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Arginase Bladder™– Nutritional Support for Urine Metabolism and Bladder

Arginase Bladder™– Nutritional Support for Urine Metabolism and Bladder

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Urination is something many people think little about unless something goes wrong.  From excessive urination to nocturnal enuresis to urinary tract infections to urinary incontinence, urinary issues are problems for many.

Most people do not realize that in order to produce urine, the body processes liquids into an intermediate stage which is high in the amino acid called arginine. Normally the liver produces enough of the enzyme arginase to convert and concentrate this liquid into urea (urine) [1]. When it does not, however, in some people this seems to cause the body to try to expel this high arginine liquid excessively, both day and night.

Decades ago a nutrition-based biological process was developed to assist the body with this aspect of urine metabolism . And now, there is actually one and only one 100% food product that utilizes this special biological process without any USP “nutrients” called Arginase Bladder. Arginase bladder is a 100% Food supplement that is intended to supply nutrients to support healthy kidney and bladder function. The kidneys process proteins and liquids and are the primary organs involved in eliminating metabolic waste products from the blood. Arginase Bladder is intended to support the cleansing ability of the kidneys.  It has been written that this type of product is indicated sometimes when there is “[p]ain in area of kidneys or bladder (may radiate through dorsal region to liver area) burning on urination; uremia, uriniferous odor of breath, itching of skin from “salty” (residue) perspiration; edema; ascites, dropsy, etc.; toxemia, body odor, pasty skin, biliousness; liver disease, enlargement, diminished urination, veinous congestion, etc”.a valuable adjunct in all problems involving the liver and kidneys, particularly where this is evidenced by systemic manifestations involving the detoxification mechanisms and fluid balance” [2].

It is a scientific fact that, “Arginase hydrolyzes arginine to urea”. In addition to raising serum arginine levels, arginase deficiency can lead to raised ammonia levels [3]. Arginase is produced in the liver [1,3].

Arginase Bladder contains ingredients which have been used to nutritionally support the bladder and various aspects of urine metabolism. 

Acerola Cherry is one of the most vitamin C dense foods [4]. Arginase is activated by vitamin C [5]. One study found that vitamin C taken prophylactically by pregnant and nursing mothers could reduce the incidence of urinary tract infections [6]. 

Beet and rice specially processed with Rhizopus oryzae and Tillandsia usneoides has long been used to support, “Intermediate processes involving urea metabolism which support liver and kidney function where toxic overload places stress on these organs” [2]. Many decades ago, Royal Lee, Bill Hansen, and David Roderick worked together. A special type of biological process for urinary support was developed around that time that David”s son Steven Roderick uses for Arginase Bladder. Beets themselves have long been used for kidney and bladder disorders [7].

Bovine kidney supplies kidney tissue. Kidney tissue naturally contains kidney enzymes, proteins, and other peptides needed for proper renal function. “The kidneys perform their most important functions by filtering the plasma and removing substances from the filtrate at a variable rate, depending upon the needs of the body. Ultimately, the kidneys “clear” unwanted substances from the filtrate (and therefore from the blood) by excreting them in the urine while returning substances that are needed back to the blood”Urine formation begins with filtration of large amounts of fluid through the glomerular capillaries into Bowman”s capsule”The kidney conserves water by excreting a concentrated urine” [8]. Helping concentrate urine also reduces the possibility of urinary tract infections, and reduces extra trips to the restroom. Kidney tissue is recommended for urinary tract infections and to strengthen the kidneys [9]. 

Bovine liver supplies liver tissue. Bovine liver tissue contains the substances naturally found in the liver, like arginase [1]. In order to convert the high arginine intermediate substrate into urea and orthinine, the body uses the enzyme arginase. “The liver has the greatest amount of this enzyme, and accounts for the majority of urea synthesis”[a] small amount is carried out by the kidney and brain”the hydrolysis of arginine to urea and orthinine makes possible the urea cycle” [1]. An excess accumulation of arginine (due to insufficient arginase) contributes to excessively frequent urination (as the body tries to flush this diluted semi-urine out) and increases in urinary tract infections (as this less concentrated semi-urine is a less hostile environment for pathogens than concentrated urine is). “The liver is well known for its ability to detoxify or excrete”many drugs”hormones” and other substances” [8]. The liver tissue found in Uro-Kid Supportis from New Zealand.

Buckwheat juice and seed has long been used as part of nutrition to support the intermediate processes involving urea metabolism and “support liver and kidney function where toxic overload places stress on these organs” [2]. “A 20% drop in systolic level is not unusual in the initial stages, progressively lowering under long term use. Importance of protracted treatment should be stressed” [10]. Though most often recommended for capillary and venous health (i.e. bruising, varicose veins) [10,11], naturopaths, chiropractors, and holistic doctors have long recommended its leaves or its immune supporting components in products to fight viral and bacterial infections [9,12,13]. In addition to containing chlorophyll, presumably active components include rutin, quercitin, and hyperoside [11] (it also contains other semi-unique Food substances that may be actively needed). It should be noted that, despite its name, buckwheat is not taxonomically related to wheat, and is often used in gluten-free, wheat-free diets [14]. 

Carrots are probably the highest concentrated Food source of the vitamin A precursor beta carotene. “Scientists in India have discovered that carrots afford significant protection for the liver” as carrots contain substances which “increase the activity of several enzymes that speed up detoxification of the liver and other organs” [15]. Carrots appear to have some bladder protection benefits [16].

Goat bladder supplies bladder tissue. Bladder tissue naturally contains the peptides and enzymes that the bladder needs for nutritional support. “The urinary bladder”is a smooth muscle chamber composed of two main parts: (1) the body, which is the major part of the bladder in which urine collects, and (2) the neck, which is a funnel-shaped extension of the body”connecting with the urethra”sensory fibers detect the degree of stretch in the bladder wall. Stretch signals from the posterior urethra are especially strong and are mainly responsible for bladder emptying” [8]. 

Peas have been shown to contain a substance that has “arginine decarboxylase (ADC) activity” [17]. This means that it can help break carbon away from arginine [1,8]. Peas have long been part of arginase related products [i.e. 2]. 

People simply take 100% Food Arginase Bladder to feel better.


[1] Bondy PK, Rosenberg LE. Duncan”s Diseases of Metabolism, 7th ed. W.B. Saunders Co., Phil., 1974
[2] Lee R. Arginex. In Product Bulletins, circa 1950
[3] Iyer R, Jenkinson CP, Vockley JG, Kern RM, Grody WW, Cederbaum S. The human arginases and arginase deficiency. J Inherit Metab Dis. 1998;21 Suppl 1:86-100
[4] Hendler SS, Rorvik D, eds. PDR for Nutritional Supplements. Medical Economics, Montvale (NJ), 2001
[5] Ruskin SL High Dosage Vitamin C in Allergy. Am J Dig Dis. 1945;12(9):281-313
[6] Ochoa-Brust GJ, Fern”ndez AR, Villanueva-Ruiz GJ, Velasco R, Trujillo-Hern”ndez B, V”squez C. Daily intake of 100 mg ascorbic acid as urinary tract infection prophylactic agent during pregnancy. Acta Obstet Gynecol Scand. 2007;86(7):783-787
[7] Ingram C. Super-Market Remedies. Knowledge House, Buffalo Grove (IL), 1998, p. 82
[8] Guyton AC, Hall JE. Textbook of Medical Physiology, 9th ed. WB Saunders, Phil., 1996
[9] Balch JF, Balch PA. Prescription for a Nutritional Healing, 2nd ed. Avery Publishing, Garden City Park (NJ), 1997
[10] Lee R. Cyruta. In Product Bulletins, circa 1950
[11] Gruenwald J, Brendler T, Jaenicke C, eds. PDR for Herbal Medicine, 4th ed. Thompson PDR, Montvale (NJ), 2007
[12] Thiel R. Serious Nutrition for Health Care Professionals, 2n ed. Center for Natural Health Research, Arroyo Grande (CA), 1996
[13] Versendaal DA. Contract Reflex Assessment and Applied Trophology. Dr. D.A. Versendaal, Holland (MI), 1990
[14] Hafstrom I, Ringertz B, Spangberg A, et al, A Vegan Diet Free of Gluten Improves the Signs and Symptoms of Rheumatoid Arthritis: The Effects on Arthritis Correlate With a Reduction in Antibodies to Food Antigens. Rheumatology, 2001;40:1175-1179
[15] Duke JA. The Green Pharmacy. Rodale Press, Emmaus (PA), 1997
[16] Mettlin C, Graham S. Dietary risk factors in human bladder cancer. Am J Epidemiol. 1979;110(3):255-263
[17] Perez-Amador MA, Carbonell J. Arginine Decarboxylase and Putrescine Oxidase in Ovaries of Pisum sativum L. Changes during Ovary Senescence and Early Stages of Fruit Development). Plant Physiol. 1995 Mar;107(3):865-872

Some of these studies (or citations) may not conform to peer review standards (though most do). Therefore, the results are not conclusive. Professionals can, and often do, come to different conclusions when reviewing scientific data. None of these statements have been reviewed by the FDA. All products distributed by Doctors” Research, Inc. are nutritional and are not intended for the treatment or prevention of any medical condition.

