactive substances (TBARS) by 13.6%, 13.6%, and 18.2% respectively [42]; no adverse side effects were noted.

Zinc is involved in insulin physiology.  It enhances the magnitude of the binding of insulin to the receptor, but simultaneously inhibits the degradation of insulin by the liver plasma membranes.  Zinc modulates insulin’s actions by stimulating lipogenesis in adipocytes in a synergistic relationship with insulin [43].  Zinc is a cofactor of key enzymes in glucose metabolism [23].  Some feel that insulin resistance may be related to zinc deficiency by impairment of insulin secretion by the pancreas; interference in insulin-receptor binding; decreased insulin-receptor synthesis; and abnormal glucose carrier structure and/or translocation inside the cell [43].  It is unclear if diabetic patients malabsorb zinc or are unable to compensate for the excessive urinary loss [43,44].  It has been speculated that zinc deficiency may account for impaired wound healing, decreased cell-mediated immunity and taste acuity in diabetic subjects [43].  One researcher noted that although many diabetics are low in zinc, supplemental zinc, as typically used in mineral salt forms, does not apparently absorb well enough to raise zinc levels [44].  On the other hand, high zinc yeast has been found to be better absorbed than non-yeast forms [45].

Vanadium is found in skim milk, vegetable oils, many vegetables, grains and cereals.  Mushrooms, parsley, dill and black pepper are particularly rich in vanadium [46].  Daily consumption in humans ranges from 10 µg to 2 mg [47].  One human study involving 11 type II diabetics found that vanadium significantly improved glycemic control, and fasting plasma glucose was reduced from 194 to 155 mg/dl, hemoglobin A1C from 8.1 to 7.6%, and fructosamine from 348 to 293 µmol/l and reduced endogenous glucose production by approximately 20%, which correlated with a reduction in fasting plasma glucose [48].  It has been reported that organic forms of vanadium are safer, more absorbable and able to deliver a therapeutic effect up to 50% greater than inorganic forms [47].

A French study found that diabetics had significantly lower levels of selenium than controls [49]. Reduced selenium concentrations in the red blood cells of the diabetic patients have been found to contribute to impaired hemorrheology [50].  One study found that high yeast selenium was 123.01 more effective than selenium methionine in preventing nonenzymatic glycation in diabetics [29].  Glycation end-products tend to also accumulate in the brains of those who develop Alzheimer’s or similar forms of dementia [51].  This same study found that high selenium yeast was more effective than ascorbic acid, niacinamide, carnosine, tocopherol, and pyridoxal [29].  Selenium “is the co-factor of glutathione peroxidse (Se GSHpx).  Low Se GSHpx is activity, observed in diabetic patients, is associated with thrombosis and cardiovascular complications” [52].

Hypophosphatemia (low phosphorus levels) is clinically associated with diabetes mellitus [23]; “Excessive amounts of phosphorus can also be lost in the urine of uncontrolled diabetics who have polyuria and acidosis” even if plasma phosphorus appears to be normal [23].  Vegetables and fruits are high in phosphorus and thus consumption of them would appear to be a logical way to improve phosphorus levels.

Some research has suggested that lithium can be helpful for diabetics [54].  Min Hu, a medical doctor who has looked into this for eight years, reported, “Lithium has some insulin-like effects. Experiments in vivo demonstrate that lithium has little effect on insulin secretion, but does have an effect on reduction of insulin resistance.  Experiments in vitro further demonstrate that lithium has some insulin-like effects, such as lithium’s ability to promote glucose uptake and glycogenesis in adipocytes and in hepatocytes.  1) Lithium inhibits hepatic gluconeogenesis and phosphoenol pyruvate carboxykinase gene expression, which can lower the blood glucose.  2) Lithium has some antioxidative effects, which can enhance insulin action in target cells. 3) Lithium increases DNA replication, polyamine content and insulin secretion by pancreatic beta cells in rats” [55].  Hu, et al. wrote, “restoration of lithium to control levels in the liver and muscle of diabetic animals is associated not only with decreased blood glucose but also with reduced oxidative stress, and consequently with the protection of insulin-secreting pancreatic islet cells” [56].  Caution is advised, however, as lithium can induce diabetes insipitus in some individuals.  “Fortunately, lithium toxicity is both entirely preventable and easily treatable” [57] with flaxseed oil and vitamin E [57].

Chromium and Saccharomyces Cerevisiae

Insufficient dietary intakes of chromium can lead to diabetes [58].  “Chromium is generally accepted as an essential nutrient that potentiates insulin action, and thus influences carbohydrate, lipid, and protein metabolism” [53].  Food chromium is safer than some non-food forms, like chromium picolinate [59].  One study found that yeast chromium was as effective as 8.62 time as much chromium chloride in causing improvement in glucose control [60].  And unlike rock-forms of chromium, Saccharomyces cerevisiae yeast-forms also contains a variety of essential vitamins, minerals, and amino acids [61].

“The biologically active form of chromium, sometimes called glucose tolerance factor or GTF, has been proposed to be a complex of chromium, nicotinic acid, and possibly the amino acids glycine, cysteine, and glutamic acid.  Many attempts have been made to isolate or synthesize the glucose tolerance factor; none have been successful” [53].  Chromium is not naturally found in the body in the commonly supplemented forms such as chromium picolinate or chromium chelate.  Only 1% or less of inorganic chromium is absorbed versus 10-25% of chromium GTF [62].

Scientific research has concluded that “supplementation of well-controlled type 2 diabetics with Cr-enriched yeast is safe and can result in improvements in blood glucose variables and oxidative stress” [63] and that “dietary high Cr yeast supplementation improved glucose tolerance, probably through a decrease in hepatic extraction of insulin” [64].  This type of food chromium really is the best form for supplementation for diabetics.

In Iraq, barley bread is commonly used in the treatment of diabetes because of its ability to modulate the glycemic response to carbohydrate ingestion, and slow weight loss and excessive water consumption.  Animal studies have verified that barley bread does contain significant amounts of food chromium [65], which may account for some of its effectiveness.

Chromium in food has accompanying food factors such as protein chaperones [66,67] which aid in absorption of chromium.  Chromium mineral salts are chemical compounds which are rocks or synthetically produced.  Chromium rocks are poorly absorbed by humans; some are less than 1% absorbed [62].  Chromium picolinate is a human-made substance, apparently created by Gary Evans [68].  Picolinic acid is used in herbicides [69]; furthermore “picolinic acid is an excretory or waste product.  It is not metabolized by or useful to the body” [70].

Saccharomyces cerevisiae is also known as nutritional or baker’s yeast and it holds several unique advantages for diabetics.  Perhaps the first is that it is the most natural medium in which to grow the GTF form of chromium.  Additionally, Saccharomyces cerevisiae has proinsulin-like substances; “the specificity of the yeast processing enzymes is so similar to the proinsulin converting enzymes in the human pancreatic beta-cell that it allows the processing of the mini-proinsulin to insulin” [71].  Saccharomyces cerevisiae also contains a variety of insulin precursors that can be helpful for diabetics [72].  In 1999, the Nobel Prize was awarded for discovering that protein chaperones are necessary for mineral transport into cellular receptors.  Saccharomyces cerevisiae, like other mineral containing foods, naturally contains protein chaperones and other factors that aid in mineral absorption [66,67].  These are lacking in mineral salts.

Saccharomyces cerevisiae is beneficial to humans and can help combat various infections [73], including Candida albicans.It should also be noted, that W. Crook, M.D., who was perhaps the nation’s best known expert on Candida albicans, wrote “yeasty foods don’t encourage candida growth…Eating a yeast-containing food does not make candida organisms multiply” [74].  It should also be noted that nutritional yeast is not the same as brewer’s yeast which is essentially a waste by-product.  Saccharomyces cerevisiae naturally contains vitamins B-1, B-2, B-6, niacinamide (B-3), folate (B-9), and pantothenate (B-5) plus phosphorus, potassium, and a variety of trace minerals.

Rice Bran, Cinnamon, Fenugreek, Gymena, and Other Herbs Substances

Various types of rice bran have been found to help lower glucose levels for people with type I or type II DM [75].  Due to its high fiber and bran content, brown rice may be an ideal food for some with diabetes, and is so used by some in Chinese medicine [73].

Cinnamon Bark Cinnamon cassia has been found to improve fasting blood glucose (FBG) [76]. Another recent study confirmed that natural ground cinnamon in amounts as little as 1 gram per day was effective in reducing fasting serum glucose levels for those with type II diabetes [77].  Cinnamon is considered to be contraindicated during pregnancy [73].  Cinnamon Bark Cinnamon cassia     has been found to improve fasting blood glucose (FBG) [76].  Another cinnamon study noticed FBG improvement with “significant decrease in plasma C-peptide, serum triglyceride, total cholesterol and blood urea nitrogen levels while serum high density lipoprotein (HDL)-cholesterol levels were significantly increased” [78] (HDL is known as “good cholesterol”). “Cinnamon extract regulates glucose transporter and insulin-signaling gene expression… and this regulation could contribute to the potential health benefits of CE” (cinnamon extracts) [79].

Fenugreek Seed Trigonella foenum-graecum has been used as part of a program for blood sugar management.  The PDR states, “Fenugreek reduces blood sugar” [80].  A human study “showed that FBS, TG and VLDL-C decreased significantly (25 %, 30 % and 30.6 % respectively) after taking fenugreek seed soaked in hot water” [81].  An animal study concluded that “fenugreek oil significantly improved blood glucose levels, glucose intolerance, and insulin sensitivity compared to the diabetic group… diabetic rats showed low activities of superoxide dismutase, catalase, glutathione peroxidase, and reduced glutathione content in kidney, which were restored to near normal levels by treatment with fenugreek oil. The increased levels of lipid peroxidation, creatinine, albumin, and urea in diabetic rats decreased significantly in diabetic rats treated with fenugreek oil. Diabetic rats treated with fenugreek oil restored almost a normal architecture of pancreas and kidney. In conclusion, this study reveals the efficacy of fenugreek oil in the amelioration of diabetes, hematological status, and renal toxicity which may be attributed to its immunomodulatory activity and insulin stimulation action along with its antioxidant potential” [82].  A recent study “confirms the anti-hyperglycaemic and anti-dyslipidemic properties of 4-hydroxyisoleucine, an unusual amino acid isolated from Trigonella foenum-graecum seeds, for the first time in a well-characterised model of type II diabetes… significantly (p < 0.05) declined their elevated blood glucose, plasma insulin, triglycerides, total cholesterol, low-density lipoprotein-cholesterol levels and raised their declined plasma high-density lipoprotein-cholesterol level. These results indicate that 4-hydroxyisoleucine exhibits significant potential as an anti-diabetic agent by suppressing progression of type II diabetic states that is suggested by enhancement of insulin sensitivity and glucose uptake in peripheral tissue.” [83].   “Diosgenin present in fenugreek improves glucose metabolism by promoting adipocyte differentiation and inhibiting inflammation in adipose tissues… Trigonella foenum-graecum (fenugreek) can ameliorate hyperglycemia and diabetes” [84].

Goat’s Rue/French Lilac Galega officinalis was the basis for the anti-diabetic medication Metformin (but Metformin is a chemical isolate) [85].  “Guanidine is an active ingredient extracted from Galega officinalis…we observed that guanidine decreased plasma glucose in STZ rats” [86]. “Galega officinalis (galega, Goat’s Rue, French Lilac) is well known for its hypoglycaemic action and has been used as part of a plant mixture in the treatment of diabetes mellitus… During pharmacological investigations … a weight reducing effect of galega was discovered… together with its established hypoglycaemic effects, galega has a novel weight reducing action that, in normal mice, is largely independent of a reduction in food intake. The mechanism of the weight reducing action of galega is unclear but involves loss of body fat” [87].

One study found that guar gum improved long-term glycemic control, postprandial glucose tolerance, and lipid concentrations.  This result suggests that insulin secretion is enhanced by guar gum as reflected by an increased C-peptide [88].  Another study found that type I diabetics taking guar gum had a significant reduction in glucose, hemoglobin A1c, low LDL cholesterol and the LDL cholesterol/HDL ratio [89].

The herb Gymnema sylvestre is sometimes used for diabetics.  It has been shown to reduce sweet taste sensations [90].  However, clinically, some natural health results suggest better success combining it with chromium GTF, vanadium, and food multi-vitamins.  Gymnema Leaf  and Callus  “Gymnema sylvestre is a plant that has found use in the traditional medicine of a number of societies for the management of blood sugar disorders” [91].  “The phyto-constituents of Gymnema sylvestre are used in the treatment of diabetes and obesity” [92].   Various animal studies have found that it has protective effects for the pancreas of diabetics.  It contains substances that researchers have concluded “showed anti-diabetic activities through regenerating beta-cells” [93].

Other researchers have noted, “Indian plants which are most effective and the most commonly studied in relation to diabetes and their complications are: Allium cepa, Allium sativum, Aloe vera, Cajanus cajan, Coccinia indica, Caesalpinia bonducella, Ficus bengalenesis, Gymnema sylvestre, Momordica charantia, Ocimum sanctum, Pterocarpus marsupium, Swertia chirayita, Syzigium cumini, Tinospora cordifolia and Trigonella foenum graecum. Among these we have evaluated M. charantia, Eugenia jambolana, Mucuna pruriens, T. cordifolia, T. foenum graecum, O. sanctum, P. marsupium, Murraya koeingii and Brassica juncea. All plants have shown varying degree of hypoglycemic and anti-hyperglycemic activity” [94].

For those with type I DM, it is possible that anti-viral herbs such as olive leaf and/or wild oregano may have a possible role.  Since the hepatitis C virus can cause or at least contribute to insulin resistance, those same herbs may be of help to some with DM II [95].

Vanadium and Acetyl-l-carnitine

N-Aceytl-L-Cysteine (NAC) (plant source) is a more stable form of the amino acid l-cysteine because it has an acetyl group (CH3CO) attached.  It seems to help with high glucose (HG) levels.  One study stated “Cotreatment with N-acetylcysteine reduced the effect of HG on aromatase gene expression, suggesting that hyperglycemia may perturb biochemical networks because of the elevation of oxidative stress” [96].  Another study concluded, “Our results clearly demonstrate protective effect of NAC is mediated through attenuation of oxidative stress and apoptosis, and suggest therapeutic potential of NAC in attenuation of diabetic neuropathy” [97].  Another diabetic study concluded that the  “antioxidant, N-acetyl-L-cysteine, suppressed glucose-induced osteopontin expression by decreasing ROS concentration” [98] .  “Epidemiological studies have suggested that the levels of advanced glycation end products (AGEs) are enhanced in patients with diabetes mellitus and during the aging process… Our data showed that APP {amyloid precursor protein} was up-regulated by AGEs in vitro and in vivo, and pretreatment of cells with an ROS inhibitor (N-acetyl-L-cysteine) blocked the effects of AGEs” [99].

Vanadium is a mineral believed to support healthy blood levels.  Vanadium “is used in pharmacological quantities to potentiate the effect of insulin” [100].   Studies suggest that vanadium improves fasting blood glucose levels [18].  Vanadium in a ferment “can effectively lower blood glucose levels of diabetic rats” [101].  Vanadium may help with carbohydrate metabolism and seems to have “insulin-like effects” [102].  “Vanadate forms compounds with other biological substances” [103]. “Vanadium has been postulated to play a role in the regulation of (NaK)-ATPase, phosphoryl transferase enzymes, adenylate cyclase, and protein kinases; as an enzyme cofactor in the form of vandyl and in hormone, glucose, lipid, and tooth metabolism” [103]. Vanadium in foods is found in an organic form. Vanadium in Food is safer than non-food forms and also appears to be about 50% more effective [104].

A Note About Synthetics

The American Diabetes Association does not recommend multi-vitamin, multi-mineral formulas for diabetics, though the HCF Nutrition Foundation does [4].  However, neither of them (and they looked at formulas containing synthetics and/or inorganic mineral salts) has actually apparently examined the role of 100% food multi-vitamin, multi-mineral formulas which certain natural health practitioners prefer.

Niacin, which is normally a synthetic form of vitamin B3, is not advised for diabetics because of its induction of insulin resistance [105].  Diabetics, more than most people, really do need to insure that the vitamins and minerals that they take are food and not synthetic.

Conclusion

Many natural health professionals have learned that foods, and high nutrien food supplements, can be of assistance in natural blood sugar control.

With regard to those food nutrients that have been shown to inhibit glycation, like in the case of Down Syndrome and Alzheimer’s [29], an important therapeutic factor to consider is that it would seem wise to administer them as soon as possible after diagnosis of diabetes and regularly through the sufferer’s lifetime when attempting to prevent diabetic complications.

“To be effective in the long term, the nutritional plan must be individually tailored.  Readily available, pre-printed diet sheets…are doomed to eventual failure” [4], which is one of the reasons why natural interventions must be tailored to the individual.  And why individuals with diabetes should seek successful, experienced health professionals.

Most diabetics need to eat more fruits and vegetables and to do more exercise.  And nearly all diabetics will benefit from properly balanced food multi-vitamin, multi-mineral formulas that contain adequate amounts of food chromium and food vanadium as well as additional food nutrients with proven antiglycation properties.  These changes can not only frequently help to improve blood sugar scores, they may also contribute to possible prevention of various complications.

REFERENCES

  1. Diabetes increasing.  Nutr Week, 2001;31(5):7
  2. Rosenthal AD, Jin F, Shu XO, Yang G, Elasy TA, Chow WH, Ji BT, Xu HX, Li Q, Gao YT, Zheng W. Body fat distribution and risk of diabetes among Chinese women. Int J Obes Relat Metab Disord. 2004 Feb 10
  3. Beers MK, Berkow R, eds.  The Merck Manual, 17th ed.  Merck Research Laboratories, Whitehouse Station (NJ), 1999
  4. Anderson JW.  Nutritional Management of Diabetes Mellitus.  In Modern Nutrition in Health and Disease, 9th ed.  Williams & Wilkins, Balt., 1999:1365-1394
  5. Guyton AC, Hall JE.  Textbook of Medical Physiology, 9th ed.  W.B. Saunders, Phil., 1996
  6. Meli M, Frey J, Perier C. Native protein glycoxidation and aging. J Nutr Health Aging. 2003;7(4):263-266
  7. Price DL, Rhett PM, Thorpe SR, Baynes JW. Chelating activity of advanced glycation end-product inhibitors. J Biol Chem. 2001;276(52):48967-48972
  8. Stahl W, Sies H, Antioxidant Defense: Vitamins E and C and Carotenoids.  Diabetes. 1997;46(Suppl.2):S14-S18
  9. Boeing H, Weisgerber UM, Jeckel A, Rose HJ, Kroke A. Association between glycated hemoglobin and diet and other lifestyle factors in a nondiabetic population: cross-sectional evaluation of data from the Potsdam cohort of the European Prospective Investigation into Cancer and Nutrition Study. Am J Clin Nutr. 200071(5):1115-1122
  10. Ford ES, Mokdad AH.  Fruit and vegetable consumption and diabetes mellitus incidence among US adults.  Prev Med, 2001;32:33-39
  11. Ylonen K, Alfthan G, Groop L, Saloranta C, Aro A, Virtanen SM. Dietary Intakes and Plasma Concentrations of Carotenoids and Tocopherols in Relation to Glucose Metabolism in Subjects at High Risk of Type 2 Diabetes: The Botnia Dietary Study. Am J Clin Nutr, 2003;77:1434-1441
  12. Liu S, Ajani U, Chae C, Hennekens C, Buring JE, Manson JE. Long-Term-Carotene Supplementation and Risk of Type 2 Diabetes Mellitus: A Randomized Controlled Trial. JAMA, 1999;282(11):1073-1075
  13. Tuomilehto J, et al.  Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance.  N Eng J Med, 2001;344(18):1343-1350
  14. Montonen J, Knekt P, Jarvinen R, Aromaa A, Reunanen A.  Whole-Grain and Fiber Intake and the Incidence of Type 2 Diabetes.  Am J Clin Nutr, 2003;77:622-629
  15. Jiang R, Manson JE, Stampfer MJ, Liu S, Willett WC, Hu FB..  Nut and Peanut Butter Consumption and Risk of Type 2 Diabetes in Women.   JAMA, 2002;288(20):2554-2560
  16. Gottleib S.  Early exposure to cow’s milk raises risks of diabetes in high risk children.  Diabetes, 2000;49:1657-1665
  17. Virtanen SM, et al.  Cow’s milk consumption, HLA-DQB1 genotype, and type1 diabetes: A nested case-control study of siblings of children with diabetes.  Diabetes, 2000;49:912-917
  18. Werbach MR.  Diabetes Mellitus.  In Textbook of Nutritional Medicine.  Third Line Press, Tarzana (CA), 1999:320-339
  19. Cunningham JJ, Mearkle PL, Brown RG.  Vitamin C: an aldose reductase inhibitor that normalizes erythrocyte sorbitol in insulin-dependent diabetes mellitus. J Am Coll Nutr. 1994;13(4):344-350
  20. MacLaren, N. Immunology of Diabetes Mellitus. Ann Allergy. 1992;68:5-9
  21. Salminen KK, Vuorinen T, Oikarinen S, Helminen M, Simell S, Knip M, Ilonen J, Simell O, Hyoty H. Isolation of enterovirus strains from children with preclinical Type 1 diabetes. Diabet Med. 2004;21(2):156-164
  22. Fritz T, Rosenquist U.  Walking for exercise-immediate effect on blood glucose levels in type 2 diabetes. Scand J Prim Health Care, 2001;19:31-33
  23. Shils ME, Olson JA, Shike M. Modern Nutrition in Health and Disease, 9th ed.  Williams & Wilkins, Balt., 1999
  24. Keijzers GB, Tack CJ, De Galan BE, Smits P. Caffeine Can Decrease Insulin Sensitivity in Humans.  Diabetes Care. 2002;25(2):364-369
  25. Amery CM, Nattrass M.  Fatty Acids and Insulin Secretion.  Diabetes Obes Metab, 2000;2:213-221
  26. Diabetes and Alcohol Consumption.  Nutr Week, 2000;30(4):7
  27. O’Dea K. Traditional diet and food preferences of Australian aboriginal hunter-gatherers. Philos Trans R Soc Lond B Biol Sci. 1991 Nov 29;334(1270):233-240; discussion 240-241
  28. Ali M.  Beyond insulin resistance and syndrome X: The oxidative-dysoxygenative insulin dysfunction (ODID) model – Part III.  Townsend Letter for Doctors & Patient 2002;232:114-118
  29. Thiel R.J., Fowkes S.W.  Can cognitive deterioration associated with Down syndrome be prevented? Med Hypo, 2005; 64(3):524-532
  30. Hofmann MA, Lalla E, Lu Y, Gleason MR, Wolf BM, Tanji N, Ferran LJ Jr, Kohl B, Rao V, Kisiel W, Stern DM, Schmidt AM. Hyperhomocysteinemia enhances vascular inflammation and accelerates atherosclerosis in a murine model. J Clin Invest. 2001;107(6): 675-683
  31. Saladri S, et al.  Homocysteine, serum folate and vitamin B12 in very young patients with diabetes mellitus type 1.  J Pediatr Endocrinol Metab, 2000;13(9):1621-1627
  32. Yeromenko Y, Lavie L, Levy Y.  Homocysteine and Cardiovascular Risk in Patients With Diabetes Mellitus. Nutr Metab Cardiovasc Dis, 2001;11:108-116
  33. Sargeant LA, Wareham NJ, Bingham S, Day NE, Luben RN, Oakes S, Welch A, Khaw KT. Vitamin C and Hyperglycemia in the European Prospective Investigation Into Cancer-Norfolk (EPIC-Norfolk Study: A Population-Based Study).  Diabetes Care. 2000;23(6):726-732
  34. Williams D. ORAC values for fruits and vegetables. Alternatives, 1999;7(22):171
  35. Proteggente AR, et al. The antioxidant effect activity of regularly consumed fruit and vegetables reflect their phenolic and vitamin C composition. Free Radic Res. 2002;36(2):217-233
  36. Sebastian J, et al. Vitamin C as an antioxidant: evaluation of its role in disease prevention. J Am Coll Nutr. 2003;22(1):18-35
  37. Boucher BJ, Mannan, N, Noonan K, Hales CN, and Evans SJW. Glucose Intolerance and Impairment of Insulin Secretion in Relation to Vitamin D Deficiency in East London Asians. Diabetologia, 1995;38:1239-1245
  38. Skyme-Jones RAP, et al.  Vitamin E supplementation improves endothilial function in type 1 diabetics: A randomized placebo-controlled study.  J Am Coll Cardiol. 2000;36(1):94-102
  39. Carroll MF, Schade DS. Timing of Antioxidant Vitamin Ingestion Alters Postprandial Proatherogenic Serum Markers.  Circulation. 2003;108:24-31
  40. Lee DM, Hoffman WH, Carl GF, et al., Lipid Peroxidation and Antioxidant Vitamins Prior to, During, and After Correction of Diabetic Ketoacidosis.  J Diabetes Complications. 2002;16:294-300
  41. Montonen J, Knekt P, Jarvinen R, Reunanen A. Dietary antioxidant intake and risk of type 2 diabetes.  Diabetes Care. 2004;27(2):362-366
  42. Anderson RA, Roussel A-M, Zouari N, et al.  Potential antioxidant effects of zinc and chromium supplementation in people with type 2 diabetes mellitus.  J am Coll Nutr, 2001:20(3):212-218
  43. Salgueiro MJ, Krebs N, Zubillaga MB, et al. Zinc and Diabetes Mellitus:  Is There a Need of Zinc Supplementation in Diabetes Mellitus Patients? Biol Trace Elem Res, 2001;81:215-228
  44. Cunningham JJ.  Micronutrients as nutriceutical interventions in diabetes mellitus. J Am Coll Nutr. 1998;17(1):7-10
  45. King JC, Cousins RJ.  Zinc.  In Modern Nutrition in Health and Disease, 10th ed.  Lipponcott Williams & Wilkins, Phil., 2005:271-285
  46. French, RJ, Jones, PJ. Role of Vanadium in Nutrition: Metabolism, Essentiality and Dietary Considerations. Life Sciences. 1993;52(4):339-346
  47. Badmaev V, Prakash S, Majeed M. Vanadium: A Review of Its Potential Role in the Fight Against Diabetes.  J Altern Complement Med. 1999;5(3):273-291
  48. Cusi K, Cukier S, DeFronzo RA, Torres M, Puchulu FM, Redondo JC.. Vanadyl Sulfate Improves Hepatic and Muscle Insulin Sensitivity in Type 2 Diabetes.  J Clin Endocrinol Metab. 2001; 86(3):1410-1417
  49. Simonoff M, Conri C, Fleury B, et al. Serum and Erythrocyte Selenium in Normal and Pathological States in France.  Trace Elem Med. 1998;5(2):64-69
  50. Osterode W, Holler C, Ulberth F.  Nutritional Antioxidants, Red Cell Membrane Fluidity and Blood Viscosity in Type I (Insulin Dependent) Diabetes Mellitus.  Diabetic Med. 1996;13:1044-1050
  51. Rottkamp CA, Nunomura A, Raina AK, et al.  Oxidative stress, antioxidants, and Alzheimer’s Disease.  Alzheimer Dis Assoc Disord, 2000;14(S1):S62-S66
  52. Faure P. Protective effects of antioxidant micronutrients (vitamin E, zinc and selenium) in type 2 diabetes mellitus. Clin Chem Lab Med. 2003;41(8):995-998
  53. Nielson F.  Chromium.  In Modern Nutrition in Health and Disease, 8th ed.  Lea & Febiger, Phil.,1994:264-268
  54. Hu M, Wu H, Chao C.  Assisting Effects of Lithium on Hypoglycemic Treatment in Patients With Diabetes,” Biol Trace Element Res. 1997;60:131-137
  55. Hamilton K.  Clinical Pearls.  ITServices, Sacramento. 2000
  56. Hu M, Wu Y, Wu H.  Influence of streptozotocin-induced diabetes in rats on the lithium content of tissue and the effect of dietary lithium supplements on this diabetic condition.  Metabolism. 1999;48(5):558-563
  57. Wright J.  Townsend Letter, 2004. 247/248:78-81
  58. Anderson RA. Chromium as an Essential Nutrient for Humans.  Regulatory Toxicol Pharmacol. 1997;26:S35-S41
  59. Stoecker B.J. Chromium.  In Modern Nutrition in Health and Disease, 10th ed.  Lippincott Williams & Wilkins, Phil., 2005: 332-337
  60. Bahijri SMA, Mufti AMB. Beneficial Effects of Chromium in People With Type 2 Diabetes, and Urinary Chromium Response to Glucose Load as a Possible Indicator of Status.  Biol Trace Elem Res, 2002;85:97-109
  61. Leavening agents, yeast, baker’s, compressed. USDA National Nutrient Database for Standard Reference, Release 18 (2005)
  62.  Ensminger AH, Ensminger ME, Konlade JE, Robson JRK.  Food & Nutrition Encyclopedia, 2nd ed.  CRC Press, New York, 1993
  63. Racek J, Trefil L, Rajdl D, Mudrova V, Hunter D, Senft V. Influence of chromium-enriched yeast on blood glucose and insulin variables, blood lipids, and markers of oxidative stress in subjects with type 2 diabetes mellitus. Biol Trace Elem Res. 2006;109(3):215-230.
  64. Guan X, Matte JJ, Ku PK, Snow JL, Burton JL, Trottier NL.  High chromium yeast supplementation improves glucose tolerance in pigs by decreasing hepatic extraction of insulin.  J Nutr 2000;130(5):1274-1279
  65. Mahdi GS, Naismith DJ. Role of Chromium in Barley in Modulating the Symptoms of Diabetes”, Ann  Nutr Metab. 1991;35:65-70
  66. Rouhi AM.  Escorting metal ions: protein chaperone protects, guides, copper ions in transit.  Chem Eng News, 1999;11:34-35
  67. Himelblau E, et al.  Identification of a functional homolog of the yeast copper homeostasis gene ATX1 from Arabidopsis.  Plant Physiol 1998;117(4):1227-1234
  68. Budavari S, et al.  The Merck Index, 12th ed.  Merck & Co., Whitehouse Station (NJ), 1996
  69. DiTomaso JM.  Yellow starthistle: chemical control.  Proceedings of the CalEPPC Symposium, 1996, as updated 5/2/02
  70. Implications of the ‘other half’ of a mineral compound.  Albion Research Notes 2000;9(3):1-5
  71. Thim L, Hansen MT, Sorensen AR. Secretion of human insulin by a transformed yeast cell.  FEBS Letters 1987, 212(2):307-312
  72. Kjeldsen T.  Yeast secretory expression of insulin precursors.  Appl Microbiol Biotechmol 2000;54(3):277-286
  73. GruenwaldJ, Brendlor T, Jaenicke C eds.  PDR for Herbal Medicines, 2nd ed.  Medical Economics Company. Montvale (NJ) 2000
  74. Crook W.  The Yeast Connection: A Medical Breakthrough.  Professional Books, Jackson, TN; 1986
  75. Qureshi AA, Sami SA, Khan FA.  Effects of Stabilized Rice Bran, Its Soluble and Fiber Fractions on Blood Glucose Levels and Serum Lipid Parameters in Humans With Diabetes Mellitus Types I and II.  J Nutr Biochem, 2002;13:175-187
  76. Nahas R, Moher M.  Complementary and alternative medicine for the treatment of type 2 diabetes.  Can Fam Physician. 2009 Jun;55(6):591-6
  77. Khan A, Safdar M, Ali Khan MM, Khattak KN, Anderson RA. Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabetes Care. 2003;26(12):3215-3218
  78. Ping H, Zhang G, Ren G.  Antidiabetic effects of cinnamon oil in diabetic KK-A(y) mice.  Food Chem Toxicol. 2010 Jun 1. [Epub ahead of print]
  79. Cao H, Graves DJ, Anderson RA.  Cinnamon extract regulates glucose transporter and insulin-signaling gene expression in mouse adipocytes.  Phytomedicine. 2010 May 27. [Epub ahead of print]
  80. Gruenwald et al editors.  PDR for Herbal Medicines,4th  ed.  Thompson Healthcare.. Montvale (NJ) 2007
  81. Kassaian N, Azadbakht L, Forghani B, Amini M.  Effect of fenugreek seeds on blood glucose and lipid profiles in type 2 diabetic patients.  Int J Vitam Nutr Res.  2009 Jan;79(1):34-9
  82. Hamden K, Masmoudi H, Carreau S, Elfeki A.  Immunomodulatory, beta-cell, and neuroprotective actions of fenugreek oil from alloxan-induced diabetes.  Immunopharmacol Immunotoxicol. 2010 Jan 25. [Epub ahead of print
  83. Singh AB, Tamarkar AK, Narender T, Srivastava AK.  Antihyperglycaemic effect of an unusual amino acid (4-hydroxyisoleucine) in C57BL/KsJ-db/db mice.  Nat Prod Res. 2010 Feb;24(3):258-65
  84. Uemura T, Hirai S, Mizoguchi N, Goto T, Lee JY, Taketani K, Nakano Y, Shono J, Hoshino S, Tsuge N, Narukami T, Takahashi N, Kawada T. Diosgenin present in fenugreek improves glucose metabolism by promoting adipocyte differentiation and inhibiting inflammation in adipose tissues. Mol Nutr Food Res. 2010 Jun 10. [Epub ahead of print]
  85.  Vuksan V, Sievenpiper JL.  Herbal remedies in the management of diabetes.  Nutr Metab Cardiovasc Dis. 2005 Jun;15(3):149-60
  86. Chang CH, Tsao CW, Huang SY, Cheng JT.  Activation of imidazoline I(2B) receptors by guanidine to increase glucose uptake in skeletal muscle of rats.  Neurosci Lett. 2009 Dec 25;467(2):147-9
  87. Palit P, Furman BL, Gray AI.  Novel weight-reducing activity of Galega officinalis in mice.  J Pharm Pharmacol.  1999 Nov;51(11):1313-9
  88. Groop PH, Aro A, Stenman S, Groop L. Long-Term Effects of Guar Gum in Subjects with Non-Insulin- Dependent Diabetes Mellitus.  Am J Clin Nutr, 1993;58:513-518
  89. Vuorinen-Markkola H, Sinisalo M, Koivisto VA..Guar Gum and Insulin-Dependent Diabetes: Effects on Glycemic Control and Serum Lipoproteins. Am J Clin Nutr. 1992;56:1056-60
  90. Porchezhian E, Dobriyal RM. An overview on the advances of Gymnema sylvestre: chemistry, pharmacology and patents. Pharmazie. 2003;58(1):5-12
  91. Burnham TH, et al, editors.  The Review of Natural Products.  Facts and Comparisons, St. Louis.  2001: 283:284
  92. Kanetkar PV, Singhal RS, Laddha KS, Kamat MY.  Extraction and quantification of gymnemic acids through gymnemagenin from callus cultures of Gymnema sylvestre. Phytochem Anal. 2006 Nov;17(6):409-13
  93.  Ahmed AB, Rao AS, Rao MV.  In vitro callus and in vivo leaf extract of Gymnema sylvestre stimulate beta-cells regeneration and anti-diabetic activity in Wistar rats.  Phytomedicine. 2010 May 26. [Epub ahead of print]
  94. Grover JK, Yadav S, Vats V. Medicinal plants of India with anti-diabetic potential. J Ethnopharmacol. 2002;81(1):81-100
  95. Shintani Y, Fujie H, Miyoshi H, Tsutsumi T, Tsukamoto K, Kimura S, Moriya K, Koike K. Hepatitis C virus infection and diabetes: Direct involvement of the virus in the development of insulin resistance. Gastroenterology. 2004;126(3):840-848
  96. Inadera H, Tachibana S, Takasaki I, Tatematsu M, Shimomura A.  Hyperglycemia perturbs biochemical networks in human trophoblast BeWo cells.  Endocr J. 2010 May 13. [Epub ahead of print]
  97. Kamboj SS, Vasishta RK, Sandhir R.  N-acetylcysteine inhibits hyperglycemia-induced oxidative stress and apoptosis markers in diabetic neuropathy.  J Neurochem. 2010 Jan;112(1):77-91
  98. Hsieh MS, Zhong WB, Yu SC, Lin JY, Chi WM, Lee HM. Dipyridamole suppresses high glucose-induced osteopontin secretion and mRNA expression in rat aortic smooth muscle cells.  Circ J. 2010 May 25;74(6):1242-50
  99. Ko SY, Lin YP, Lin YS, Chang SS.  Advanced glycation end products enhance amyloid precursor protein expression by inducing reactive oxygen species.  Free Radic Biol Med. 2010 Aug 1;49(3):474-80
  100.  Eckhert CD.  In Modern Nutrition in Health and Disease, 10th ed. .Lippincott Williams & Wilkins, Baltimore, 2006: 348
  101.  Hu R, He C, Liu J, Wu Y, Li J, Feng Z, Huang J, Xi XG, Wu Z.  Effects of insulin-mimetic vanadyl-poly(gamma-glutamic acid) complex on diabetic rat model.  J Pharm Sci. 2010 Jul;99(7):3041-7
  102.  Kimura K.  [Role of essential trace elements in the disturbance of carbohydrate metabolism]  Nippon Rinsho. 1996 Jan;54(1):79-84
  103.  Nielsen F. Ultratrace Minerals. In Modern Nutrition in Health and Disease, 8th ed. Lea & Febiger, Phil.,1994:269-286
  104. Badmaev V, Prakash S, Majeed M. Vanadium: a review of its potential role in the fight against diabetes. J Altern Complement Med. 1999;5(3):273-291
  105. Poblete HM, Talucci RC.  Cardiac Drugs.  In Handbook of Drug-Nutrient Interactions.  Humana Press, Totowa (NJ), 2004:257-270

Some of these studies (or citations) may not conform to peer review standards. Therefore, the results are not conclusive. Professionals can, and often do, come to different conclusions when reviewing scientific data. None of these statements have been reviewed by the FDA. All products distributed by Doctors’ Research, Inc. are nutritional and are not intended for the treatment or prevention of any medical condition

Food Antioxidants Are Superior To Isolated Antioxidants

Abstract: Although many people take isolated nutrients as antioxidant supplements, they may not be getting the benefits they hope for. While isolated nutrients have powerful antioxidant abilities in vitro, they rarely have significant antioxidant benefits in vivo. High antioxidant containing foods have proven benefit in humans (in vivo) and high antioxidant effects in vitro as well. High antioxidant containing plants and other herbs are recommended for those interested in obtaining true antioxidant benefits.