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Some natural health products contain glandular ingredients and many doctors have used glandulars for years with great success.  Glandular organs, such as heart, aorta, and liver, have been a food source in the human diet for centuries. The consumption of glandulars is believed to provide nutritional support to the corresponding gland in the human body. Glandular organs contain food vitamins and minerals and were often used in the past to supply various nutrients.

Glandulars also contain nutritional peptides, enzymes, and substances believed to be hormone precursors. However, it is unclear precisely how these substances may affect energy levels, health, and/or mental function.  Glandular therapy has alternative names such as: organotherapy, cell therapy where extracts are injected; and live cell therapy which normally uses extracts orally or intravenously.

Unlike plants, fauna have most of the same biological materials (like enzymes and other peptides) that humans do [1]. While it was once believed that there were 7,000-9,000 enzymes in the human body, it is now believed that there are as many as 75,000 [2].

Consuming glandulars helps directly supply enzymes. Enzymes are biological catalysts that encourage metabolic, catabolic, and digestive processes in the body. They help rebuild and detoxify. Enzymes tend to be specific, such as eye enzymes tend to help the eyes, but are ignored in the ear. Enzymes help the respective organs they are involved with function better.

Vastly more of the enzymes that humans use are in glandulars than in plants.

Adrenal glandular support is often used by people who are under stress, fatigued, having difficulty getting up in the morning, who have adrenal stress headaches, or have an abnormal craving for salts [3].  Adrenal tissue is normally taken with meals.

Brain glandulars contain “specific brain cell activators”[4]  and have been advised for slowness of thought, loss of memory, uncontrolled mental activity, nightmares, mental retardation, and epilepsy [5,6]. A double-blind study involving bovine-brain derived phosphatidylserine found it was able to improve both behavior and cognition in elderly people with cognitive decline [7].  “…phosphatidylserine enhances the ability of enzymes in membranes of nerve cells to relay messages in and out of the cells.  Research suggests that the glandular source phosphatidylserine is more effective than soy isolate sources [8].

Cardiovascular glandulars are normally made from bovine heart. This tissue is sometimes used by people with low blood pressure, overwhelming fatigue, people who need strength, people who feel cold, and athletes interested in improved performance. It is normally best not to take heart tissue late in the day (at breakfast and lunchtime is best for most people), as any heart glandular support product can affect sleep if taken late in the day [9]. Heart tissue, if appropriate, tends to show its benefits rather quickly (within a week or two for most people), though this varies.  Heart tissue has historically also been used as an aid in glucose uptake and the manufacture of ATPs [6].

Ear glandular tissue, if available, is often taken for people with hearing concerns.  If also taken with a form of moss, some report assistance with tinnitus.

Eye glandular tissue, if available, is often taken for eye and vision issues, including macular degeneration. It has been written that eye glandular extracts have been shown to improve “the general intregity of the eye tissue” and may be useful for eye strain as well as… “for failing vision associated with the aging process” [6].

The hypothalamus is the body’s master endochrine gland [10]. As such, it can effect basically all body systems and hormones. The hypothalamus also can increase feelings of tranquility [10].

Liver is probably the most widely used glandular supplements.  The liver is the chemical factory of the body and feeding the liver can help when other approaches have not been effective.  Historically, bovine liver has also been used for some enlarged livers, forms of anemia, and for support when chronic degenerative diseases are encountered [6]. Clinically, it seems helpful for many who have raised liver enzymes, especially if given with detoxifying herbs like silymarin, red beet, and garlic.

Bovine lung tissue has historically been used by those with respiratory disorders (such as bronchitis, asthma, chronic coughs, chest colds), convalescent stages (of pneumonia, colds, flu), and pulmonary involvements (including accidents, industrial fumes, dust inhalation, and even adrenal insufficiency) [11].

Some women take bovine mammary tissue. The breasts are involved in lactation, sexual attraction, and sexual response. Bovine mammary tissue has been sometimes advised for disorders related to female breasts such as nipple pain, lymph node enlargement, breast underdevelopment, mastitis, menstrual pain, nipple inflammation, congestion, and lactation difficulties [12]. It may be of interest to note that the National Cancer Institute has studied bovine mammary tissue to find out what may be in it that helps prevent cows from getting breast cancer.

Orchic is a word for testicle. Royal Lee claimed bovine orchic gland extracts could be indicated for those with nervous tension, lowered tolerance to stress, depression, loss of psychic tone, bruising on slight trauma, loss of appetite, skin lesions, adrenal insufficiency, nervousness, insecurity, mental aberrations, lack of feeling of well-being.

The ovaries are involved in female reproduction.  Bovine ovarian tissue is sometimes advised to help some woman sleep at night, reduce the production of acne, improve mood, sometimes aid in menopausal issues, and for some women, increase fertility [13]. As it has effects that differ from thyroid support, it is often advised to take ovarian tissue before bed.

The pancreas is instrumental in the regulation of blood sugar and is one of the most important organs related to a healthy digestive system. The pancreas produces trypsin and is operational in intermediate protein metabolism [6]. Bovine pancreas is often used to assist in the digestion of grains and other foods.

Cytotrophic bovine spleen extracts have historically been taken by people with allergic reactions (hives, canker sores, cold blisters), lymph node swelling, blood concerns (anemia, lymphocytosis), demineralization accompanied by hyperirritability, as well as those with lowered resistance to infections and boils [14]. Some have suggested that bovine spleen “may aid in the elimination of allergic breakouts” [6].

Bovine thymus tissue is often used for immune system support.  It is sometimes taken by people with staph, strep, and other bacterial concerns.  Because it has few ingredients, it is useful to consider for those with other allergies, young children, and even pregnant women when they need immune system support. Bovine thymus has also been historically recommended when hyperglandular conditions, like hyperthyroid, hyperadrenal, etc., are encountered [15].  Oral supplementation with bovine thymus has been shown to be capable of enhancing T-lymphocyte activity, probably due to a thymosin-like activity [16].

Bovine thyroid tissue (note: bovine thyroid glands are thyroxine-free, thus do not result in a shutting down of the thyroid gland when taken). Thyroid tissue is used by people with symptoms associated with low thyroid such as afternoon tiredness, poor circulation, poor temperature tolerance, headaches, low metabolism, diminished female libido, weight concerns, and sometimes dry skin [17]. It is normally best not to take thyroid tissue late in the day (at breakfast and lunchtime is best for most people), as any thyroid support product can affect sleep if taken late in the day. Some people will find that their appetite will temporarily increase when taking it, but not only does this tend to normalize, it normalizes to the point that most people will find that they crave junk food, caffeine, and similar items less, but water, fruits, and even vegetables more.

Bovine uterus extracts have long been used for women with leucorrhea, uterine cysts, fibroids, uterine displacement, excessive or scanty mense, some types of sterility, menstruation cramps, prolapse uterus [6, 18].  Some practitioners have found uterine glandulars to be helpful for female moods.  Some practitioners recommend uterine glandulars during the last month of pregnancy to provide nutritional support for the uterus in order to strengthen it to make it easier to push out a baby.  Some also believe, that if continued after parturition, that supporting the uterus in this manner improves recovery by aiding the uterus, reducing its swollen condition. Furthermore, women have tended to report little or no postpartum depression if they began consuming uterine glandulars a few weeks before delivery through several weeks after delivery.

General Information on Glandulars

Glandulars contain nutritional peptides, enzymes, and substances believed to be hormone precursors. Although some believe that oral consumption of dried glandulars is no different than consuming any other protein-containing food, this belief appears to be based on the fact that the stomach breaks down proteins into their constituent amino acids and that there is no benefit from consuming foods containing specific peptides. However, this belief ignores the fact that some ingested protein is not broken down into its constituent amino acids.