Introduction

We live in a world where free radicals can come from many sources and contribute to deterioration of health. “Sources of free radicals include pollutants, drugs, metal ions, radiation, high intakes of polyunsaturated fatty acids, strenuous exercise, mitochondrial dysfunction and smoking. These may result in damage to membrane lipids, proteins, nucleic acids and carbohydrates, which can result in cancer, neurological diseases, lung diseases, diabetes, vascular diseases, autoimmune diseases, aging and eye diseases” [1]. Each day, each cell in the human body endures 104 hits from free radicals—that is about three hundred trillion hits to the body per day!

Antioxidants can inhibit oxidation by giving away an oxygen molecule without requiring much energy. Oxidation is the addition of oxygen or the removal of hydrogen and can be caused by free radicals. An antioxidant can slow down or even stop the chain reaction of oxidation by giving away an electron without changing its stability. Many believe that since real antioxidants can prevent free radical damage, that perhaps aging and various chronic conditions can, to some degree, be slowed down through the consumption of isolated antioxidant nutrients. Is this belief correct?

It is true that free radical damage to the skin contributes greatly to the aged appearance of the skin [2]. It is true that the consumption of high antioxidant containing foods is associated with a decreased risk of cancer and cardiovascular disease [3]. It is true that the consumption of high amounts of antioxidant containing foods is correlated with reduced risk of Alzheimer’s [4]. “Epidemiological studies have shown that consumption of fruits and vegetables is associated with reduced risk of chronic diseases. Increased consumption of fruits and vegetables containing high levels of phytochemicals has been recommended to prevent chronic diseases related to oxidative stress in the human body” [5].

Yet, it is also true that every large clinical trial, which has used isolated antioxidant supplements, has failed to show benefit for cancer and cardiovascular disease [6,7]. It is also true that in a recent trial, “The intake of {ISOLATED} vitamin C, beta-carotene and vitamin E supplements was not significantly associated with the risk of Alzheimer’s disease” [8]. “In two recent observational studies, higher dietary intakes of antioxidants {FOOD}, especially {FOOD} vitamin E, were found to be associated with a lower risk of Alzheimer’s disease. Neither study showed that supplemental {ISOLATED} vitamin E and vitamin C reduced the risk of Alzheimer’s disease. These findings suggest the involvement of other nutritional factors that may be involved in the reduced risk” [9].

(Note: Any words in this paper contained within {} are supplied by this investigator for clarification.)

Food vs. Isolated Form Nutrients

It should be understood that some who have concluded that antioxidant vitamins have little positive effect in vivo have normally failed to realize that the chemical forms of antioxidants used in these trials are often not quite the same as the form found in food.

Food antioxidants, be they vitamins, minerals, or concentrated herbs are superior to the commonly sold non-foods (note only officially recognized vitamins/minerals are listed below):

Food NutrientCompared to USP Vitamin/Mineral Salt
BetacaroteneProvides much greater betacarotene diversity in blood [10]
Vitamin COver 15.6 times antioxidant effect [11]
Vitamin EUp to 4.0 times the free radical scavenging strength [12]
SeleniumNearly 2 times better retained [13]
ZincBetter absorption, better form [14,15]

Many have erroneously concluded that taking many times the quantity of isolated antioxidants will give the same effect as consuming food antioxidants. However, the differences are more than absorption or antioxidant effectiveness. Most isolated ‘antioxidant’ nutrients are chemically and structurally different from those found in foods and do not have the same effect in the human body.

Beta-carotene has been found to have antioxidant effect in vitro…Whether {ISOLATED} beta-carotene has significant antioxidant effect in vivo is unclear” [16]. Carrots, a food high in betacarotene, do have high antioxidant ability [5,16]. Natural betacarotene, as found in foods, is composed of both all-trans and 9-cis isomers, while synthetic betacarotene is all-trans isomers [17]. Carrots, yellow and green leafy vegetables, and turmeric contain natural betacarotene along with multiple carotenoids. Natural betacarotene was found to significantly decrease serum conjugated diene levels for children exposed to high levels of irradiation, though it is not known if synthetic betacarotene would provide similar benefits [17].

Regarding isolated betacarotene, “The data presented provide convincing evidence of the harmful properties of this compound if given alone to smokers, or to individuals exposed to environmental carcinogens, as a micronutrient supplement” [7]. “The three beta-carotene intervention trials: the Beta Carotene and Retinol Efficacy Trial (CARET), Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (ATBC), and Physician’s Health Study (PHS) have all pointed to a lack of effect of synthetic beta-carotene in decreasing cardiovascular disease or cancer risk in well-nourished populations. The potential contribution of beta-carotene supplementation to increased risk of lung cancer in smokers has been raised as a significant concern. The safety of synthetic beta-carotene supplements and the role of isomeric forms of beta-carotene (synthetic all-trans versus “natural” cis-trans isomeric mixtures)… have become topics of debate in the scientific and medical communities” [18]. Now, although the consumption of both synthetic betacarotene and food betacarotene raise serum vitamin A levels about the same, this obscures the fact that synthetic betacarotene tends to mainly increase serums all-trans betacarotene, while food betacarotene increases other forms as well [19].

It is possible that synthetic betacarotene can negatively affect vitamin E’s antioxidant ability as a clinical study found, “These results support earlier findings for the protective effect of a-tocopherol against LDL oxidation, and suggest that beta-carotene participates as a prooxidant in the oxidative degradation of LDL under these conditions. Since high levels of alpha-tocopherol did not mitigate the prooxidative effect of beta-carotene, these result indicate that increased LDL beta-carotene may cancel the protective qualities of alpha-tocopherol” [20]. In a consumer-directed publication, Stephen Sinatra (M.D.) observes, “Research has shown that high doses of synthetic beta-carotene—the kind found in many popular brands—may actually increase your risk for lung cancer. Because at high levels it can become prooxidative—exactly the opposite of what you want…I’ve seen harmful effects (such as serious vision loss) in people who have taken up to 80,000 IU of beta-carotene per day. The bottom line is: Less is more when it comes to beta-carotene. To be safe I recommend between 12,500 and 25,000 IU of beta-carotene per day from food sources such as carrots” [21].

In my opinion, betacarotene in carrots, however, is safer than even Dr. Sinatra suggests (there is about 12,000 i.u. of betacarotene in one raw carrot). The reason for this is because betacarotene in carrots is attached to lipoproteins which appear to aid in preventing toxicity. Isolated USP betacarotene, even if it allegedly comes from “natural” sources, simply does not have the attached lipoproteins or other potentially protective substances as found in foods like carrots.

Vitamin C in foods exists in at least two distinguishable forms with accompanying food factors [22]. Yet, regular ascorbic acid as well as mineral ascorbates are too incomplete to be properly called vitamin C as they do not contain both forms (i.e., they lack DHAA) and the accompanying food factors [22]! Foods contain both natural forms of vitamin C [22]! Also, foods containing vitamin C are normally less acidic than ascorbic acid.

In vitro studies found that food vitamin C has negative oxidative reductive potential [23], while isolated ascorbic acid had positive ORP [24]. Why is that so important? Because while antioxidants can stop free radical damage, only those substances with proper oxidative reductive potential can actually ‘clean up’ the damage that the free radicals cause. Please understand that “negative ORPs indicate active reducing power, which is immediately capable of antioxidant activity, whereas items with positive ORPs are not” [25]. It should be noted that the Merck Index shows that isolated ascorbic acid has positive redox potential [26].

A Cornell University study found that food vitamin C (as found in whole fruit) was 263 times more eftective as a free radical scavenger than isolated ascorbic acid [27]. This appears to be because fruits contain various naturally occurring phytochemicals are responsible for most of the antioxidant activity [27].

Although ascorbic acid has strong antioxidant effects in vitro, it is even possible isolated ascorbic acid has no in vivo antioxidant effects because “Despite epidemiological and some experimental studies, it has not been possible to show conclusively that higher than anti-scorbutic intake of {SYNTHETIC} vitamin C has antioxidant clinical benefit…{ISOLATED} Vitamin C may be a weak antioxidant in vivo, or its antioxidant actions may have no physiological role, or its role may be small. The oxidative hypothesis is unproven” [28]. Why should people take supplemental synthetic ascorbic acid when it is NOT been proven to have antioxidant effects in humans? On the other hand, high vitamin C containing foods do have proven in vitro and in vivo antioxidant effects [27,29].

One study found that food complex vitamin C had 492 micro moles per gram T.E. (Trolox equivalents) of hydrophilic ORAC (oxygen radical absorbance capacity) [30]—ORAC is essentially a measurement of the ability to quench free radicals (antioxidant ability)—while blueberries (one of the highest ORAC sources [11]) only had 195 micro moles per gram T.E. [30]—thus food complex vitamin C has 2.52 times the ORAC ability of blueberries. Vitamin C containing food has over 15.6 times the ORAC of isolated ascorbic acid [11] (food complex vitamin C is even higher). Actually, there are doubts that isolated ascorbic acid has any significant antioxidant effects in humans [28]. Food vitamin C is clearly superior for any interested in ORAC.


“Cross sectional and longitudinal studies show that the occurrence of cardiovascular disease and cancer is inversely related to vitamin C intake…the protective effects seen in these studies are attributable to fruit and vegetable {FOOD} intake…In general, beneficial effects of supplemental {SYNTHETIC} vitamin C have been noted in small studies, while large well controlled studies have failed to show benefit” [28]. The other quantitative is that in humans, “Plasma is completely saturated in doses of 400 mg and higher daily producing a steady-state plasma concentration of 80 mM…Tissues, however, saturate before plasma” [28]. De-emphasizing vitamin C containing foods by attempting to consume higher quantities of isolated ascorbic acid simply will not have the effects on plasma vitamin C levels, ORP, ORAC, or other health aspects that many consumers of isolated ascorbic acid hope it will [25,28].

So-called ‘natural’ ascorbic acid is made by fermenting refined sugar into sorbitol, then hydrogenating it until it turns into sorbose, then acetone (commonly referred to as nail polish remover) is added to break the molecular bonds which creates ascorbic acid [31]! How ‘natural’ is that?

While it is true that ascorbic acid has certain proven health benefits, no matter how much isolated ascorbic acid one takes orally:

1) It will never saturate plasma and/or tissue vitamin C levels significantly more than can be obtained by consuming sufficient vitamin C containing foods.
2) It will never have negative ORP, thus can never ‘clean-up’ oxidative damage like food vitamin C can.
3) It will never have the free radical fighting capacity of food vitamin C.
4) It will never contain DHAA (the other ‘half’ of vitamin C) or the promoting food factors.
5) It will never have the same effect on health issues, such as aging and cardiovascular disease as high vitamin C foods can.
6) It will not ever be utilized the way food vitamin C is.
7) It will always be a synthetic.

Although vitamin C, “can readily donate electrons to quench a variety of reactive free radical and oxidative species and is easily returned to its reduced state”, simply taking ascorbic acid C with two or three different antioxidants is not enough. Why? Because all free radical and oxidative substances do not get neutralized by all antioxidants.

Vitamin E “as found in foods is [d]-alpha tocopherol, whereas chemical synthesis produces a mixture of eight epimers” [32]. Natural vitamin E has recently been renamed to be called RRR-alpha-tocopherol whereas the synthetic has now been renamed to all-rac-alpha-tocopherol, though supplement labels rarely make this clear; on supplement labels d-alpha-tocopherol is generally ‘natural’, whereas dl-alpha-tocopherol is synthetic [32]. All acetate forms of vitamin E are synthetic. “The antioxidant function of vitamin E cannot be fulfilled by just any antioxidant” [12]. Natural RRR-alpha-tocopherol, which is found in food, has 1.7 – 4.0 times the free radical scavenging strength of the other tocopherols [12]. RRR-alpha tocopherol has 3 times the biological activity of the alpha-tocotrienol form, and synthetic vitamin E simply does not have the same biologic activity of natural vitamin E (some synthetic forms have only 2% of the biological activity of RRR-alpha-tocopherol) [12]. The biologic activity of vitamin E is based on its ability to reverse specific vitamin E-deficiency symptoms [12], therefore it is a scientific fact that, overall, synthetic vitamin E has less ability to correct vitamin E deficiencies than food vitamin E. There is an interesting reason for this, which is that the body regulates plasma vitamin E through a specific liver alpha-tocopherol transfer protein, whereas it has no such protein for other vitamin E forms [12]. Or in other words, the liver produces a protein to handle vitamin E found in Food, but not for the synthetic forms!

The body retains natural vitamin E 2.7 times better than synthetic forms [33]—it attempts to rid itself of synthetic forms as quickly as possible [33]. Vitamin E has been shown to reduce the risk of various cancers, coronary heart disease, cataract formation, and even air pollution [12,34]. It also is believed it may slow the aging process and decrease exercise-induced oxidative stress [12,34]. Artificial fats seem to increase the need for vitamin E [35]. Vitamin E content is highest in oils such as soy, but is also relatively high in rice bran [36].

Both chemical form and source of vitamin E may play a role as “chemically synthesized alpha-tocopherol is not identical to the naturally occurring form” [12]. Thus those who claim that a synthetic vitamin, even when it is in the same “chemical form” (it is never in the same actual form due to the presence of food constituents), is as good as one in a natural, food form, are simply overlooking the scientific facts about vitamins.

Food vitamin E, as found in specially grown rice, has been proven to have 12 micro moles per gram T.E. of lipophilic ORAC (oxygen radical absorbance capacity) [57]—ORAC is essentially a measurement of the ability to quench free radicals (antioxidant ability). It is interesting to note that so-called “natural” forms (like succinate) do not even work like food vitamin E. Even though many consider d-alpha-tocopherol as the best (isolated) natural form of vitamin E, the PDR notes, “d-Alpha-Tocopherol succinate itself has no antioxidant activity” [16] so why would anyone want that for their vitamin E supplement?

High dose isolated vitamin E can have pro-oxidant effects [37]. Jerome Block (M.D.) reports, “My research of the literature and my patients supports that this {ISOLATED} vitamin E supplement by itself does not supply adequate antioxidant protection…If one takes the {ISOLATED} commercial form of vitamin E…there is evidence that the effect of the antioxidant is not present…vitamin E found in foods is much more effective than the single alpha-tocopherol supplements…Although vitamin E has an excellent safety record, studies show that alpha-tocopherol alone…has been pro-oxidant rather than antioxidant” [38]. Food vitamin E, which has proven antioxidant abilities [12], is clearly superior to the isolated versions.

Selenium is a mineral with antioxidant abilities and is also “a necessary mineral for the production of antioxidants in the body” [27]. The three most common forms of selenium in supplements are sodium selenite, seleniomethionine, and food selenium. The predominant form of selenium found in the body and in food selenium is selenocysteine [39]. Human research suggests that food selenium is less toxic than industrial/mineral salt form [39].Food selenium (which is normally a specially grown yeast food) should not be confused with yeasts which have been simply fortified with sodium selenite, which can be quite toxic. Sodium selenite is not a food, but is the result of combining sodium hydroxide and selenious acid; sodium selenite is commonly used to remove green color from glass during glass manufacturing [26]. Why would anyone want to take that as part of their antioxidant supplement?

One study using 247 mcg/day of high-selenium yeast found that plasma selenium levels were 2-fold higher than baseline values after 3 and 9 months and returned to 136% of baseline after 12 months, whereas there was a 32% increase in blood glutathione levels also seen after 9 months. This change coincided with a 26% decrease in protein-bound glutathione and a 44% decrease in the ratio of protein-bound glutathione to blood glutathione. The changes in glutathione and protein-bound glutathione were highly correlated with changes in plasma selenium levels and were believed to reflect a reduction in oxidative stress [40].

It has been reported that food selenium seems to reduce toxicity associated with cisplatin chemotherapy [41], hence many people take it when undergoing conventional cancer treatments. Furthermore, Larry Clark, Ph.D. and others have found that selenium in yeast appears to reduce risk of certain cancers [42]. Julian Whitaker, M.D. reports, “The best absorbed form of selenium, and the one used by Dr. Clark’s research, is high-selenium yeast” [42].

Food selenium is about twice as well retained as non-food forms [13,40].

Zinc is an important component of superoxide dismutase (see below). “Dietary zinc has potent antioxidant and anti-inflammatory properties” [43]. Additionally, “Poor zinc nutrition may be an important risk factor in oxidant release and the development of DNA damage and cancer. Approximately 10% of the United States population ingests <50% of the recommended daily allowance for zinc, a cofactor in proteins involved in antioxidant defenses, electron transport, DNA repair and p53 protein expression” [44].

High zinc-containing foods include wheat bran, beef, miso, spinach, mushrooms, alfalfa sprouts, brewer’s yeast, turkey, lamb, bean sprouts, tofu, and to a lessor degree in whole wheat bread [45] (shellfish also contains zinc, but this researcher cannot recommend that as a source). Zinc in unleavened whole wheat bread is less bioavailable than zinc in whole wheat bread leavened with yeast [15]; enzymatically-processed food grade yeast seems to contain some of the most bioavailable food zinc. Research also suggests that certain food forms of zinc are better absorbed and retained than non-food forms [15,16].

Superoxide Dismutase

Superoxide dismutase (S.O.D.) is naturally found in foods such as nutritional yeast and barley green. It is not considered to be an essential nutrient, nor is it an herb (though it does exist in plants). However, S.O.D. “is one of the most important enzymes that functions as a cellular antioxidant…The absence of this enzyme is lethal” [46]. Although S.O.D. (like glutathione, lipoic acid, etc.) is not a vitamin/mineral it is listed here separately because it may be the single most important antioxidant (it is possible that some other antioxidant will take over that role, but more studies appear to have been published about S.O.D. than possibly any other non-vitamin, non-mineral antioxidant).

“It protects intracellular components from oxidative damage, converting the superoxide ion to hydrogen peroxide” [47]. S.O.D. appears to be able to prevent activation of “phospholipase A2 and proanoid synthesis by scavenging free radicals, thereby reducing lipid peroxidation products” [48]. It is a powerful free radical scavenger, which has been clinically shown to protect the brain, heart, liver, lungs, kidneys, skin, muscles, penis, nerves, and spinal cord from ischemic injury [48].

S.O.D. has been shown to inhibit articular tissue damage associated with osteoarthritis [49], decreases lipid peroxidation in damaged skin cells [50], protect against late radiation-induced tissue injury [51], improves clinical symptoms associated with Bechet’s syndrome [52], helps protect the retina [53], helps protect against iron toxicity [54], inhibits vasogenic brain edema after brain injury [55], increases flu survival rates in mice [56], plays a role in bacterial defense [57], helps normalize blood pressure [58,59] helpful for cardiovascular problems [48,60,61], reduces LDL oxidation involved in atherosclerosis [61], is reduced in Alzheimer’s patients [62], improves sperm motility [63], and even helped patients with TMJ who did not respond to traditional therapy [64]; there over a thousand recent (within the last 5 years) peer-reviewed papers on S.O.D. High levels of S.O.D. have been associated with reduced growth of Candida albicans [65]. It is often sold in a “purified” version (from animal products) as an antiaging product [44]; S.O.D. seems to have “antiaging” properties [48]. Ingestion of polyethylene glycol-conjugated superoxide dismutase is not as effective as CuZn (copper/zinc) superoxide dismutase [66,67]. CuZn superoxide dismutase, along with Mn superoxide dismutase [68] exists naturally, in foods such as nutritional yeast (Saccharomyces cerevisiae).

Antioxidant Herbs

There are many antioxidant plants and other herbs. All antioxidants in plants and herbs exist in their natural food forms, hence (unless isolated) are true antioxidants. The following list is not exhaustive (and intentionally does not include green tea as the caffeine it contains is a problem for some):

Barley Grass Concentrate contains a variety of antioxidant substances, including natural S.O.D. (see Superoxide dismutase earlier in this paper) which is also able scavenge reactive oxygen species [69,70]. “Research at the University of California Davis has demonstrated that a flavonoid in barley grass known as 2-0-glycosylisovitexin (2-0-GIV) is a potent antioxidant which is more powerful than other antioxidants in protecting against fat oxidation (lipid peroxidation) in human cells’ [71]. Others state, “the major flavonoid antioxidants in young green barley leaves are in fact the flavone-C-glycosides, saponarin and lutonarin” [72]. Barley grass (like wheat grass and other green plants) also contains chlorophyll, which has antioxidant ability [15].

Carrots provide betacarotene (see Betacarotene earlier in this paper) and other antioxidant carotenoids. Carrots also contain “xanthophyll, a very powerful anticancer phytochemical” [71]. Carrots are one the vegetables with high total antioxidant activity [5].

Citrus Fruits, which are common in Western diets, contain a variety of antioxidants such as flavonoids [15] and food vitamin C (see Vitamin C above). Citrus fruits have been shown to have significant antioxidants in vivo (and in vitro) [5]. Pink grapefruit is a source of lycopene (as are tomatoes) [15]. The peel and pulp of citrus has more of the flavonoid hesperidian than the juice [15].

Eleuthro Root, which was formerly called Siberian Ginseng, is an adaptagen, which means that it helps the body deal with various forms of stress [73]. It has been found to have “strong antioxidant against scavenging on DPPH free radical and also ethyl acetate fractionation exhibited high antilipid peroxidative activities. In the cytotoxic effects were evaluated on seven human cancer cell lines, the values of 50% growth inhibition (GI(50)) were mostly below 30 microg/ml for crude extracts to be considered as significantly active” [74]. A Russian study found that it had strong antioxidant abilities [75].

Ginger Root has constituents with antioxidant effects and can improve peripheral circulation [73]. Specifically it has at least “four shogaols that protect IMR32 human neuroblastoma and normal human umbilical vein endothelial cells from beta-amyloid(25 – 35) insult at EC50 = 4.5 – 81 microM” [76]. Ginger is one of the plants that contain the most antioxidants [77].

Ginkgo Leaf contains about 40 different bioflavonoids, including proanthocyanidins (see Grape Seed/Skin extract below) and quercetin, that “act as free radical scavengers” [73]. “Quercitin is a phenolic antioxidant that and has been shown to inhibit lipid peroxidation” in vitro, but it may need food substances to be an effective antioxidant in vivo [15]. “Cerebral insufficiency many cause anxiety and stress, memory, concentration, and mood impairment, and hearing disorders, all of which may benefit from ginkgo therapy” [73]. “Recent studies conducted with various molecular, cellular and whole animal models have revealed that leaf extracts of Ginkgo biloba may have anticancer (chemopreventive) properties that are related to their antioxidant, anti-angiogenic and gene-regulatory actions. The antioxidant and associated anti-lipoperoxidative effects of Ginkgo extracts appear to involve both their flavonoid and terpenoid constituents…In humans, Ginkgo extracts inhibit the formation of radiation-induced (chromosome-damaging) clastogenic factors and ultraviolet light-induced oxidative stress – effects that may also be associated with anticancer activity. Flavonoid and terpenoid constituents of Ginkgo extracts may act in a complementary manner to inhibit several carcinogenesis-related processes, and therefore the total extracts may be required for producing optimal effects” [78]. Ginkgo biloba extracts, “could reduce cytokine-stimulated endothelial adhesiveness by downregulating intracellular reactive oxygen species formation, nuclear factor-kappaB and activator protein 1 activation, and adhesion molecule expression in HAECs, supporting the notion that the natural compound Ginkgo biloba may have potential implications in clinical atherosclerosis disease” [79].

Grape Seed/Skin Extract contains a variety of antioxidant substances and is over 90% proanthocyanidins, which are a type of bioflavonoid with powerful free radical fighting ability [73]. “Oligomeric proanthocyanidins, naturally occurring antioxidants widely available in fruits, vegetables, nuts, seeds, flowers and bark, have been reported to possess a broad spectrum of biological, pharmacological and therapeutic activities against free radicals and oxidative stress. We have assessed the concentration- or dose-dependent free radical scavenging ability of a novel IH636 grape seed proanthocyanidin extract (GSPE) both in vitro and in vivo models, and compared the free radical scavenging ability of GSPE with {ISOLATED} vitamins C, E and beta-carotene. These experiments demonstrated that GSPE is highly bioavailable and provides significantly greater protection against free radicals and free radical-induced lipid peroxidation and DNA damage than vitamins C, E and beta-carotene. Oxidative tissue damage was determined by lipid peroxidation and DNA fragmentation, while apoptotic cell death was assessed by flow cytometry. GSPE provided significantly better protection as compared to vitamins C and E, singly and in combination. GSPE also demonstrated excellent protection against acetaminophen overdose-induced liver and kidney damage by regulating bcl-X(L) gene, DNA damage and presumably by reducing oxidative stress. GSPE demonstrated excellent protection against myocardial ischemia-reperfusion injury and myocardial infarction in rats. GSPE was also shown to upregulate bcl(2) gene and downregulate the oncogene c-myc. Topical application of GSPE enhances sun protection factor in human volunteers, as well as supplementation of GSPE ameliorates chronic pancreatitis in humans. These results demonstrate that GSPE provides excellent protection against oxidative stress and free radical-mediated tissue injury” [80]—it should be noted that this study compared against isolated (non-food) vitamins and isolated betacarotene. Interestingly it is believed that “grape-skin extract may have a sparing effect on vitamin C” in human plasma [81]. Grape seeds, but mainly grape skin, contains resveratrol which has antioxidant abilities and may be “associated with a reduced incidence of cardiovascular disease and a reduced incidence of cancer” [15]. Resveratrol is prized by many for its anti-aging properties and “has recently been found to possess glutathione-sparing activity” [15].

Kudzu Root contains a powerful antioxidants, including an isoflavone known as puerarin [82]. “Kudzu was found to be an effective adsorbent for basic dye colour removal” [83]. Kudzu and puerarin are being investigated for their apparent ability to suppress alcohol desire for alcoholics [84]; it is also being investigated for its ability to glucose control for diabetics. One study found that kudzu in crude form appears to have greater antioxidant effects than isolated puerarin [85].

Milk Thistle Seed contains silymarin, which is a polyphenolic antioxidant flavonoid [17]. “Silymarin is an antihepatotoxic substance isolated from fruits of Silybum marianum. Possibly due to their antioxidant and membrane stabilizing properties, the compounds have been shown to protect different organs and cells against a number of insults” [86]. Silybinin is a component of silymarin and has been shown to reduce lipid peroxidation [87]. Furthermore, “silibinin inhibits the growth of human prostate cancer cells (PCA) both in vitro and in vivo” [88].

Rosemary Leaf contains flavonoid antioxidants [71] and can “increase detoxification of carcinogens” in certain instances [73]. It contains such flavonoids as cirismarin, diosmin, hesperidin, homoplantiginin, and phegopolin [89]. Topically, rosemary is used to promote wound healing and as an analgesic for myalgias and neuralgias [89].

Saccharomyces cerevisiae, also known as nutritional yeast, contains antioxidants such as S.O.D. (see above) and glutathione (actually most isolated glutathione comes from fermented yeast [15]). Certain food antioxidant nutrients grown in Saccharomyces cerevisiae, such as zinc and selenium have been shown to have higher antioxidant effects and/or better absorption than the isolated mineral salt versions that are commonly sold [13,14,35,43,45]. Saccharomyces cerevisiae also naturally contains protein chaperones, which are essential for mineral absorption. Saccharomyces cerevisiae also stimulates phagocytosis [89]. The bioavailability of coenzyme q10 (a substance with antioxidant properties) is enhanced when it is in a media containing Saccharomyces cerevisiae [90].

Schisandra Fruit “has pronounced liver protective effects” [73] and strong antioxidant activity [91]. Schisandra contains at least 9 dibenzocyclooctene lignans, “Seven of the 9 lignans (1 mM) inhibited iron/cysteine-induced lipid peroxidation (malondialdehyde, MDA, formation)…The actions of the 7 lignans were much more potent than vitamin E at the same concentration of 1 mM. Among the lignans, schisanhenol was the most active one. This compound also prevented the decrease of membrane fluidity of liver microsomes induced by iron/cysteine. The results indicated that seven of the lignans such as schisanhenol have anti-oxidant activities” [91].

Tomatoes are a source of lycopene [15] and food vitamin C [21]. “Lycopene is a member of the carotenoid family…[and] is responsible for the red color of red tomatoes” [15]. “In vitrostudies have demonstrated that lycopene has the highest antioxidant activity of all the carotenoids” [15]. Yet, it does not seem to have the same effect in vivo as tomatoes themselves do. One recent study that compared tomatoes to isolated lycopene found that tomatoes inhibited prostate carcinogenesis but that lycopene did not [92].

Turmeric Root contains curcuminoids which have antioxidant and cancer-inhibiting properties [73]. Many “laboratory studies have identified a number of different molecules involved in inflammation that are inhibited by curcumin including phospholipase, lipooxygenase, cyclooxygenase 2, leukotrienes, thromboxane, prostaglandins, nitric oxide, collagenase, elastase, hyaluronidase, monocyte chemoattractant protein-1 (MCP-1), interferon-inducible protein, tumor necrosis factor (TNF), and interleukin-12 (IL-12)” [93].

Water Thyme is one of the most mineral-dense foods and contains nutritional antioxidants, including vitamin C (see Vitamin C above) and chlorophyll. It is sometimes included in food antioxidant formulas.

Conclusion

Herbs and plants containing antioxidants offer unique benefits, which have not been synthetically duplicated.

Actually, no matter how much synthetic vitamins or industrially-processed rock ‘nutrients’ one takes orally, they will:

1) Never be a truly complete nutrient source.
2) Never replace all the functions of food/herbal vitamins and minerals.
3) Always be unnatural substances to the body.
4) Always strain the body by requiring that it detoxify or somehow dispose of their unnatural structures/chemicals.
5) Never be utilized, absorbed, and retained the same as food/herbal nutrients.
6) Not be able to prevent advanced protein glycation end-product formation the same as food/herbal nutrients.
7) NEVER BE ABLE TO HAVE THE PROVEN ANTIOXIDANT EFFECTS THE SAME AS FOOD NUTRIENTS.
8) Always be industrial products.
9) Always be composed of petroleum-derivatives, hydrogenated sugars, and/or industrially-processed rocks.
10) Never build optimal health the same as food nutrients.

The standards of naturopathy agreed to in 1947 (at the Golden Jubilee Congress) included the statements, “Naturopathy does not make use of synthetic or inorganic vitamins…Naturopathy makes use of the healing properties of…natural foods, organic vitamins” [94]. Even back in the 1940s, professionals interested in natural health recognized the value of food, over non-food, vitamins.

Although many studies have demonstrated that isolated nutrients such as betacarotene, ascorbic acid, and alpha-tocopherol do have significant antioxidant effects in test tubes (in vitro), more recent research has raised serious questions as to whether these chemical isolates have significant antioxidant effects in humans (in vivo) [15,23,33]. Furthermore, in 1999 the Nobel prize for medicine was awarded to Gunter Blobel who discovered that nutritional minerals need protein chaperones for absorption. Such protein chaperones do not exist in mineral salt forms which are commonly included in ‘antioxidant’ or multivitamin formulas. Protein chaperones do, of course, exist in foods such as Saccharomyces cerevisiae [95,96].

While it is known that diets focused on foods high in antioxidants can help prevent cancers [3], synthetic antioxidants appear to be so ineffective that they may actually increase cancer risk [6]. Additionally, regarding cancer and other diseases, “The available evidence points to the benefits of food-derived antioxidants, but more evidence is needed before {ISOLATED} antioxidant…supplementation can be routinely recommended” [97]. “A predominantly plant-based diet reduces the risk for development of several chronic diseases. It is often assumed that antioxidants contribute to this protection, but results from intervention trials with single antioxidants administered as supplements quite consistently do not support any benefit. Because dietary plants contain several hundred different antioxidants” [77], it makes sense to consume food antioxidants and not individual, isolated ones.

Although some scientists think isolated nutrients have questionable and even negative effects, “It is doubtful that antioxidant-rich foods would have a negative impact on brain aging” [9]—or anything else for that matter. Humans are supposed to eat foods and not consume isolated USP nutrients (even if they are called ‘natural’ and even if they are called ‘antioxidants’). Since all free radical and oxidative substances do not get neutralized by all antioxidants, it makes sense to consume a variety of plants and/or antioxidant containing herbs—plants which contain hundreds of antioxidant compounds [15,77,89].

“Unfortunately, a single purified substance will not always have the same antioxidant activity, nor provide the same clinical benefits as…combinations occurring in natural extracts” [98]. Some of these ‘purified’ substances have been shown to sometimes have pro-oxidant instead of antioxidant effects [19,20,32,33].

Why would anyone want to take isolated ‘antioxidants’ instead of foods or those antioxidant formulas which are only composed of 100% food?