Evidence suggests that with oral consumption of glandular extracts, a small percentage (5-10%) of their peptides are not broken down into their constituent amino acids but are available for intact absorption in the small intestine [19-22].  A small amount of these absorbed peptides then circulate and some of them appear to assist the human body (especially for ill persons) in performing various anabolic and catabolic processes [18-22]. Howell and others have reported that the amount of enzymes that pass through the stomach is even higher (nearly 50% [23]). Howell has also reported that individuals with significant health problems have been found to have lower levels of enzymes than healthy individuals and that oral enzyme supplementation has been helpful for many such people [22]. Although this position is not universally accepted [24], a study in the Journal of Surgery showed that oral pancreatic supplementation resulted in improved enzyme and growth levels for children who had a pancreaticoduodenectomy [25]. Research has suggested that bovine glandulars may be helpful for thyroid support [26], myoclonic seizures [27], and even CHARGE syndrome [28].

Some glandular extracts also contain small, safe amounts of hormones that may contribute to their possible effectiveness. The thymus gland contains thymic hormones which Schulof found may enhance immune response for people with HIV [14]. It should be noted that many substances contained within animal tissues are similar or identical to their human counterparts [1,29-31], including certain enzymes [29] and even T cell gene regions [30]. One advantage of glandulars over herbs is that raw ovine (sheep) and bovine (cow) glandulars often contain enzymes that are identical to those in the human body, while herbs rarely do.

Some research indicates that protein contained within cow’s milk appears to slow the growth of certain human toxic cells [28]; also cows do not appear to be that susceptible to getting breast cancer [32]. Thus it may be reasonable to conclude that other substances contained within or derived from bovine/ovine sources may be helpful for other human diseases.

Harrower, a pioneering researcher of oral glandulars, believed glandulars were effective because endocrine glands experienced something he referred to as “hormone hunger” [33].  Harrower wrote:

 “The practical application of this idea concerns the administration of combinations of glands in presumed pluriglandular disturbances. If, for instance, in the conditions mentioned above there is a noticeable deficiency in several of the glands of internal secretion, the thyroid, ovaries and pituitary gland for instance, there may be varying degrees of hormone hunger on the part of the organs involved, and this will influence very definitely the amount of hormones that may be missing or needed by the glands to be stimulated.”

It should be noted that when Harrower used the term “hormone” this probably should be interpreted to also include nutrients, both known and unknown, including enzymes, peptides, and hormone precursors. Harrower referred to vitamins (then newly discovered) as “plant hormones” and he called hormones the “active principles obtained from certain glands” [33].

“There is a lot of controversy about the activity of glandulars given orally… It appears the effectiveness of glandulars comes in a multi-facteted way. These facets may be grouped into three basic categories: A. Hormonal; B. Enzymatic; C. Nutritive… Any gland given for therapeutic use should contain the whole nondenatured gland… The hormones are at the same strength as those found in the natural organ, except that the water has been removed leaving only the dried concentrated tissue.  These hormones fall into various categories and forms:

        1. Steroids;
        2. Peptides;
        3. Catecholamines;
        4. Amino Acids;
        5. Prostaglandins;
        6. Nucleotides.

Their hormonal factors can be broken down into two categories:  A. Lipid soluble hormones;  B. Water soluble amino bases and acids… The problem with steroid or prostaglandin therapy is that the medical sciences have removed them from the naturally occurring matrix which has a fine balance of steroids and prostaglandins. There is a natural law which applies in the universe and even more so in biochemistry. For every biochemical reaction or mechanism, there is an opposing ‘feedback’ mechanism. For this reason the balance must be maintained and taking glandulars are both therapeutic and very safe since this balance is maintained.  It is only when the hormones are isolated and given in large doses that side effects take place, such as ulcers in steroid therapy or liver destruction in synthetic testosterone therapy. The second class of hormones is more diverse, but just as effective and important. These are the polypeptides and phyiogenic amines such as neurotransmitters and catecholamines… And the incredible thing about these peptides is that they become more active upon digestion. They are normally secreted in long chain proteins which are then broken down into endorphins which are then digested by specific proteases into the active hormones… Therefore, most of the protein is assimilated in peptide form not amino acid form.  What this means is that glandulars can actually be activated by digestion” [34]. It should be noted that bovine thyroid does not itself contain substantial amounts of thyroxin which is why it is appropriate to feed the human thyroid gland. Many raw glandular preparations contain substances that can facilitate the conversion of various susbtrates into hormones.

Cooking destroys enzymes [23]. The primary difference between raw and desiccated glandulars is the enzyme content [34]. “1. Processing is very important in maintaining enzyme activity; 2. Digestion is required to activate enzymes and peptides… how are they absorbed? …they are absorbed through standard biological processes.  Up to a third of your food is absorbed through the lymph system.  This is basically an open portal system which permeates through the entire digestive tract allowing large molecules such as fat micelles, enzymes, and other molecules to pass into the blood stream. Other routes of absorption are active transport mechanisms such as chemotaxis… another route is immune-absorption where the protein or molecule combines with another protein and is carried in piggy back… The third category for glandular therapy is as a food… They are rich in protein and minerals and B-complex” [34].  It should be noted that when, for example, an adrenal enzyme reaches the toes basically nothing happens as the adrenal enzymes (as well as others) are specific to, in this case, the adrenal glands.  Once reaching the adrenal glands, they help the adrenal glands through various anabolic and catabolic reactions.

Animal glands have been consumed since the beginning of history [35], and even now scientific studies involving them are being published [e.g. 36]. “Glandular products have been produced and used in the U.S. for over 60 years with absolutely no reports of microbial contamination or resultant illness” [36]. They are consumed in many countries, including the U.S. as food [35,38]; they may even contain substances to reverse diseases associated with Western diets [35]. Regarding glandulars, it has been reported that, “overdosing is not a concern.  Even when excess amounts have been ingested, the body can easily deaminize them” [35]. A search of the literature found one report (in a letter to the editor) of a single, temporary complaint; the glandular raised thyroid hormones levels which normalized when consumption was discontinued, from using a thyroid glandular product combined with lithium, but the daily consumption (45 tablets) was in excess of any reasonable consumption (daily quantity of thyroid hormones present: 0.5mg T4 and .09mg of T3) [38].

No long-term, negative side effects from taking glandular supplements are known [37].

New Zealand and Argentine Glandulars

New Zealand and Argentinean farmers tend to raise their cows and sheep naturally more than those raised in places like the USA. The animals almost exclusively consume unfertilized natural grasses as are found in the pastures of those lands. Neither New Zealand nor Argentina has ever had a case of BSE (bovine spongiform encephalopathy) nor scrapie, a similar disease found in sheep [38-42].

Ovine, Bovine, and Goat

Many of the pioneering glandular researchers [42] prefer ruminant source (bovine {cow}, goat, or ovine {sheep}) glandulars to glandulars from other animals for many reasons:

        1. Doctors using them have a history of receiving positive results from people with a wide variety of disorders.
        2. Bovine/ovine tissues are the most commercially available.
        3.  Ruminant glandulars have a long history of being safe to consume.
        4. Ruminant tissues are considered to be dietary supplements under the Dietary Supplement Health and Education Act of 1994 (DSHEA) and as such are not considered to be food additives.
        5. Earlier research has demonstrated that heterologous tissues (such as bovine/ovine for humans) do not produce the adverse and possibly toxic side effects that more homologous tissues can (such as simian for humans) [42].
        6. Some earlier research suggested that immune response in humans was improved at a much greater rate with the use of substances from ruminant sources as opposed to non-ruminant sources (simian and feline) [43]. At least one researcher reported long ago that rat tissue extracts also appear to cause a variety of problems when forced into some animals [42].

Clinically, ovine, goat, and bovine glandulars are also preferable to porcine (pork) glandulars as followers of many religious faiths (Islam, Judaism, Seventh-day Adventists, and various Churches of God) will not consume pork, but will consume meat extracts from sheep, goats, or cows.

Bovine glands contain essentially nutrients such as protein, essentially fatty acids, calcium, iron, magnesium, phosphorus, potassium, and zinc [44,45]. Depending on the gland, they also can contain essential vitamins such as vitamin C, thiamin, riboflavin, vitamin B-3, vitamin B-6, folate, vitamin B-12, vitamin D, vitamin E, and vitamin K [44,45].

Freeze Drying vs. Desiccation

“Another term for freeze-drying is sublimation. It is the shifting of a solid directly into a gas. Freeze drying is a slow process that preserves nutrients, enzymes, and protein structures while making the food shelf stable, so it does not require refrigeration. Orijen explains their take on freeze-drying and the process that they use: ‘Freeze drying does not involve cooking, it requires only two stages: solid and vapor. This means that only the water is removed, so all of the flavour and nutrients remain locked inside. We start by flash-freezing our fresh ingredients to lock in their goodness. Then using extremely low temperatures (-50C) and special pressurized chambers, our 18 hour freeze-drying process converts the frozen water in our ingredients directly into vapor, without creating any liquid. That means H20, and ONLY H20 is removed, leaving all of the goodness in the food.’ Freeze-dried food is nutritionally equal to raw food, except for the lack of moisture [46].” It also results in a product that can be more finely ground to increase absorption.

Glandulars supplements can be made in several ways. The cheapest way is through desiccation, which essentially dries the glandular at high temperatures. The biggest problem with desiccation is that it destroys all the enzymes that are in the tissue. Desiccation may also destroy other active substances contained within the gland. Some companies use a salt-drying process, but this tends to result in glands with a high sodium content which can cause digestive complaints for adrenal-containing products. One of the most expensive ways to produce glandulars is through a non-heat, vacuum-drying process (“freeze-drying”). This low temperature process helps preserve many of the naturally-present enzymes. When looking for enzymatic activity, researchers have concluded that the “process  of  freeze  drying  resulted  in  a  more  complete  drying  and  preserved  more  enzyme  activity” [47].

“Freeze-dried foods have some high quality characteristic compared to products of alternative drying process … Drying removes the moisture from the food so bacteria, yeast and mold cannot grow and spoil the food, so can extend the shelf life. Drying also slows down the action of enzymes, but does not inactivate them. … The application of freeze-drying process to foods is most important appears to be for meats such as beef” [48]. “Freeze drying can best preserve meat original color, aroma, taste and nutrients. Freeze drying was conducted under the conditions of low temperature and high oxygen, thus microbes and enzymes have no effect on it, food is also not affected by oxidation, food color, aroma, taste and nutrition loss minimum, so especially suitable for drying food of extremely thermal and oxidation easily. Freeze-dried is not damaging protein in meat, fat soluble vitamins VA, VD, etc have no loss” [49]. “Freeze dried foods retain nearly 100% of the health benefits of the original food product. Active enzymes, nutrients, antioxidants, amino acids, and more remain “locked in”. When frozen, vital molecules remain in place and so the overall integrity of the nutritional composition remains intact. The freeze dried food is still considered a “raw food” that remains vibrant and alive in a dormant state just waiting for moisture to reactivate” [50].

Natural health doctors generally prefer non-heat drying methods to desiccation even though that does increase the cost of the product. Non-heat drying results in a glandular that is the closest to ‘whole food.’

Protomorphology and EnzoMorphoGens

Royal Lee often used a salt-drying process for glandulars. This may be why, although he advocated whole glands for acute problems, he tended to prefer more processed glandular extracts for long term consumption. While that was fine for his time, freeze-drying later became commercially available. In this author’s view, that made a generally superior glandular product for long term consumption.

Anyway, it appears to partially boost the efficacy of salt-dried glandulars, Royal Lee came up with a process to add back part of the gland and he referred to the end product as a protomorophogen.

Here is some of what he reported:

It is obvious that the ability of molecules to hang together and maintain a complex intricate structure must be limited. … Beatle (1946) … postulates … a hypothetical “protogene.” This “protegene” … is the “skeleton” of the living protein molecule, which we prefer to term “protomorophogen”  …  We propose to advance our hypothesis that further extensive development of the living protein depends on a “skeleton” to maintain its stable complicated forms. … The “skeleton” of the complicated protein molecule, the chromosomes of the higher organism … are specialized units whose primary responsibility is that of preserving the integrity of organization.  …

The species specific qualities of protein can be identified only by their biological effect. … We suggest that the “skeleton” of the specific protein molecule has the unique function of creating and maintaining the specific character and form of the molecule. We speculate that the essential duty of this organizer is to act as an organizer. …

We define a protomorphogen as a comparatively stable but complex group of molecules linked together by chemical affinities of mineral material, which by reason of its physical and chemical structure determines the exact plan or pattern by which the component parts of a specific protein are combined. …

Protomorphogens, as found in living organisms, are virus-like nucleoprotein molecules … Being nucleoprotein in nature (in its functional state) … they are soluable in saline solution; …

Protomorphogen is, therefore, the initiating stimulates to formation of connective tissue in the organism. … thyroid activity is more complicated … [51].

Yes, specific biological effects are important. Dr. Lee’s protomorphogens were essentially a component of the whole animal gland extracted in a liquid form that were added to a base.

Of course, since not everyone is the same, some will do better with some modified glandulars or blends, while others will do better with whole glandular products.

As it turned out, it is this author’s understanding that, in time, Royal Lee’s original protomorphology extract process was replaced with a different process. In this author’s opinion, the later process was not an improvement consistent with some of Royal Lee’s writings.

However, a different company founded by people who once worked for Royal Lee also developed an enzymatic extraction process to boost certain biological effects of glands. The end result of this process produces glandulars that are known as enzyomorphogens (EMGs). For certain applications, this results in a superior product.

Clinically, most protomorphogen and enzyomorphogen extract-containing products have a similar effect. Also, clinically, for many glandular applications, whole freeze-dried glands have similar effects. This is logical as the whole gland does also contain whatever substance(s) that could possibly be extracted from it.

That being said, however, clinically this author has found that while many EMGs and whole freeze-dried glands can be interchanged, this is often NOT the case with thyroid glandulars. A whole thyroid glandular product tends to be “stronger” than an EMG-type product. Hence, not nearly as interchangeable.

Typically, when seeking a milder effect, this author will recommend an EMG-type product (particularly for elderly women). On the other hand, if a stronger effect is indicated (like, perhaps, in the case of someone who is severely obese), a whole thyroid glandular tends to be recommended (also, for about one week per month, whole thyroid glandular supplements tend to be better for women with PMS symptoms).

Anyway, everyone is different, and clinically what is best for one is not always best for another.

Why Aren’t They Used More?

In this age of COVID-19, there are multiple reports of long-term damage to lungs, kidneys, and other organs [52], glandulars of many types should be considered as something that people can do to help their bodies.

Sadly, most healthcare professionals do not realize that. Few have had much training on glandulars.

Since glandulars combined with herbs tend to work faster and sometimes better than herbs alone, why else aren’t glandulars used more?

Beyond lack of knowledge another reason is that, generally speaking, glandular ingredients cost more money than herbal ingredients. Many companies simply will not use them for that reason. Another reason is many people believe that plants are always the answer. And although for some problems they are, they are not always the best choice as plants almost never contain identical glandular enzymes.

Glandulars can help replenish enzymes, peptides, and other nutrients for the body in ways vegan supplements cannot.

Glandulars should be considered more by health care professionals.


[1] Hulsey MG, Martin, RJ.  The role of animals in nutritional research.  Nutr Today,1993;28 (5):1993
[2] The Handy Answer Book Series, 2nd edition. Visible Ink Press, 2014

[3] Lee R. Adrenamin.  In Product Bulletins, circa 1950

[4] Lee R.  Therapeutic Food Manual, Lee Foundation for Nutritional Research, Milwaukee, circa 1950;14

[5] Lee R.  Brain Cytotrophin. Lee Foundation for Nutritional Research, Milwaukee, circa 1950

[6] Profiles in Nutritional Progress.  Rubicon Productions, Bakersfield, 1993

[7] Cenacchi T, et al.  Cognitive decline in the elderly: a double-blind placebo-controlled multicenter study on the efficacy of phosphatidylserine administration.  Aging Clin Exp Res. 1993;5:123-133

[8] Dean W, Morgenthaler J, Fowkes SW.  Phosphatidylserine.  In Smart Drugs II: The Next Generation.  Smart Publications, Petaluma (CA), 1993:75-80

[9] Thiel R. Serious Nutrition for Health Care Professionals, 2nd ed.  Center for Natural Health Research, Arroyo Grande (CA), 1996

[10] Guyton AC, Hall JE.  Textbook of Medical Physiology, 9th ed.