References:

[1]Lachance PA, Nakat Z, Jeong W-S. Antioxidants: An Integrative Approach. Nutr, 2001;17:835-838

[2] Kagan VE, Kisin ER, Kawai K, Serinkan BF, Osipov AN, Sertbinova EA, Wolinsky I, Shvedova AA. Towards mechanism-based antioxidant interventions. Ann NY Acad Sci 2002;959:188-198

[3] Francheschi S, Parpinel M, La Vecchia C, Favero A, Talamini R, Negri E. Role of different types of vegetables and fruit in the prevention of cancer of the colon, rectum, and breast. Epidemiology 1998;9(3):338-341

[4] Engelhart MJ, Geerlings MI, Ruitenberg A, et al. Dietary Intake of Antioxidants and Risk of Alzheimer Disease. JAMA 2002;287(24):3223-3229

[5] Chu YF, Sun J, Wu X, Liu RH. Antioxidant and antiproliferative activities of common vegetables. J Agric Food Chem. 2002;50(23):6910-6916

[6] Rautalahti M, Huttunen J. Antioxidants and carcinogenesis. Ann Med 1993;25:435-441

[7] Paolini M, Abdel-Rahman SZ, Sapone A, Pedulli GF, Perocco P, Cantelli-Forti G, Legator MS. Beta-carotene: a cancer chemopreventive agent or a co-carcinogen? Mutat Res. 2003;543(3):195-200

[8] Morris MC, Evans DA, Bienias JL, et al. Dietary Intake of Antioxidant Nutrients and the Risk of Incident Alzheimer Disease in a Biracial Community Study. JAMA 2002;287(24):3230-3237

[9] Foley DJ, White LR. Dietary Intake of Antioxidants and Risk of Alzheimer Disease: Food for Thought. JAMA, 2002;287(24):3261-3263

[10] van het Hof KH, Gartner C, Wiersma A, Tijburg LB, Weststrate JA. Comparison of the bioavailability of natural palm oil carotenoids and synthetic beta-carotene in humans. J Agric Food Chem. 1999;47(4):1582-6

[11] Williams D. ORAC values for fruits and vegetables. Alternatives, 1999;7(22):171

[12] Traber MG. Vitamin E. In Modern Nutrition in Health and Disease, 9th ed. Williams & Wilkins, 1999:347-362

[13] Biotechnology in the Feed Industry. Nottingham Press, UK, 1995: 257-267

[14] Andlid TA, Veide J, Sandberg AS. Metabolism of extracellular inositol hexaphosphate (phytate) by Saccharomyces cerevisiae. Int J. Food Microbiology. 2004;97(2):157-169

[15] King JC, Cousins RJ. Zinc. In Modern Nutrition in Health and Disease, 10 th ed. Lipponcott Williams & Wilkins, Phil., 2006:271-285

[16] Hendler S, Rorvik D ed. PDR for Nutritional Supplements. Medical Economics, Montvale (NJ), 2001

[17] Ben-Amotz A, et al. Effect of natural beta-carotene supplementation in children exposed to radiation from the Chernobyl accident. Radiat Environ Biophys 1998;37:187-193

[18] Patrick L. Beta-carotene: the controversy continues. Altern Med Rev. 2000;5(6):530-45

[19] Ben Amotz; van het Hof KH, Gartner C, Wiersma A, Tijburg LB, Westrate JA. Comparison of the bioavailability of natural palm oil carotenoid and synthetic beta-carotene in humans. J Agric Food Chem, 1999;47(4):1582-1586

[20] Bowen HT, Omaye ST. Oxidative changes associated with beta-carotene and alpha-tocopherol enrichment of human low-density lipoproteins. J Am Coll Nutr. 1998;17(2):171-179

[21] Sinatra S. Consumer Alert: Don’t Touch this Button, 2003:34-35

[22] Jacob RA. Vitamin C. In Modern Nutrition in Health and Disease, 9th ed. Williams & Wilkins, Balt.,1999:467-483

[23] Thiel R. ORP Study on Durham-produced Food Vitamin C for Food Research LLC. Doctors’ Research Inc., Arroyo Grande (CA), February 17, 2006

[24] Thiel RJ. Natural vitamin C is better than isolated ascorbic acid. ANMA Monitor, 1999;3(3):5-7

[25] Thiel R.J, Fowkes S.W. Can cognitive deterioration associated with Down syndrome be reduced? Medical Hypotheses, 2005; 64(3):524-532

[26] Budavari S, et al. The Merck Index, 12th ed. Merck & Co., Whitehouse Station (NJ), 1996

[27] Eberhardt MV, Lee CY, Liu RH. Antioxidant activities of fresh apples. Nature 2000;405:903-904

[28] Sebastian J, et al. Vitamin C as an antioxidant: evaluation of its role in disease prevention. J Am Coll Nutr, 2003;22(1):18-35

[29] Proteggente AR, et al. The antioxidant effect activity of regularly consumed fruit and vegetables reflect their phenolic and vitamin C composition. Free Radic Res, 2002;36(2):217-233

[30] ORAC Test by Brunswick Laboratories, Wareham (MA), February 2006

[31] Vitamin-Mineral Manufacturing Guide: Nutrient Empowerment, volume 1. Nutrition Resource, Lakeport (CA), 1986

[32] Farrel PM, Robert RJ. Vitamin E. In Modern Nutrition in Health and Disease, 8th ed. Lea & Febiger, Phil.;1994:326-341

[33] Traber MG, Elsner A, Brigelius-Flohe R. Synthetic as compared with natural vitamin E is preferentially excreted as alpha-CEHC in human urine: studies using deuterated alpha-tocopherol acetates. FEBS Letters, 1998;437:145-148

[34] An Overview of Vitamin E Efficacy. VERIS Research Information Service, November 1998

[35] Schlagheck TG, et al. Olestra’s effect on vitamins D and E in humans can be offset by increasing dietary levels of these vitamins. J Nutr,1997;127(8):1666S-1685S

[36] Rice bran, crude. USDA National Nutrient Database for Standard Reference, Release 18, 2005

[37] Ikemoto M, Okamura Y, Kano M, Hirasaka K, Tanaka R, Yamamoto T, Sasa T, Ogawa T, Sairyo K, Kishi K, Nikawa T. A relative high dose of vitamin E does not attenuate unweighting-induced oxidative stress and ubiquitination in rat skeletal muscle. J Physiol Anthropol Appl Human Sci. 2002;21(5):257-263

[38] Block J. To E or not to E, that is the question. Orig Internist 2003;10(3):23

[39] Levander OA, Burk RF. Selenium. In Modern Nutrition in Health and Disease, 8th ed. Lea & Febiger, Phil., 1994:242-263

[40] El-Bayoumy K, Richie JP Jr, Boyiri T, Komninou D, Prokopczyk B, Trushin N, Kleinman W, Cox J, Pittman B, Colosimo S. Influence of Selenium-Enriched Yeast Supplementation on Biomarkers of Oxidative Damage and Hormone Status in Healthy Adult Males: A Clinical Pilot Study. Cancer Epidemiol Biomarkers Prev. 2002;11:1459-1465

[41] Ya-Jun, H, et al. The protective role of selenium on the toxicity of cisplatin-contained chemotherapy regimen in cancer patients. Bio Trace Element Res, 1997;56:331-341

[42] Whitaker J. Minerals, part 1: Cut your cancer risk with selenium. Health & Healing, 1999;9(4):6-8

[43] Meerarani P, Reiterer G, Toborek M, Hennig B. Zinc modulates PPARgamma signaling and activation of porcine endothelial cells. J Nutr. 2003 Oct;133(10):3058-3064

[44] Ho E, Courtemanche C, Ames BN. Zinc deficiency induces oxidative DNA damage and increases p53 expression in human lung fibroblasts. J Nutr. 2003 Aug;133(8):2543-2548

[45] Whitney EN, Hamilton EMN. Understanding Nutrition, 4th ed. West Publishing, NY, 1987

[46] Thomas JA. Oxidative stress, oxidant defense, and dietary constituents. In Modern Nutrition in Health and Disease, 8th ed. Lea & Febiger, Phil.;1994:501-512

[47] Turnland JR. Copper. In Modern Nutrition in Health and Disease, 8th ed. Lea & Febiger, Phil.,1994:231-241

[48] Null G. Superoxide Dismutase. In The Clinician’s Handbook of Natural Healing. Kensington Books, New York, 1997:137-144

[49] Hoedt-Schmidt S, et al. Histomorphological studies on the effect of recombinant human superoxide dismutase in biochemically induced osteoporosis. Pharmacol,1993;47(4):252-260

[50] Okumura K, Nishiguchi K, Tanigawa Y, Mori S, Iwakawa S, Komada F. Enhanced anti-inflammatory effects of Cu, Zn-superoxide dismutase delivered by genetically modified skin fibroblasts in vitro and in vivo. Pharm Res,1997;14(9):1223-1227

[51] Delanian S, Baillet F, Huart J, Lefaix JL, Maulard C, Housset M. Successful treatment of radiation-induced fibrosis using liposomal Cu/Zn superoxide dismutase: clinical trial. Radiother Oncol,1994;32(1):12-20

[52] Merit J, et al. Preliminary study of the therapeutic effect of superoxide dismutase in 7 cases of Bechet’s syndrome. C R Acad Sci III,1986;302(7):243-246

[53] Behndig A, Svensson B, Marklund SL, Karlsson K. Superoxide dismutase isoenzymes in the human eye. Invest Opthalmol Vis Sci,1998;39(3):471-475

[54] Wi’snicka R, Krzepiko A, Wawryn J, Krawiec Z, Bili’nski T. Protective role of superoxide dismutase in iron toxicity in yeast. Biochem Mol Biol Int,1998;44(3):635-641

[55] Chan PH, et al. Protective effects of liposome-entrapped superoxide dismutase on posttraumatic brain injury. Ann Neur,1987;21(6):540-547

[56] Sharonov BP, et al. The effective use of superoxide dismutase from human erythrocytes in the late stages of experimental influenza infection. Vopr Virusol,1991;36(6):477-480

[57] San Mateo LR, Hobbs MM, Kawula TH. Periplasmic copper-zinc superoxide dismutase protects Haemophilus ducreyi from exogenous superoxide. Mol Microbiol,1998;27(2):391-404

[58] Zhang XM, Ellis EF. Effects of superoxide dismutase decreases mortality, blood pressure, and cerebral blood flow responses induced by acute hypertension in rats. Chung Kuo Yao Li Hsueh Pao,1990;11(4):324-328

[59] Przyklenk K, Kloner RA. Superoxide dismutase plus catalase improve contractile function in the canine model of the stunned myocardium. Circulatory Res,1986;58(1):148-156

[60] Nelson SK, Bose SK, McCord JM. The toxicity of high dose superoxide dismutase suggests that superoxide can both initiate and terminate lipid peroxidation in the reperfused heart. Free Radic Biol Med,1994;16(2):195-200

[61] Wang P, et al. Overexpression of human copper, zinc-superoxide dismutase (SOD1) prevents postischemic injury. Proc Natl Acad Sci U S A,1998;95(8):4556-4560

[62] De Deyn PP, et al. Superoxide dismutase activity in cerebrospinal fluid of patients with dementia and some other neurological disorders. Alzheimer Dis Assoc Discord,1998;12(1):26-32

[63] Kobayshi T, Miyazaki T, Natori M, Nozawa S. Protective role of superoxide dismutase in human sperm motility: superoxide dismutase activity and lipid peroxide in human seminal plasma and spermatozoa. Hum Reprod,1991;6(7):987-991

[64] Lin Y, et al. Use of superoxide dismutase (SOD) in patients with temporomandibular joint dysfunction. Intl J Oral Maxillofac Surg,1994;23(6pt2):428-429

[65] Romandini P, Bonotto C, Bertoloni G, Beltramini M, Salvato B. Superoxide dismutase, catalase and cell dimorphism in Candida albicans cells exposed to methanol and different temperature. Comp Biochem Physiol Pharm Toxicol Endocrinol,1994;108(1):53-57

[66] Haun SE, Kirsch JR, Helfaer MA, Kubos KL, Traystman RJ. Polyethylene glycol-conjugated superoxide dismutase fails to augment brain superoxide dismutase activity in piglets. Stroke,1991;22(5):655-659

[67] Tibell L, Aasa R, Marklund SL. Spectral and physical properties of human extracellular superoxide dismutase: a comparison with CuZn superoxide dismutase. Arch Biochem Biophys, 1993;304(2):429-433

[68] Turi TG, Kalb VF, Loper JC. Cytochrome P450 lanosterol 14 alpha-demethylase (ERG11) and manganese superoxide dismutase (SOD1) are adjacent genes in Saccharomyces cerevisiae. Yeast,1991;7(6):627-630

[69] Cremer L, Herold A, Avram D, Szegli G. A purified green barley extract with modulatory properties upon the TNF alpha and ROS released human specialised cells isolated from RA patients. Roum Arch Microbiol Immunol 1998;57(3-4):231-242

[70] Yu YM, Chang WC, CHang CT, Hsieh CL, Tsai CE. Effects of young barley leaf extract and antioxidative vitamins on LDL oxidation and free radical scavenging activities in type 2 diabetes. Diabetes Metab 2002;28(2):107-114

[71] Duarte A. Health Alternatives. Megasystems, Morton Grove (IL), 1995

[72] Markham KR, Mitchell KA. The mis-identification of the major antioxidant flavonoids in young barley (Hordeum vulgare) leaves. Z Naturforsch [C] 2003;58(1-2):53-56

[73] DerMarderosian A, editor. The Review of Natural Products, 1st ed. Facts and Comparisons, St. Louis, 2001

[74] Yu CY, Kim SH, Lim JD, Kim MJ, Chung IM. Intraspecific relationship analysis by DNA markers and in vitro cytotoxic and antioxidant activity in Eleutherococcus senticosus. Toxicol In Vitro. 2003;17(2):229-236

[75] Bol’shakova IV, Lozovskaia EL, Sapezhinskii II. Antioxidant properties of a series of extracts from medicinal plants. Biofizika. 1997 Mar-Apr;42(2):480-483

[76] Kim DS, Kim DS, Oppel MN. Shogaols from Zingiber officinale protect IMR32 human neuroblastoma and normal human umbilical vein endothelial cells from beta-amyloid(25-35) insult. Planta Med. 2002;68(4):375-376

[77] Halvorsen BL, Holte K, Myhrstad MC, Barikmo I, Hvattum E, Remberg SF, Wold AB, Haffner K, Baugerod H, Andersen LF, Moskaug O, Jacobs DR Jr, Blomhoff R. A systematic screening of total antioxidants in dietary plants. J Nutr. 2002 Mar;132(3):461-471

[78] DeFeudis FV, Papadopoulos V, Drieu K. Ginkgo biloba extracts and cancer: a research area in its infancy. Fundam Clin Pharmacol. 2003;17(4):405-417

[79] Chen JW, Chen YH, Lin FY, Chen YL, Lin SJ. Ginkgo biloba Extract Inhibits Tumor Necrosis Factor-{alpha}-Induced Reactive Oxygen Species Generation, Transcription Factor Activation, and Cell Adhesion Molecule Expression in Human Aortic Endothelial Cells. Arterioscler Thromb Vasc Biol. 2003; 23(9):1559-1566

[80] Bagchi D, Bagchi M, Stohs SJ, Das DK, Ray SD, Kuszynski CA, Joshi SS, Pruess HG. Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention. Toxicology. 2000;148(2-3):187-197

[81] Young JF, Dragsted LO, Daneshvar B, Lauridsen ST, Hansen M, Sandstrom B. The effect of grape-skin extract on oxidative status.Br J Nutr. 2000;84(4):505-513

[82] Guerra MC, Speroni E, Broccoli M, Cangini M, Pasini P, Mingett A, Crespi-Perellino N, Mirasoli M, Cantelli-Forti G, Paolini M. Comparison between Chinese medical herb Peuraria lobata crude extract and its main isoflavone puerarin antioxidant properties and effects on rat liver CYP-catalased drug metabolism. Life Sci 2000;67(24):2997-3006

[83] Allen SJ, Gan Q, Matthews R, Johnson PA. Comparison of optimised isotherm models for basic dye adsorption by kudzu. Bioresour Technol. 2003;88(2):143-152

[84] Rezvani AH, Overstreet DH, Perfumi M, Massi M. Plant derivatives in the treatment of alcohol dependency. Pharmacol Biochem Behav. 2003;75(3):593-606

[85] Guerra MC, Speroni E, Broccoli M, Cangini M, Pasini P, Minghett A, Crespi-Perellino N, Mirasoli M, Cantelli-Forti G, Paolini M. Comparison between chinese medical herb Pueraria lobata crude extract and its main isoflavone puerarin antioxidant properties and effects on rat liver CYP-catalysed drug metabolism. Life Sci. 2000;67(24):2997-3006

[86] Kvasnicka F, Biba B, Sevcik R, Voldrich M, Kratka J. Analysis of the active components of silymarin. J Chromatogr A. 2003;990(1-2):239-245

[87] Shimizu I. Antifibrogenic therapies in chronic HCV infection. Curr Drug Targets Infect Disord. 2001;1(2):227-240

[88] Dhanalakshmi S, Agarwal P, Glode LM, Agarwal R. Silibinin sensitizes human prostate carcinoma DU145 cells to cisplatin- and carboplatin-induced growth inhibition and apoptotic death. Int J Cancer. 2003 Sep 20;106(5):699-705].

[89] Gruenwald J, Brendler T, Jaenicke C, ed. PDR for Herbal Medicine, 2 nd ed. Medical Economics, Montvale (NJ) 2000

[90] Kurowska EM, Dresser G, Deutsch L, Bassoo E, Freeman DJ. Relative bioavailability and antioxidant potential of two coenzyme q10 preparations. Ann Nutr Metab. 2003;47(1):16-21

[91] Lu H, Liu GT. Anti-oxidant activity of dibenzocyclooctene lignans isolated from Schisandraceae. Planta Med 1992;58(4):311-313

[92] Boileau TW, Liao Z, Kim S, Lemeshow S, Erdman JW, Clinton SK. Prostate carcinogensis in N-methyl-N-nitrosourea (NMU) testosterone-treated rats fed tomato powder, lycopene, or energy restricted diets. J Natl Cancer Inst 2003;95(21):1578-1586

[93] Chainani-Wu N. Safety and anti-inflammatory activity of curcumin: a component of tumeric. J Altern Complement Med. 2003;9(1):161-168

[94] Gehman JM. From the Office of the President: Pseudo-Group Once Again Misleading the Naturopathic Field. Official Bulletin ANA, January 25, 1948:7-8

[95] Rouhi AM. Escorting metal ions: protein chaperone protects, guides, copper ions in transit. Chem Eng News, 1999;11:34-35

[96] Himelblau E, et al. Identification of a functional homolog of the yeast copper homeostasis gene ATX1 from Arabidopsis. Plant Physiol 1998;117(4):1227-1234

[97] Adams AK, Best TM . The Role of Antioxidants in Exercise and Disease Prevention. Physician & Sportsmed, 2002;30(5):37-46

[98] Hardy G, Hardy I, Ball PA. Nutraceuticals – a pharmaceutical viewpoint: part II. Curr Opin Clin Nutr Metab Care. 2003;6(6):661-71

Some of these studies (or citations) may not conform to peer review standards. Therefore, the results are not conclusive. Professionals can, and often do, come to different conclusions when reviewing scientific data. None of these statements have been reviewed by the FDA. All products distributed by Doctors’ Research, Inc. are nutritional and are not intended for the treatment or prevention of any medical condition.

Why are Synthetics Sold as Imitations of Natural Foods and Drugs?

If you have read this far, you probably have already asked yourself that question.  Instead of me trying to answer that, I felt it might be helpful to know that this question was raised a half-century ago.  To answer it, Dr. Royal Lee, in 1948, wrote the following paper which he titled, How and Why are Synthetic Poisons Sold as Imitations of Natural Foods and Drugs?, “

An honestly enforced food and drug law is just as essential to the proper operation of commerce in foods and drugs as the rules and an umpire to administer them in a ball game.

It is obvious to all that such a law should stop the sale of poisonous imitations of common foods and drugs, except where proper labeling warns the buyer of just what he is getting, New synthetic products are constantly appearing, and are sold without proper tests or proper in­vestigation of what their real proper‑ties are.

In fact, the Food & Drug laws seem to be suspended where synthetic imitations of good foods are concerned, and often actually perverted to persecute makers and sellers of real products, as we shall later show.

Let us first get to the bottom of this question of how synthetic products differ from natural. There are two ways in which a difference may exist:

a.   The synthetic product may not be the same thing, but something that resembles the natural product.
b.   The synthetic product is always a simple chemical substance, while the natural is a complex mixture of related and similar materials.

The first situation, where the synthetic material is not the same thing, is common. Take lactic acid, originally made from sour milk, now made synthetically in large quantities. The sour milk lactic‑acid consisted entirely of molecules that were of a right‑handed character. The synthetic is a mixture of equal parts of right‑handed molecules (dextro‑lactic acid) and left­-handed molecules (laevo‑lactic acid). Such mixtures are known as racemic compounds. (In catalogs, etc., the prefixes I‑, d‑, or r‑, are used before the name of the substance.)

About thirty years ago, Dr. Crofton, an English endocrinologist explained how digestive enzymes could only act upon part of the food available. Here are his words:

“It will not be unprofitable now to inquire into the raison d’etre of this curious adaptor mechanism. How is it that the ferments of the tissue‑cells themselves cannot deal with the comparatively simple food material presented to them without the aid of adapters?

Pasteur first discovered that there are certain compounds of carbon which, while identical in every other respect having the same chemical formulae and the same chemical reactions differ only in their behavior to polarized light, that is one compound rotated the light to the right, the other to the left. Such compounds have the same specific gravity, molecular volume melting point, solubility, heat of solution, of combustion and of neutralization. They have the same amount of chemical affinity and index of refraction. Their absorption spectra are the same, and they have the same chemical action, yet one body rotates the light to the right as much as the other to the left. Pasteur’s discovery was made with ammonium tartrates, and he found that if the common mould penicillium glaucum was made to grow in a solution of both (ammonium racemate) it lived on the dextro‑isomer but left the levo‑salt, as he thought, quite untouched, But it now appears it is broken up to a small extent.”[1] (This requirement of the living cell for a minute amount of the laevo‑salt, and the reason for their requirement for the major amount to be the dextro‑ form is explained by Lee and Hanson in their discussion of cell reactions in their book, “Protomorphology”, 1947, Lee Foundation [2].)

Few people know that dextro‑lactic acid is a food and laevo‑lactic acid is a poison. (One is converted into sugar in digestion, the other is a waste product.) Lactic acid once was found useful as a source of carbohydrate as a milk modifier for babies., and began to get into use in special cases where sugars were not well tolerated. In Halifax, some time ago, a number of babies died from the administration of lactic acid in milk, and here was a case where the synthetic product was inadvertently used in place of the natural, because of inadequate labeling precautions. [3] The doctors who recommended its use probably did not even know that there was a difference between the synthetic and natural lactic acid, although the drug catalog of Eli Lilly and Company of 1938, page 195, offers some information on the subject. The basic trouble is that the makers of synthetic products do not want a stigma of inferiority to be put on their imitation products, and will not label their imitations as different unless forced by conscientious food and drug inspectors to do so. And it is a notorious fact that the law is being ignored in many ways.

Where a food product must be composed of, say right‑handed molecules, the left‑hand may be as useless as in the case of left and right hand bolts and nuts in machinery. If you needed right hand cap screws to put the head of your auto engine back on, left hand screws would only serve to cause confusion and probably a failure to get the machine back into operation, unless you could find among them enough of the right screws to finish the job. To feed racemic or wrong “handed” food products is just as foolish. In the case of the babies in Halifax it caused death to feed the racemic product.

In 1895 Paul Walden, of the University of Rostock, (Germany), announced his discovery of the ‘Walden Effect,” the phenomena of the alteration of the optical inversion of natural organic substances that had been isolated M‑ crystal purity, over a period of time, apparently a result of removal from their normal environment and association with other protective and colloidal factors.

Walden, in a series of lectures at Cornell University, (1927‑28), stated:

“The phenomenon of autoracemization is of interest in connection with the question of permanency of optically active substances. Let us consider a pure organic substance such as the dextrorotatory bromo‑succinic ester. When it is kept for some time in a closed flask at ordinary temperatures, it undergoes spontaneous intramolecular rearrangement and a gradual decrease of the optical rotation results; in other words, it racemizes. Several examples may be cited to illustrate this remarkable fact…Might we
not speak of ‘dying molecules’ much as we speak of ‘dead catalysts’?… The effect of
these reactions is, as we may express it, a complete turning ‘inside out’ of the molecule.”

Dr. Emil Fischer, in 1906, said:

“This discovery is the most surprising observation in the field of optically active substances since the fundamental investigations of Pasteur.”

Amino acids are also useless if not toxic when present in synthetic forms. only left handed (laevo‑) amino acids can be assimilated. All synthetic aminos are racemic.

Adrenalin is an outstanding example of a synthetic product that is being commercialized in disregard of the difference in physiological action. The natural adrenalin is fifteen times as 35 active as the synthetic dextro form [4] in its effect on blood vessels, while the dextroadrenalin is eighteen times as effective in promoting glycosuria.

Now, since the commonest use of adrenalin is to promote the vascular changes that relieve the asthmatic patient, the glycosuria (diabetes promoting) effect is definitely not wanted. But to get the same vascular effect, 15 x 18 or 270 times as much of the synthetic stuff must be used, in terms of its unwanted effect of putting sugar into the urine.[5]

The cost of calling a doctor and of getting a shot of adrenalin by the asthmatic patient when he is struggling for a breath of air is far too much to offset the two‑cent saving made by the pharmaceutical manufacturer who puts synthetic adrenalin in the ampule used by that doctor. But, if neither the doctor or the patient knows the difference, the synthetic stuff certainly win be the one he gets. Although natural adrenalin can be made as a by‑product in the processing of glands in making adreno‑cortin, makers of this material tell us there is no market for natural adrenalin because of the low price of the synthetic product.

Pantothenic acid is a vitamin now commercially available only in the synthetic form. Probably this is the reason for its effect of causing a loss of sex function, particularly in females. This castrating action has been found both in test animals and in human patients receiving the “vitamin”, according to unpublished reports to us.

Pure natural Vitamin E was found three times as potent as pure synthetic Vitamin E.[6]

Of course, the poisonous nature of the synthetic Vitamin D sold as “Viosterol” and “Vigantol” is well established. It causes blood in the urine very quickly in children, by its destructive action to the kidneys. Deaths have been reported from the ordinary dosages used to “protect” from rickets. [7]

WHY DO NOT THE PEOPLE AND MEDICAL MEN KNOW THESE FACTS? Is it because the commercial promoters of cheap imitation food and drug products spend enough money to stop the leaking out of information?

Here is a good example of how hard it is to get the facts. In “Good Housekeeping” for September, 1943, in the “Question Box”‘ department, the question was asked, “Are synthetic vitamins as beneficial as those from food sources?” The answer was made “Manufactured vitamins are identical with those found in foods. They are just as beneficial.

When asked what references they could offer to substantiate that statement, “Good Housekeeping quoted the journal of the American Medical Association, December . 21, 1940, page 2185: ‘There is no detectable difference between the synthetic chemical vitamin and the natural ones. Ascorbic acid is just as good Vitamin C as one gets from an orange.”

When pressed for actual experimental evidence instead of swivel chair opinions, the Editor of “Good Housekeeping” referred the question to a group of “experts.” Here are their opinions:

Dr. E. V. McCollum of Johns Hopkins:”…each and every one of these synthetic vitamins is identical with the natural product.”

Dr. Henry C. Sherman, Columbia University: “In some cases the natural and synthetic forms seem to be identical while in other cases there may be more than one natural or more than one synthetic form.” When asked for factual evidence from experimental work to prove that the synthetic vitamins in “enriched” flour, were equal to the natural, he replied, “I think any answers that a scientific worker would give you would be based upon facts and that nothing would be gained by spending time on library researches in order to attach specific references to our answers.”

Dr. George R. Cowgill, Yale University School of Medicine: “In answering the question raised in your letter about relative values of synthetic as compared with “natural” vitamins one should keep clearly in mind the meaning of the terms involved. There is no difference between these two sources of the vitamins as such. However, in many nutritional experiments one works with highly artificial diets containing the synthetic vitamins and there is no supply of various unknown factors that are needed for nutrition. If these unknown factors are missing, obviously some malnutrition will result, but it seems clear in this situation that one is not thereby justified in concluding that the synthetic vitamins are inferior to the “natural” vitamins”.

“This is the position taken by most of the authorities in the vitamin field. Thiamine as thiamine will meet the body’s needs for this vitamin whether it is the synthetic variety or if it comes as a part of a food like a whole‑grain breakfast food. The natural food, of course, may contain the unknown factors that are missing from a specific mixture of vitamins, and therefore, be superior to this extent.”

(Dr. Cowgill was not aware of the fact that natural thiamine can not be separated from B4, the vitamin that prevents some kinds of heart disease.[8] Therefore, it is impossible to compare natural thiamine with synthetic thiamine. He is comparing the synthetic B1 to a pro­duct purely hypothetical that is not known to science, not available for tests.)

We also obtained the opinion of Dr. S. Ansbacher, U. S. Vitamin Corporation, New York: “There is no difference whatsoever in the physiological activity of vitamins from natural sources and the ones made synthetically.”

(Dr. Ansbacher here differs from a book his own firm published, “Vitamin and Mineral Therapy,” by H. E. Dubin and Casimir Funk, 1936, (Dr. Funk was the discoverer of Vitamin B and the man who invented the word “vitamin.”), in which is the comment: “Synthetic Vitamins: These are highly inferior to vitamins from natural sources, also, the synthetic product is well known to be far more toxic.” Page 65)

Dr. Funk’s opinion is significantly different from that of Dr. Ansbacher, present Research Director of the company. Why is it that none of these men seem able to refer to any concrete reason for their present opinions? Could it be that the profits involved in the sale of synthetic foods and drugs are so great that there is a constant campaign on to cover up the facts?

In the September 1948 issue of “Reader’s Digest” is an article by Paul de Kruff, “Harry Steenbock Trapped the Sun,” that appears to be for the express purpose of reviving the reputation of Steenbock and Viosterol the synthetic and poisonous form of Vitamin D. Aside from the dangerous nature of Steenbock’s vitamin, its promotion by the Wisconsin Alumni Research Foundation was an unconscionable racket. its nature is well exposed in the appended reprint from “This Month,” June 1945…

Viosterol is still on the market. It will still poison your child if YOU do not watch out. Your doctor has not yet been informed by his medical society, (if he is a member of the A. M. A.), that they made a mistake in approving it as real Vitamin D, although all vitamin authorities, including Steenbock himself, who first published the fact, knows that Viosterol is NOT Vitamin D. [9]

The same issue of “Reader’s Digest” carries an article on the nickel‑cadmium storage battery, a
common article in Europe for the last 40 years. it is completely unknown in this country.
WHY? Simply because the American makers of lead storage batteries have succeeded in
keeping out any knowledge of this battery from all American territories, and have stopped any
production in this country by hook or crook, (as the article tells it, by acquiring control of the
European concerns), all to protect their racket of selling a short‑lived battery to their customers text books ignore the cadmium battery.

In Canada the adulteration of white flour with synthetic vitamins is a criminal offense. In this country it is an approved practice, and the makers of synthetic vitamins reap a fat harvest for their contribution to the advertising propaganda of the flour millers. The real vitamins are removed to keep insects and molds out of the flour. Synthetic vitamins are added to fool the public, which knows that white flour without vitamins is unfit to eat. The fact that insects and molds still can not live in the flour any better than before the synthetic vitamins were added is not mentioned. Neither is the fact mentioned that test animals fed enriched” diets, (“enriched” with synthetic imitations of natural vitamins), DIE SOONER than control animals fed the deficient diets. Proof that synthetic vitamins are worse than none as food fortifiers, [10], proof that they are put into foods to defraud the buyers, cheat him out of his health and life, as well as his money.

This situation cannot be an accident. It must be a carefully planned conspiracy, with varying degrees of guilt for all the pseudo‑ scientists who have varying degrees of knowledge of the real situation, and who do not dare to expose the truth.

Food & Drug Inspectors and Officials are as helpless to combat this overwhelming influence as they would be to stop the sale of bootleg whiskey during prohibition days. To keep their jobs they have to keep one eye shut.

Dr. Harvey W. Wiley, the first head of the Federal Food & Drug Department tried to stop the use of synthetic sugar, known as glucose of com sugar, in preserved fruits and canned goods. He felt that it was a fraudulent practice to load up such foods with synthetic materials of unknown effect on the human body. Further, people eat sugar as a sweetener, and the synthetic sugar was far less sweet than cane sugar, and would have to eat much more to get the same taste when added to preserves, etc. Dr. Wiley lost out in his desire to even get the label warning on containers that the product carried synthetic sugar, in fact, lost his job because he tried to protect the public.

Only this year have supporting tests confirmed Dr. Wiley’s fears. On May 10, 1948, the University of Pennsylvania released the news to the Associated Press that they had found that the feeding of glucose to test animals caused diabetes. (Dr. Francis D. W. Lukens and Dr.
F. Curtis Dohan.)

Dr. Wiley thought that glucose was a possible cause of diabetes, but had no way to prove it. He felt that the makers of glucose should not be permitted to experiment on the whole population of the United States to find out.

It is the use of glucose in candy, soft drinks, bakery goods, ice cream, canned fruit etc., the low price of which enables their users to undersell all competitors who may try to use better sugars, and put them out of business. It is a clear case of where the public SHOULD be protected by a law, but, as Dr. Wiley said when he was forced to leave his job                       “thus the very law which the Supreme Court has said was enacted chiefly to protect the public health has
been turned into a measure to threaten public health and to defraud the purchaser of flour.

When you add up the industries that depend upon their foisting of synthetics as foods alone, (not considering drugs), you will find you have a list of the biggest in the country. Naturally, they are watching all loopholes where their rackets might start to crack. It is probably impossible for any research worker operating under the auspices of a university or in a government laboratory to be free from their indirect influence, Such items as have been quoted here are leaks that have commonly been quickly suppressed. No further work is done on these important questions. If a book like Dr. Daniel W. Quigley’s, “The National Malnutrition which exposes these food racketeers, gets into public libraries, these influences get it off the shelves. This happened at Rochester, New York, where twelve of the Quigley books were donated by request, for the library and its branches. Later, when it was found that the books had been taken off the circulating list, the librarian admitted that no book inimical to local, industries could remain on the library shelves. Later, that same librarian was Written up in the local paper as a “Champion of FREE libraries where no outside influence could alter the nature of the “free speech” of the library. (Rochester Democrat & Chronicle, November 21, 1944.) Was this a deliberate attempt to nullify a truth by circulating a lie? Or, maybe just a coincidence.

The Food & Drug Administration, and the Federal Trade Commission, instead of getting the facts in this situation and protecting the public against these dangerous imitations of natural foods, are bending their energies it seems to cover up for the racketeers.

We cannot find a single instance of where a maker of synthetic imitation vitamins has been prosecuted by the Food & Drug Administration for improper claims on his labels or advertising. But many makers of NATURAL products have been prosecuted for making claims IDENTICAL to what the makers of synthetic products are constantly and continually promoting. WHY THE SELECTION OF THE MAKERS OF NATURAL PRODUCTS FOR PERSECUTION? In one case in which we have the transcript at hand, the prosecuting attorney was successful in getting the testimony of a key witness REVERSED in the process of printing the record, which the Court of Appeals was able to use to support their argument to uphold the original judgment Without this help, it is hard to see where the original verdict could have been sustained, obtained as it was by obvious fraud, where Government “experts” declared no, vitamin deficiency could create either a degenerative, infectious, or a functional disease.

The Federal Trade Commission has issued orders and interpretations to makers of natural vitamins to “cease and desist” stating that a synthetic vitamin is in any way inferior to a natural.

Pages could be filled with examples of misuse of authority of this kind, where special business interests are being protected by police activity. If one asks the question, “Why do they prosecute one concern for a violation, and then let far bigger ones continue to use the pro­hibited advertising‑‑if it is wrong for one to make a statement why is it not wrong for another? The answer you get is “action can only be taken where a complaint is made, no one has filed a complaint against these concerns.”