[11] Lee R. Pneumotrophin.  In Product Bulletins, circa 1950

[12] Lee R. Mammary Cytotrophin.  In Product Bulletins, circa 1950

[13] Lee R. Ovary Cytotrophin.  In Product Bulletins, circa 1950

[14] Lee R. Spleen Cytotrophin.  In Product Bulletins, circa 1950

[15] Lee R.  Thymex. In Product Bulletins, circa 1950

[16] Schulof RS, et al.  Phase I/II trial of thymosin fraction 5 and thymosin alpha one on HTLV-III seropositive subjects.  J of Biologic Response Modifiers,1986; 5: 429-443

[17] Neumann C. Serious Nutrition: Incorporating Clinically Effective Nutrition Into Your Practice.  Source Graphics, Kelowna (B.C.), 2005

[18] Lee R. Uterus Cytotrophin.  In Product Bulletins, circa 1950

[19] Gardner M. Intestinal assimilation of intact peptides and protein from the diet – a

neglected field?  Cambridge Philosophical Society, Biological Reviews,1984;59: 289-331

[20] Popov I.M., et al.  Cell therapy.  J International Academy of Preventive Medicine,1977; 3:74-82

[21] Burns D. Accumulating scientific evidence supports glandular therapy.  The Digest of Chiropractic Economics, Nov/Dec 1987: 74-79

[22] Schwartz EF. Glandular therapy.  The American Chiropractor, January/February 1983:14-18

[23] Howell E. Enzyme Nutrition.  Avery Publishing Group: Wayne (New Jersey): 11-29, 1985

[24] Green S. A critique of the rationale for cancer treatment with coffee enemas and diet.  JAMA, 1992; 268 (22): 3224-3227

[25] Shamberger RC, Hendron WH, Leictner AM.  Long-term nutritional and metabolic consequences of pancreaticoduodenectomy in children.  Surgery, 1994;115(3): 382-388

[26] Thiel R., Fowkes S.W.  Down syndrome and thyroid dysfunction: Should nutritional support be the first-line treatment? Medical Hypotheses, 2007; 69:809-815

[27] Thiel R. Might disorders of calcium cause or contribute to myoclonic seizures?  Medical Hypotheses, 2006; 66(5):969-974

[28] Thiel R. Thiel R. CHARGE (Hall-Hittner) Syndrome and Nutrition: A novel case report, 2006

[29] McCarren M.  Animals in research: researchers use animals to learn more about human diabetes.  Diabetes Forecast,1993; 46 (8): 26

[30] California Institute of Technology.  Large genome comparison reveals details of genomic evolution.  Cancer Weekly Feb 10, 1992;6: 3

[31] Bland J.  Glandular Therapy.  Circa 1989

[32] Protein in cow’s milk slows growth of cancer cells in lab tests: Mammary derived growth inhibitor (Cornell University). Cancer Weekly April 20, 1992;12:2

[33] Harrower H. Practical Organotherapy.  3rd ed.  W.B.  Conkey Co.: Hammond (Indiana): 31-36, 1921

[34] Raw Glandular Therapy.  ABCO Labs, Concord (CA), circa 1998

[35] Dunbar R. Foraging for nature’s balanced diet.  New Scientist August 31, 1991:25-28

[36] Thiel R. Might disorders of calcium cause or contribute to myoclonic seizures?  Med Hypo. 2006; 66(5):969-974

[37] DeCava JA. Glandular supplements. Nutrition News and Views 1997; 1(3):1-10

[38] Cooper N, Palmer B. Thyroid hormone in a health food capsule.  New Zealand Medical Journal 1994: 231

[39] JOINT STATEMENT FROM THE NEW ZEALAND FOOD SAFETY AUTHORITY AND MINISTRY OF AGRICULTURE AND FORESTRY. BSE in the US has no food safety impact in New Zealand or threat to our animal health status. 24 December 2003

[40] New Zealand’s Scrapie Freedom. New Zealand Food Safety Authority. 2/16/06

[41] Scudel A.A, et al. Analysis of risk factos and active surveillance for BSE in Argentina. 02/16/06

[42] Lee R, Hanson W. Protomorphology: The Principles of Cell Auto-Regulation. Lee Foundation for Nutritional Research, Milwaukee, 1947

[43] Nuttall, Dr. Blood Immunity and Blood Relationships.  Cambridge University Press, London, 1904
[44] Basic Report: 13321, Beef, variety meats and by-products, heart, raw. National Nutrient Database for Standard Reference Legacy Release, April, 2018

[45] Basic Report: 13325, Beef, variety meats and by-products, liver, raw. National Nutrient Database for Standard Reference Legacy Release, April, 2018

[46] The Difference Between Freeze-Dried, Dehydrated and Raw Foods. Trail Blazers Pets, December 13, 2017

[47] Jesus SS, Filho RM. DRYING OF α-AMYLASE BY SPRAY DRYING AND FREEZE-DRYING – A COMPARATIVE STUDY. Brazilian J Chem Engineering. Vol. 31,  No. 03. July – September,  2014: 625-631

[48] Valentina V, Pratiwi AR, Hsiao PY, Tseng HT, Hsieh JF and Chen CC. Sensorial Characterization of Foods Before and After Freeze-drying. Austin Food Sci. 2016; 1(6): 1027

[49] Ma Y, et al. Key composition optimization of meat processed protein source by vacuum freeze-drying technology. Saudi J Biological Sciences, Volume 25, Issue 4, May 2018: 724-732

[50] What Is The Freeze Drying Process? Spruot Living, June 13, 2011

[51] Lee R, Hanson W.  Protomorphology: The Principles of Cell Auto-Regulation. Lee Foundation for Nutritional

Research, Milwaukee, 1947
[52] Moffit M. What they don’t tell you about surviving COVID-19. SFGate, June 22, 2020

Some of these studies (or citations) may not conform to peer review standards (though most do). Therefore, the results are not conclusive. Professionals can, and often do, come to different conclusions when reviewing scientific data. None of these statements have been reviewed by the FDA. All products distributed by Doctors” Research, Inc. are nutritional and are not intended for the treatment or prevention of any medical condition.

•  Photos and Images are all used by permission from & except for those that are Owned and Copyrighted by Doctors Research, Inc.

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Biofilm: What is it? Can enzymes or herbs help?

Biofilm: What is it? Can enzymes or herbs help?

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“Microorganisms attach to surfaces and develop biofilms … Biofilms have great importance for public health because of their role in certain infectious diseases and importance in a variety of device-related infections. A greater understanding of biofilm processes should lead to novel, effective control strategies for biofilm control and a resulting improvement in patient management …A biofilm is an assemblage of surface-associated microbial cells that is enclosed in an extracellular polymeric substance matrix … Several studies have shown that treatment of adsorbed cells with proteolytic enzymes caused a marked release of attached bacteria” [1].

“Biofilmaccounts for 65-80 % of microbial infections in humans” [2].

“Candida albicans … cells proliferate in a planktonic (suspension) state, but they also form biofilms, organized and tightly packed communities of cells attached to a solid surface. Biofilmscolonize many niches of the human body and persist on implanted medical devices, where they are a major source of new C. albicans infections” [3].

“Urinary tract infections (UTIs) are one of the most important causes of morbidity and health care spending affecting persons of all ages. Bacterial biofilms play an important role in UTIs, responsible for persistent infections leading to recurrences and relapses” [4].

Betagluconase is an enzyme that breaks down beta-glucans, a substance that has been implicated with bacterial caused biofilm plaque [5]. Furthermore, glucanaseand protease, degraded fungal cell walls to clear up biofilm [6].

Bilberry is a plant rich in antioxidants known as anthocyanins and polyphenols. “Urease-producing bacteria are known to produce crystalline biofilms and encrustation on catheters” and bilberry is a plant extracted urease-inhibitor, hence can be helpful to deal with biofilm and UTIs [4].

Black Walnut hull “is widely used in traditional medicine for alleviating pain and treating skin diseases” [7]. It has antioxidant properties [7] and has also long been used in traditional medicine as a blood purifier [8] and to treat parasites.

Cellulase is anenzyme that helps break down cellulose. The cell walls of fungi, including Candida, is made of cellulose. Cellulase can “Break down harmful microbial biofilms … In vitrostudies show that the cellulase enzyme can stop the growth and increase the breakdown of biofilms produced by the bacteria Pseudomonas. This may help detoxify the intestinal tract, as well as the body’s major organ systems … Other tests found an improvement in immune function for the patients. Furthermore, when the enzyme supplement was withdrawn, the positive benefits ended” [9].