If a police authority can stop a murderer only after someone files a complaint, lets get busy and start filing complaints. For a lot of people are being murdered, slowly maybe in most cases, but none the less surely, by food racketeers, who are constantly finding ways to make a poor product worse, and sell it for less, thereby driving better ones off the market. On top of this, they are using the police power to stop the maker of better products from telling the truth on his label as to the difference.

Just WHY should the TRUTH be subservient to the OPINIONS of hired crooks who sell their reputations as EXPERT WITNESSES?

Can you imagine a better way to protect racketeers under the Federal laws? Or a better way for them to discredit their competitors?  ”[12]

References (These references are listed the same way that Royal Lee listed them)

[1]      Crofton, W. M.: AN OUTLINE OF ENDOCRINOLOGY. Wm. Wood and Company, New York,
Second Edition, 1929.

]2] Lee, R. and W. A. Hanson: PROTOMORPHOLOGY. Lee Foundation for Nutritional Research,, Milwaukee, Wisconsin, 1947.

[3] Young, E. G. and R. P. Smith: LACTIC ACID: A CORROSIVE POISON. Journal of American Medical Association 125:1179‑1181) 1944.

[4] Harrow and Sherman: THE CHEMISTRY OF THE HORMONES. Williams & Wilkins, Baltimore, Maryland, page 122, 1934.

[5] Dyson: THE CHEMISTRY OF CHEMOTHERAPY. The Chemical Publishing Company, Brooklyn, New York, page 66.

[6] THE RELATIVE ACTIVITY OF NATURAL AND SYNTHETIC VITAMIN E. Nutrition Reviews 5:251‑253,1947.

[7] Bauer, J. M. and R. H. Freyberg: VITAMIN D INTOXICATION WITH METASTATIC CALCIFICATION. Journal of American Medical Association 130:1208‑1215,1946.

[8] Stepp, W., Kuhnau, J. and H. Schroeder: THE VITAMINS AND THEIR CLINICAL APPLICATIONS. English translation published by The Vitamin Products Company, Milwaukee, Wisconsin, page 24, 1938

[9] Steenbock, H., Kletzein, S. N. F. and J. G. Halpin: THE REACTION OF THE CHICKEN TO IRRADIATED ERGOSTEROL AND IRRADIATED YEAST AS CONTRASTED WITH THE NATURAL VITAMIN D OF FISH LIVER OIL. Journal of Biological Chemistry 97:249,1932.

DeSanctis, A. and J. D. Craig: A FIVE‑YEAR CLINICAL STUDY OF THE PROPHYLACTIC VALUE OFANTIRACHITIC AGENTS. New York journal of Medicine 34:712‑714,1934.

[10] Morgan, Agnes Fay: THE EFFECT OF IMBALANCE IN THE “FILTRATE FRACTION” OF THE VITAMIN B COMPLEX IN DOGS. Science page 261, March 14,1941.

[11] Wiley, H. W.: THE HISTORY OF A CRIME AGAINST THE PURE FOOD LAW. Published by himself, page 391, 1929.

[12] Lee R.  How and Why Synthetic Poisons are Sold as Imitations of Natural Foods and Drugs.  Lee Foundation for Nutritional Research, Milwaukee, 1948

The above is an excerpt written by Royal Lee and from the book, Serious Nutrition: Incorporating Clinically Effective Nutrition Into Your Practice.

Royal Lee, in addition:

The late Dr. Royal Lee knew that food vitamins were superior to synthetic ones.

For another example, Dr. Royal Lee felt that food vitamin C was superior to ascorbic acid. “Dr. Lee felt it was not honest to use the name ‘vitamin C’ for ascorbic acid. That term ‘should be reserved for the vitamin C COMPLEX'” [DeCava, J. The Lee Philosophy-Part II. Nutrition News and Views 2003;7(1):1-6].

Why then, according to the ingredients listed in a recent catalog, would a supplement company that Dr. Lee originally founded currently include ascorbic acid, inorganic mineral salts, and/or other isolated nutrients in the majority of its products?

Dr. Lee, like the late Dr. Bernard Jensen [Jensen B. Chemistry of Man. Bernard Jensen, Escondido (CA), 1983], was also opposed to the use of other isolated, synthetic, nutrients [DeCava, J. The Lee Philosophy-Part II. Nutrition News and Views 2003;7(1):1-6].

As shown earlier, Dr Lee specifically wrote, “In fact, the Food & Drug laws seem to be suspended where synthetic imitations of good foods are concerned, and actually perverted to prosecute makers and sellers of real products. The synthetic product is always a simple chemical substance, while the natural is a complex mixture of related and similar materials. Pure natural Vitamin E was found three times as potent as pure synthetic Vitamin E. Of course the poisonous nature of the synthetic Vitamin D is well established. WHY DO NOT THE PEOPLE AND MEDICAL MEN KNOW THESE FACTS? Is it because the commercial promoters of cheap imitation food and drug products spend enough money to stop the leaking out of information?” [Lee R. How and Why Synthetic Poisons Sold as Imitations of Natural Foods and Drugs? 1948].

All products distributed by Doctors’ Research, Inc. are nutritional and are not intended for the treatment or prevention of any medical condition.

The Truth About Minerals in Nutritional Supplements

Abstract: Even though natural health professionals agree that humans should not try to consume industrial chemicals, most seem to overlook this fact when mineral supplementation is involved.  And even though many people interested in natural health take minerals, the truth is that nearly all the minerals taken are “natural” for nothing except plants and/or industrial chemicals.  While plants are designed to ingest and break-down minerals, humans are not.  The truth about nearly all minerals in supplements is that they are really industrial chemicals made from processing rocks with one or more acids.  The consumption of this “other half” of the mineral compound is not only unnatural, it can lead to toxicity concerns.  Humans were designed to eat food and to get their minerals from foods. Foods DO NOT naturally contain minerals bound to substances such as picolinic acid, carbonates, oxides, phosphates, etc.  When supplementation is indicated, only supplements made from 100% food should be considered for supporting optimal health.

In a nutritional context, minerals are certain elements, such as iron and phosphorus that are essential for the physiology of living organisms to exist.

When it comes to nutrition, plants and humans differ: “a typical plant makes its own food from raw materials… A typical animal eats its food” [1].  For plants, these raw materials include soil-based inorganic mineral salts [2].  Soil-based mineral salts can be depleted through synthetic fertilizers, herbicides, pesticides, as well as repeatedly growing crops on the same soil [3,4].

Plants, with the aid of enzymes and soil-based microorganisms, can take in from soil the mineral salts that they have an affinity for through their roots or hyphae [4].  After various metabolic processes, when these minerals no longer exist as salts, they become complexed with various carbohydrates, lipids, and proteins present in the plant as part of the living organism [5].  Thus for nutrition, humans eat plants and/or animals that eat plants, whereas plants can obtain their nutrients from the soil [4].  This process is commonly referred to as the “food chain” [5].

Unfortunately most mineral supplements contain minerals in the form referred to as ‘mineral salts’.  Even though mineral salts are often called “natural”, they  are rocks (e.g. calcium carbonate exists as the rock commonly known as limestone) or they are chemically produced in accordance with the United States Pharmacopoeia (USP).  Mineral salts are natural food for plants, they are not a natural food for humans–humans do not have roots or hyphae!

Dietary Guideline number 18 of the Weston A. Price Foundation, an organization devoted to consuming real foods, is: “Use only natural, food-based supplements” [6].  One of the standards of naturopathy agreed to in 1947 was, “Naturopathy does not make use of synthetic or inorganic vitamins or minerals” [7].  Why would naturopaths have mentioned minerals since they are ‘natural’?  Because even back then, most naturopaths knew that the inorganic minerals being placed into supplements were often simply industrial rocks and not foods.  Little has changed in the nearly seven decades since.  This paper documents the availability, sources, and some of the chemical differences between minerals found in foods and the industrially processed mineral salts that are found in most ‘natural’ mineral supplements.

Absorption

Mineral absorption is affected by many factors including the chemical form, structural form, existence or lack of protein chaperones, health, dietary factors, and even medications.

“Absorptive efficiency for many minerals is governed by homeostatic feedback regulation.  When the body is in a depleted state, the intestine upregulates absorption of the nutrient.  At the biochemical level , this regulation must be expressed by the control of intraluminal binding lignans, cell-surface receptors, intracellular carrier proteins, intracellular storage proteins, or the energetics of the transmembrane transport…In general mineral bioavailability decreases because of many drugs, decreases with age, and in the presence of malnutrition, is associated with poorer integrity of the small intestine.  Therefore, older individuals who are often taking numerous medications and who are eating more poorly than young people are at greater risk of mineral deficiencies” [8].

Chemical Differences

The basic difference between minerals found in foods and those found in industrial mineral salts is chemical. 

The chemical form of a mineral is an important factor in its absorption and bioavailability…there is evidence that the form in which minerals are ingested affects absorption.  For example, particle size, surface area, and solubility of a substance affects is dilution rate…In many solid foods, elements are not free, but firmly bound in the food matrix” [8]. 

This, of course, is not true of most minerals in supplements as they are normally industrially processed inorganic rocks (mineral salts) hence they are void of the factors found in a food matrix.  Only 100% food minerals have minerals attached in a food matrix.

Minerals are normally found in food and in the body they are attached with some peptide [9,10]. When humans eat plants or animals they are consuming minerals in those forms.  Humans are not supposed to directly consume soil components [1].  With the exception of sodium chloride (common table salt), humans do not normally in any significant quantity consume minerals in the chemical forms known as mineral salts.  When they do, it is considered to be a disorder called ‘geophagia’ or ‘pica’ [11,12].

It is a fact that mineral salts are often called “natural”, but they are not food minerals.  Mineral salts are normally inorganic molecular compounds that look like rocks [13].  Mineral salts are a compound containing a mineral element, which is the mineral normally listed on a supplement label, and some other substance it is chemically bound to.  Mineral salts are either rocks (e.g. calcium carbonate exists as the rock commonly known as limestone) or they are rocks that are chemically-altered.  Mineral salts are natural food for plants which can chemically change and detoxify them [14]; they are not a natural food for humans, although some people do consider crushed bones and naturally-calcified sea algae, etc. as food.  Minerals bound in mineral salts simply are not treated the same way in the body as are minerals found in food.

Minerals vs. Industrial Chemicals

The following list describes what many mineral salts/chelates used in supplements actually are and what they are used for when not in supplements:

  • Boric acid is the rock known as sassolite.  It is used in weatherproofing wood, fireproofing fabrics, and as an insecticide [15].
  • Calcium ascorbate is calcium carbonate processed with ascorbic acid and acetone.  It is a manufactured product used in ‘non-food’ supplements [15].
  • Calcium carbonate is the rock known as limestone or chalk.  It is used in the manufacture of paint, rubber, plastics, ceramics, putty, polishes, insecticides, and inks.  It is also used in fillers for adhesives, matches, pencils, crayons, linoleum, insulating compounds, and welding rods [15].
  • Calcium chloride is calcium carbonate and chlorine and is the by product of the Solvay ammonia-soda process.  It is used for antifreeze, refrigeration, fire extinguisher fluids, and to preserve wood and stone.  Other uses include cement, coagulant in rubber manufacturing, controlling dust on unpaved roads, freezeproofing of coal, and increasing traction in tires [15].
  • Calcium citrate is calcium carbonate processed with lactic and citric acids.  It is used to alter the baking properties of flour [15].
  • Calcium gluconate is calcium carbonate processed with gluconic acid, which is used in cleaning compounds.  It is used in sewage purification and to prevent coffee powders from caking [15].
  • Calcium glycerophosphate is calcium carbonate processed with dl-alpha-glycerophosphates.  It is used in dentifrices, baking powder, and as a food stabilizer [15].
  • Calcium hydroxyapatite is crushed bone and bone marrow.  It is used as a fertilizer [16].
  • Calcium iodide is calcium carbonate processed with iodine.  It is an expectorant [15].
  • Calcium lactate is calcium carbonate processed with lactic acid.  It is used as a dentifrice and as a preservative [15].
  • Calcium oxide is basically burnt calcium carbonate.  It is used in bricks, plaster, mortar, stucco, and other building materials.  It is also used in insecticides and fungicides [15].
  • Calcium phosphate, tribasic is the rock known as oxydapatit or bone ash.  It is used in the manufacture of fertilizers, milk-glass, polishing powders, porcelain, pottery, and enamels [15].
  • Calcium stearate is an octodecanoic calcium salt and can be extracted from animal fat.  It is used for waterproofing fabrics and in the production of cement, stucco, and explosives [15].
  • Chromium chloride is a preparation of hexahydrates.  It is used as a corrosion inhibitor and waterproofing agent [15].
  • Chromium picolinate is chromium III processed with picolinic acid.  Picolinic acid is used in herbicides [17].
  • Copper aspartate is made “from the reaction between cupric carbonate and aspartic acid (from chemical synthesis)” [18].  It is a manufactured product used in ‘non-food’ supplements [18].
  • Copper (cupric) carbonate is the rock known as malachite.  It is used as a paint and varnish pigment, plus as a seed fungicide [15].
  • Copper gluconate is copper carbonate processed with gluconic acid.  It is used as a deodorant [19].
  • Copper (cupric) glycinate is a copper salt processed with glycine.  It is used in photometric analysis for copper [15].
  • Copper sulfate is copper combined with sulfuric acid.  It is used as a drain cleaner and to induce vomiting; it is considered as hazardous heavy metal by the City of Lubbock, Texas that “can contaminate our water supply” [20].
  • Dicalcium phosphate is the rock known as monetite, but can be made from calcium chloride and sodium phosphate.  It is used in ‘non-food’ supplements [18].
  • Ferric pyrophosphate is an iron rock processed with pyrophosphoric acid.  It is used in fireproofing and in pigments [15].
  • Ferrous lactate is a preparation from isotonic solutions.  It is used in ‘non-food’ supplements [15].
  • Ferrous sulfate is the rock known as melanterite.  It is used as a fertilizer, wood preservative, weed-killer, and pesticide [15].
  • Magnesium carbonate is the rock known as magnesite.  It is used as an antacid, laxative, and cathartic [15].
  • Magnesium chloride is magnesium ammonium chloride processed with hydrochloric acid.  It fireproofs wood, carbonizes wool, and is used as a glue additive and cement ingredient [15].
  • Magnesium citrate is magnesium carbonate processed with acids.  It is used as a cathartic [15].
  • Magnesium glycinate is a magnesium salt processed with glycine.  It is used in ‘non-food’ supplements.
  • Magnesium oxide is normally burnt magnesium carbonate.  It is used as an antacid and laxative [15].
  • Manganese carbonate is the rock known as rhodochrosite.  It is used as a whitener and to dry varnish [15].
  • Manganese gluconate is manganese carbonate or dioxide processed with gluconic acid.  It is a manufactured item used in ‘non-food’ supplements [15].
  • Manganese sulfate is made “from the reaction between manganese oxide and sulfuric acid” [18].  It is used in dyeing and varnish production [15].
  • Molybdenum ascorbate is molybdenite processed with ascorbic acid and acetone.  It is a manufactured item used ‘non-food’ supplements [21].
  • Molybdenum disulfide is the rock known as molybdenite.  It is used as a lubricant additive and hydrogenation catalyst [15].
  • Potassium chloride is a crystalline substance consisting of potassium and chlorine.  It is used in photography [15].
  • Potassium iodide is made from HI and KHCO3 by melting in dry hydrogen and undergoing electrolysis.  It is used to make photographic emulsions and as an expectorant [15].
  • Potassium sulfate appears to be prepared from the elements in liquid ammonia.  It is used as a fertilizer and to make glass [15].
  • Selenium oxide is made by burning selenium in oxygen or by oxidizing selenium with nitric acid.  It is used as a reagent for alkaloids or as an oxidizing agent [15].
  • Seleniomethionine is a selenium analog of methionine.  It is used as a radioactive imaging agent [15].
  • Silicon dioxide is the rock known as agate.  It is used to manufacture glass, abrasives, ceramics, enamels, and as a defoaming agent [15].
  • Vanadyl sulfate is a blue crystal powder known as vanadium oxysulfate.  It is used as a dihydrate in dyeing and printing textiles, to make glass, and to add blue and green glazes to pottery [15].
  • Zinc acetate is made from zinc nitrate and acetic anhydride.  It is used to induce vomiting [15].
  • Zinc carbonate is the rock known as smithsonite or zincspar.  It is used to manufacture rubber [15].
  • Zinc chloride is a combination of zinc and chlorine.  It is used as an embalming material [15].
  • Zinc citrate is smithsonite processed with citric acid.  It is used in the manufacture of some toothpaste [15].
  • Zinc gluconate is a zinc rock processed with gluconic acid.  Gluconic acid is used in many cleaning compounds [15].
  • Zinc lactate is smithsonite processed with lactic acid.  Lactic acid lactate is used as a solvent [15].
  • Zinc monomethionine is a zinc salt with methionine.  It is used as a ‘non-food’ supplement.
  • Zinc orotate is a zinc rock processed with orotic acid.  Orotic acid is a uricosuric (promotes uric acid excretion) [15].
  • Zinc oxide is the rock known as zincite.  It is used as a pigment for white paint and as part of quick-drying cement [15].
  • Zinc phosphate is the rock known as hopeite.  It is used in dental cements [15].
  • Zinc picolinate is a zinc rock processed with picolinic acid.  Picolinic acid is used in herbicides [17].
  • Zinc sulfate can be a rock processed with sulfuric acid.  It is used as a corrosive in calico-printing and to preserve wood [15].

 

There is a relatively easy way to tell if minerals are industrial chemicals.  Whenever there are two-words on a label describing a mineral, it is a logical to conclude that the substance is an industrial mineral product and not 100% foodThe exception is chromium GTF (the GTF stands for glucose tolerance factor) which is food if it is from nutritional yeast [18].

Chelated Minerals

Chelated minerals are generally crushed industrial rocks that are processed with one or more acids.

Probably the biggest difference in minerals now compared to 1947 is that some companies have decided to industrially produce versions of minerals attached to peptides.  Essentially they take a rock or industrial mineral salt, chemically alter it, and attempt to attach it to the mineral.  This results in a mineral that is different from normal mineral salts, but does not turn the substance into a food.  Examples of this include the various mineral ascorbates, picolinates, aspartates, glycinates, and chelates.  It needs to be understood that since there is not a universally accepted definition of the term ‘chelate’, when this term is used on a label, one generally does not know if the chelate is amino-acid based or some type of industrial acid.

While it is true that humans can, and do, utilize minerals from USP mineral salts or chelated minerals, this is not as safe (or even normally as effective) as consuming them from foods (or in the case of real food supplements, food concentrates).

Non-Food Attachments, Including Some “Chelates,” Are Not Desirable

Is it wise to consume non-food minerals? 

Dr. Bernard Jensen, an early 20th century advocate of food-based nutrition, once wrote, “When we take out from foods some certain salt, we are likely to alter the chemicals in those foods.  When extracted from food, that certain chemical salt is extracted, may even become a poison.  Potash by itself is a poison, whether it comes from a food or from the drugstore.  This is also the case with phosphorus.  You thereby overtax your system, and your functions must work harder, in order to throw off those inorganic salts or poisons introduced… The chemical elements that build our body must be in biochemical, life-producing form.  They must come to us as food, magnetically, electrically alive, grown from the dust of the earth… When we are lacking any element at all, we are lacking more than one element.  There is no one who ever lacked just one element.  We don’t have a food that contains only one element, such as a carrot entirely of calcium or sprouts totally made of silicon” [22]. 

It should be noted that the addition of “citric acid and picolinic acid do not appear to enhance zinc absorption” [23].  Chromium picolinate is a human-made substance, created by Gary Evans [24]; it is not a natural food.  Picolinic acid is used in herbicides [17]; furthermore “picolinic acid is an excretory or waste product.  It is not metabolized by or useful to the body” [25].  Scientists report, “some research groups recently suggested that chromium (III) picolinate produces significantly more oxidative stress and potential DNA damage than other chromium supplements” [26]. 

Concerns are being raised from various sources about the implications of intentional ingestion of inorganic substances in supplements by human beings [22,25,26].  These substances are not natural for humans to consume and a long period of consumption may cause some type of toxic accumulation [22,25,26].   Yet, many people supposedly interested in natural health are daily consuming various carbonates, gluconates, oxides, picolinates, phosphates, sulfates and other rock components that were not intended to be ingested that way.  Since there are many possible negative implications associated with “the other half” of these non-food minerals [25], people truly interested in their health would be much better off consuming foods that are high in minerals or supplements made from those foods.

Jay Patrick claims to have originally developed procedures to manufacture all seven of the mineral ascorbates [21]; thus it would seem highly inappropriate to call supplements with ascorbate attached minerals ‘food’.

Actually, it does not appear that any of the minerals marketed as ‘chelated’ are food concentrates, though there are foods which contain naturally chelated minerals, but these are normally marketed as food minerals.  Even though there are some theoretical advantages to industrially-produced mineral ‘chelates’ as compared to inorganic mineral salts, these chelates are not natural food.

More on Bioavailability 

It is well known among nutrition researchers that most essential minerals are not well absorbed; for some minerals, absorption is less than 1% [27].  “Bioavailability of orally administered vitamins, minerals, and trace elements is subject to a complex set of influences…In nutrition science the term ‘bioavailability’ encompasses the sum of impacts that may reduce or foster the metabolic utilization of a nutrient” [28].  Research demonstrates that the bioavailability and/or effectiveness of mineral containing foods is greater than that of isolated inorganic mineral salts or mineral chelates [e.g. 28-52].  These studies have concluded that natural food minerals may be better absorbed, utilized, and/or retained than mineral salts.

Furthermore, minerals used in most supplements do not contain protein chaperones or other food factors needed for absorption into the cell.  In 1999, the Nobel Prize for medicine was awarded to Guenter Blobel who discovered that minerals need protein chaperones to be absorbed into cellular receptors. When mineral salts without protein chaperones are consumed, “It is after digestion when other mineral forms {mineral salts} have their mineral cleaved from their carriers. In this situation, these minerals become charged ions, and their absorbability becomes in jeopardy. These charged free minerals are known to block the absorption of one another, or to combine with other dietary factors to form compounds that are unabsorbable” [53].  The body must discard the residual chemicals.

Foods used in supplements that commonly provide significant quantities of essential minerals include dulse, horsetail herb, kelp, nutritional yeast, rice bran, and water thyme.  These types of foods have been shown to contain not only minerals in natural food forms, but also important protein chaperones such as ATX1 and ceruplasmin [54,55].  Industrial mineral salts do not contain the protein chaperones or other food factors needed for proper mineral absorption. Furthermore, some foods also contain factors which reduce the probability of certain minerals to be toxic to the body [32,33,55]; industrial mineral salts and chelates are simply not that complete. 

 

Quantitative and Qualitative Differences

There are quantitative and qualitative differences in food vs. non-food minerals. Table 1 lists some of them by mineral.

Table 1 Quantitative and Qualitative Differences

Food Mineral

 

Compared to Mineral Salt/Chelate

Calcium

 

Up to 8.79 times more absorbed into the blood [47] and 7 times as effective in raising serum ionic calcium levels [30].

Chromium

 

Up to 25 times more bioavailable [31].

Copper

 

85% more absorbed [45]; also contains substances that reduce potential toxicity [32,46].

Iron

 

Safer, non-constipating, 77% more absorbed [33, 34, 45].

Magnesium

 

Up to 2.20 times better absorbed [52] and retained [35].

Manganese

 

Better absorbed and retained [45,46] and not as likely to contribute to toxicity as mined forms [36,56].

Molybdenum

 

Up 6.28 times better absorbed into the blood and 16.49 times better retained [45].

Phosphorus

 

Less likely to cause diarrhea or electrolyte disorders [37].

Selenium

 

17.6 time the antioxidant effect [46], 123.01 times more effective in preventing nonenzymatic protein glycation [17], and  2.26 times better retained [29,38,44].

Vanadium   

 

Safer and 50% more effective [39].

Zinc 

Up to 6.46 times better absorbed [45,46,51], better form [40,41].

Foods, almost by definition, are not toxic, and as mentioned earlier, can have protective factors to prevent certain potential mineral toxicities, such as those sometimes associated with copper, iron, manganese, or other minerals [32,33,55,56].

Information by Individual Mineral

Some differences between food complexed minerals and mineral salts have been documented by published research and are shown by individual mineral below:

Boron “Boron complexes with organic compounds containing hydroxyl groups” [9], which is how it is found in foods. Boron affects macromineral and steriodal hormone metabolism; without sufficient boron bone composition, strength, and structure weaken [9]. 

Calcium  “The amount of calcium absorbed depends on its interaction with other dietary constituents…The absorbability of calcium is mainly determined by the presence of other food constituents” [56].  This is one of the reasons why isolated calcium mineral salts (such as calcium carbonate) are not absorbed as well as calcium found in natural food complexes [56,57].  “Calcium carbonate, an antacid, counteracts not only the absorption of calcium, but also the absorption of iron” [11] (though its calcium absorption appears to be better with food [58]).  At least one researcher has concluded that commonly used mineral salts such as calcium lactate and calcium gluconate primarily succeed in creating high blood calcium levels (hypercalcemia) instead of alleviating symptoms of low tissue calcium [59].  “Calcium has a structural role in bones and teeth” as well as in some enzymes involved with blood clotting [48]. Calcium can affect mood and blood pressure [57,60].  Clinical reports consistently confirm that dietary/food calciums [5-8] are important in the management of blood pressure.  This does not appear to be the case with isolated calcium salts (the results appear inconsistent [30,61-63]).  One study found that calcium in Food raised serum ionic calcium levels from 1.08 to 1.15 mmoles, but that serum ionic calcium levels were not raised with calcium carbonate [30].  Serum calcium levels affect blood pressure [60,64].  Since low bone mass is somewhat inversely correlated with high levels of diastolic blood pressure [9], this suggests that calcium from Food may be superior when hypertension issues are present. Calcium is important for optimal health as calcium deficiencies can contribute to osteoporosis, muscle cramps (especially in the legs), insomnia, mood/behavioral/nerve problems, hypertension,  kidney stones, and colon cancer [61,65,66].  It appears that overdose of calcium can only occur when taking mineral salt forms of calcium supplement as opposed to food [66].  A human study found that Natural Food Complex calcium is 8.79 times more bioavailable than calcium carbonate (which is the most common form found in supplements) and 2.97 times more than calcium gluconate [47]. This same study found that Food calcium “produced no undesirable side effects and was the most suitable form of calcium for long-term supplementation” [47].

Chromium, GTF  “The biologically active form of chromium, sometimes called glucose tolerance factor or GTF, has been proposed to be a complex of chromium, nicotinic acid, and possibly the amino acids glycine, cysteine, and glutamic acid.  Many attempts have been made to isolate or synthesize the glucose tolerance factor; none have been successful” [67].  Chromium is not naturally found in the body in the commonly supplemented forms such as chromium picolinate or chromium chelate.  “Chromium is generally accepted as an essential nutrient that potentiates insulin action, and thus influences carbohydrate, lipid, and protein metabolism” [67].  Research suggests that there is much less likelihood of toxicity from natural food complex chromium than from forms such as chromium picolinate [26].  Only 1% or less of inorganic chromium is absorbed vs.10-25% of chromium GTF [31].  One small study found that Food  chromium GTF reduced blood glucose levels by 16.8% versus 6.0% for inorganic chromium [48], thus it was 2.80 times more effective. One study found that Food  chromium benefited certain diabetics by improving blood glucose control, lowering serum lipids, and decreasing the risk of coronary heart disease [49]. Chromium GTF only comes from nutritional yeast [58].

Copper  In the human body, in addition to various plasma-bound coppers, “at least one copper peptide complex” has been isolated [60].  Copper is predominantly found in Food nutrients in a copper peptide complex (such as Cu/Zn superoxide-dismutase). Copper is not naturally found in the body in the form of copper gluconate or copper sulfate.  “Anemia, neutropenia, and osteoporosis are observed with copper deficiency”; copper is involved in connective tissue, iron metabolism, the central nervous system, melanin pigment, thermal regulation,  cholesterol metabolism, immune function, and cardiac function [60].  Copper in foods like nutritional yeast contains protective factors that reduce the possibility of toxicity issues [32,46].  A human study found that Food copper was 1.44 times more absorbed into the blood than copper sulfate and 1.43 times more than copper gluconate [45]. Animal studies showed similar results, plus concluded that Food copper was retained in the liver 1.85 times more than copper gluconate and 1.42 times more than copper sulfate [45].

Iodine Most of the iodine in the body exists in the form of iodine-containing amino acids [61].  Iodine is needed by the thyroid gland to produce thyroid hormones which influence most of the body’s metabolic processes [61].  Kelp is an excellent food source of iodine [61].

Iron  Most researchers acknowledge that organic iron is better absorbed than inorganic iron [71].  The body has different mechanisms for the absorption of iron depending upon its form [72].  Iron in foods is found in an organic form.  Iron is required for growth and hemoglobin formation; inadequate amounts can lead to “weakness, fatigue, pallor, dyspnea on exertion, palpitation, and a sense of being overly tired” [72].  Iron in food is safer, less-constipating (actually it is non-constipating), and better absorbed than non-food forms [33,34].  An animal study found that Food iron was absorbed into the blood 1.01 times more than ferrous sulfate and 1.77 times more than amino acid chelated iron and was retained in the liver 1.21 times more than ferrous sulfate and 1.68 times more than amino acid chelated iron [45,46].

Magnesium  “The percentage of absorption of ingested magnesium is influenced by its dietary concentration and by the presence of inhibiting or promoting dietary components [73].  There are no promoting dietary components in inorganic isolated magnesium salts. “Magnesium is involved in many enzymatic steps in which components of food are metabolized and new products are formed”; it is involved in over 300 such reactions [6].  Clinical deficiency of magnesium can results in “depressed tendon reflexes, muscle fasciculations, tremor, muscle spasm, personality changes, anorexia, nausea, and vomiting” [73].   Magnesium in foods is better absorbed and retained than magnesium from inorganic mineral salts [35].  A human study found that Natural Food Complex magnesium was 2.20 times more absorbed into blood than magnesium oxide and 1.60 times more than amino acid chelated magnesium [52].

Manganese  In the body, absorbed manganese complexes with various peptides [9].  Manganese is predominantly found in foods in a manganese peptide complex (such as Mn superoxide-dismutase).  It is not found in the body in forms like manganese sulfate.  Manganese deficiency can cause “impaired growth, skeletal abnormalities, disturbed or depressed reproductive function, ataxia of the newborn, and defects in lipid and carbohydrate metabolism” [9].  It can also affect skin, hair, nails, and problems with calcium metabolism [9].  Manganese in foods is safer and much less likely to cause any toxicity compared to mined forms [36,56].  ]. An animal study found that Natural Food Complex manganese was absorbed 1.56 times more into the blood and was retained 1.63 times more in the liver than manganese sulfate [45,46].

Molybdenum  Molybdenum…in foods…is readily absorbed” [9].  “Molydenum in {nearly all} nutritional supplements is in the form of either sodium molybdate or ammonium molybdate.  Molybdenum in food is principally in the form of molydenum cofactors” [67]. “Molybdenum functions as an enzyme cofactor”, thus “detoxifies various pyrimidines, purines, pteridines, and related compounds” [9]; it may also affect growth and reproduction [9].  An animal study found that Food molybdenum was absorbed 6.28 times more into the blood and was retained 16.49 times more in the liver than ammonium molybdate and 10.27 times more than molybdenum amino acid chelate [45].

Phosphorus Phosphorus is found in plants [11].  Phosphorus salts can cause diarrhea and other problems [37]—problems that do not happen with phosphorus in foods.  Phosphorus works with calcium to produce strong bones [57].

Potassium  Potassium is found in plants [11].  Potassium is the leading intracellular electrolyte and is necessary for electrolyte balance, stimulating aldersterone for the adrenal glands, and blood pressure regulation [11].  Dr. Bernard Jensen seemed to believe potassium is only safe in its natural food complex form [22].

Selenium   “The predominant form of selenium in animal tissues is selenocysteine” [74].  That is how it is predominantly found in certain foods.  One study found that diets naturally high in selenium (daily consumption as high as 724mcg) produced no signs or symptoms of selenium overexposure while another found that exceedingly high consumption of  selenium salts could induce selenium poisoning [74].  Selenium seems to support thyroid hormone production, function as part of many enzymes, and have antioxidant effects [74].  Larry Clark, Ph.D. and others have found that selenium in yeast appears to reduce  risk of certain cancers [75].  Julian Whitaker, M.D. reports, “The best absorbed form of selenium, and the one used by Dr. Clark’s research, is high-selenium yeast” [75].  A study using 247 mcg/day of high-selenium yeast found that plasma selenium levels were 2-fold higher than baseline values after 3 and 9 months and returned to 136% of baseline after 12 months, whereas there was a 32% increase in blood glutathione levels also seen after 9 months [29].  Food selenium is about twice as well retained as non-food forms [29,38].  Research suggests that Food selenium is 2.26 times more retained in the liver and 1.22 times more absorbed in the blood than sodium selenite [44]. An in vitro study found that Food selenium had 17.6 times the antioxidant effect than did selenomethionine [44]. One study found that Food selenium was 123.01 times more effective than sodium selenite in preventing nonenzymatic glycation in diabetics [50].

Silicon “In animals, silicon is found both free and bound” [9].  Silicon absorption is quite dependent upon the form [9].  Silicon is involved in bone calcification and connective tissue formation [9].  It is also needed for healthy hair and skin [51].  Silicon is found in foods in an organic form.

Trace Minerals  Trace minerals, including “ultra trace minerals” are necessary for the proper functioning of human health [9,51].  There are many in the human body, some of which are known to be essential and others of which their “essentialness” is under investigation.  Sea vegetables and certain yeasts are a good source of trace minerals [11,31,61]. 

Vanadium  “Vanadate forms compounds with other biological substances” [9].  “Vanadium has been postulated to play a role in the regulation of (NaK)-ATPase, phosphoryl transferase enzymes, adenylate cyclase, and protein kinases; as an enzyme cofactor in the form of vandyl and in hormone, glucose, lipid, and tooth metabolism” [9].  Vanadium in foods is found in an organic form.  Vanadium in food is safer than non-food forms and also appears to be about 50% more effective [39].

Zinc  Most researchers acknowledge that organic zinc is better absorbed than inorganic zinc [71].  Zinc itself is generally found in the human body in ionic form [71,76]; it is often bound with albumin [23,76] or alpha2-macroglobulin [23] or exists as part of one of the many zinc metalloenzymes [23,76].  Zinc is predominantly found in foods as zinc peptide complex (such as that complexed with superoxide dismutase).  Zinc is not naturally found in the body as zinc gluconate, zinc orotate, zinc sulfate, nor zinc picolinate. In humans “zinc deficiency does not exist without deficiency of other nutrients” [76]. Zinc deficiency in humans can cause alopecia, impotence, skin problems, immune deficiencies, night blindness, impaired taste, delayed wound healing, impaired appetite, photophobia, difficulty in dark adaptation, growth retardation, and male infertility [23].  Zinc in yeast-containing foods is better absorbed and is a better form for humans than inorganic forms [40,41].  Studies indicate that Food zinc appears to be 1.72-1.75 times more absorbed in the blood than zinc sulfate (1.71 times more than zinc chelate; 6.46 times more than zinc gluconate; 3.11 times more than zinc orotate) and 1.75-1.87 times more retained in the liver than zinc sulfate (1.45 times more than zinc amino acid chelate; 3.68 times more than zinc gluconate; 1.50 times more than zinc orotate) [45,46,51].

Food and Food Processing

“In the historic struggle for food, humans ate primarily whole foods or so-called natural foods, which underwent little processing…The nutrient content of food usually decreases when it is processed” [77].  “Intensive animal rearing, manipulation of crop production and food processing have altered the qualitative and quantitative balance of nutrients of food consumed by Western society.  This change, to which the physiology and biochemistry of man may not be presently adapted to, is thought to be responsible for the chronic diseases that are rampant in the Industrialized Western Countries” [78].  Some reports suggest that simply taking a synthetic multi-vitamin/mineral formula does not change this [79,80].

Dr. Burr-Madsen has written,

Nutrition ‑ in its most basic sense the process by which the organism finds, consumes,liberates, absorbs, and utilizes the nutrients it must have to live. Although food and therefore nutrients are seemingly plentiful, because of modern use of chemical herbicides and pesticides as well as poor air quality and bad water, the nutrients we buy in the market are very inferior. Human bodies require nutrition found in the form of plants, meat, milk, eggs and water, but all animals get their food directly or indirectly from plants, and all plants get their food from the soil. Therefore mineral deficient soil may be one of the greatest original sources of disease in the world today.

Real soil

We cannot appreciate enough the importance of our relationship with the land, with soil.  This is particularly so in this era of artificial chemicals, artificial foods, and the abundance of artificial materials on which we have come to depend. This system cannot replace real soil and the living food crops it produces. Our dependence on artificial, man­made products interferes with our relationship with the soil and the natural world in general. Because of this Nutritional supplementation is necessary.

Soil condition.
After genetics and weather, the condition of the soil is the most important factor in thenutrient content of any plant food and, indirectly, of animal foods. The soils of the world have suffered, and continue to suffer, at the hands of farming. The present food production system, while correcting some abuses of the past, inflicts on the soil a variety of new and old insults that diminish its nutrient value. Because of intensive farming, poor crop management, erosion, commercial fertilization, the use of pesticides, and other problematic factors, much of the soil in which our crops are now raised has been depleted, particularly of essential minerals.

The Human Food Chain.

The human food chain includes animals, animal products and plants, which depend directly or indirectly on the soil. Plants draw their nutrients and general health from a complex of inorganic and organic factors. Inorganic substances include oxygen and carbon, nitrogen, phosphorus, and potassium, along with iron, calcium, and an array of other minerals. The chief organic factors range from decaying plant material and animal wastes to earthworms and an amazing variety of microscopic organisms including bacteria, fungi, algae, and protozoa (Hall 1976: 134). All of these elements are important to the health and nutrient value of the crop ‑ and of the animals that feed on it.

Healthy soil.

Healthy soil is America’s greatest natural resource. But few realize that the current state of wide spread soil erosion in North America threatens our way of life. It may be hard to believe, but only a few inches of topsoil stand between you, me, and starvation. We cannot appreciate enough the importance of our relationship with the land, with soil. What is popularly called topsoil is the rich, nutrient‑laden cover of the Earth’s crust from which food crops draw their sustenance. Underneath the topsoil there may be clay, shale, or rock ‑ Substances that do not support food crops. It is only in the precious shallow topsoil that plants are seeded, germinated, sprouted, nurtured, and grown. These plants serve as food for animals on the lowest ends of the food chain. Animals that eat these plants supply food to animals on the highest ends of the food chain. Attention is important because topsoil is easily exhausted from lack of care. The best farmers replenish the soil as it is farmed. Unfortunately, this practice has become an exception to the rule, this is particularly so today.

Depleted Soil.

When the soil becomes depleted, the plants often show symptoms of poor nutrition, much like human deficiency diseases. For example, a general yellow or pale green color (chlorosis) indicates a lack of sulfur and nitrogen and a white or pale‑yellow color iron deficiency. Some of these deficiencies are apparent enough to hurt the marketability of the crop. Most, however, are not visible to the shopper’s or even the farmer’s eye, and the crop is shipped to market deficient as it is. The toll that fertilization and pesticides take on the soil is wide‑reaching, ultimately including the kind of soil erosion that is now plaguing the Midwest. The most direct and immediate loss are the mineral and vitamin deficiencies in the soil that are passed up the food chain to humans (it is a domino effect) [81].

Commercial food processing definitely reduces the nutrient content of food [81, 82] and can be dangerous to human health [83].  The refining of whole grains (including wheat, rice, and corn) has resulted in a dramatic reduction of their natural food complex nutrition [11,82]; specifically the milling of wheat to white flour reduces the natural food complex vitamin and mineral content by 40-60% [82].  Food refining appears to reduce trace minerals such as manganese, zinc, and chromium [2] and various macrominerals (such as magnesium) as well [10,56].  The treatment of canned or frozen vegetables with ethylenediaminetetraacetic acid (EDTA) can strip much of the zinc from foods [11].  The high incidences of disorders of calcium metabolism [28] suggest that the forms of calcium many are consuming simply do not agree with the body (and sometimes result in calcium loss [11]). 

Organically-grown produce appears to contain higher levels of some essential minerals than does conventionally (non-organically) grown produce [84,85] and appears to contain lower levels of toxic heavy metals [86].   Even if modern food practices did not affect nutrition (which they do), all minerals that humans need for optimal health do not exist uniformly in soils. “Soils in many areas of the world are deficient in certain minerals; this can result in low concentrations of major or trace minerals in drinking water, plant crops, and even tissues of farm animals, thus contributing to marginal or deficient dietary intakes of humans [76]. From a geological perspective, a few examples include iodine, molybdenum, cobalt, selenium, and boron [2,70,77].  Although humans need at least twenty minerals (over sixty have been found in the body), most plants can be grown with only the addition of nitrogen, phosphorus, and potassium compounds [2].  If other minerals necessary for human health are reduced in the soil, the plant can (and will) grow without them.  This means, though, that constantly farming the same ground can result in the reduction of some of the essential minerals we as humans require for optimal health [78].

Ground Up Rocks Pose Risks

Rock minerals are not optimal for human health and post health risks.  Perhaps it should be mentioned that typical multi-vitamin-mineral formulas are dangerous and do not result in optimal health.  A study involving 38,772 women in the USA who took synthetic multi-vitamins with ground up rock minerals found that the women died earlier than those who did not take them [87].  Other studies have concluded that the acid-processed rocks that many take as calcium supplements increase risk of cardiovascular disease and other problems [88]—yet those studies did not find problems with food calcium.

Ground-up rocks are dangerous to ingest.  Yet, 100% food vitamins and minerals are beneficial as well as essential to human health and longevity.

Conclusion

No matter how many industrially produced mineral supplements one takes orally, they will:

1) Never be a truly complete nutrient source.
2) Never replace all the functions of food minerals.
3) Always be unnatural substances to the body.
4) Always strain the body by requiring that it detoxify or somehow dispose of their unnatural structures/chemicals.
5) Never be utilized, absorbed, and retained the same as food nutrients.
6) Not be able to prevent advanced protein glycation end-product formation the same as food nutrients.
7) Never be able to have the antioxidant effects the same as food nutrients.
8) Always be industrial products.
9) Always be composed of petroleum-derivatives, hydrogenated sugars, acids, and/or industrially-processed rocks.
10) Never build optimal health the same as food nutrients.

Industrially processed minerals can have some positive nutritional effects, yet they are not food for humans, but they also pose risks [87-88]. 

Unlike humans, plants have roots or hyphae which aid in the absorption of minerals.  Plants actually have the ability to decrease the toxicity of compounds by changing their biochemical forms [14].  Plants are naturally intended to ingest rocks; humans are not [1]. 

The truth is that plants, or supplements only made from plants, are the best form of mineral supplement for humans, yet most people who take nutritional mineral support consume some type of industrially processed rock.

REFERENCES
[1] Cronquist A. Plantae. In Synopsis and Classification of Living Organisms, Vol 1. McGraw-Hill, NY, 1982:57
[2] Schroeder HA. The Trace Elements and Man. Devin-Adair, New Greenwich (CT), 1973
[3] Howell E. Enzyme Nutrition. Avery Publishing, Wayne (NJ), 1985
[4] Milne L, Milne M. The Arena of Life: The Dynamics of Ecology. Natural History Press, Garden City (NJ), 1972
[5] Wallace RA. Biology: The World of Life, 6th ed. Harper Collins, New York, 1992
[6] Dietary guidelines in The Weston A. Price Foundation brochure. Weston A. Price Foundation, Washington, 1999
[7] Gehman JM. From the Office of the President: Pseudo-Group Once Again Misleading the Naturopathic Field. Official Bulletin ANA, January 25, 1948:7-8
[8] Shapes SA, Schlussel YR, Cifuentes M.  Drug-Nutrient Interactions That Affect Mineral Status.  In Handbook of Drug-Nutrient Interactions.  Humana Press, Totowa (NJ), 2004: 301-328
[9] Nielsen F. Ultratrace Minerals. In Modern Nutrition in Health and Disease, 8th ed. Lea & Febiger, Phil.,1994:269-286
[10] Turnland JR. Copper. In Modern Nutrition in Health and Disease, 8th ed. Lea & Febiger, Phil.,1994:231-241
[11] Whitney EN, Hamilton EMN. Understanding Nutrition, 4ed. West Publishing, New York, 1987
[12] Beers MH, Berkow R, eds. The Merck Manual of Diagnosis and Therapy, 17th ed. Merck Research Laboratories, Whitehouse Station (NJ), 1999
[13] Thiel RJ. Mineral salts are for plants, food complexed minerals are for humans. ANMA Monitor 1999;3(2):5-10
[14] Huang Y, Chen Y, Tao S. Effect of rhizospheric environment of VA-mycorrhizal plants on forms of Cu, Zn, PB and Cd in polluted soil. Ying Yong Sheng Tai Xye Bao 2000;11(3):431-434
[15] Budvari S, et al eds. The Merck Index, An Encyclopedia of Chemicals, Drugs, and Biologicals, 12th ed. Merck Research Laboratories, Whitehouse Station (NJ), 1996
[16] Anagisawa KY, Rendon-Angeles JC, Shizawa NI, Ishi SO. Topotaxial replacement of chlorapatite by hydroxy during hydrothermal ion exchange. Am Mineralogist 1999;84:1861-1869
[17] DiTomaso JM. Yellow starthistle: chemical control. Proceedings of the CalEPPC Symposium, 1996, as updated 5/2/02
[18] Vitamin-Mineral Manufacturing Guide Nutrient Empowerment, volume 1. Nutrition Resource, Lakeport (CA), 1986
[19] Hojo Y, Hashimoto I, Miyamoto Y, Kawazoe S, Mizutani T. In vivo toxicity and glutathione, ascorbic acid, and copper level changes induced in mouse liver and kidney by copper (II) gluconate, a nutrient supplement. Yakugaku Zasshi 2000;120(3):311-314
[20] City of Lubbock. www.solidwaste.ci.lubbock.tx.us/hhw/hhw.htm 7/18/02
Cunnane SC. Zinc: Clinical and Biochemical Significance. CRC Press, Boca Raton (FL),1988
[21] Patrick J. What most people don’t know about vitamin C. The Alacer Health Report, Foothill Ranch (CA), 1994
[22] Jensen B.  The Chemistry of Man.  Bernard Jensen, Escondido (CA),1983
[23] King JC, Keen CL. Zinc. In Modern Nutrition in Health and Disease, 9th ed. Williams & Wilkins, Balt., 1999:223-239
[24] Chromium picolinate, rev. 6/96B.BLI website, July 16, 2002
[25] Implications of the ‘other half’ of a mineral compound. Albion Research Notes 2000;9(3):1-5
[26] Stoecker B.J. Chromium.  In Modern Nutrition in Health and Disease, 10th ed.  Lippincott Williams & Wilkins, Phil., 2005: 332-337
[27] Turnland JR. Bioavailability of dietary minerals to humans: the stable isotope approach. Crit Rev Food Sci Nutr 1991;30(4);387-396
[28] Schumann K, et al. Bioavailability of oral vitamins, minerals, and trace minerals in perspective. Arzneimittelforshcung 1997;47(4):369-380
[29]  El-Bayoumy K, Richie JP Jr, Boyiri T, Komninou D, Prokopczyk B, Trushin N, Kleinman W, Cox J, Pittman B, Colosimo S.  Influence of Selenium-Enriched Yeast Supplementation on Biomarkers of Oxidative Damage and Hormone Status in Healthy Adult Males: A Clinical Pilot Study. Cancer Epidemiol Biomarkers Prev. 2002;11:1459-1465
[30] Hamet P, et al. The evaluation of the scientific evidence for a relationship between calcium and hypertension.  J Nutr, 1995;125:311S-400S
[31] Ensminger AH, Ensminger ME, Konlade JE, Robson JRK.  Food & Nutrition Encyclopedia, 2nd ed.  CRC Press, New York, 1993
[32] Avery SV, Howlett NG, Radice S. Copper toxicity towards Saccharomyces cerevisiae: dependence on plasma fatty acid composition. Appl Environ Microbiol 1996;62(11):3960-3966
[33] Wi’snicka R, Krzepiko A, Krawiec Z, Bili’nski T. Protective role of superoxide dismutase in iron toxicity in yeast. Biochem Mol Biol Int 1998;44(3):635-641
[34] Wood R.J., Ronnenberg A.G.  Iron. In Modern Nutrition in Health and Disease, 10th ed.  Lippincott William & Wilkins, Phil, 2006: 248-270
[35]  Rude R.K., Shils M.E. Magnesium.  In Modern Nutrition in Health and Disease, 10th ed.  Lippincott William & Wilkins, Phil, 2006: 223-247
[36] Buchman A. Manganese.  In Modern Nutrition in Health & Disease, 10th ed. Lippincott William & Wilkins, Phil, 2006:326-331
[37] Beloosesky Y, Grinblat J, Weiss A, Grosman B, Gafter U, Chagnac A.  Electrolyte disorders following oral sodium phosphate administration for bowel cleansing in elderly patients.  Arch Intern Med. 2003;163(7):803-808
[38] Biotechnology in the Feed Industry.  Nottingham Press, UK, 1995: 257-267
[39] Badmaev V, Prakash S, Majeed M.  Vanadium: a review of its potential role in the fight against diabetes.  J Altern Complement Med. 1999;5(3):273-291
[40] Andlid TA, Veide J, Sandberg AS.  Metabolism of extracellular inositol hexaphosphate (phytate) by Saccharomyces cerevisiae.  Int J. Food Microbiology. 2004;97(2):157-169
[41] King JC, Cousins RJ.  Zinc.  In Modern Nutrition in Health and Disease, 10th ed.  Lipponcott Williams & Wilkins, Phil., 2005:271-285
[42] Thiel R, Fowkes S.  Can cognitive deterioration associated with Down syndrome be reduced?  Med Hypo, 2005; 64(3):524-532
[43] Jenkins DJA, Wolever TMS, and Jenkins AL. Diet Factors Affecting Nutrient Absorption and Metabolism. In Modern Nutrition in Health and Disease, 8th ed. Lea and Febiger, Phil.:583-602, 1994
[44] Vinson, J.A., Jennifer M. Stella, J.M.,  Flanagan, T.J. Selenium yeast is an effective in vitro and in vivo antioxidant and hypolipemic agent in normal hamsters.  Nutritional Research, 1998, Vol 18, No. 4: 735–742
[45] Vinson J, Bose P, Lemoine L, Hsiao KH. Bioavailability studies. In Nutrient Availability: Chemical and Biological Aspects. Royal Society of Chemistry, Cambridge (UK) 1989:125-127
[46] Vinson JA, Bose P. Comparison of bio-availability of trace elements in inorganic salts, amino acid chelates, and yeast. Mineral Elements 80, Proceedings II, Helsinki, Dec 9-11, 1981
[47] Vinson J, Mazur T, Bose P. Comparisons of different forms of calcium on blood pressure of normotensive males. Nutr Reports Intl, 1987;36(3):497-505
[48] Vinson JA, Hsiao, KH. Comparative effect of various forms of chromium on serum glucose: an assay for biologically active chromium. Nutr Reports Intl,1985;32(1):1-7
[49] Vinson JA, Bose P. The effect of high chromium yeast on the blood glucose control and blood lipids of normal and diabetic human subjects. Nutr Reports Intl, 1984;30(4):911-918
[50] Vinson JA, Howard TB. Inhibition of protein glycation and advanced glycation end products by ascorbic acid and other vitamins and nutrients. Nutr Biochemistry, 1996;7:659-663
[51] Vinson J. Rat zinc bioavailability study. University of Scranton, Scranton (PA)
[52] Vinson J. Bioavailability of magnesium. University of Scranton, Scranton (PA), 1991
[53] Frequently Asked Questions. www.albionlabs.com July 19, 2002
[54] Rouhi AM. Escorting metal ions: protein chaperone protects, guides, copper ions in transit. Chem Eng News 1999;11:34-35
[55] Himelblau E, et al. Identification of a functional homolog of the yeast copper homeostasis gene ATX1 from Arabidopsis. Plant Physiol 1998;117(4):1227-1234
[56] Lapinskas PJ, Lin SJ, Culotta VC. The role of Saccharomyces cerevisiae CCC1 gene in the homeostasis of manganese ions. Mol Microbiol 1996;21(3):519-528
[57] Allen LH, Wood RJ.  Calcium and Phosphorus.  In Modern Nutrition in Health and Disease, 8th ed.  Lea & Febiger, Phil.,1994:144-163
[58] Heaney RP, Dowell MS, Barger-Lux MJ.  Absorption of calcium as the carbonate and citrate salts, with some observations on  method.  Osteoporosis Int, 1999;9:19-23
[59] Timon S.  Mineral Logic: Understanding the Mineral Transport System.  Advanced Nutrition Research: Ellicottville (NY),1985
[60] Burger S.  Vitamins and Minerals for Health.  Wild Rose College of Natural Healing, Calgary,1988
[61] Orlov SN, Li JM, Tremblay J, Hamet P. Genes of intracellular calcium metabolism and blood pressure control in primary hypertension. Semin Nephrol. 1995 Nov;15(6):569-592
[62] Osborne G, et al.  Evidence for the relationship of calcium to blood pressure.  Nutr Reviews, 1996;54(12):365-381
[63] Yamamoto ME., et al. Lack of blood pressure effect with calcium and magnesium supplementation with adults with high-normal blood pressure results from phase I of the Trials of Hypertension and Prevention (TOHP).  Ann Epidem, 1995;5:96-107
[64] Afghani A, Johnson CA.  Resting blood pressure and bone mineral content are inversely related in overweight and obese Hispanic women.  Am J Hypertens. 2006;19(3):286-292
[65] Knight KB, Keith RE. Effects of oral calcium supplementation via calcium carbonate versus diet on blood pressure and serum calcium in young, normotensive adults.  J Opt Nutr, 1994;3(4):152-158
[66] Weaver CM, Heaney R.  Calcium.  In Modern Nutrition in Health & Disease, 10th ed.  Lippincott Williams & Wilkins, Phil., 2006:194-210
[67] Nielson F.  Chromium.  In Modern Nutrition in Health and Disease, 8th ed.  Lea & Febiger, Phil.,1994:264-268
[68] Hendlor S, Rorvik D, eds.  PDR for Nutritional Supplements, 1st ed.  Medical Economics, Montvale (NJ), 2001
[69] Turnland JR.  Copper.  In Modern Nutrition in Health and Disease, 8th ed.  Lea & Febiger, Phil.,1994:231-241
[70] Hetzel BS, Clugston GA.  Iodine.  In Modern Nutrition in Health and Disease, 9th ed.  Lea & Febiger, Phil.,1999:253-264
[71] Greene HL and Moran JR.  The Gastrointestinal Tract: Regulation of Nutrient Absorption.  In Modern Nutrition in Health and Disease, 8th ed.  Lea and Febiger, Phil.,1994:549-568
[72] Fairbanks VF.  Iron in Medicine and Nutrition.  In Modern Nutrition in Health and Disease, 8th ed.  Lea & Febiger, Phil.,1994:185-213
[73] Shils M.  Magnesium.  In Modern Nutrition in Health and Disease, 8th ed.  Lea & Febiger, Phil.,1994:164-184
[74] Levander OA, Burk RF.  Selenium.  In Modern Nutrition in Health and Disease, 8th ed.  Lea & Febiger, Phil.,1994:242-263
[75] Whitaker J.  Minerals, part 1: Cut your cancer risk with selenium.  Health & Healing, 1999;9(4):6-8
[76] Cunnane SC.  Zinc: Clinical and Biochemical Significance.  CRC Press, Boca Raton (FL),1988
[77] Bauernfeind JC.  Nutrification of foods.  In Modern Nutrition in Health and Disease, 8th ed.  Lea & Febiger, Phil.,1994:1579-1592
[78] Ghebremeskel K, Crawford MA.  Nutrition and health in relation to food production and processing.  Nutr Health, 1994;9(4):237-253
[79] Bazzarre TL, Hopkins RG, Wu SM, Murdoch SD.  Chronic disease risk factors in vitamin/mineral 9supplement users and nonusers in a farm population.  J Am Coll Nutr, 1991;10(3):247-257
[80] Sax NI, Lewis RJ.  Hawley’s Condensed Chemical Dictionary, 11th ed.  Van Nostrand Rheinhold, New York,1987
[81] Burr-Madsen A.  Gateways College of Natural Therapies, Module 1.  Gateway College, Shingle Springs (CA), 1996
[82] Erdman JW, Poneros-Schneir AG.  Factors affecting the nutritive value in processed foods. In Modern Nutrition in Health and Disease, 8th ed.  Lea & Febiger, Phil.,1994:1569-1578
[83]  Ascherio A and Willett WC.  Health effects of trans fatty acids.  Am J Clin Nutr, 1997;66:1006S-1010S
[84] Hornick SB.  Factors affecting the nutritional quality of crops.  AM J Alternative Ag,1992;7(1-2)
[85] Organic tomatoes, vitamin C, and calcium.  Nutr Week, 1998;28(24):7
[86] Smith BL.  Organic foods vs. supermarket foods: J Applied Nutr,1993;45(1):35-39
[87] Mursu J., et al.  Dietary Supplements and Mortality Rate in Older WomenThe Iowa Women’s Health Study. Arch Intern Med. 2011;171(18):1625-1633
[88] Boland MJ, et al. Calcium Supplements and Cardiovascular Risk. Ther Adv in Drug Safe. 2013;4(5):199-210

Some of these studies (or citations) may not conform to peer review standards. Therefore, the results are not conclusive. Professionals can, and often do, come to different conclusions when reviewing scientific data. None of these statements have been reviewed by the FDA. All products distributed by Doctors’ Research, Inc. are nutritional an

In a nutritional context, minerals are certain elements, such as iron and phosphorus that are essential for the physiology of living organisms to exist.

When it comes to nutrition, plants and humans differ: “a typical plant makes its own food from raw materials… A typical animal eats its food” [1].  For plants, these raw materials include soil-based inorganic mineral salts [2].  Soil-based mineral salts can be depleted through synthetic fertilizers, herbicides, pesticides, as well as repeatedly growing crops on the same soil [3,4].

Plants, with the aid of enzymes and soil-based microorganisms, can take in from soil the mineral salts that they have an affinity for through their roots or hyphae [4].  After various metabolic processes, when these minerals no longer exist as salts, they become complexed with various carbohydrates, lipids, and proteins present in the plant as part of the living organism [5].  Thus for nutrition, humans eat plants and/or animals that eat plants, whereas plants can obtain their nutrients from the soil [4].  This process is commonly referred to as the “food chain” [5].

Unfortunately most mineral supplements contain minerals in the form referred to as ‘mineral salts’.  Even though mineral salts are often called “natural”, they  are rocks (e.g. calcium carbonate exists as the rock commonly known as limestone) or they are chemically produced in accordance with the United States Pharmacopoeia (USP).  Mineral salts are natural food for plants, they are not a natural food for humans–humans do not have roots or hyphae!

Dietary Guideline number 18 of the Weston A. Price Foundation, an organization devoted to consuming real foods, is: “Use only natural, food-based supplements” [6].  One of the standards of naturopathy agreed to in 1947 was, “Naturopathy does not make use of synthetic or inorganic vitamins or minerals” [7].  Why would naturopaths have mentioned minerals since they are ‘natural’?  Because even back then, most naturopaths knew that the inorganic minerals being placed into supplements were often simply industrial rocks and not foods.  Little has changed in the nearly seven decades since.  This paper documents the availability, sources, and some of the chemical differences between minerals found in foods and the industrially processed mineral salts that are found in most ‘natural’ mineral supplements.

Absorption

Mineral absorption is affected by many factors including the chemical form, structural form, existence or lack of protein chaperones, health, dietary factors, and even medications.

“Absorptive efficiency for many minerals is governed by homeostatic feedback regulation.  When the body is in a depleted state, the intestine upregulates absorption of the nutrient.  At the biochemical level , this regulation must be expressed by the control of intraluminal binding lignans, cell-surface receptors, intracellular carrier proteins, intracellular storage proteins, or the energetics of the transmembrane transport…In general mineral bioavailability decreases because of many drugs, decreases with age, and in the presence of malnutrition, is associated with poorer integrity of the small intestine.  Therefore, older individuals who are often taking numerous medications and who are eating more poorly than young people are at greater risk of mineral deficiencies” [8].

Chemical Differences

The basic difference between minerals found in foods and those found in industrial mineral salts is chemical.

The chemical form of a mineral is an important factor in its absorption and bioavailability…there is evidence that the form in which minerals are ingested affects absorption.  For example, particle size, surface area, and solubility of a substance affects is dilution rate…In many solid foods, elements are not free, but firmly bound in the food matrix” [8].

This, of course, is not true of most minerals in supplements as they are normally industrially processed inorganic rocks (mineral salts) hence they are void of the factors found in a food matrix.  Only 100% food minerals have minerals attached in a food matrix.

Minerals are normally found in food and in the body they are attached with some peptide [9,10]. When humans eat plants or animals they are consuming minerals in those forms.  Humans are not supposed to directly consume soil components [1].  With the exception of sodium chloride (common table salt), humans do not normally in any significant quantity consume minerals in the chemical forms known as mineral salts.  When they do, it is considered to be a disorder called ‘geophagia’ or ‘pica’ [11,12].

It is a fact that mineral salts are often called “natural”, but they are not food minerals.  Mineral salts are normally inorganic molecular compounds that look like rocks [13].  Mineral salts are a compound containing a mineral element, which is the mineral normally listed on a supplement label, and some other substance it is chemically bound to.  Mineral salts are either rocks (e.g. calcium carbonate exists as the rock commonly known as limestone) or they are rocks that are chemically-altered.  Mineral salts are natural food for plants which can chemically change and detoxify them [14]; they are not a natural food for humans, although some people do consider crushed bones and naturally-calcified sea algae, etc. as food.  Minerals bound in mineral salts simply are not treated the same way in the body as are minerals found in food.

Minerals vs. Industrial Chemicals

The following list describes what many mineral salts/chelates used in supplements actually are and what they are used for when not in supplements:

  • Boric acid is the rock known as sassolite.  It is used in weatherproofing wood, fireproofing fabrics, and as an insecticide [15].
  • Calcium ascorbate is calcium carbonate processed with ascorbic acid and acetone.  It is a manufactured product used in ‘non-food’ supplements [15].
  • Calcium carbonate is the rock known as limestone or chalk.  It is used in the manufacture of paint, rubber, plastics, ceramics, putty, polishes, insecticides, and inks.  It is also used in fillers for adhesives, matches, pencils, crayons, linoleum, insulating compounds, and welding rods [15].
  • Calcium chloride is calcium carbonate and chlorine and is the by product of the Solvay ammonia-soda process.  It is used for antifreeze, refrigeration, fire extinguisher fluids, and to preserve wood and stone.  Other uses include cement, coagulant in rubber manufacturing, controlling dust on unpaved roads, freezeproofing of coal, and increasing traction in tires [15].
  • Calcium citrate is calcium carbonate processed with lactic and citric acids.  It is used to alter the baking properties of flour [15].
  • Calcium gluconate is calcium carbonate processed with gluconic acid, which is used in cleaning compounds.  It is used in sewage purification and to prevent coffee powders from caking [15].
  • Calcium glycerophosphate is calcium carbonate processed with dl-alpha-glycerophosphates.  It is used in dentifrices, baking powder, and as a food stabilizer [15].
  • Calcium hydroxyapatite is crushed bone and bone marrow.  It is used as a fertilizer [16].
  • Calcium iodide is calcium carbonate processed with iodine.  It is an expectorant [15].
  • Calcium lactate is calcium carbonate processed with lactic acid.  It is used as a dentifrice and as a preservative [15].
  • Calcium oxide is basically burnt calcium carbonate.  It is used in bricks, plaster, mortar, stucco, and other building materials.  It is also used in insecticides and fungicides [15].
  • Calcium phosphate, tribasic is the rock known as oxydapatit or bone ash.  It is used in the manufacture of fertilizers, milk-glass, polishing powders, porcelain, pottery, and enamels [15].
  • Calcium stearate is an octodecanoic calcium salt and can be extracted from animal fat.  It is used for waterproofing fabrics and in the production of cement, stucco, and explosives [15].
  • Chromium chloride is a preparation of hexahydrates.  It is used as a corrosion inhibitor and waterproofing agent [15].
  • Chromium picolinate is chromium III processed with picolinic acid.  Picolinic acid is used in herbicides [17].
  • Copper aspartate is made “from the reaction between cupric carbonate and aspartic acid (from chemical synthesis)” [18].  It is a manufactured product used in ‘non-food’ supplements [18].
  • Copper (cupric) carbonate is the rock known as malachite.  It is used as a paint and varnish pigment, plus as a seed fungicide [15].
  • Copper gluconate is copper carbonate processed with gluconic acid.  It is used as a deodorant [19].
  • Copper (cupric) glycinate is a copper salt processed with glycine.  It is used in photometric analysis for copper [15].
  • Copper sulfate is copper combined with sulfuric acid.  It is used as a drain cleaner and to induce vomiting; it is considered as hazardous heavy metal by the City of Lubbock, Texas that “can contaminate our water supply” [20].
  • Dicalcium phosphate is the rock known as monetite, but can be made from calcium chloride and sodium phosphate.  It is used in ‘non-food’ supplements [18].
  • Ferric pyrophosphate is an iron rock processed with pyrophosphoric acid.  It is used in fireproofing and in pigments [15].
  • Ferrous lactate is a preparation from isotonic solutions.  It is used in ‘non-food’ supplements [15].
  • Ferrous sulfate is the rock known as melanterite.  It is used as a fertilizer, wood preservative, weed-killer, and pesticide [15].
  • Magnesium carbonate is the rock known as magnesite.  It is used as an antacid, laxative, and cathartic [15].
  • Magnesium chloride is magnesium ammonium chloride processed with hydrochloric acid.  It fireproofs wood, carbonizes wool, and is used as a glue additive and cement ingredient [15].
  • Magnesium citrate is magnesium carbonate processed with acids.  It is used as a cathartic [15].
  • Magnesium glycinate is a magnesium salt processed with glycine.  It is used in ‘non-food’ supplements.
  • Magnesium oxide is normally burnt magnesium carbonate.  It is used as an antacid and laxative [15].
  • Manganese carbonate is the rock known as rhodochrosite.  It is used as a whitener and to dry varnish [15].
  • Manganese gluconate is manganese carbonate or dioxide processed with gluconic acid.  It is a manufactured item used in ‘non-food’ supplements [15].
  • Manganese sulfate is made “from the reaction between manganese oxide and sulfuric acid” [18].  It is used in dyeing and varnish production [15].
  • Molybdenum ascorbate is molybdenite processed with ascorbic acid and acetone.  It is a manufactured item used ‘non-food’ supplements [21].
  • Molybdenum disulfide is the rock known as molybdenite.  It is used as a lubricant additive and hydrogenation catalyst [15].
  • Potassium chloride is a crystalline substance consisting of potassium and chlorine.  It is used in photography [15].
  • Potassium iodide is made from HI and KHCO3 by melting in dry hydrogen and undergoing electrolysis.  It is used to make photographic emulsions and as an expectorant [15].
  • Potassium sulfate appears to be prepared from the elements in liquid ammonia.  It is used as a fertilizer and to make glass [15].
  • Selenium oxide is made by burning selenium in oxygen or by oxidizing selenium with nitric acid.  It is used as a reagent for alkaloids or as an oxidizing agent [15].
  • Seleniomethionine is a selenium analog of methionine.  It is used as a radioactive imaging agent [15].
  • Silicon dioxide is the rock known as agate.  It is used to manufacture glass, abrasives, ceramics, enamels, and as a defoaming agent [15].
  • Vanadyl sulfate is a blue crystal powder known as vanadium oxysulfate.  It is used as a dihydrate in dyeing and printing textiles, to make glass, and to add blue and green glazes to pottery [15].
  • Zinc acetate is made from zinc nitrate and acetic anhydride.  It is used to induce vomiting [15].
  • Zinc carbonate is the rock known as smithsonite or zincspar.  It is used to manufacture rubber [15].
  • Zinc chloride is a combination of zinc and chlorine.  It is used as an embalming material [15].
  • Zinc citrate is smithsonite processed with citric acid.  It is used in the manufacture of some toothpaste [15].
  • Zinc gluconate is a zinc rock processed with gluconic acid.  Gluconic acid is used in many cleaning compounds [15].
  • Zinc lactate is smithsonite processed with lactic acid.  Lactic acid lactate is used as a solvent [15].
  • Zinc monomethionine is a zinc salt with methionine.  It is used as a ‘non-food’ supplement.
  • Zinc orotate is a zinc rock processed with orotic acid.  Orotic acid is a uricosuric (promotes uric acid excretion) [15].
  • Zinc oxide is the rock known as zincite.  It is used as a pigment for white paint and as part of quick-drying cement [15].
  • Zinc phosphate is the rock known as hopeite.  It is used in dental cements [15].
  • Zinc picolinate is a zinc rock processed with picolinic acid.  Picolinic acid is used in herbicides [17].
  • Zinc sulfate can be a rock processed with sulfuric acid.  It is used as a corrosive in calico-printing and to preserve wood [15].

There is a relatively easy way to tell if minerals are industrial chemicals.  Whenever there are two-words on a label describing a mineral, it is a logical to conclude that the substance is an industrial mineral product and not 100% foodThe exception is chromium GTF (the GTF stands for glucose tolerance factor) which is food if it is from nutritional yeast [18].

Chelated Minerals

Chelated minerals are generally crushed industrial rocks that are processed with one or more acids.

Probably the biggest difference in minerals now compared to 1947 is that some companies have decided to industrially produce versions of minerals attached to peptides.  Essentially they take a rock or industrial mineral salt, chemically alter it, and attempt to attach it to the mineral.  This results in a mineral that is different from normal mineral salts, but does not turn the substance into a food.  Examples of this include the various mineral ascorbates, picolinates, aspartates, glycinates, and chelates.  It needs to be understood that since there is not a universally accepted definition of the term ‘chelate’, when this term is used on a label, one generally does not know if the chelate is amino-acid based or some type of industrial acid.

While it is true that humans can, and do, utilize minerals from USP mineral salts or chelated minerals, this is not as safe (or even normally as effective) as consuming them from foods (or in the case of real food supplements, food concentrates).

Non-Food Attachments, Including Some “Chelates,” Are Not Desirable

Is it wise to consume non-food minerals?

Dr. Bernard Jensen, an early 20th century advocate of food-based nutrition, once wrote, “When we take out from foods some certain salt, we are likely to alter the chemicals in those foods.  When extracted from food, that certain chemical salt is extracted, may even become a poison.  Potash by itself is a poison, whether it comes from a food or from the drugstore.  This is also the case with phosphorus.  You thereby overtax your system, and your functions must work harder, in order to throw off those inorganic salts or poisons introduced… The chemical elements that build our body must be in biochemical, life-producing form.  They must come to us as food, magnetically, electrically alive, grown from the dust of the earth… When we are lacking any element at all, we are lacking more than one element.  There is no one who ever lacked just one element.  We don’t have a food that contains only one element, such as a carrot entirely of calcium or sprouts totally made of silicon” [22].