DPP IV(“DPP 4”) is the acronym for the enzyme Dipeptidyl Peptidase IV. It has been found to inhibit bacterial caused biofilm [10]. DPPIV has gluten-detoxification abilities [11].

Echinacea Echinacea purpurea can help prevent viral and other infections and seems to reduce types of biofilm [9].

Endopeptidase is a proteolytic enzyme that breaks peptide bonds other than terminal ones in a peptide chain. Exopeptidase is any peptidase that catalyzes the cleavage of the terminal (or the penultimate) peptide bond; the process releases a single amino acid or dipeptide from the peptide chain.“A peptidaseis a catalytically active protein that cleaves one or more peptide bonds in a protein or peptide by hydrolysis” [12].

GarlicAllium sativahas antimicrobial properties [9]. Allicin from garlic has been shown to inhibit infectious biofilm [13].

Glucoamylase are inverting exo-acting starch hydrolases/enzymes releasing β-glucose from the non-reducing ends of starch and related substrates. “Glucoamylase, when combined with other enzymes may ease the negative effects of irritable bowel syndrome (IBS) … Studies show that glucoamylase combined with other enzymes can promote a normal autoimmunity response. In the case of autoimmune disorders, antigens, and antibodies, when not cleared out over time, can create tissue damage in the body” [14]. Hence, glucoamylase can help in detoxification.

Goldenseal Hydrastis Canadensiscontains berberine “Berberine has broad-spectrum antibiotic activity … and immune-enhancing properties. … Berberine has shown antimicrobial activity against bacteria, protozoa, and fungi … Berberine, a constituent of goldenseal, when used to treat urinary tract infections, is known to reduce synthesis of Escherichia colifimbrae, thus preventing adhesion to the bladder lining” [9]. “Berberine has been … found to reduce biofilm [15].

Grapefruit Seed Extract has certain antimicrobial properties [16,17]. It seems to help prevent biofilm when used with other substances [18].

Hemicellulase is an enzyme which “breaks down hemicellulose, which is a type of cellulose and a key component of the cell wall in all plants … Some research suggests that an increase in this enzyme can help prevent and reduce yeast infestations such as Candida. This is perhaps related to the fact that the cell wall of candida is composed of hemicellulose” [19].

Lysozyme is an enzymecatalyzes the breakdown of some carbohydrates found in the cell walls of certain bacteria that can reduce biofilm [20]. Lysozyme has been shown to inhibit Candida biofilm [21].

Milk Thistle Silybin marianum “has been shown to have a positive hepatoprotective effect in the treatment of liver cirrhosis associated with alcohol or viruses” [9]. Silymarin (a constituent of Milk Thistle) seems to have inhibitory effects on bacterial biofilm [22].

Pectinase is an enzymethat breaks down pectin, a polysaccharide found in plant cell walls. It also helps inhibit bacterial biofilm [23].

Proteolytic enzymeslike various peptidases and proteases have been shown to reduce bacterial [e.g.24] and fungal biofilm [e.g. 1,3].

Serrapeptase Serratia pepitase is a proteolytic enzyme. Its use as a biofilm buster has been speculated for Lyme disease [25]. It has also been claimed to reduce toxins associated with Alzheimer’s disease [26].

Shiitake MushroomCang Er Zi has positive immune-enhancing [27] and anti biofilm properties [28].

 Wild OreganoOrganum vulgare has “antibacterial and antifungal activity” as well as antiparasitic effects [9]. Its constituent carvacral has antibiofilm effects against pathogens such as Escherichia coli [29].

Naturopathic philosophy teaches that one is susceptible to infection if one there is an accumulation of toxins that the body does not eliminate which makes an environment that infections can thrive in [30-32]. Biofilms are such an environment.

Even those not interested in natural health realize that biofilm is a major cause of infectious disease.

Herbs and enzymes are “novel approaches’ that more health care professionals may wish to try.


[1] Donlan RM. Biofilms: Microbial Life on Surfaces. Emerg Infect Dis. 2002 Sep; 8(9): 881–89
[2] Aynapudi J, et al. Involvement of signal peptidase I in Streptococcus sanguinis biofilm formation. Microbiology. 2017 Sep;163(9):1306-1318
[3] Winter MB, et al. Global Identification of Biofilm-Specific Proteolysis in Candida albicans. MBio. 2016 Sep 13;7(5). pii: e01514-16
[4] Delcaru C, et al. Microbial Biofilms in Urinary Tract Infections and Prostatitis: Etiology, Pathogenicity, and Combating strategies. Pathogens. 2016 Dec; 5(4): 65

[5] Honma K, Ruscitto A, Sharma A. β-glucanase activity of the oral bacterium Tannerella forsythia contributes to the growth of a partner species, Fusobacterium nucleatum, in co-biofilms. Appl Environ Microbiol. 2017 Oct 27. pii: AEM.01759-17

[6] Ni M, et al. Identification and comprehensive evaluation of a novel biocontrol agent Bacillus atrophaeus JZB120050. J Environ Sci Health B. 2018 Sep 10:1-9

[7] Meshkini A1, Tahmasbi M. Antiplatelet Aggregation Activity of Walnut Hull Extract via Suppression of Reactive Oxygen Species Generation and Caspase Activation. J Acupunct Meridian Stud. 2017 Jun;10(3):193-203
[8] Gruenwald J, Brendler T, Jaenick C, eds. PDR for Herbal Medicine, 4thedition. Thomson, 2007

[9] Group E. The Health Benefits of Cellulase. Global Healing Center, June 19, 2018

[10] De A, et al. Antidiabetic “gliptins” affect biofilm formation by Streptococcus mutans. Microbiol Res. 2018 Apr;209:79-85

[11] Ehren J, et al. A food-grade enzyme preparation with modest gluten detoxification properties. PLoS One. 2009 Jul 21;4(7):e6313

[12] RawlingsND, Barrett AJ. Peptidases. Wiley ELS, Published online: July 2014

[13] Ranjbar-Omid M, et al. Allicin from garlic inhibits the biofilm formation and urease activity of Proteus mirabilis in vitro. FEMS Microbiol Lett. 2015 May;362(9)pii: fnv049

[14] Group E. The Health Benefits of Glucoamylase. Global Healing Center, June 19, 2018
[15] da Silva AR, et al. Berberine Antifungal Activity in Fluconazole-Resistant Pathogenic Yeasts: Action Mechanism Evaluated by Flow Cytometry and Biofilm Growth Inhibition in Candida spp. Antimicrob Agents Chemother. 2016 May 23;60(6):3551-7
[16] Kanmani P1, Rhim JW. Antimicrobial and physical-mechanical properties of agar-based films incorporated with grapefruit seed extract. Carbohydr Polym. 2014 Feb 15;102:708-1

[17] Choi JS, et al. Antibacterial effect of grapefruit seed extract (GSE) on Makgeolli-brewing microorganisms and its application in the preservation of fresh Makgeolli. J Food Sci. 2014 Jun;79(6):M1159-67

[18] Kim JH, Hong WS, Oh SW. Effect of layer-by-layer antimicrobial edible coating of alginate and chitosan with grapefruit seed extract for shelf-life extension of shrimp (Litopenaeus vannamei) stored at 4 °C. Int J Biol Macromol. 2018 Dec;120(Pt B):1468-1473

[19] Group E. The Health Benefits of Hemicellulase. Global Healing Center, October 5, 2015

[20] Hou Y, et al. Lysozyme Associated Liposomal Gentamicin Inhibits Bacteria. Int J Mol Sci. 2017 Apr 9;18(4). pii: E784

[21] Sebaa S, Hizette N, Boucherit-Otmani Z, Courtois P. Dose‑dependent effect of lysozyme upon Candida albicans biofilm. Mol Med Rep. 2017 Mar;15(3):1135-1142

[22] Vimberg V, et al. Hydnocarpin-Type Flavonolignans: Semisynthesis and Inhibitory Effects on Staphylococcus aureus Biofilm Formation. J Nat Prod. 2015 Aug 28;78(8):2095-103

[23] Villa F, Secundo F, Polo A, Cappitelli F. Immobilized Hydrolytic Enzymes Exhibit Antibiofilm Activity Against Escherichia coli at Sub-Lethal Concentrations. Curr Microbiol. 2015 Jul;71(1):106-14