It should be noted that the addition of “citric acid and picolinic acid do not appear to enhance zinc absorption” [23].  Chromium picolinate is a human-made substance, created by Gary Evans [24]; it is not a natural food.  Picolinic acid is used in herbicides [17]; furthermore “picolinic acid is an excretory or waste product.  It is not metabolized by or useful to the body” [25].  Scientists report, “some research groups recently suggested that chromium (III) picolinate produces significantly more oxidative stress and potential DNA damage than other chromium supplements” [26].

Concerns are being raised from various sources about the implications of intentional ingestion of inorganic substances in supplements by human beings [22,25,26].  These substances are not natural for humans to consume and a long period of consumption may cause some type of toxic accumulation [22,25,26].   Yet, many people supposedly interested in natural health are daily consuming various carbonates, gluconates, oxides, picolinates, phosphates, sulfates and other rock components that were not intended to be ingested that way.  Since there are many possible negative implications associated with “the other half” of these non-food minerals [25], people truly interested in their health would be much better off consuming foods that are high in minerals or supplements made from those foods.

Jay Patrick claims to have originally developed procedures to manufacture all seven of the mineral ascorbates [21]; thus it would seem highly inappropriate to call supplements with ascorbate attached minerals ‘food’.

Actually, it does not appear that any of the minerals marketed as ‘chelated’ are food concentrates, though there are foods which contain naturally chelated minerals, but these are normally marketed as food minerals.  Even though there are some theoretical advantages to industrially-produced mineral ‘chelates’ as compared to inorganic mineral salts, these chelates are not natural food.

More on Bioavailability 

It is well known among nutrition researchers that most essential minerals are not well absorbed; for some minerals, absorption is less than 1% [27].  “Bioavailability of orally administered vitamins, minerals, and trace elements is subject to a complex set of influences…In nutrition science the term ‘bioavailability’ encompasses the sum of impacts that may reduce or foster the metabolic utilization of a nutrient” [28].  Research demonstrates that the bioavailability and/or effectiveness of mineral containing foods is greater than that of isolated inorganic mineral salts or mineral chelates [e.g. 28-52].  These studies have concluded that natural food minerals may be better absorbed, utilized, and/or retained than mineral salts.

Furthermore, minerals used in most supplements do not contain protein chaperones or other food factors needed for absorption into the cell.  In 1999, the Nobel Prize for medicine was awarded to Guenter Blobel who discovered that minerals need protein chaperones to be absorbed into cellular receptors. When mineral salts without protein chaperones are consumed, “It is after digestion when other mineral forms {mineral salts} have their mineral cleaved from their carriers. In this situation, these minerals become charged ions, and their absorbability becomes in jeopardy. These charged free minerals are known to block the absorption of one another, or to combine with other dietary factors to form compounds that are unabsorbable” [53].  The body must discard the residual chemicals.

Foods used in supplements that commonly provide significant quantities of essential minerals include dulse, horsetail herb, kelp, nutritional yeast, rice bran, and water thyme.  These types of foods have been shown to contain not only minerals in natural food forms, but also important protein chaperones such as ATX1 and ceruplasmin [54,55].  Industrial mineral salts do not contain the protein chaperones or other food factors needed for proper mineral absorption. Furthermore, some foods also contain factors which reduce the probability of certain minerals to be toxic to the body [32,33,55]; industrial mineral salts and chelates are simply not that complete.

Quantitative and Qualitative Differences

There are quantitative and qualitative differences in food vs. non-food minerals. Table 1 lists some of them by mineral.

Table 1 Quantitative and Qualitative Differences

Food Mineral  Compared to Mineral Salt/Chelate
Calcium Up to 8.79 times more absorbed into the blood [47] and 7 times as effective in raising serum ionic calcium levels [30].
Chromium Up to 25 times more bioavailable [31].
Copper 85% more absorbed [45]; also contains substances that reduce potential toxicity [32,46].
Iron Safer, non-constipating, 77% more absorbed [33, 34, 45].
Magnesium Up to 2.20 times better absorbed [52] and retained [35].
Manganese Better absorbed and retained [45,46] and not as likely to contribute to toxicity as mined forms [36,56].
Molybdenum Up 6.28 times better absorbed into the blood and 16.49 times better retained [45].
Phosphorus Less likely to cause diarrhea or electrolyte disorders [37].
Selenium 17.6 time the antioxidant effect [46], 123.01 times more effective in preventing nonenzymatic protein glycation [17], and  2.26 times better retained [29,38,44].
Vanadium Safer and 50% more effective [39].
Zinc Up to 6.46 times better absorbed [45,46,51], better form [40,41].

Foods, almost by definition, are not toxic, and as mentioned earlier, can have protective factors to prevent certain potential mineral toxicities, such as those sometimes associated with copper, iron, manganese, or other minerals [32,33,55,56].

Information by Individual Mineral

Some differences between food complexed minerals and mineral salts have been documented by published research and are shown by individual mineral below:

Boron “Boron complexes with organic compounds containing hydroxyl groups” [9], which is how it is found in foods. Boron affects macromineral and steriodal hormone metabolism; without sufficient boron bone composition, strength, and structure weaken [9].

Calcium  “The amount of calcium absorbed depends on its interaction with other dietary constituents…The absorbability of calcium is mainly determined by the presence of other food constituents” [56].  This is one of the reasons why isolated calcium mineral salts (such as calcium carbonate) are not absorbed as well as calcium found in natural food complexes [56,57].  “Calcium carbonate, an antacid, counteracts not only the absorption of calcium, but also the absorption of iron” [11] (though its calcium absorption appears to be better with food [58]).  At least one researcher has concluded that commonly used mineral salts such as calcium lactate and calcium gluconate primarily succeed in creating high blood calcium levels (hypercalcemia) instead of alleviating symptoms of low tissue calcium [59].  “Calcium has a structural role in bones and teeth” as well as in some enzymes involved with blood clotting [48]. Calcium can affect mood and blood pressure [57,60].  Clinical reports consistently confirm that dietary/food calciums [5-8] are important in the management of blood pressure.  This does not appear to be the case with isolated calcium salts (the results appear inconsistent [30,61-63]).  One study found that calcium in Food raised serum ionic calcium levels from 1.08 to 1.15 mmoles, but that serum ionic calcium levels were not raised with calcium carbonate [30].  Serum calcium levels affect blood pressure [60,64].  Since low bone mass is somewhat inversely correlated with high levels of diastolic blood pressure [9], this suggests that calcium from Food may be superior when hypertension issues are present. Calcium is important for optimal health as calcium deficiencies can contribute to osteoporosis, muscle cramps (especially in the legs), insomnia, mood/behavioral/nerve problems, hypertension,  kidney stones, and colon cancer [61,65,66].  It appears that overdose of calcium can only occur when taking mineral salt forms of calcium supplement as opposed to food [66].  A human study found that Natural Food Complex calcium is 8.79 times more bioavailable than calcium carbonate (which is the most common form found in supplements) and 2.97 times more than calcium gluconate [47]. This same study found that Food calcium “produced no undesirable side effects and was the most suitable form of calcium for long-term supplementation” [47].

Chromium, GTF  “The biologically active form of chromium, sometimes called glucose tolerance factor or GTF, has been proposed to be a complex of chromium, nicotinic acid, and possibly the amino acids glycine, cysteine, and glutamic acid.  Many attempts have been made to isolate or synthesize the glucose tolerance factor; none have been successful” [67].  Chromium is not naturally found in the body in the commonly supplemented forms such as chromium picolinate or chromium chelate.  “Chromium is generally accepted as an essential nutrient that potentiates insulin action, and thus influences carbohydrate, lipid, and protein metabolism” [67].  Research suggests that there is much less likelihood of toxicity from natural food complex chromium than from forms such as chromium picolinate [26].  Only 1% or less of inorganic chromium is absorbed vs.10-25% of chromium GTF [31].  One small study found that Food  chromium GTF reduced blood glucose levels by 16.8% versus 6.0% for inorganic chromium [48], thus it was 2.80 times more effective. One study found that Food  chromium benefited certain diabetics by improving blood glucose control, lowering serum lipids, and decreasing the risk of coronary heart disease [49]. Chromium GTF only comes from nutritional yeast [58].

Copper  In the human body, in addition to various plasma-bound coppers, “at least one copper peptide complex” has been isolated [60].  Copper is predominantly found in Food nutrients in a copper peptide complex (such as Cu/Zn superoxide-dismutase). Copper is not naturally found in the body in the form of copper gluconate or copper sulfate.  “Anemia, neutropenia, and osteoporosis are observed with copper deficiency”; copper is involved in connective tissue, iron metabolism, the central nervous system, melanin pigment, thermal regulation,  cholesterol metabolism, immune function, and cardiac function [60].  Copper in foods like nutritional yeast contains protective factors that reduce the possibility of toxicity issues [32,46].  A human study found that Food copper was 1.44 times more absorbed into the blood than copper sulfate and 1.43 times more than copper gluconate [45]. Animal studies showed similar results, plus concluded that Food copper was retained in the liver 1.85 times more than copper gluconate and 1.42 times more than copper sulfate [45].

Iodine Most of the iodine in the body exists in the form of iodine-containing amino acids [61].  Iodine is needed by the thyroid gland to produce thyroid hormones which influence most of the body’s metabolic processes [61].  Kelp is an excellent food source of iodine [61].

Iron  Most researchers acknowledge that organic iron is better absorbed than inorganic iron [71].  The body has different mechanisms for the absorption of iron depending upon its form [72].  Iron in foods is found in an organic form.  Iron is required for growth and hemoglobin formation; inadequate amounts can lead to “weakness, fatigue, pallor, dyspnea on exertion, palpitation, and a sense of being overly tired” [72].  Iron in food is safer, less-constipating (actually it is non-constipating), and better absorbed than non-food forms [33,34].  An animal study found that Food iron was absorbed into the blood 1.01 times more than ferrous sulfate and 1.77 times more than amino acid chelated iron and was retained in the liver 1.21 times more than ferrous sulfate and 1.68 times more than amino acid chelated iron [45,46].

Magnesium  “The percentage of absorption of ingested magnesium is influenced by its dietary concentration and by the presence of inhibiting or promoting dietary components [73].  There are no promoting dietary components in inorganic isolated magnesium salts. “Magnesium is involved in many enzymatic steps in which components of food are metabolized and new products are formed”; it is involved in over 300 such reactions [6].  Clinical deficiency of magnesium can results in “depressed tendon reflexes, muscle fasciculations, tremor, muscle spasm, personality changes, anorexia, nausea, and vomiting” [73].   Magnesium in foods is better absorbed and retained than magnesium from inorganic mineral salts [35].  A human study found that Natural Food Complex magnesium was 2.20 times more absorbed into blood than magnesium oxide and 1.60 times more than amino acid chelated magnesium [52].

Manganese  In the body, absorbed manganese complexes with various peptides [9].  Manganese is predominantly found in foods in a manganese peptide complex (such as Mn superoxide-dismutase).  It is not found in the body in forms like manganese sulfate.  Manganese deficiency can cause “impaired growth, skeletal abnormalities, disturbed or depressed reproductive function, ataxia of the newborn, and defects in lipid and carbohydrate metabolism” [9].  It can also affect skin, hair, nails, and problems with calcium metabolism [9].  Manganese in foods is safer and much less likely to cause any toxicity compared to mined forms [36,56].  ]. An animal study found that Natural Food Complex manganese was absorbed 1.56 times more into the blood and was retained 1.63 times more in the liver than manganese sulfate [45,46].

Molybdenum  Molybdenum…in foods…is readily absorbed” [9].  “Molydenum in {nearly all} nutritional supplements is in the form of either sodium molybdate or ammonium molybdate.  Molybdenum in food is principally in the form of molydenum cofactors” [67]. “Molybdenum functions as an enzyme cofactor”, thus “detoxifies various pyrimidines, purines, pteridines, and related compounds” [9]; it may also affect growth and reproduction [9].  An animal study found that Food molybdenum was absorbed 6.28 times more into the blood and was retained 16.49 times more in the liver than ammonium molybdate and 10.27 times more than molybdenum amino acid chelate [45].

Phosphorus Phosphorus is found in plants [11].  Phosphorus salts can cause diarrhea and other problems [37]—problems that do not happen with phosphorus in foods.  Phosphorus works with calcium to produce strong bones [57].

Potassium  Potassium is found in plants [11].  Potassium is the leading intracellular electrolyte and is necessary for electrolyte balance, stimulating aldersterone for the adrenal glands, and blood pressure regulation [11].  Dr. Bernard Jensen seemed to believe potassium is only safe in its natural food complex form [22].

Selenium   “The predominant form of selenium in animal tissues is selenocysteine” [74].  That is how it is predominantly found in certain foods.  One study found that diets naturally high in selenium (daily consumption as high as 724mcg) produced no signs or symptoms of selenium overexposure while another found that exceedingly high consumption of  selenium salts could induce selenium poisoning [74].  Selenium seems to support thyroid hormone production, function as part of many enzymes, and have antioxidant effects [74].  Larry Clark, Ph.D. and others have found that selenium in yeast appears to reduce  risk of certain cancers [75].  Julian Whitaker, M.D. reports, “The best absorbed form of selenium, and the one used by Dr. Clark’s research, is high-selenium yeast” [75].  A study using 247 mcg/day of high-selenium yeast found that plasma selenium levels were 2-fold higher than baseline values after 3 and 9 months and returned to 136% of baseline after 12 months, whereas there was a 32% increase in blood glutathione levels also seen after 9 months [29].  Food selenium is about twice as well retained as non-food forms [29,38].  Research suggests that Food selenium is 2.26 times more retained in the liver and 1.22 times more absorbed in the blood than sodium selenite [44]. An in vitro study found that Food selenium had 17.6 times the antioxidant effect than did selenomethionine [44]. One study found that Food selenium was 123.01 times more effective than sodium selenite in preventing nonenzymatic glycation in diabetics [50].

Silicon “In animals, silicon is found both free and bound” [9].  Silicon absorption is quite dependent upon the form [9].  Silicon is involved in bone calcification and connective tissue formation [9].  It is also needed for healthy hair and skin [51].  Silicon is found in foods in an organic form.

Trace Minerals  Trace minerals, including “ultra trace minerals” are necessary for the proper functioning of human health [9,51].  There are many in the human body, some of which are known to be essential and others of which their “essentialness” is under investigation.  Sea vegetables and certain yeasts are a good source of trace minerals [11,31,61].

Vanadium  “Vanadate forms compounds with other biological substances” [9].  “Vanadium has been postulated to play a role in the regulation of (NaK)-ATPase, phosphoryl transferase enzymes, adenylate cyclase, and protein kinases; as an enzyme cofactor in the form of vandyl and in hormone, glucose, lipid, and tooth metabolism” [9].  Vanadium in foods is found in an organic form.  Vanadium in food is safer than non-food forms and also appears to be about 50% more effective [39].

Zinc  Most researchers acknowledge that organic zinc is better absorbed than inorganic zinc [71].  Zinc itself is generally found in the human body in ionic form [71,76]; it is often bound with albumin [23,76] or alpha2-macroglobulin [23] or exists as part of one of the many zinc metalloenzymes [23,76].  Zinc is predominantly found in foods as zinc peptide complex (such as that complexed with superoxide dismutase).  Zinc is not naturally found in the body as zinc gluconate, zinc orotate, zinc sulfate, nor zinc picolinate. In humans “zinc deficiency does not exist without deficiency of other nutrients” [76]. Zinc deficiency in humans can cause alopecia, impotence, skin problems, immune deficiencies, night blindness, impaired taste, delayed wound healing, impaired appetite, photophobia, difficulty in dark adaptation, growth retardation, and male infertility [23].  Zinc in yeast-containing foods is better absorbed and is a better form for humans than inorganic forms [40,41].  Studies indicate that Food zinc appears to be 1.72-1.75 times more absorbed in the blood than zinc sulfate (1.71 times more than zinc chelate; 6.46 times more than zinc gluconate; 3.11 times more than zinc orotate) and 1.75-1.87 times more retained in the liver than zinc sulfate (1.45 times more than zinc amino acid chelate; 3.68 times more than zinc gluconate; 1.50 times more than zinc orotate) [45,46,51].

Food and Food Processing

“In the historic struggle for food, humans ate primarily whole foods or so-called natural foods, which underwent little processing…The nutrient content of food usually decreases when it is processed” [77].  “Intensive animal rearing, manipulation of crop production and food processing have altered the qualitative and quantitative balance of nutrients of food consumed by Western society.  This change, to which the physiology and biochemistry of man may not be presently adapted to, is thought to be responsible for the chronic diseases that are rampant in the Industrialized Western Countries” [78].  Some reports suggest that simply taking a synthetic multi-vitamin/mineral formula does not change this [79,80].

Dr. Burr-Madsen has written,

Nutrition ‑ in its most basic sense the process by which the organism finds, consumes,liberates, absorbs, and utilizes the nutrients it must have to live. Although food and therefore nutrients are seemingly plentiful, because of modern use of chemical herbicides and pesticides as well as poor air quality and bad water, the nutrients we buy in the market are very inferior. Human bodies require nutrition found in the form of plants, meat, milk, eggs and water, but all animals get their food directly or indirectly from plants, and all plants get their food from the soil. Therefore mineral deficient soil may be one of the greatest original sources of disease in the world today.

Real soil

We cannot appreciate enough the importance of our relationship with the land, with soil.  This is particularly so in this era of artificial chemicals, artificial foods, and the abundance of artificial materials on which we have come to depend. This system cannot replace real soil and the living food crops it produces. Our dependence on artificial, man­made products interferes with our relationship with the soil and the natural world in general. Because of this Nutritional supplementation is necessary.

Soil condition.
After genetics and weather, the condition of the soil is the most important factor in thenutrient content of any plant food and, indirectly, of animal foods. The soils of the world have suffered, and continue to suffer, at the hands of farming. The present food production system, while correcting some abuses of the past, inflicts on the soil a variety of new and old insults that diminish its nutrient value. Because of intensive farming, poor crop management, erosion, commercial fertilization, the use of pesticides, and other problematic factors, much of the soil in which our crops are now raised has been depleted, particularly of essential minerals.

The Human Food Chain.

The human food chain includes animals, animal products and plants, which depend directly or indirectly on the soil. Plants draw their nutrients and general health from a complex of inorganic and organic factors. Inorganic substances include oxygen and carbon, nitrogen, phosphorus, and potassium, along with iron, calcium, and an array of other minerals. The chief organic factors range from decaying plant material and animal wastes to earthworms and an amazing variety of microscopic organisms including bacteria, fungi, algae, and protozoa (Hall 1976: 134). All of these elements are important to the health and nutrient value of the crop ‑ and of the animals that feed on it.

Healthy soil.

Healthy soil is America’s greatest natural resource. But few realize that the current state of wide spread soil erosion in North America threatens our way of life. It may be hard to believe, but only a few inches of topsoil stand between you, me, and starvation. We cannot appreciate enough the importance of our relationship with the land, with soil. What is popularly called topsoil is the rich, nutrient‑laden cover of the Earth’s crust from which food crops draw their sustenance. Underneath the topsoil there may be clay, shale, or rock ‑ Substances that do not support food crops. It is only in the precious shallow topsoil that plants are seeded, germinated, sprouted, nurtured, and grown. These plants serve as food for animals on the lowest ends of the food chain. Animals that eat these plants supply food to animals on the highest ends of the food chain. Attention is important because topsoil is easily exhausted from lack of care. The best farmers replenish the soil as it is farmed. Unfortunately, this practice has become an exception to the rule, this is particularly so today.

Depleted Soil.

When the soil becomes depleted, the plants often show symptoms of poor nutrition, much like human deficiency diseases. For example, a general yellow or pale green color (chlorosis) indicates a lack of sulfur and nitrogen and a white or pale‑yellow color iron deficiency. Some of these deficiencies are apparent enough to hurt the marketability of the crop. Most, however, are not visible to the shopper’s or even the farmer’s eye, and the crop is shipped to market deficient as it is. The toll that fertilization and pesticides take on the soil is wide‑reaching, ultimately including the kind of soil erosion that is now plaguing the Midwest. The most direct and immediate loss are the mineral and vitamin deficiencies in the soil that are passed up the food chain to humans (it is a domino effect) [81].

Commercial food processing definitely reduces the nutrient content of food [81, 82] and can be dangerous to human health [83].  The refining of whole grains (including wheat, rice, and corn) has resulted in a dramatic reduction of their natural food complex nutrition [11,82]; specifically the milling of wheat to white flour reduces the natural food complex vitamin and mineral content by 40-60% [82].  Food refining appears to reduce trace minerals such as manganese, zinc, and chromium [2] and various macrominerals (such as magnesium) as well [10,56].  The treatment of canned or frozen vegetables with ethylenediaminetetraacetic acid (EDTA) can strip much of the zinc from foods [11].  The high incidences of disorders of calcium metabolism [28] suggest that the forms of calcium many are consuming simply do not agree with the body (and sometimes result in calcium loss [11]).

Organically-grown produce appears to contain higher levels of some essential minerals than does conventionally (non-organically) grown produce [84,85] and appears to contain lower levels of toxic heavy metals [86].   Even if modern food practices did not affect nutrition (which they do), all minerals that humans need for optimal health do not exist uniformly in soils. “Soils in many areas of the world are deficient in certain minerals; this can result in low concentrations of major or trace minerals in drinking water, plant crops, and even tissues of farm animals, thus contributing to marginal or deficient dietary intakes of humans [76]. From a geological perspective, a few examples include iodine, molybdenum, cobalt, selenium, and boron [2,70,77].  Although humans need at least twenty minerals (over sixty have been found in the body), most plants can be grown with only the addition of nitrogen, phosphorus, and potassium compounds [2].  If other minerals necessary for human health are reduced in the soil, the plant can (and will) grow without them.  This means, though, that constantly farming the same ground can result in the reduction of some of the essential minerals we as humans require for optimal health [78].

Ground Up Rocks Pose Risks

Rock minerals are not optimal for human health and post health risks.  Perhaps it should be mentioned that typical multi-vitamin-mineral formulas are dangerous and do not result in optimal health.  A study involving 38,772 women in the USA who took synthetic multi-vitamins with ground up rock minerals found that the women died earlier than those who did not take them [87].  Other studies have concluded that the acid-processed rocks that many take as calcium supplements increase risk of cardiovascular disease and other problems [88]—yet those studies did not find problems with food calcium.

Ground-up rocks are dangerous to ingest.  Yet, 100% food vitamins and minerals are beneficial as well as essential to human health and longevity.

Conclusion

No matter how many industrially produced mineral supplements one takes orally, they will:

1) Never be a truly complete nutrient source.
2) Never replace all the functions of food minerals.
3) Always be unnatural substances to the body.
4) Always strain the body by requiring that it detoxify or somehow dispose of their unnatural structures/chemicals.
5) Never be utilized, absorbed, and retained the same as food nutrients.
6) Not be able to prevent advanced protein glycation end-product formation the same as food nutrients.
7) Never be able to have the antioxidant effects the same as food nutrients.
8) Always be industrial products.
9) Always be composed of petroleum-derivatives, hydrogenated sugars, acids, and/or industrially-processed rocks.
10) Never build optimal health the same as food nutrients.

Industrially processed minerals can have some positive nutritional effects, yet they are not food for humans, but they also pose risks [87-88].

Unlike humans, plants have roots or hyphae which aid in the absorption of minerals.  Plants actually have the ability to decrease the toxicity of compounds by changing their biochemical forms [14].  Plants are naturally intended to ingest rocks; humans are not [1].

The truth is that plants, or supplements only made from plants, are the best form of mineral supplement for humans, yet most people who take nutritional mineral support consume some type of industrially processed rock.

REFERENCES
[1] Cronquist A. Plantae. In Synopsis and Classification of Living Organisms, Vol 1. McGraw-Hill, NY, 1982:57
[2] Schroeder HA. The Trace Elements and Man. Devin-Adair, New Greenwich (CT), 1973
[3] Howell E. Enzyme Nutrition. Avery Publishing, Wayne (NJ), 1985
[4] Milne L, Milne M. The Arena of Life: The Dynamics of Ecology. Natural History Press, Garden City (NJ), 1972
[5] Wallace RA. Biology: The World of Life, 6th ed. Harper Collins, New York, 1992
[6] Dietary guidelines in The Weston A. Price Foundation brochure. Weston A. Price Foundation, Washington, 1999
[7] Gehman JM. From the Office of the President: Pseudo-Group Once Again Misleading the Naturopathic Field. Official Bulletin ANA, January 25, 1948:7-8
[8] Shapes SA, Schlussel YR, Cifuentes M.  Drug-Nutrient Interactions That Affect Mineral Status.  In Handbook of Drug-Nutrient Interactions.  Humana Press, Totowa (NJ), 2004: 301-328
[9] Nielsen F. Ultratrace Minerals. In Modern Nutrition in Health and Disease, 8th ed. Lea & Febiger, Phil.,1994:269-286
[10] Turnland JR. Copper. In Modern Nutrition in Health and Disease, 8th ed. Lea & Febiger, Phil.,1994:231-241
[11] Whitney EN, Hamilton EMN. Understanding Nutrition, 4ed. West Publishing, New York, 1987
[12] Beers MH, Berkow R, eds. The Merck Manual of Diagnosis and Therapy, 17th ed. Merck Research Laboratories, Whitehouse Station (NJ), 1999
[13] Thiel RJ. Mineral salts are for plants, food complexed minerals are for humans. ANMA Monitor 1999;3(2):5-10
[14] Huang Y, Chen Y, Tao S. Effect of rhizospheric environment of VA-mycorrhizal plants on forms of Cu, Zn, PB and Cd in polluted soil. Ying Yong Sheng Tai Xye Bao 2000;11(3):431-434
[15] Budvari S, et al eds. The Merck Index, An Encyclopedia of Chemicals, Drugs, and Biologicals, 12th ed. Merck Research Laboratories, Whitehouse Station (NJ), 1996
[16] Anagisawa KY, Rendon-Angeles JC, Shizawa NI, Ishi SO. Topotaxial replacement of chlorapatite by hydroxy during hydrothermal ion exchange. Am Mineralogist 1999;84:1861-1869
[17] DiTomaso JM. Yellow starthistle: chemical control. Proceedings of the CalEPPC Symposium, 1996, as updated 5/2/02
[18] Vitamin-Mineral Manufacturing Guide Nutrient Empowerment, volume 1. Nutrition Resource, Lakeport (CA), 1986
[19] Hojo Y, Hashimoto I, Miyamoto Y, Kawazoe S, Mizutani T. In vivo toxicity and glutathione, ascorbic acid, and copper level changes induced in mouse liver and kidney by copper (II) gluconate, a nutrient supplement. Yakugaku Zasshi 2000;120(3):311-314
[20] City of Lubbock. www.solidwaste.ci.lubbock.tx.us/hhw/hhw.htm 7/18/02
Cunnane SC. Zinc: Clinical and Biochemical Significance. CRC Press, Boca Raton (FL),1988
[21] Patrick J. What most people don’t know about vitamin C. The Alacer Health Report, Foothill Ranch (CA), 1994
[22] Jensen B.  The Chemistry of Man.  Bernard Jensen, Escondido (CA),1983
[23] King JC, Keen CL. Zinc. In Modern Nutrition in Health and Disease, 9th ed. Williams & Wilkins, Balt., 1999:223-239
[24] Chromium picolinate, rev. 6/96B.BLI website, July 16, 2002
[25] Implications of the ‘other half’ of a mineral compound. Albion Research Notes 2000;9(3):1-5
[26] Stoecker B.J. Chromium.  In Modern Nutrition in Health and Disease, 10th ed.  Lippincott Williams & Wilkins, Phil., 2005: 332-337
[27] Turnland JR. Bioavailability of dietary minerals to humans: the stable isotope approach. Crit Rev Food Sci Nutr 1991;30(4);387-396
[28] Schumann K, et al. Bioavailability of oral vitamins, minerals, and trace minerals in perspective. Arzneimittelforshcung 1997;47(4):369-380
[29]  El-Bayoumy K, Richie JP Jr, Boyiri T, Komninou D, Prokopczyk B, Trushin N, Kleinman W, Cox J, Pittman B, Colosimo S.  Influence of Selenium-Enriched Yeast Supplementation on Biomarkers of Oxidative Damage and Hormone Status in Healthy Adult Males: A Clinical Pilot Study. Cancer Epidemiol Biomarkers Prev. 2002;11:1459-1465
[30] Hamet P, et al. The evaluation of the scientific evidence for a relationship between calcium and hypertension.  J Nutr, 1995;125:311S-400S
[31] Ensminger AH, Ensminger ME, Konlade JE, Robson JRK.  Food & Nutrition Encyclopedia, 2nd ed.  CRC Press, New York, 1993
[32] Avery SV, Howlett NG, Radice S. Copper toxicity towards Saccharomyces cerevisiae: dependence on plasma fatty acid composition. Appl Environ Microbiol 1996;62(11):3960-3966
[33] Wi’snicka R, Krzepiko A, Krawiec Z, Bili’nski T. Protective role of superoxide dismutase in iron toxicity in yeast. Biochem Mol Biol Int 1998;44(3):635-641
[34] Wood R.J., Ronnenberg A.G.  Iron. In Modern Nutrition in Health and Disease, 10th ed.  Lippincott William & Wilkins, Phil, 2006: 248-270
[35]  Rude R.K., Shils M.E. Magnesium.  In Modern Nutrition in Health and Disease, 10th ed.  Lippincott William & Wilkins, Phil, 2006: 223-247
[36] Buchman A. Manganese.  In Modern Nutrition in Health & Disease, 10th ed. Lippincott William & Wilkins, Phil, 2006:326-331
[37] Beloosesky Y, Grinblat J, Weiss A, Grosman B, Gafter U, Chagnac A.  Electrolyte disorders following oral sodium phosphate administration for bowel cleansing in elderly patients.  Arch Intern Med. 2003;163(7):803-808
[38] Biotechnology in the Feed Industry.  Nottingham Press, UK, 1995: 257-267
[39] Badmaev V, Prakash S, Majeed M.  Vanadium: a review of its potential role in the fight against diabetes.  J Altern Complement Med. 1999;5(3):273-291
[40] Andlid TA, Veide J, Sandberg AS.  Metabolism of extracellular inositol hexaphosphate (phytate) by Saccharomyces cerevisiae.  Int J. Food Microbiology. 2004;97(2):157-169
[41] King JC, Cousins RJ.  Zinc.  In Modern Nutrition in Health and Disease, 10th ed.  Lipponcott Williams & Wilkins, Phil., 2005:271-285
[42] Thiel R, Fowkes S.  Can cognitive deterioration associated with Down syndrome be reduced?  Med Hypo, 2005; 64(3):524-532
[43] Jenkins DJA, Wolever TMS, and Jenkins AL. Diet Factors Affecting Nutrient Absorption and Metabolism. In Modern Nutrition in Health and Disease, 8th ed. Lea and Febiger, Phil.:583-602, 1994
[44] Vinson, J.A., Jennifer M. Stella, J.M.,  Flanagan, T.J. Selenium yeast is an effective in vitro and in vivo antioxidant and hypolipemic agent in normal hamsters.  Nutritional Research, 1998, Vol 18, No. 4: 735–742
[45] Vinson J, Bose P, Lemoine L, Hsiao KH. Bioavailability studies. In Nutrient Availability: Chemical and Biological Aspects. Royal Society of Chemistry, Cambridge (UK) 1989:125-127
[46] Vinson JA, Bose P. Comparison of bio-availability of trace elements in inorganic salts, amino acid chelates, and yeast. Mineral Elements 80, Proceedings II, Helsinki, Dec 9-11, 1981
[47] Vinson J, Mazur T, Bose P. Comparisons of different forms of calcium on blood pressure of normotensive males. Nutr Reports Intl, 1987;36(3):497-505
[48] Vinson JA, Hsiao, KH. Comparative effect of various forms of chromium on serum glucose: an assay for biologically active chromium. Nutr Reports Intl,1985;32(1):1-7
[49] Vinson JA, Bose P. The effect of high chromium yeast on the blood glucose control and blood lipids of normal and diabetic human subjects. Nutr Reports Intl, 1984;30(4):911-918
[50] Vinson JA, Howard TB. Inhibition of protein glycation and advanced glycation end products by ascorbic acid and other vitamins and nutrients. Nutr Biochemistry, 1996;7:659-663
[51] Vinson J. Rat zinc bioavailability study. University of Scranton, Scranton (PA)
[52] Vinson J. Bioavailability of magnesium. University of Scranton, Scranton (PA), 1991
[53] Frequently Asked Questions. www.albionlabs.com July 19, 2002
[54] Rouhi AM. Escorting metal ions: protein chaperone protects, guides, copper ions in transit. Chem Eng News 1999;11:34-35
[55] Himelblau E, et al. Identification of a functional homolog of the yeast copper homeostasis gene ATX1 from Arabidopsis. Plant Physiol 1998;117(4):1227-1234
[56] Lapinskas PJ, Lin SJ, Culotta VC. The role of Saccharomyces cerevisiae CCC1 gene in the homeostasis of manganese ions. Mol Microbiol 1996;21(3):519-528
[57] Allen LH, Wood RJ.  Calcium and Phosphorus.  In Modern Nutrition in Health and Disease, 8th ed.  Lea & Febiger, Phil.,1994:144-163
[58] Heaney RP, Dowell MS, Barger-Lux MJ.  Absorption of calcium as the carbonate and citrate salts, with some observations on  method.  Osteoporosis Int, 1999;9:19-23
[59] Timon S.  Mineral Logic: Understanding the Mineral Transport System.  Advanced Nutrition Research: Ellicottville (NY),1985
[60] Burger S.  Vitamins and Minerals for Health.  Wild Rose College of Natural Healing, Calgary,1988
[61] Orlov SN, Li JM, Tremblay J, Hamet P. Genes of intracellular calcium metabolism and blood pressure control in primary hypertension. Semin Nephrol. 1995 Nov;15(6):569-592
[62] Osborne G, et al.  Evidence for the relationship of calcium to blood pressure.  Nutr Reviews, 1996;54(12):365-381
[63] Yamamoto ME., et al. Lack of blood pressure effect with calcium and magnesium supplementation with adults with high-normal blood pressure results from phase I of the Trials of Hypertension and Prevention (TOHP).  Ann Epidem, 1995;5:96-107
[64] Afghani A, Johnson CA.  Resting blood pressure and bone mineral content are inversely related in overweight and obese Hispanic women.  Am J Hypertens. 2006;19(3):286-292
[65] Knight KB, Keith RE. Effects of oral calcium supplementation via calcium carbonate versus diet on blood pressure and serum calcium in young, normotensive adults.  J Opt Nutr, 1994;3(4):152-158
[66] Weaver CM, Heaney R.  Calcium.  In Modern Nutrition in Health & Disease, 10th ed.  Lippincott Williams & Wilkins, Phil., 2006:194-210
[67] Nielson F.  Chromium.  In Modern Nutrition in Health and Disease, 8th ed.  Lea & Febiger, Phil.,1994:264-268
[68] Hendlor S, Rorvik D, eds.  PDR for Nutritional Supplements, 1st ed.  Medical Economics, Montvale (NJ), 2001
[69] Turnland JR.  Copper.  In Modern Nutrition in Health and Disease, 8th ed.  Lea & Febiger, Phil.,1994:231-241
[70] Hetzel BS, Clugston GA.  Iodine.  In Modern Nutrition in Health and Disease, 9th ed.  Lea & Febiger, Phil.,1999:253-264
[71] Greene HL and Moran JR.  The Gastrointestinal Tract: Regulation of Nutrient Absorption.  In Modern Nutrition in Health and Disease, 8th ed.  Lea and Febiger, Phil.,1994:549-568
[72] Fairbanks VF.  Iron in Medicine and Nutrition.  In Modern Nutrition in Health and Disease, 8th ed.  Lea & Febiger, Phil.,1994:185-213
[73] Shils M.  Magnesium.  In Modern Nutrition in Health and Disease, 8th ed.  Lea & Febiger, Phil.,1994:164-184
[74] Levander OA, Burk RF.  Selenium.  In Modern Nutrition in Health and Disease, 8th ed.  Lea & Febiger, Phil.,1994:242-263
[75] Whitaker J.  Minerals, part 1: Cut your cancer risk with selenium.  Health & Healing, 1999;9(4):6-8
[76] Cunnane SC.  Zinc: Clinical and Biochemical Significance.  CRC Press, Boca Raton (FL),1988
[77] Bauernfeind JC.  Nutrification of foods.  In Modern Nutrition in Health and Disease, 8th ed.  Lea & Febiger, Phil.,1994:1579-1592
[78] Ghebremeskel K, Crawford MA.  Nutrition and health in relation to food production and processing.  Nutr Health, 1994;9(4):237-253
[79] Bazzarre TL, Hopkins RG, Wu SM, Murdoch SD.  Chronic disease risk factors in vitamin/mineral 9supplement users and nonusers in a farm population.  J Am Coll Nutr, 1991;10(3):247-257
[80] Sax NI, Lewis RJ.  Hawley’s Condensed Chemical Dictionary, 11th ed.  Van Nostrand Rheinhold, New York,1987
[81] Burr-Madsen A.  Gateways College of Natural Therapies, Module 1.  Gateway College, Shingle Springs (CA), 1996
[82] Erdman JW, Poneros-Schneir AG.  Factors affecting the nutritive value in processed foods. In Modern Nutrition in Health and Disease, 8th ed.  Lea & Febiger, Phil.,1994:1569-1578
[83]  Ascherio A and Willett WC.  Health effects of trans fatty acids.  Am J Clin Nutr, 1997;66:1006S-1010S
[84] Hornick SB.  Factors affecting the nutritional quality of crops.  AM J Alternative Ag,1992;7(1-2)
[85] Organic tomatoes, vitamin C, and calcium.  Nutr Week, 1998;28(24):7
[86] Smith BL.  Organic foods vs. supermarket foods: J Applied Nutr,1993;45(1):35-39
[87] Mursu J., et al.  Dietary Supplements and Mortality Rate in Older WomenThe Iowa Women’s Health Study. Arch Intern Med. 2011;171(18):1625-1633
[88] Boland MJ, et al. Calcium Supplements and Cardiovascular Risk. Ther Adv in Drug Safe. 2013;4(5):199-210

Some of these studies (or citations) may not conform to peer review standards. Therefore, the results are not conclusive. Professionals can, and often do, come to different conclusions when reviewing scientific data. None of these statements have been reviewed by the FDA. All products distributed by Doctors’ Research, Inc. are nutritional and are not intended for the treatment or prevention of any medical condition.

The Truth About Vitamins in Nutritional Supplements

Abstract: Even though natural health professionals agree that humans should not try to consume petroleum derivatives or hydrogenated sugars, most seem to overlook this fact when vitamin supplementation is involved. This paper explains some of the biochemical reasons that food vitamins are superior for humans. It also explains what substances are commonly used to make vitamins in supplements. Furthermore, it explains some of the advantages of food vitamins over the non-food vitamins that are commonly available.

Introduction

For decades the ‘natural’ health industry has been touting thousands of vitamin supplements. The truth is that most vitamins in supplements are made or processed with petroleum derivatives or hydrogenated sugars [1-5]. Even though they are often called natural, most non-food vitamins are isolated substances which are crystalline in structure [1]. Vitamins naturally in food are not crystalline and never isolated. Vitamins found in any real food are chemically and structurally different from those commonly found in ‘natural vitamin’ formulas. Since they are different, naturopaths should consider non-food vitamins as vitamin analogues (imitations) and not actually vitamins.

The standards of naturopathy agreed to in 1947 (at the Golden Jubilee Congress) included the statements, “Naturopathy does not make use of synthetic or inorganic vitamins…Naturopathy makes use of the healing properties of…natural foods, organic vitamins” [5]. Even back in the 1940s, professionals interested in natural health recognized the value of food, over non-food, vitamins. Also, it should be mentioned that naturopathic definition of organic back then was similar to the official US government definition today–why does this need to be stated? Because one pseudo-naturopath once told this researcher that a particular brand of synthetic vitamins contained “organic vitamins”, because a sales representative had told him so. Sadly, that sales representative either intentionally gave out false information or gave out misleading information–misleading because by its ‘scientific’ definition, the term ‘organic’ can mean that it is a carbon containing substance, hence by that definition all petroleum derivatives (hydro-carbons) are organic. But false, because those type of vitamins are not organic from the true naturopathic, or even the U.S. government’s, perspective.

Officially, according to mainstream science, “Vitamins are organic substances that are essential in small amounts for the health, growth, reproduction, and maintenance of one or more animal species, which must be included in the diet since they cannot be synthesized at all or in sufficient quantity in the body. Each vitamin performs a specific function; hence one cannot replace another. Vitamins originate primarily in plant tissues” [6]. Isolated non-food ‘vitamins’ (often called ‘natural’ or USP or pharmaceutical grade) are not naturally “included in the diet”, do not necessarily “originate primarily in plant tissues”, and cannot fully replace all natural vitamin activities. As a natural health professional, you should be able to read and interpret, even misleading supplement labels. For those who are unsure, hopefully this article will provide sufficient information to determine if vitamin tablets are food or imitations.

What is Your Vitamin Really?

Most vitamins in supplements are petroleum extracts, coal tar derivatives, and chemically processed sugar (plus sometimes industrially processed fish oils), with other acids and industrial chemicals (such as formaldehyde) used to process them [1-5]. Synthetic vitamins were originally developed because they cost less [7]. Assuming the non-food product does not contain fish oils, most synthetic, petroleum-derived, supplements will call their products ‘vegetarian’, not because they are from plants, but because they are not from animals. Most vitamins in vitamin supplements made from food are in foods such as acerola cherries, broccoli, cabbage, carrots, lemons, limes, nutritional yeast, oranges, and rice bran (some companies also use animal products).

Table 1. Composition of Food and Non-Food Vitamins [1-10]

VitaminFood Nutrient*‘Natural’ Vitamin Analogue & Some Process Chemicals
Vitamin A/BetacaroteneCarrotsMethanol, benzene, petroleum esters; acetylene; refined oils
Vitamin B-1Nutritional yeast, rice bran

Coal tar derivatives, hydrochloric acid; acetonitrole with ammonia

Vitamin B-2Nutritional yeast, rice branSynthetically produced with 2N acetic acid
Vitamin B-3Nutritional yeast, rice branCoal tar derivatives, 3-cyanopyridine; ammonia and acid
Vitamin B-5 Nutritional yeast, rice branCondensing isobutyraldehyde with formaldehyde
Vitamin B-6Nutritional yeast, rice branPetroleum ester & hydrochloric acid with formaldehyde
Vitamin B-8Rice

Phytin hydrolyzed with calcium hydroxide and sulfuric acid

Vitamin B-9Broccoli, rice branProcessed with petroleum derivatives and acids; acetylene
Vitamin B-12Nutritional yeast Cobalamins reacted with cyanide
Vitamin ‘B-x’PABA Nutritional yeastCoal tar oxidized with nitric acid (from ammonia)
Choline Nutritional yeast, rice bran Ethylene and ammonia with HCL or tartaric acid
Vitamin CAcerola cherries, citrus fruitsHydrogenated sugar processed with acetone
Vitamin DNutritional yeast Irradiated animal fat/cattle brains or solvently extracted
Vitamin ERice, vegetable oilsTrimethylhydroquinone with isophytol; refined oils
Vitamin HNutritional yeast, rice branBiosynthetically produced
Vitamin K Cabbage Coal tar derivative; produced with p-allelic-nickel

* Note: Although some companies use liver extracts as a source for vitamins A and/or D, and at least one company has a herring oil product supplying some vitamin E, no company this researcher is aware of whose products are made out of 100% food use animal products in any of their multiple vitamins. Some companies also use brewer’s yeast which is inferior to nutritional yeast in many ways (including the fact that it has not had the cell wall enzymatically processed to reduce possible sensitivities).

Read The Label to See the Chemical Differences!

Although many doctors have been taught that food and non-food vitamins have the same chemical composition, this is simply untrue for most vitamins. As shown in table 2, the chemical forms of food and synthetic nutrients are normally different. Health professionals need to understand that since there is no mandated definition of the term ‘natural’; just seeing that term on a label does not mean that the supplement contains only natural food substances. One of the best ways to tell whether or not a vitamin supplement contains natural vitamins as found in food is to know the chemical differences between food and non-food vitamins (sometimes called USP vitamins). Because they are not normally in the same chemical form as vitamins found in foods, non-food vitamins should be considered by natural health professionals as vitamin analogues (artificial imitations), and not actually as true vitamins for humans.

Table 2. Chemical Form of Food and Non-Food Vitamins [1-10]

Primary Chemical Vitamin Form in Food Vitamin Analogue Chemical Form (Often Called Natural*)
Vitamin A/Betacarotene; retinyl esters; mixed carotenoidsVitamin A acetate; vitamin A palmitate; betacarotene (isolated)
Vitamin B-1; thiamin pyrophosphate (food)Thiamin mononitrate; thiamin hydrochloride; thiamin HCL
Vitamin B-2; riboflavin, multiple forms (food)Riboflavin (isolated); USP vitamin B2
Vitamin B-3; niacinamide (food) Niacin (isolated); niacinamide (isolated)
Vitamin B-5; pantothenate (food)Pantothenic acid; calcium pantothenate; panthenol
Vitamin B-6; 5’0 (beta-D) pyridoxinePyridoxine hydrochloride; pyridoxine HCL
Vitamin B-9; folateFolic acid
Vitamin B-12; methylcobalamin; deoxyadenosylcobalamin Cyanocobalamin; hydroxycobalamin
Choline (food); phosphatidyl choline (food) Choline chloride; choline bitartrate
Vitamin C; ascorbate (food); dehydroascorbate

Ascorbic acid; most mineral ascorbates (i.e. sodium

ascorbate)

Vitamin D; mixed forms, primarily D3 (food) Vitamin D1 (isolated); Vitamin D2 (isolated); Vitamin D3 (isolated) ; Vitamin D4; ergosterol (isolated); cholecalciferol (isolated); lumisterol
Vitamin E; RRR-alpha-tocopherol (food)

Vitamin E acetate; Mixed tocopherols; all-rac-alpha-tocopherol; d-l–alpha-tocopherol; d-alpha-tocopherol (isolated); dl-alpha-tocopheryl acetate; all acetate forms

Vitamin H; biotin All non-yeast or non-rice vegetarian biotin forms
Vitamin K; phylloquinone (food)

Vitamin K3; menadione; phytonadione; naphthoquinone; dihydro-vitamin K1

* Note: This list is not complete and new analogues are being developed all the time. Also the term “(isolated)” means that if the word “food” is not near the name of the substance, it is probably an isolate (normally crystalline in structure) and is not the same as the true vitamin found in food.

Read the label of any supplement to see if the product is truly 100% food. If even one USP vitamin analogue is listed, then the entire product is probably not food (normally it will be less than 5% food). Vitamin analogues are cheap (or not so cheap) imitations of vitamins found in foods.

Beware of any supplement label that says that its vitamins are vegetarian and contain no yeast. This researcher is unaware of any frequently used vegetarian non-yeast way to produce vitamin D or many of the B vitamins, therefore, if a label states that the product “contains no yeast” then in pretty much all cases, this demonstrates that the product is synthetic or contains items so isolated that they should not be considered to be food.

Saccharomyces cerevisiae (the primary yeast used in baking and brewing) is beneficial to humans and can help combat various infections [11], including according to the German E monograph Candida albicans. In the text, Medical Mycology John Rippon (Ph.D., Mycology, University of Chicago) wrote, “There are over 500 known species of yeast, all distinctly different. And although the so-called bad yeasts do exist, the controversy in the natural foods industry regarding yeast related to health problems which is causing many health-conscious people to eliminate all yeast products from their diet is ridiculous. It should also be noted, that W. Crook, M.D., perhaps the nation’s best known expert on Candida albicans, wrote, “yeasty foods don’t encourage candida growth…Eating a yeast-containing food does not make candida organisms multiply” [12]. Some people, however, are allergic to the cell-wall of yeast [12] and concerned supplement companies which have nutrient-containing yeast normally have had the cell-wall enzymatically processed to reduce even this unlikely occurrence.

Food Vitamins are Superior to Non-Food Vitamins

Although many mainstream health professionals believe, “The body cannot tell whether a vitamin in the bloodstream came from an organically grown cantaloupe or from a chemist’s laboratory” [13], this belief is quite misleading for several reasons. First it seems to assume that the process of getting the amount of the vitamin into the bloodstream is the same (which is frequently not the case [3-10]). Secondly, scientists understand that particle size is an important factor in nutrient absorption even though particle size is not detected by chemical assessment. Thirdly, scientists also understand that, “The food factors that influence the absorption of nutrients relate not only to the nature of the nutrients themselves, but also their interaction with each other and with the nonabsorbable components of food” [14]. Fourthly, “the physiochemical form of a nutrient is a major factor in bioavailability” (and food and non-food vitamins are not normally in the same form) [15]. Fifthly, most non-food vitamins are crystalline in structure [1].

Published scientific research has concluded, “natural vitamins are nutritionally superior to synthetic ones” [8].

Food vitamins are in the physiochemical forms which the body recognizes, generally are not crystalline in structure, contain food factors that affect bioavailability, and appear to have smaller particle sizes (see illustrations in table 3). This does not mean that non-food vitamins do not have any value (they clearly do), but it is important to understand that natural food complex vitamins have actually been shown to be better than isolated, non-food, vitamins (see table 4).

Look at Electronic Photos to See the Structural Differences

Electronic photos demonstrate that isolated USP vitamins have a crystalline appearance compared to vitamins in foods which have more of a rounded appearance (see table 3).

Table 3. Physical and Structural Differences


Food Vitamin C

Ascorbic Acid

Food Vitamin B1

Thiamine Hydrochloride

Electronic Photographs

Even before these types of pictures were available, the late Dr. Royal Lee knew that food vitamin C was superior to ascorbic acid. “Dr. Lee felt it was not honest to use the name ‘vitamin C’ for ascorbic acid. That term ‘should be reserved for the vitamin C COMPLEX’” [16]. Why then, according to the ingredients listed in a recent catalog, would a supplement company that Dr. Lee originally founded currently include ascorbic acid, inorganic mineral salts, and/or other isolated nutrients in the majority of its products? Dr. Lee, like the late Dr. Bernard Jensen [17], was also opposed to the use of other isolated, synthetic, nutrients [16].

Dr Lee specifically wrote, “In fact, the Food & Drug laws seem to be suspended where synthetic imitations of good foods are concerned, and actually perverted to prosecute makers and sellers of real products…The synthetic product is always a simple chemical substance, while the natural is a complex mixture of related and similar materials…Pure natural Vitamin E was found three times as potent as pure synthetic Vitamin E. Of course the poisonous nature of the synthetic Vitamin D…is well established. WHY DO NOT THE PEOPLE AND MEDICAL MEN KNOW THESE FACTS? Is it because the commercial promoters of cheap imitation food and drug products spend enough money to stop the leaking out of information?” [18].

 Table 4. Comparison of Certain Biological Effects of Food and Non-Food Vitamins

Food VitaminCompared to USP/’Natural’/Non-Food Vitamins
Vitamin AMore complete, as scientists teach that vitamin A is not an isolate [19]
Vitamin BComplex More effective in maintaining good health and liver function [20,21]
Vitamin B-9More utilizable above 266mcg (Recommended Daily Intake is 400mcg) [22]
Vitamin COver 15.6 times antioxidant effect [23]
Vitamin DOver 10 times the antirachitic effect [24]
Vitamin EUp to 4.0 times the free radical scavenging strength [25]
Vitamin HUp to 100 times more biotin effect [1]
Vitamin KSafer for children [26]

The difference is more than quantitative.

Let’s take vitamin C for an example. Even if one were to take 3.2 times as much of the so-called natural, non-food, ascorbic acid than food vitamin C, although the antioxidant effects might be similar in vitro, the ascorbic acid still will not contain DHAA [1], nor will it ever have negative oxidative reductive potential (ORP). An in vitro study performed at this researcher’s lab with a digital ORP meter demonstrated that a citrus food vitamin C has negative ORP, but that ascorbic acid had positive ORP [27].

It takes negative ORP to clean up oxidative damage [28], and since ascorbic acid has positive ORP (as well as positive redox potential [1]), it can never replace food vitamin C no matter what the quantity! Furthermore, foods which are high in vitamin C tend to have high Oxygen Radical Absorbance Capacity (ORAC, another test which measures the ability of foods and other compounds to subdue oxygen free radicals [23]). A US government study which compared the in vivo effects of a high vitamin C food (containing 80 mg of vitamin C) compared to about 15.6 times as much isolated ascorbic acid (1250 mg) found that the vitamin C-containing food produced the greatest increase in blood antioxidant levels (it is believed that bioflavonoids and other food factors are responsible) [23].

Furthermore, it is even possible isolated ascorbic acid only has in vitro and no in vivoantioxidant effects: “it has not been possible to show conclusively that higher than anti-scorbic intake of {SYNTHETIC} vitamin C has antioxidant clinical benefit” [29]. Why should people take supplemental synthetic ascorbic acid when it is NOT been proven to have antioxidant effects in humans?

“Cross sectional and longitudinal studies show that the occurrence of cardiovascular disease and cancer is inversely related to vitamin C intake…the protective effects seen in these studies are attributable to fruit and vegetable {FOOD} intake…In general, beneficial effects of supplemental {SYNTHETIC} vitamin C have been noted in small studies, while large well controlled studies have failed to show benefit” [29]. The other quantitative is that in humans, “Plasma is completely saturated in doses of 400 mg and higher daily producing a steady-state plasma concentration of 80 mM…Tissues, however, saturate before plasma” [29]. De-emphasizing vitamin C containing foods by attempting to consume higher quantities of isolated ascorbic acid simply will not have the effects on plasma vitamin C levels, ORP, ORAC, or other health aspects that many consumers of isolated ascorbic acid hope it will [3,27,29].

No matter how much isolated ascorbic acid one takes orally

  • It will never saturate plasma and/or tissue vitamin C levels significantly more than can be obtained by consuming sufficient vitamin C containing foods.
  • It will never have negative ORP, thus can never ‘clean-up’ oxidative damage like food vitamin C can.
  • It will never have the free radical fighting capacity of food vitamin C.
  • It will never contain DHAA (the other ‘half’ of vitamin C) or the promoting food factors.
  • It will never have the same effect on health issues, such as aging and cardiovascular disease as high vitamin C foods can.
  • It will not ever be utilized the way food vitamin C is.
  • It will always be a synthetic.

Let’s take vitamin E as another example—the body has a specific liver transport for the type of vitamin E found in food [10]—it does not have this for the synthetic vitamin E forms (nor for the ‘new’ vitamin E analogues that are frequently marketed)—thus no amount of synthetic vitamin E can truly equal food vitamin E—the human body actually tries to rid itself of synthetic vitamin E as quickly as possible [30]. As another example, it should be understood that certain forms of vitamin analogues of B-6 [19], D [10], and biotin [1] have been shown to have almost no vitamin activity.

Fractionated, synthetic, vitamins do not replace all the natural function of food vitamins in the body. This is due to the fact that they are normally chemically and structurally different (they also do not have the naturally occurring food factors which are needed by the body) from vitamins found in foods (or vitamin supplements made up entirely of foods).

Food Vitamins and Non-Food Vitamin Analogues

Vitamin A/Betacarotene: Vitamin A naturally exists in foods, but not as a single compound. Vitamin A primarily exists in the form of retinyl esters, and not retinol and beta carotene is always in the presence of mixed carotenoids with chlorophyll [10]. Vitamin A acetate is from methanol, it is a retinol which is crystalline in structure [1]. Vitamin A palmitate can be fish oil [1] or synthetically derived [2]; but once isolated it bears little resemblance to food and can be crystalline in structure [1,2]. Synthetic betacarotene is “prepared from condensing aldehyde (from acetone) with acetylene” [2]; “not much natural beta-carotene is available due to the high costs of production” [2].

“Beta-carotene has been found to have antioxidant effect in vitro…Whether {ISOLATED} beta-carotene has significant antioxidant effect in vivo is unclear” [32]. Carrots, a food high in betacarotene, do have high antioxidant ability [32,33]. Natural betacarotene, as found in foods, is composed of both all-trans and 9-cis isomers, while synthetic betacarotene is all-trans isomers [34]. Carrots, yellow and green leafy vegetables, and turmeric contain natural betacarotene along with multiple carotenoids. Natural betacarotene was found to significantly decrease serum conjugated diene levels for children exposed to high levels of irradiation, though it is not known if synthetic betacarotene would provide similar benefits [34].

Regarding isolated betacarotene, “The data presented provide convincing evidence of the harmful properties of this compound if given alone to smokers, or to individuals exposed to environmental carcinogens, as a micronutrient supplement” [35]. “The three beta-carotene intervention trials: the Beta Carotene and Retinol Efficacy Trial (CARET), Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (ATBC), and Physician’s Health Study (PHS) have all pointed to a lack of effect of synthetic beta-carotene in decreasing cardiovascular disease or cancer risk in well-nourished populations. The potential contribution of beta-carotene supplementation to increased risk of lung cancer in smokers has been raised as a significant concern. The safety of synthetic beta-carotene supplements and the role of isomeric forms of beta-carotene (synthetic all-trans versus “natural” cis-trans isomeric mixtures)… have become topics of debate in the scientific and medical communities” [36]. Now, although the consumption of both synthetic betacarotene and food betacarotene raise serum vitamin A levels about the same, this obscures the fact that synthetic betacarotene tends to mainly increase serums all-trans betacarotene, while food betacarotene increases other forms as well [37].

It is possible that synthetic betacarotene can negatively affect vitamin E’s antioxidant ability as a clinical study found, “These results support earlier findings for the protective effect of a-tocopherol against LDL oxidation, and suggest that beta-carotene participates as a prooxidant in the oxidative degradation of LDL under these conditions. Since high levels of alpha-tocopherol did not mitigate the prooxidative effect of beta-carotene, these result indicate that increased LDL beta-carotene may cancel the protective qualities of alpha-tocopherol” [38]. In a consumer-directed publication, Stephen Sinatra (M.D.) observes, “Research has shown that high doses of synthetic beta-carotene—the kind found in many popular brands—may actually increase your risk for lung cancer. Because at high levels it can become prooxidative—exactly the opposite of what you want…I’ve seen harmful effects (such as serious vision loss) in people who have taken up to 80,000 IU of beta-carotene per day. The bottom line is: Less is more when it comes to beta-carotene. To be safe I recommend between 12,500 and 25,000 IU of beta-carotene per day from food sources such as carrots” [39].

In my opinion, betacarotene in carrots, however, is safer than even Dr. Sinatra suggests (there is about 12,000 i.u. of betacarotene in one raw carrot). The reason for this is because betacarotene in carrots is attached to lipoproteins which appear to aid in preventing toxicity. Isolated USP betacarotene, even if it allegedly comes from “natural” sources, simply does not have the attached lipoproteins or other potentially protective substances as found in foods like carrots.

While isolated synthesized vitamin A and polar bear livers have posed toxicity issues, this is simply not considered to be the case of any other food that is supplying vitamin A/beta-carotene [40,41]. Foods containing vitamin A and/or beta carotene are superior [8].

Vitamin B-1, Thiamin: Vitamin B-1 exists in food in the forms of thiamin pyrophosphate, thiamin monophosphate, and thiamin [10]. The non-food thiamin mononitrate is a coal tar derivative [4], never naturally found in the body [10], and is a crystalline isolate [1] (the same is true for thiamin hydrochloride and other chloride forms). Synthetic forms are often used in “food fortification” (where processing removes the naturally occurring thiamin) as they are cheaper and, in that context more stable. However, they are inferior to naturally occurring thiamin forms [8,42]. “The nutritive value of straight-run white flour…has been found to be inferior to that of wholemeal flour, even when the defects of the former in protein, minerals and {SYNTHETIC} vitamin B1 have been corrected” [42].

Vitamin B-2, Riboflavin: Naturally exists as riboflavin and various co-enzyme forms in food [10]. In non-foods it is most often synthetically made with 2N acetic acid, is a single form isolate, and is crystalline in structure [1]. Some synthetic riboflavin analogues have weak vitaminic activity [43]. Some natural variations, especially in coenzyme forms, occur in plants (including fungal) species [44]. Various studies suggests that food riboflavin are superior to non-food forms [8,41].

Vitamin ‘B-3’, Niacinamide: Primarily exists in foods in forms other than niacin [10]. “Niacin is a generic term…the two coenzymes that are the metabolically active forms of niacin (are)…nicotinamide adenine dinucleotide (NAD) and NAD phosphate (NADP)…Only small amounts of free forms of niacin occur in nature. Most of the niacin in food is present as a component of NAD and NADP…nicotinamide is more soluble in water, alcohol, and ether than nicotinic acid…many analogues of niacin have been synthesized, some of which have antivitamin activity ” [10]. Niacinamide (also called nicotinamide) is considered to have less potential side-effects than niacin [10]; it also does not seem to cause gastrointestinal upset or hepatotoxicity that the synthetic time-released niacin can cause [45]. Processing losses for this vitamin are mainly due to water leaching [46]. Isolated, non-food, niacinamide is normally from 3-cyanopyridine and can form crystals [1]. This non-food ‘niacin’ is synthesized from acetaldehyde through several chemical reactions often involving formalydehyde and ammonia [2,47]. Beef, legumes, cereal grains, yeast, and fish are significant natural food sources of vitamin B3 [45].

Vitamin ‘B-5’, Pantothenate: Naturally exists in foods as pantothenate [10]. “Pantothenate, usually in the form of CoA, performs multiple roles in cellular metabolism, being central to energy-yielding oxidation of glycolytic products and other metabolites through the mitochondrial tricarboxylic acid cycle…Synthesis of fatty-acids and membrane phospholipids, including regulatory sphingolipids requires pantothenate, and synthesis of the amino acids leucine, arginine, and methionine requires a pantothenate requiring step. CoA is required for synthesis of isoprenoid derivatives, such as cholesterol, steroid hormones, dolichol, vitamin A, vitamin D, and heme A” [10]. “It also appears to be involved in the regulation of gene expression and signal transduction…may have antioxidant and radioprotective properties…It has putative anti-inflammatory, wound healing and antiviral activities…may be helpful in the management of some with rheumatoid arthritis…shown to accelerate wound healing” [32]. “Synthetic D-pantothenate…is available as a calcium or sodium salt” [10], and is sold in forms such as sodium D-pantothenate or calcium D-pantothenate or sometime just listed as pantothenic acid [32]. Other synthetic “multivitamin preparations commonly contain its…alcohol derivative, panthenol” [10]. “Dexopanthenol is a synthetic form which is not found naturally” [32]. USP pantothenic acid is made by condensing isobutyraldehyde with formaldehyde [2]. “Pantothenic acid consists of pantoic acid in amide linkage to beta-alanine”, but vitamin B-5 is not found that way in nature [48]. Vitamin B-5 is found in food as pantothenate forms; foods do not naturally contain pantothenic acid [48]. The vegetarian foods which are highest in natural pantothenate are nutritional yeast, brown rice, peanuts, and broccoli [10,32,48]. Specifically, Saccharomyces cerevisiae is one of the best natural sources of food pantothenate [10,32]. Calcium pantothenate is a synthetic enantiomer [10] and is a calcium salt [1] and is crystalline [2].

Vitamin B-6: Plants naturally primarily contain vitamin B6 in forms such as 5’0-(beta-D-glycopyransosyl) and other pyridoxines, not pyridoxal forms [10]. Pyridoxine hydrochloride is not naturally found in the body [10], is a crystalline isolate [1], and is generally made from petroleum and hydrochloric acid and processed with formaldehyde [4]. Pyridoxal-5-phosphate is made by combining phosphorus oxychloride and/or adenosine triphosphate with pyridoxal [1]; it becomes a crystalline isolate [1] and bears almost no resemblance to food vitamin B6. At least one synthetic vitamin B-6 analogue has been found to inhibit natural vitamin B-6 action [49]. A study of healthy elderly individuals found about 1/3 had marginal vitamin B-6 deficiency [32].

Vitamin ‘B-9’, Folate: Folate was once known as vitamin B-9, as well as vitamin M. Initially food folate was given for people with a pregnancy-related anemia in the form of autolyzed yeast; later a synthetic USP isolate was developed [10]. Pteroylglutamic acid (folic acid), the common pharmacological (USP) form of folate is not found significantly as such in the body [10]. “Folic acid is a synthetic folate form” [50]. Folic acid, such as in most supplements, is not found in food, folates are [15]. Insufficient folate can result in fatigue, depression, confusion, anemia, reduced immune function, loss of intestinal villi, and an increase in infections [11]. Folate deficiency is the most important determinant in high homocysteine levels [11], and supplemental folate is effective in reducing homocysteine [51,52]. “The highest concentrations of folate exist in yeast…and brocolli” [10]. Insufficient folate can result in fatigue, depression, confusion, anemia, reduced immune function, loss of intestinal villi, and an increase in infections [11]. “(C)onsumption of more than 266 mcg of synthetic folic acid (PGA) results in absorption of unreduced PGA, which may interfere with folate metabolism for a period of years” [10]. A 2004 paper from the British Medical Journal confirmed what many natural health professional have known all along: since folic acid is unnatural and the body cannot fully convert large amounts of it into usable folate, this artificial substance can be absorbed and may have unknown negative consequences in the human body [22]–folate supplementation obviously should be in food folate forms and not folic acid.

Vitamin B-12: The naturally active forms are methylcobalamin and deoxyadenosylcobalamin and are found in food [10]. Cyanocobalamin is not a naturally active form [10]; it is an isolate which is crystalline in structure [1]. Initially natural food complexvitamin B12 was given for people with pernicious anemia in the form of raw liver, but due to cost considerations a synthetic USP isolate was developed [7]. According to Dr. Victor Herbert (and others) vitamin B-12 when ingested in its human-active form is non-toxic, yet Dr. Herbert (and others) have warned that “the efficacy and safety of the vitamin B12 analogues created by nutrient-nutrient interaction in vitamin-mineral supplements is unknown” [52]. Some synthetic vitamin B12 analogues seem to be antagonistic to vitamin B12 activity in the body [53,54]. Most synthetic B-12 is made through a fermentation process with the addition of cyanide [4].

Vitamin B-x, Vitamin B-8, Vitamin B factors like Choline: PABA was once called vitamin B-x, while inositol was once called vitamin B-8. They and choline are considered to be vitamin B co-factors.

In large doses, PABA is “indicated for Peyronie’s disease, scleroderma, morphea and linear scleroderma” [11]. The non-food version of PABA is made from coal tar [2]. In addition, there is a non-food potassium salt synthetic form, called aminobenzoate potassium [11]. PABA is found in foods such as kidney, liver, molasses, fungal foods, spinach, and whole grains [55].

The non-food version of inositol is made from phytin processed with sulfuric acid [2]. Inositol is a lipotrophic factor, as is also necessary for hair growth. While nutritional yeast is probably the best source of inositol, it is also found in fruits, lecithin, legumes, meats, milk, unrefined molasses, raisins, vegetables, and whole grains [55].

Choline bitartrate and choline chloride, the types most often encountered in allegedly “natural” vitamin supplements, are actually “commercial salts” [11]—they are synthetic forms. Ethylene is involved in the production of one or more of the synthetic forms [2].

Phosphatidyl-choline is the major delivery form of choline, and is naturally found in many foods such as beef liver, egg yolks, and soya [11]. Specially grown nutritional yeast appears to be the best food form for supplements.

Vitamin C: Vitamin C naturally occurs in fruits in two ascorbate forms with bioflavonoids [10]. Non-food, so-called ‘natural’ ascorbic acid is made by fermenting corn sugar into sorbitol, then hydrogenating it until it turns into sorbose, then acetone (commonly referred to as nail polish remover) is added to break the molecular bonds which creates isolated, crystalline, ascorbic acid. It does not contain both vitamin C forms (nor bioflavonoids), thus is too incomplete to properly be called vitamin C [2]. The patented ‘vitamin C’ compounds that are touted as less acidic than ascorbic acid also are not food (it is not possible to get a US patent on naturally occurring vitamins as found in food–anytime a health professional hears that some vitamin is patented, that should set off warning signals that it is not real food). An in vitro study found that food complex vitamin C has negative ORP (oxidative reductive potential) [27], yet the Merck Index shows that so-called ‘natural’ ascorbic acid has positive ORP [1] (negative ORP is much better as it helps ‘clean up’ oxidative damage whereas items with positive ORP do not) [56]. Food complex vitamin C is also 10x less acidic than ascorbic acid.

Some of the many functions that vitamin C is involved in include collagen formation, carnitine biosynthesis, neurotransmitter synthesis, enhancement of iron absorption, immunocompetence, antioxidant defense, possible anticarcenogenic effects, protection of folate and vitamin E from oxidation, and cholesterol catabolism [1].

One study found that food complex vitamin C had 492 micro moles per gram T.E. (Trolox equivalents) of hydrophilic ORAC (oxygen radical absorbance capacity) [57]—ORAC is essentially a measurement of the ability to quench free radicals (antioxidant ability)—while blueberries (one of the highest ORAC sources [23]) only had 195 micro moles per gram T.E. [57]—thus food complex vitamin C has 2.52 times the ORAC ability of blueberries. Vitamin C containing food has over 15.6 times the ORAC of isolated ascorbic acid [23] (food complex vitamin C is even higher). Actually, there are doubts that isolated ascorbic acid has any significant antioxidant effects in humans [29]. Food vitamin C is clearly superior for any interested in ORAC.

Although food vitamin C is superior to isolated ascorbic acid [8], at least one mainstream researcher has written, “The bioavailability of vitamin C in food and ‘natural form’ supplements is not significantly different from that of pure synthetic AA” [10] this is simply not true. As “proof” that particular author cites two papers. The first citation is a study that concludes since serum ascorbic acid levels were at similar levels after various vitamin C containing foods and synthetic ascorbic acid were consumed, that the bioavailability is similar [58]. The conclusions reached seem to ignore that fact that it may be possible that DHAA or other food constituents associated with natural vitamin C may have positive effects other than raising serum ascorbate levels. The second citation is a study that probably should not have been cited as it never compared vitamin C as complexed in food versus synthetic ascorbic acid (it compared synthetic ascorbic acid to Ester-C which is a commercial blend of synthetic ascorbic acid and select metabolites as well as to synthetic ascorbic acid mixed with some bioflavonoids) [59]. Hence, those who claim that there is no difference really do not have strong scientific proof for there contrary opinion.

More recent scientific investigations (cited previously. i.e. 8,23,27,57) have demonstrated that food vitamin C is superior to isolated ascorbic acid.

Vitamin D: The history of synthetic vitamin D is a shocking one. “The first vitamin isolated was a photoproduct from the irradiation of the fungal sterol ergosterol. This vitamin was known as D1…vitamin D obtained from irradiation of ergosterol had little antirachitic activity” [60]–in other words, the first synthetic vitamin D did not act the same as natural vitamin D. “At the time of its identification, it was assumed that the vitamin D made in the skin during exposure to sunlight was vitamin D2”, but it was later learned that human skin produced something called vitamin D3 [60]. It was first believed that provitamin D3 was directly converted to vitamin D3, but that was incorrect. The skin actually contains a substance commonly called provitamin D3; after exposure to sunlight previtamin D3 is produced and it begins to isomerize into vitamin D2 in a process which is temperature dependent, with isomerized vitamin D3 being jettisoned from the plasma membrane into extracellular space. Vitamin D2 was used to fortify milk in the US and Canada for about forty years until it was learned that D3 was the substance which had better antirachitic activity, so D3 has been used for the past twenty-five years [60]. But vitamin D has many benefits which are unrelated to rickets: B and T lymphocytes have been shown to have receptors for vitamin D similar to those found in the intestines, vitamin D seems to affect phagocytosis, and may even have some antiproliferation effect for tumor cells [60]. It has not been proven that any single USP isolated form of vitamin D has all the benefits as natural occurring forms of vitamin D. (Also, since the vitamin D was not particularly stable, manufacturers used to put in 1.5 to 2 times as much of synthetic vitamin D as they claimed on the product labels. This led to neonatal problems and hypercalcemia. [60].) One older report found that “natural vitamin D is about 100 times more potent in protecting chickens and children from rickets than…irradiated ergosterol” [61], USP vitamin D2.