[24] Shukla SK, Rao TS. Staphylococcus aureus biofilm removal by targeting biofilm-associated extracellular proteins. Indian J Med Res. 2017 Jul;146(Supplement):S1-S8

[25] Lacout A. Biofilms busters to improve the detection of Borrelia using PCR. Med Hypotheses. 2018 Mar;112:4-6

[26] Fadl NN, Ahmed HH, Booles HF, Sayed AH. Serrapeptase and nattokinase intervention for relieving Alzheimer’s disease pathophysiology in rat model. Hum Exp Toxicol. 2013 Jul;32(7):721-35

[27] Vetvicka V, Vetvickova J. Immune-enhancing effects of Maitake (Grifola frondosa) and Shiitake (Lentinula edodes) extracts. Ann Transl Med. 2014 Feb;2(2):14

[28] Papetti A, et al. Components in Lentinus edodes mushroom with anti-biofilm activity directed against bacteria involved in caries and gingivitis. Food Funct. 2018 Jun 20;9(6):3489-3499

[29] Lee JH, Kim YG, Lee J. Carvacrol-rich oregano oil and thymol-rich thyme red oil inhibit biofilm formation and the virulence of uropathogenic Escherichia coli. J Appl Microbiol. 2017 Dec;123(6):1420-1428

[30] Tilden JK. Toxemia Explained. Life Science Institute reprint. Written circa 1926

[31] Cordingley EW. Principles and Practices of Naturopathy. Health Research reprint. Written 1924

[32] Thiel R. Naturopathy for the 21stCentury. Whitman Books, 2011.

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Aller-Lung Support™ for Perennial or Seasonal Allergies

Aller-Lung Support™ for Perennial or Seasonal Allergies

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Imagine just one supplement that contains foods that have been shown to help with perennial and/or seasonal allergy symptoms:

  • sneezing
  • congestion
  • phlegm accumulation
  • runny nose

  • red eyes
  • teary eyes
  • watery eyes
  • histamine release

The immune system is quite complex, but when it reacts to normally harmless foods and pollens allergies, sinus complaints, and/or asthma can result (although there are many possible causes of asthma). Of course, not all airborne substances are harmless, as tobacco smoke, fires, and environmental pollutants also seem to contribute to allergies and asthma [1].  And all of these problems can cause or worsen sinus, lung, and bronchial congestion. Throughout the past couple of centuries, many Foods have been consumed to help reduce the histamine-type reactions that allergies tend to produce.

Acerola Cherry is one of the most vitamin C dense Foods [2].  Not only does it have free radical scavenging abilities, it also has been shown to increase the antioxidant abilities of some other foods [3].  “Acerola”contains bioflavonoids” [3], anthocynins, and quercitin [4].  One study concluded that vitamin C “supplementation provides a protective effect against exercise-induced airway narrowing in asthmatic subjects” [5].

Bioflavonoids, such as Quercitin dihydrate have long been used for allergies.  Even the PDR admits that quercetin may “have benefit in some allergic conditions, in conditions characterized by capillary fragility, in chronic prostates and in some cancers”Quercetin is one of several flavonoids that have effects on mast cells and basophils”it might be useful in some allergies, such as hay fever.  Quercetin can help prevent the release of histamine and other mediators of allergies, possibly stabilize cell membranes so that they are less reactive to allergens” [2].  “The major active biological constituents in Citrus herbs are flavonoids, especially hesperidin, naringin and alkaloids, mainly synephrine, with beneficial medical effects on human health” [6].  Quercetin is often advised for those with asthma, allergic rhinitis, or hay fever [7].  Bioflavonoids are also sometimes simply called flavonoids.  Citrus bioflavonoids have been found to have anti-allergic effects and may be useful to improve symptoms associated with seasonal allergic rhinitis [8].

Bromelain fruit Ananas comosus is a widely used pineapple extractAnd while it is most commonly used for inflammation, it has been used for “asthmatic conditions” [9-10].  Furthermore, the PDR reports, “Bromelains reported mucolytic activity has prompted some use of it in respiratory tract diseases.  It has been shown to be of benefit in chronic bronchitis and, in a double-blind study, acute sinusitis”In the realm of immunity, bromelain is being tested for possible effects in T cell-mediated autoimmune diseases”In combination with tyrpsin and the flavonoids rutin, bromelain has been reported to protect against experimental allergic encephalitis” [2].

Fenugreek Trigonella foenum-graecum has been used for “upper respiratory catarrah” [9].  It is “often used for breathing” [11].  It is a common ingredient in curries.  It has been advised for allergies, asthma, bronchial conditions, emphysema, lung infections, and sinus  conditions [12].  “Fenugreek has been shown to soften and dissolve hardened masses of accumulated mucous”It loosens and expels mucus and phlegm accumulated in the bronchial tubes ” [12].

Fructus aurantia immaturi is also known as immature bitter orange.  “The predominant adrenergic protoalkaloid found in the peel and fruit of bitter orange, Citrus aurantium, is synephrine” [13], m-synephrine.   M- synephrine (phenylephrine) promotes normal nighttime breathing by relieving congestion and phlegm in nasal passages, helps inhibit histamine production, and sometimes is used in anti-snoring products.  A pharmaceutical form of synephrine is used in allergy/hay fever medications like Neo-Synephrine [14].

Stinging Nettle Urtica dioica  “Nettle can alleviate allergic symptoms such as teary eyes and a runny nose” [12]. It is sometimes used those with asthma, bronchitis, or catarrhal conditions [12].  Nettles are “[g]ood for hay fever and other allergic disorders”and mucous conditions of the lungs” [7].  It is sometimes advised to help “ward off  severe allergic reactions” [7].  A double-blind study found nettles to be more effective than a placebo for people with allergic rhinitis [15].

Thyme Thymus vulgaris has been approved for use by the European Commission E for cough and bronchitis [9]. The PDR states, “The herb is used internally for catarrh of the upper respiratory tract, dyspeptic complaints, asthma, laryngitis, chronic gastritis, and whopping cough” [9].  One study reported,  “It is well known that nitric oxide (NO) plays an important role in the pathogenesis of inflammatory diseases. . Thymus vulgaris L. have been used in traditional medicine in the treatment of bronchitis, asthma and other respiratory diseases. The present study focuses on the effects of these” extracts on NO production induced by lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma) in the murine macrophage cell line J774A.1. In addition, cell viability, scavenging activity and inducible nitric oxide synthase (iNOS) mRNA expression were evaluated”T. vulgaris extracts significantly inhibited the enhanced production of NO induced by LPS and IFN-gamma in a dose-dependent manner. Treatment with these “extracts did not reduce cell viability at any dose used” plant extracts showed significant scavenging of NO radicals released by an NO donor, PAPA-NONOate. Results also show that pre-treatment with”T. vulgaris extracts significantly inhibits iNOS mRNA expression. This study thus suggests that the inhibition of net NO production by these”extracts may be due to their NO scavenging activity and/or their inhibitory effects on iNOS gene expression” [16].

Note: People with allergies can be allergic to many things, including herbs used with allergies.  Also, if one has some type of Staphylococci infection, it is normally best to avoid bovine (cow) dairy and sometimes oat-containing products.

The 100% Food Aller-Lung Support formula contains herbs that can help support the lungs and sinuses.  For people with year-round or seasonal allergies, naturally-inclined doctors advise Food Aller-Lung Support.

Note: People with allergies can be allergic to many things, including herbs used with allergies.  Also, if one has some type of Staphylococci infection, it is normally best to avoid bovine (cow) dairy and sometimes oat-containing products.

The 100% Food Aller-Lung Support formula contains herbs that can help support the lungs and sinuses.  For people with year-round or seasonal allergies, naturally-inclined doctors advise Food Aller-Lung Support.