New vitamin D analogues are still being developed: some which may have greater affects on calcium utilization [62], some even may be helpful for breast cancer [63]–but these really may be pharmacological, and not naturopathic, applications since these analogues are not food. In view of the historical errors in the supplementation with forms of vitamin D, it is reasonable to conclude that additional benefits of natural source vitamin D may be discovered, further distinguishing it from synthetic isolates.

Vitamin D is not an isolate, it exists as a combination of substances (including vitamin D3), with promoting metabolites [10]. Non-food vitamin analogues D1, D2, D3, and D4 are isolates without the promoting metabolites. USP D1 does not have appreciable antirachitic effects [10], is crystalline, and is made with benzene [1]. USP D2 is considered a synthetic form and is made by bombarding ergosterol with electrons [1] and is “recovered by solvent extraction” [2]. USP D3 and D4 are both made through irradiating animal fat [1,10,31] or through irradiating “the spinal cords and brains of cattle” [2]. Scientists are even developing a ‘new’ form of vitamin D (which is admitted to be an analogue) which is supposed to be helpful for osteoporosis [64]—natural vitamins cannot be invented! The fact that some drugs are chemically similar to vitamin D as found in foods, does not make them true vitamins. Food vitamin D has been reported to have at least 10 times the antirachitic effects than one or more isolated USP forms [65].

Vitamin E: Natural vitamin E “as found in foods is [d]-alpha tocopherol, whereas chemical synthesis produces a mixture of eight epimers” [66] (natural vitamin E has recently been renamed to be called RRR-alpha-tocopherol whereas the synthetic has now been renamed to all-rac-alpha-tocopherol, though supplement labels rarely make this clear; on supplement labels d-alpha-tocopherol is generally ‘natural’, whereas dl-alpha-tocopherol is synthetic [25]). Natural RRR-alpha-tocopherol has 1.7 – 4.0 times the free radical scavenging strength of the other tocopherols, RRR-alpha tocopherol has 3 times the biological activity of the alpha-tocotrienol form, and synthetic vitamin E simply does not have the same biologic activity of natural vitamin E (some synthetic forms have only 2% of the biological activity of RRR-alpha-tocopherol) [25]. The biologic activity of vitamin E is based on its ability to reverse specific vitamin E-deficiency symptoms [25], therefore it is a scientific fact that, overall, synthetic vitamin E has less ability to correct vitamin E deficiencies than food vitamin E. There is an interesting reason for this, which is that the body regulates plasma vitamin E through a specific liver alpha-tocopherol transfer protein, whereas it has no such protein for other vitamin E forms [25]. Or in other words, the liver produces a protein to handle vitamin E found in food, but not for the synthetic forms. The body retains natural vitamin E 2.7 times better than synthetic forms [30].

Even mainstream researchers teach, “Vitamin E is the exception to the paradigm that synthetic and natural vitamins are the equivalent because their molecular structures are identical…Synthetic vitamin E is produced by commercially coupling trimethylhydroquinone (TMHQ) with isophytol. This chemical reaction produces a difficult-to-separate mixture of eight isomers” [67] (vitamin E, of course, is not the only exception–all nutrients are better if they are Food). Isolated natural vitamin E has been found to have twice the bioavailability as synthetic vitamin E [68]. The form of vitamin E found in Foodhas been found to be 2.7 times better retained in the body than a synthetic form [26]—this appears to be because the body attempts to rid itself of synthetic forms as quickly as possible [26]. Food vitamin E, as found in specially grown rice, has been proven to have 12 micro moles per gram T.E. of lipophilic ORAC (oxygen radical absorbance capacity) [57]—ORAC is essentially a measurement of the ability to quench free radicals (antioxidant ability). It is interesting to note that so-called “natural” forms (like succinate) do not even work like Food vitamin EEven the PDR notes, “d-Alpha-Tocopherol succinate itself has no antioxidant activity” [32], so why would anyone want that for their vitamin E supplement?

Both chemical form and source of vitamin E may play a role as “chemically synthesized alpha-tocopherol is not identical to the naturally occurring form” [25]. Thus those who claim that a synthetic vitamin, even when it is in the same “chemical form” (it is never in the same actual form due to the presence of food constituents), is as good as one in a natural, food form, are simply overlooking the scientific facts about vitamins.

Vitamin E is necessary for the optimal development and maintenance of the nervous system as well as skeletal muscle [67]. Vitamin E deficiency can lead to certain anemias, nutritional muscular dystrophy, reproductive problems, and hyperlipidemia [66]. Vitamin E has been shown to reduce the risk of various cancers, coronary heart disease, cataract formation, and even air pollution [25,67]. It also is believed it may slow the aging process and decrease exercise-induced oxidative stress [25,67]. Artificial fats seem to increase the need for vitamin E [69]. Vitamin E content is highest in vegetable oils, also relatively high in avocados (4.31 i.u. each) [70] and rice bran [71].

Natural vitamin E as found in foods is [d]-alpha tocopherol (also called RRR-alpha tocopherol) and is never found as an isolate [10]. The so-called ‘natural’ forms are most frequently in supplements as isolates, a way they are never found in nature.

Vitamin ‘H’, Biotin: The only active form found in nature is d-(+) biotin and is usually protein bound [10]. Non-food biotin is normally an isolated, synthesized, crystalline form that is not protein bound [1]. Biotin l-sulfoxide is a lessor used isolated and/or non-food form, involves pimelic acid, is an isolate, and has less than 1% of the vitamin H activity of food biotin [1].

Vitamin K: Vitamin K naturally is found in plants as phylloquinone [10]. Non-food vitamin K3 menadione is now recognized as dangerous and is a synthetic naphthoquinone derivative (naphthalene is a coal tar derivative) [1]. USP K1, though also called phylloquinone, is an isolate normally synthesized with p-allylic-nickel [1]. There is another form of vitamin K inadvertently formed during the hydrogenation of oils called dihydro-vitamin K1 [72]; however since the consumption of hydrogenated oils appears to be dangerous [73], it does not seem that this form would be indicated for most humans. Dark leafy vegetables, as well as cabbage [74], appear to be the primary food source of vitamin K [75].

Types of Available Vitamins

There are really only two types of vitamins sold: food vitamins and non-food vitamins. Food vitamins will normally state something like “100% Food” on the label. Sometimes the label will also state “No USP nutrients” or “No synthetic nutrients”.

Non-food vitamins, however are somewhat less obvious. First of all, no non-food vitamin this researcher has seen says “100% food” on the label and none of them state ‘No USP or synthetic nutrients”—thus if none of these expressions are present, it is normally safe to conclude that the vitamins are not from food. If a label states that the product contains USP vitamins or ‘pharmaceutical grade’ nutrients, then it should be obvious to all naturopathic practitioners that the product is not food. Also, if a multi-vitamin or a B-complex formula states something to the effect that it “contains no yeast” that is basically a guarantee that it contains synthetic nutrients.

However, just because a company uses the term ‘natural’ or ‘all natural’ as a description of its vitamins does not make them, in fact, natural—this is because the US Government has no definition of natural! Also, just because a company may have a reputation for having natural products, this does not mean its vitamins are not synthetic—carefully check the label for proof that the product is truly 100% food.

Some companies seem to confuse the issue by using the term ‘food-based’ on their supplement labels. ‘Food-based’ vitamins are almost always USP vitamins mixed with a small amount of food. This mixing does not change the chemical form of the vitamin, so it is still a vitamin analogue and not a food vitamin (this differs from food, as true food vitamins are not simple mixture).

Some other companies (that do not use the term ‘food-based’) mix foods with the vitamin analogue and seem to imply that the vitamin is a food. For example, if a label states something like Vitamin C (Vitamin C, acerola) then it is also normally a synthetic mixed with a food. If the product were a food, it would normally state that the vitamin C was in food or from acerola and not use the term ‘vitamin C’ twice in a row on the label (many companies mix ascorbic acid with acerola).

Many companies use the term ‘yeast-free’ on their synthetic vitamin labels, apparently implying that yeast should not be used in vitamins. There are a couple of problems with this. The first is that several non-food isolated vitamins are produced by yeast, before they are industrially processed and isolated, thus it is unlikely that any multiple vitamin formula has not been partially made up of yeast, yeast extracts, or yeast by-products [1,2]. The second problem is that nutritional yeast is not the same as brewer’s yeast, which is essentially a waste by-product.

Conclusion

Most vitamins sold are not food–they are synthetically processed petroleum and/or hydrogenated sugar extracts–even if they say “natural” on the label. They are not in the same chemical form or structural form as real vitamins are in foods; thus they are not natural for the human body. True natural food vitamins are superior to synthetic ones [8,16,41]. Food vitamins are functionally superior to non-food vitamins as they tend to be preferentially absorbed and/or retained by the body. Isolated, non-food vitamins, even when not chemically different are only fractionated nutrients.

Studies cited throughout this paper suggest that the bioavailability of food vitamins is better than that of most isolated USP vitamins, that they may have better effects on maintaining aspects of human health beyond traditional vitamin deficiency syndromes, and at least some seem to be preferentially retained by the human body. It is not always clear if these advantages are due to the physiochemical form of the vitamin, with the other food constituents that are naturally found with them, or some combination. Regardless, it seems logical to conclude that for purposes of maintaining normal health, natural vitamins are superior to synthetic ones [8,16,41]. Unlike some synthetic vitamins, no natural vitamin has been found to not perform all of its natural functions.

The truth is that only foods, or supplements composed of 100% foods, can be counted on as not containing non-food vitamin analogues. Natural health advocates are supposed to build health on foods or nutrients contained in foods. That was the standard set for the profession in 1947—that standard—that commitment to real naturopathy should remain for natural health professionals today.

References

[1] Budvari S, et al editors. The Merck Index: An encyclopedia of Chemicals, Drugs, and Biologicals, 12 th ed. Merck Research Laboratories, Whitehouse Station (NJ), 1996

[2] Vitamin-Mineral Manufacturing Guide: Nutrient Empowerment, volume 1. Nutrition Resource, Lakeport (CA), 1986

[3] DeCava JA. The Real Truth About Vitamins and Antioxidants. A Printery, Centerfield (MA), 1997

[4] Hui JH. Encyclopedia of Food Science and Technology. John Wiley, New York, 1992

[5] Gehman JM. From the Office of the President: Pseudo-Group Once Again Misleading the Naturopathic Field. Official Bulletin ANA, January 25, 1948:7-8

[6] Ensminger AH, et al. Food & Nutrition Encyclopedia, 2 nd ed. CRC Press, New York, 1993

[7] Mervyn L. The B Vitamins. Thorsons, Wellingborough ( UK), 1981

[8] Thiel R. Natural vitamins may be superior to synthetic ones. Med Hypo 2000 55(6):461-469

[9] Haynes W. Chemical Trade Names and Commercial Synonyms, 2nd ed. Van Nostrand Co., New York, 1955

[10] Shils M, et al, editors. Modern Nutrition in Health & Disease, 9 th ed. Williams & Wilkins, Balt.,1999

[11] Gruenwald et al editors. PDR for Herbal Medicines, 2nd ed. Medical Economics Company. Montvale (NJ) 2000

[12] Crook W. The Yeast Connection: A Medical Breakthrough, 3 rd ed. Professional Books, Jackson, TN; 1986

[13] Whitney EN, Rolfes S. Understanding Nutrition, 4 th ed. West Publishing, New York, 1987

[14] Jenkins DJA, Wolever TMS, and Jenkins AL. Diet Factors Affecting Nutrient Absorption and Metabolism. In Modern Nutrition in Health and Disease, 8th ed. Lea & Febiger, Phil.,1994:583-602

[15] Macrae R, Robson RK, Sadler MJ. Encyclopedia of Food Science and Nutrition. Academic Press, New York, 1993

[16] DeCava, J. The Lee Philosophy-Part II. Nutrition News and Views 2003;7(1):1-6

[17] Jensen B. Chemistry of Man. Bernard Jensen, Escondido (CA), 1983

[18] Lee R. How and Why Synthetic Poisons Sold as Imitations of Natural Foods and Drugs? 1948

[19] Ross A.C. Vitamin A and Carotenoids. In Modern Nutrition in Health and Disease, 10th ed. Lippincott William & Wilkins, Phil, 2005: 351-375

[20] Ha SW. Rabbit study comparing yeast and isolated B vitamins (as described in Murray RP. Natural vs. Synthetic. Mark R. Anderson, 1995:A3). Ann Rev Physiol, 1941;3:259-282

[21] Elvehjem C. Chick study comparing Goldberg diet (as described in Murray RP. Natural vs. Synthetic. Mark R. Anderson, 1995:A4). J Am Diet Assoc, 1940;16(7):654

[22] Lucock M. Is folic acid the ultimate functional food component for disease prevention? BMJ, 2004;328:211-214

[23] Williams D. ORAC values for fruits and vegetables. Alternatives, 1999;7(22):171

[24] Thiel R. Vitamin D, rickets, and mainstream experts. Int J Naturopathy, 2003; 2(1)

[25] Traber MG. Vitamin E. In Modern Nutrition in Health and Disease, 9th ed. Williams & Wilkins, 1999:347-362

[26] Olson R.E. Vitamin K. In Modern Nutrition in Health and Nutrition, 9th ed. Williams & Wilkins, Balt., 1999: 363-380

[27] Thiel R. ORP Study on Durham-produced Food Vitamin C for Food Research LLC. Doctors’ Research Inc., Arroyo Grande (CA), February 17, 2006

[28] Fowkes SW. Antioxidants & reduction. Smart Life News, 2000;7(9):6-8

[29] Sebastian J, et al. Vitamin C as an antioxidant: evaluation of its role in disease prevention. J Am Coll Nutr, 2003;22(1):18-35

[30] Traber MG, Elsner A, Brigelius-Flohe R. Synthetic as compared with natural vitamin E is preferentially excreted as alpha-CEHC in human urine: studies using deuterated alpha-tocopherol acetates. FESB Letters, 1998;437:145-148

[31] Nakano H, McMahon LG, Gregory JF. Pyridoxine-5’-beta-glucoside exhibits incomplete bioavailability as a source of vitamin B-6 and partially inhibits the utilization of co-ingested pyridoxine in humans. J Nutr,1997;127(8):1508-1513

[32] Hendler S, Rorvik D, editors. PDR for Nutritional Supplements. Medical Economics, Montvale (NJ), 2001

[33] Chu YF, Sun J, Wu X, Liu RH. Antioxidant and antiproliferative activities of common vegetables. J Agric Food Chem. 2002;50(23):6910-6916

[34] Ben-Amotz A, et al. Effect of natural beta-carotene supplementation in children exposed to radiation from the Chernobyl accident. Radiat Environ Biophys 1998;37:187-193

[35] Paolini M, Abdel-Rahman SZ, Sapone A, Pedulli GF, Perocco P, Cantelli-Forti G, Legator MS. Beta-carotene: a cancer chemopreventive agent or a co-carcinogen? Mutat Res. 2003;543(3):195-200

[36] Patrick L. Beta-carotene: the controversy continues. Altern Med Rev. 2000;5(6):530-45

[37] Ben Amotz; van het Hof KH, Gartner C, Wiersma A, Tijburg LB, Westrate JA. Comparison of the bioavailability of natural palm oil carotenoid and synthetic beta-carotene in humans. J Agric Food Chem, 1999;47(4):1582-1586

[38] Bowen HT, Omaye ST. Oxidative changes associated with beta-carotene and alpha-tocopherol enrichment of human low-density lipoproteins. J Am Coll Nutr. 1998;17(2):171-179

[39] Sinatra S. Consumer Alert: Don’t Touch this Button, 2003:34-35

[40] Stepp W, Kuhnau J. Schroeder J. The vitamins and their clinical applications (as described in Murray RP. Natural vs. Synthetic. Mark R. Anderson, 1995:A2). Ferdinand Enke, Stuttgart, Germany 1936.

[41] Murray RP. Anderson MR. Natural vs. Synthetic. Mark R. Anderson, 1995:A1-2

[42] Chick H. Rat study comparing fortified white flour to wholegrain flour (as described in Murray RP. Natural vs. Synthetic. Mark R. Anderson, 1995:A3). Lancet, 1940;2:511-512

[43] McCormick DB, Riboflavin. In Modern Nutrition in Health and Disease, 9th ed. William & Wilkins, Balt.,1999:391-399

[44] McCormick DB. Riboflavin. In Modern Nutrition in Health and Disease, 8th ed. Lea & Febiger, Phil.,1994:366-375

[45] Cervantes-Lauren D, McElvaney NG, Moss J. Niacin. In Modern Nutrition in Health and Disease, 9th ed. Williams & Wilkins, Balt.,1999:401-411

[46]Williams AW, Erdman JW. Food processing: nutrition, safety, and quality balances. In Modern Nutrition in Health and Disease, 9th ed. William & Wilkins, Balt.,1999:1813-1821

[47] Hui JH. Encyclopedia of Food Science and Technology. John Wiley, New York, 1992

[48] Shils M, et al, editors. Modern Nutrition in Health and Disease, 8th ed. Lea & Febiger, Phil.,1994

[49] ] Mervyn L. The B Vitamins. Thorsons, Wellingborough ( UK), 1981

[50] Verhoef P. Homocysteine metabolism and risk of myocardial infarction: Relation with vitamin B6, B12, and Folate. Am J Epidemiol 1996;143(9):845-859

[51] Brattstrom L. Vitamins as homocysteine-lowering agents: A mini review. Presentation at The Experimental Biology 1995 AIN Colloquium, April 13, 1995, Atlanta Georgia

[52] Herbert V, Das KC. Folic acid and vitamin B12. In Modern Nutrition in Health and Disease, 8th ed. Lea & Febiger, Phil.,1994:402-425

[53] Ishida A, Kanefusa H, Fujita H, Toraya T. Microbiological activities of nucleotide loop-modified analogues of vitamin B12. Arch Microbiol,1994;161(4):293-299

[54] Tandler B, Krhenbul S, Brass EP. Unusual mitochondria in the hepatocytes of rats treated with a vitamin B12 analogue. Anat Rec,1991;231(1):1-6

[55] Balch JF, Balch PA. Prescription for a Nutritional Healing, 2 nd ed. Avery Publishing, Garden City Park (NY), 1997

[56] Thiel RJ. The truth about vitamins in supplements. ANMA Monitor, 2003;6(2):6-14

[57] ORAC Test by Brunswick Laboratories, Wareham (MA), February 2006

[58] Mangels AR, et al. The bioavailability to humans of ascorbic acid from oranges, orange juice and cooked broccoli is similar to that of synthetic ascorbic acid. J Nutr, 1993;123(6):1054-1061

[59] Johnson C, Luo B. Comparison of the absorption and excretion of three commercially available sources of vitamin C. J Am Diet Assoc, 1994;94:779-781

[60] Holick MF. Vitamin D. In Modern Nutrition in Health and Disease, 9th ed. William & Wilkins, Balt.,1999:329-345

[61] Supplee G, Ansbacher S, Bender R, Flinigan G. Reports on prevention of rickets in chickens and children using natural and USP forms of vitamin D (as described in Murray RP. Natural vs. Synthetic. Mark R. Anderson, 1995:A6). J Biol Chem, 1936;1(107)957

[62] Miyamoto K, Murayama E, Ochi K, Watanabe H, Kubodera N. Synthetic studies of vitamin D analogues. XIV. Synthesis and calcium regulating activity of vitamin D3 analogues bearing a hydroxlkoxy group at the 2 beta-position. Chem Pharm Bull, 1993;41(6):1111-1113

[63] Fioravanti L, Miodini P, Cappelletti V, DiFronzo G. Synthetic analogs of vitamin D3 have inhibitory effects on breast cancer cell lines. Anticancer Res, 1998;18:1703-1708

[64] Research Breakthroughs. USA Weekend, November 15-17, 2002

[65] Thiel R. Vitamin D, rickets, and mainstream experts. Int J Naturopathy, 2003; 2(1):15-19

[66] Farrel PM, Robert RJ. Vitamin E. In Modern Nutrition in Health and Disease, 8th ed. Lea & Febiger, Phil.;1994:326-341

[67] An Overview of Vitamin E Efficacy. VERIS Research Information Service, November 1998

[68] Burton GW, et al. Human plasma and tissue alpha-tocopherol concentrations in response to supplementation with deuterated natural and synthetic vitamin E. Am J Clin Nutr, 1998;67(4):669-684

[69] Schlagheck TG, et al. Olestra’s effect on vitamins D and E in humans can be offset by increasing dietary levels of these vitamins. J Nutr,1997;127(8):1666S-1685S

[70] Avocados rise to the top. Nutr Week, 2001;31(24):7

[71] Rice bran, crude. USDA National Nutrient Database for Standard Reference, Release 18, 2005

[72] Booth SL, Pennington JA, Sadowski JA. Dihydro-vitamin K1: primary food sources and estimated dietary intakes in the American diet. Lipids, 1996;31:715-720

[73] Aschero A, Willett WC. Health affects of trans fatty acids. Am J Clin Nutr, 1997;66:1006S-1010S

[74] Cabbage, raw. USDA National Nutrient Database for Standard Reference, Release 18, 2005

[75] Booth SL, Pennington JA, Sadowski JA. Food sources and dietary intakes of vitamin K-1 (phylloquinone) in the American diet: data from the FDA Total Diet Study. J Am Diet Assoc, 1996;96(2):149-154

Some of these studies (or citations) may not conform to peer review standards. Therefore, the results are not conclusive. Professionals can, and often do, come to different conclusions when reviewing scientific data. None of these statements have been reviewed by the FDA. All products distributed by Doctors’ Research, Inc. are nutritional and are not intended for the treatment or prevention of any medical condition.

Looking for an Easy Way to Incorporate Nutrition into YOUR Practice?

As a doctor of chiropractic, you have been taught that there is a relationship, a “Chiropractic Connection”, between the spine and other body systems.

The three primary causes of vertebral subluxation complex are physical, chemical, and mental.  Adjustments treat the physical, proper nutrition treats the chemical, and feeling better can help treat the mental.

Now, here are three easy steps to combine Chiropractic with nutrition:

1)   After determining which vertebrae have problems, chiropractically treat as you normally would.

2)   Then, further help your patients by advising nutritional supplements for each problem vertebra.  Look at the Chiro Nutrition Chart™  (this link opens a window).  In general:

3)   Since most people take a synthetic multiple vitamin, it would be better for their health to take 100% Food Vita-Mineral directly from you – so consider recommending this unique 100% Food multi-vitamin.  Since it is 100% Food, Vita-Mineral does not contain toxins and unnatural compounds—is not that the type of product you should recommend?

Now, Inflam-Enzymes is the primary supplement used by many chiropractors.  It can be an excellent choice when inflammation and/or pain are present.  Inflam-Enzymes contains herbs like acerola cherry, bromelain, papain, serrapeptase, plus 100% Food manganese, magnesium, calcium, and vitamin C.

Magnesium Complex is a great choice when muscle tightness is involved.  Since it is 100% Food, it is better retained in the muscles and does not cause diarrhea like the commonly-used mineral salt forms of magnesium can.

Advance Joint Complex is the best knee and hip product we know of.  Unlike other formulas, it DOES NOT CONTAIN isolated chondroitin or glucosamine, nor does it contain any mineral salts.   Advance Joint Complex contains herbs, Food minerals, and glandulars which have been shown to be beneficial for joint and connective tissue health (including knees).

Doctors’ Research, Inc.

1248 E. Grand Avenue, Suite A

Arroyo Grande, CA 93420

WEB: www.doctorsresearch.com

FAX: 1-805-489-0334         Call 1-805-489-7185

Some of these studies (or citations) may not conform to peer review standards. Therefore, the results are not conclusive. Professionals can, and often do, come to different conclusions when reviewing scientific data. None of these statements have been reviewed by the FDA. All products distributed by Doctors’ Research, Inc. are nutritional and are not intended for the treatment or prevention of any medical condition.

Food Research; 100% Whole Food Supplements for Healthcare Professionals

Food Research International is Caribbean company dedicated to providing the highest quality nutritional supplements, in a form that is as close as possible to those naturally found in foods. It is well understood by nutrition researchers that we, as humans, should derive nutrition from food. It is our goal at Food Research to provide the best, scientifically researched, natural food supplements which meet the needs of those who live in our “modern” society. Food Research products are environmentally friendly. They are natural food complexes which have been shown to be better for the internal human environment.

Why are Food Research International products the best?

At least 98.97% of vitamins consumed are synthetic isolates, though they are often labeled as natural. Yet, there are no isolated USP nutrients that exist naturally. So, nearly all companies combine synthetic isolates with industrially-processed minerals in order to produce their vitamin-mineral formulas.

Food Research International is different.

None of our products contain any synthetic/isolated USP nutrients.

In order to obtain potencies that members of modern societies need, many of the nutrients in our products are hydroponically-grown to improve the concentration of nutrients in the specific raw foods that we use.

We essentially take advantage of a law of nature that a plant will absorb more of the nutrient when that nutrient is more available. Essentially, the plant is fed an enzyme-containing liquid that will be higher in one particular mineral. The plant will absorb more of that mineral, since more of it is present. The nutrient foods are grown in an FDA registered facility.

In reality we are duplicating the process of nature when we create food nutrients. Nature’s process takes inorganic, non-food substances from the soil and delivers them to the cells of the plant. This natural process is the merging of different elements into a union creating one. Creating a whole from different elements is nature in action. The best method of creating a union, like those created by nature, between inorganic fractions and the whole food matrix seems to be utilizing hydroponic technologies.

We wanted to supply the best possible form of nutrients so we looked into modern technologies that would be compatible with the natural life processes that nature uses to improve the nutrients in natural plants.

This led to the acquisition of foods combined with a natural cold fusion process. The definition of fusion is the merging of different elements into a union, creating an enhanced whole from different elements. A natural cold fusion process is used to produce superior nutrients that are always 100% food. Enhanced nutrients occur from the merging of specific elements through a living plant into a whole food matrix through low temperature hydroponic farming. The reason that the process is “cold” is in order to preserve the naturally-occurring enzymes and other beneficial substances in the foods. Many of the processes and equipment had to be custom-made or altered to accommodate our need to maintain the fresh frozen raw foods used to create the usable raw materials. Cold fusion processing was not an after thought. No expense was spared to create these cold fusion processes and the state of the art manufacturing plant needed to keep Food Research International products the best available on the planet.

Furthermore, this form of “cold fusion-hydroponic” farming is pesticide free, and hence the quality of the food nutrients produced this way can be considered superior to conventionally grown foods. After growing, the plant is then harvested and dried.

No Genetically-Modified Organisms (GMO) have ever been found in our nutrient foods upon average analysis (which means none have ever been detected any time that they have been tested for).

These superior foods are also free of artificial colors, preservatives, and similar chemicals. The grown nutrients are also HPLC (high performance liquid chromatography) validated. And the nutrient content of each batch is tested for potency.

Food Research International represents the best of all worlds: Real food nutrients, in real foods, with naturally occurring substances (such as enzymes, amino acids, lipids, and/or bioflavonoids) bottled and tested for potency.

100% food nutrients, 100% of the time.

Food Research International your best choice for 100% food nutrients. Additionally, you may view some of the specialized equipment from which Food Research International food nutrients are grown and processed.w

We also have the best known refractive drying process of any food nutrients. You may also view information about the drying process.

Who heads up the Food Research?
Food Research International Ltd. was intitially headed up by Clyde Skeete, of Barbados. Financial affairs handled by Canadian Barbara Gibbs.

The research group at Food Research consists of a variety of independent research scientists.

One researcher is Robert Thiel, Naturopath who also holds a Ph.D. in nutrition science. He has conducted, and had published, many scientific health studies. Thiel received the Leadership Award from the Orthomolecular Health Medicine Society. Thiel has been named Research Scientist of the Year, Physician of the Year, and Disability Researcher of the Year by the largest American naturopathic association. Doc. Thiel has had the only comprehensive paper published in a medical peer-reviewed journal (Medical Hypotheses) on the advantages of natural food vitamins over synthetic ‘nutrients’. He also specializes in nutritional interventions for fatigue, sports performance, and various genetic and non-genetic disabilities.

Another is Steve Xue Ph.D., who runs Natural Medicine Without Borders. Dr. Xue also teaches Alternative Medicine to senior students at Portland State University and aspects of Traditional Chinese Medicine at top TCM universities in China. Dr. Xue received the Best Teaching Award by the Center for Teaching Excellence of Ohio University and the Award for Excellence of Research by the College of Education of Arkansas State University. He has authored various papers and books. He also specializes in alternative interventions for communications disorders.

Another researcher is Dr. James Schutz who has a doctorate in nutrition. He works with Kay Minders who holds a B.S. in nutrition. Both Dr. Schutz and Ms. Minders are also a board certified holistic health practitioners. Dr. Schutz has been registered internationally as a specialist in fibromylagia, immune disorders, and nutrition. Ms. Minders also has been registered as a therapeutic specialist in nutrition and immune disorders. Both also work with genetic and non-genetic disabilities.

Input is also provided by health professionals throughout the world.

Why are Food Research nutrients better than isolated USP nutrients?
Human beings should get their nutrition from foods. “The body is designed to handle foods” [1]. It is important to realize “that in nature vitamins are never isolated. They are always present in the form of vitamin-complexes” [2-5]. Vitamins are natural complexes which produce a variety of actions in the body whereas some isolated USP vitamins are analogues of vitamins which appear to have at least some of these activities [5]. Food nutrients are complexed just as nutrients found in all foods, because they are food. USP vitamins are synthesized (according to strict federal standards), standardized chemical isolates (as listed in the United States Pharmacopoeia or the USAN and USP Dictionary of Drug Names) [6]; they are not food.

It is well known among nutrition researchers that most essential minerals are not well absorbed (some are less than 1%) [7]. “Bioavailability of orally administered vitamins, minerals, and trace elements is subject to a complex set of influences…In nutrition science the term ‘bioavailability’ encompasses the sum of impacts that may reduce or foster the metabolic utilization of a nutrient” [8]. Studies show that natural food complex nutrients are better than isolated USP vitamins or inorganic mineral salts or mineral chelates [e.g. 9-25].

Vegetarian FOOD NutrientCompared to USP/Mineral Salt
  
Vitamin AMore complete, as scientists teach that vitamin A is not an isolate [13]
Vitamin B-9More utilizable above 266mcg (Recommended Daily Intake is 400mcg) [14]
Vitamin COver 15.6 times antioxidant effect [15]
Vitamin D Over 10 times the antirachitic effect [16]
Vitamin EUp to 4.0 times the free radical scavenging strength [17]
Vitamin K Safer for children [18]
Calcium7 times as effective in raising serum ionic calcium levels [19]
ChromiumUp to 25 times more bioavailable [20]
IronNon-constipating, better absorbed [21]
MagnesiumBetter absorbed and retained [22]
SeleniumNearly 2 times better retained [23]
ZincBetter absorption, better form [24,25]

Numerous university studies have concluded that supplements containing food nutrients are better than USP isolates. Food nutrients are better because they contain important enzymes, peptides, and phytonutrients CRITICAL to the UTILIZATION of vitamins and minerals which are not present in isolated USP nutrients. Published research has concluded that food vitamins are superior synthetic/USP vitamins.

References:
[1] Whitney EN, Hamilton EMN. Understanding Nutrition, 4th ed. West Publishing, New York, 1987
[2] Airola P. How to Get Well. Health Plus, Sherwood (OR), 1989
[3] Olson JA. Vitamin A, retinoids, and carotenoids. In Modern Nutrition in Health and Disease, 8th ed. Lea & Febiger, Phil.,1994:287-307
[4] Farrell PA, Roberts RJ. Vitamin E. In Modern Nutrition in Health and Disease, 8th ed. Lea & Febiger, Phil.,1994:326-358
[5] DeCava JA. The Real Truth about Vitamins & Antioxidants. A Printery, Centerfield (MA), 1997
[6] The United States Pharmacopeial Convention. USAN and USP Dictionary of Drug Names. Mack Printing, Easton (PA),1986
[7] Turnland JR. Bioavailability of dietary minerals to humans: the stable isotope approach. Crit Rev Food Sci Nutr,1991;30(4);387-396
[8] Schumann K, et al. Bioavailability of oral vitamins, minerals, and trace minerals in perspective. Arzneimittelforshcung,1997;47(4):369-380
[9] Ha SW. Rabbit study comparing yeast and isolated B vitamins (as described in Murray RP. Natural vs. Synthetic. Mark R. Anderson, 1995, p:A3). Ann Rev Physiol,1941; 3:259-282
[10] Thiel R. Natural vitamins may be superior to synthetic ones. Med Hypo.2000;55(6):461-469
[11] Thiel R.J, Fowkes S.W. Can cognitive deterioration associated with Down syndrome be reduced? Medical Hypotheses, 2005; 64(3):524-532
[12] Traber MG, Elsner A, Brigelius-Flohe R. Synthetic as compared with natural vitamin E is preferentially excreted as alpha-CEHC in human urine: studies using deuterated alpha-tocopherol acetates. FEBS Letters, 1998;437:145-148
[13] Ross A.C. Vitamin A and Carotenoids. In Modern Nutrition in Health and Disease, 10th ed. Lippincott William & Wilkins, Phil, 2005: 351-375
[14] Lucock M. Is folic acid the ultimate functional food component for disease prevention? BMJ, 2004;328:211-214
[15] Williams D. ORAC values for fruits and vegetables. Alternatives, 1999;7(22):171
[16] Thiel R. Vitamin D, rickets, and mainstream experts. Int J Naturopathy, 2003; 2(1)
[17] Traber MG. Vitamin E. In Modern Nutrition in Health and Disease, 9th ed. Williams & Wilkins, 1999:347-362
[18] Olson R.E. Vitamin K. In Modern Nutrition in Health and Nutrition, 9th ed. Williams & Wilkins, Balt., 1999: 363-380
[19] Hamet P, et al. The evaluation of the scientific evidence for a relationship between calcium and hypertension. J Nutr, 1995;125:311S-400S
[20] Ensminger AH, Ensminger ME, Konlade JE, Robson JRK. Food & Nutrition Encyclopedia, 2nd ed. CRC Press, New York, 1993
[21] Wood R.J., Ronnenberg A.G. Iron. In Modern Nutrition in Health and Disease, 10th ed. Lippincott William & Wilkins, Phil, 2005: 248-270
[22] Rude R.K., Shils M.E. Magnesium. In Modern Nutrition in Health and Disease, 10th ed. Lippincott William & Wilkins, Phil, 2005: 223-247
[23] Biotechnology in the Feed Industry. Nottingham Press, UK, 1995: 257-267
[24] Andlid TA, Veide J, Sandberg AS. Metabolism of extracellular inositol hexaphosphate (phytate) by Saccharomyces cerevisiae. Int J. Food Microbiology. 2004;97(2):157-169
[25] King JC, Cousins RJ. Zinc. In Modern Nutrition in Health and Disease, 10 th ed. Lipponcott Williams & Wilkins, Phil., 2005:271-285

Some of these studies (citations) may not conform to peer review standards. Therefore the results are not conclusive. Professionals can, and often do, come to different conclusions when reviewing scientific data (peer-reviewed or not).

This site provides information for doctors, wholesalers, and health care professionals and is not intended for use by consumer.