[1] Tecer LH, Alagha O, Karaca F, Tuncel G, Eldes N. Particulate Matter (PM(2.5), PM(10-2.5), and PM(10)) and Children’s Hospital Admissions for Asthma and Respiratory Diseases: A Bidirectional Case-Crossover Study. J Toxicol Environ Health A. 2008;71(8):512-20
[2] Sheldon SH, Rorvik D, eds.  PDR for Nutritional Supplements.  Medical Economics, Montvale (NJ), 2001
[3] Hwang J, Hodis HN, Sevanian A.  Soy and alfalfa phytoestrogen extracts become potent low-density lipoprotein antioxidants in the presence of acerola cherry extract.  J Agric Food Chem. 2001;49(1):308-314
[4] Hanamura T, Mayama C, Aoki H, Hirayama Y, Shimizu M.  Antihyperglycemic effect of polyphenols from Acerola (Malpighia emarginata DC.) fruit.  Biosci Biotechnol Biochem. 2006 Aug;70(8):1813-20
[5] Tecklenburg SL, Mickleborough TD, Fly AD, Bai Y, Stager JM.  Ascorbic acid supplementation attenuates exercise-induced bronchoconstriction in patients with asthma.  Respir Med. 2007 Aug;101(8):1770-8
[6] Ding L, Luo X, Tang F, Yuan J, Liu Q, Yao S.  Simultaneous determination of flavonoid and alkaloid compounds in Citrus herbs by high-performance liquid chromatography-photodiode array detection-electrospray mass spectrometry.  J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Oct 1;857(2):202-9
[7] Balch JF, Balch PA.  Prescription for Nutritional Healing.  Avery Publishing, Garden City (NY), 1997
[8] Tanabe S, Kinuta Y, Yasumatsu H, Takayanagi M, Kobayashi S, Takido N, Sugiyama M. Effects of Citrus unshiu Powder on the Cytokine Balance in Peripheral Blood Mononuclear Cells of Patients with Seasonal Allergic Rhinitis to Pollen. Biosci. Biotechnol. Biochem. 2207, 71 (11), 2852″2855
[9] Gruenwald J, Brendler T, Jaenicke C, editors. PDR for Herbal Medicines, 4th ed.  Thomson, Montvale (NJ), 2007
[10]  Secor ER, Carson WF, Singh A, Pensa M, Guernsey LA, Schramm CM, Thrall RS.  Oral Bromelain Attenuates Inflammation in an Ovalbumin-induced Murine Model of Asthma.  Evid Based Complement Alternat Med. 2008 Mar;5(1):61-9
[11] Profiles in Nutritional Progress.  Rubicon Productions, Bakersfield, 1993
[12] Ritchason J.  The Little Herb Encyclopedia, 3rd ed.  Woodland Health Books, Provo (UT), 1995
[13] Nelson BC, Putzbach K, Sharpless KE, Sander LC.  Mass spectrometric determination of the predominant adrenergic protoalkaloids in bitter orange (Citrus aurantium).  J Agric Food Chem. 2007 Nov 28;55(24):9769-75
[14] Griffith HW.  Complete Guide to Prescription & Non-Prescription Drugs.  The Body Press, Los Angeles, 1989:782-3
[15] Mittman P. Randomized, double-blind study of freeze-dried Urtica dioica in the treatment of allergic rhinitis.  Planta Med. 1990 Feb;56(1):44-7
[16] Vigo E, Cepeda A, Gualillo O, Perez-Fernandez R.  In-vitro anti-inflammatory effect of Eucalyptus globulus and Thymus vulgaris: nitric oxide inhibition in J774A.1 murine macrophages.  J Pharm Pharmacol. 2004 Feb;56(2):257-63

Some of these studies (or citations) may not conform to peer review standards. Therefore, the results are not conclusive. Professionals can, and often do, come to different conclusions when reviewing scientific data. None of these statements have been reviewed by the FDA. All products distributed by Doctors” Research, Inc. are nutritional and are not intended for the treatment or prevention of any medical condition

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Vegetarian Thyro™ – 100% Vegan Food Thyroid Support

Vegetarian Thyro™ – 100% Vegan Food Thyroid Support

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The thyroid is responsible for hormones that affect mood, improve circulation, increase metabolism, retain calcium, affect cardiovascular health, improve tolerance to temperature fluctuations, minimize body fat, reduce the tendency for obesity, minimize menstrual disturbances, improve energy, reduce the dryness of skin and hair, and reduce premature hair loss [1-3].   Yet thyroid problems are very common [2].

Unfortunately, medical interventions are often incomplete as blood tests often do not recognize certain forms of hypothyroidism [2,3].  Furthermore, even when found medically, most medical interventions are limited to the prescribing of synthetic T4 (levothyroxine), which tends to shut the thyroid down [4], and thus possibly increasing the tendency for osteoporosis [3-5], as well as sometimes increasing mood problems and some other symptoms associated with low thyroid function.

Vegetarian Thyro is a 100% vegan Food supplement intended to nutritionally support the thyroid and improve metabolism.  Vegetarian Thyro is basically Food intended for thyroid gland. If additional endocrine support is indicated, consider adding Vegetarian Adrenal or Vegetarian Tyrosine.

Burdock Root has long been used to support the thyroid nutritionally [6].  It is sometimes used in products that are given to people who take synthetic thyroid medicines [6].

Carrots contain a variety of carotenoids, which is a vitamin A precursor.  Low levels of vitamin A are associated with increased risk of thyroid goiters and deficiencies affect thyroid metabolism [7].  “[A] decade-long Harvard study indicat[ed] that by getting 50 milligrams of carotenoids in every other day…significantly reduce[d] the risk of cancer, cardiovascular disease, and cataracts” [8].

Dong Quai has long been used to support the thyroid nutritionally [6].  It is sometimes used in products that are given to people who take synthetic thyroid medicines [6].  

Folate forms have long been used to support the thyroid nutritionally [6].  It is sometimes used in products that are given to people who take synthetic thyroid medicines [6].  Additionally, it has been reported that deficiencies of folate have been found in those with inadequate production of TSH (thyroid-stimulating hormone) [9].

Iodine can be properly called THE THYROID mineral since the body’s sole use of the mineral iodine is for the thyroid to make thyroid hormones (T1,T2,T3, & T4) [1,5,8].  The primary thyroid hormone (T1) is called monoiodotyrosine, which means it needs iodine and tyrosine [5].  It gets converted to T2 with the addition of more iodine, then to T3 with more iodine then to T4 with even more iodine.  Iodine is naturally contained in Foods such as kelp and other sea vegetables [10].

Irish Moss Chondrus crispus contains humic and fulvic acids (FAs) which increase the solubility of toxic metals [11],  thus it is sometimes used to detoxify.  Detoxification can be an issue with thyroid health as some believe that substances like chloride and fluoride can bind with the thyroid and interfere with iodine absorption.  “Irish moss and Kelp combination is used to balance hormonal indeficiency especially in the thyroid gland.  It increases the metabolic rate, thyroid activity, and the detoxifying function of the body.  The herbs {also} supply trace minerals…[and] is commonly used in conjunction with…the complex of B vitamins, vitamin A,…and zinc” [12] .

Kelp is a Food  source of trace minerals, and an excellent source of iodine [10].  Kelp has long been used (since 3000 B.C.) to provide nutritional support for the thyroid gland [8,13]. Gary Null, Ph.D., has written, “Kelp can rebalance thyroid metabolism, resulting in successful weight management and the reversal of many conditions which are caused by a thyroid imbalance, including stomach and respiratory disorders” [13].  

L-tyrosine an amino acid required for the production of thyroid hormones, T1,T2,T3, and T4 [5].  Tyrosine may reduce the net rate of protein breakdown in the body and appears to help with endurance [14].  Tyrosine has an effect nerve impulse transmission and may “improve vigilance and lessen anxiety” [17]. Gary Null (Ph.D.) considers tyrosine to  be  a  therapeutic amino acid for depression as well was an antiencephalopathic, antiparkinsonian, and an
antidepressant [16].  Women on oral contraceptives have been found to have less plasma and brain levels of tyrosine which results in a reduction in catecholamines, which affect mood. [17]. Oral consumption of tyrosine has, in some case, been shown to completely alleviate depression while increasing plasma tyrosine levels [18,19].  It has also been shown to help when MAO inhibitors did not [19].  In rat models vitamin C has enhanced the ability of tyrosine to decrease blood pressure [8,20].  Interestingly, “Tyrosine has been known to normalize blood pressure whether high or low. Tyrosine is being tested by the Air Force to enhance performance under stress” [21].

The body naturally produces tyrosine by converting it from phenylalanine [8].  “Compared with tyrosine which has a de novo synthesis component limited by phenylalanine oxidation, most nonessential amino acids have a very large de novo synthesis components because of the metabolic pathways they are involved in” [8].  This might explain why taking separate tyrosine is more helpful for many than taking other separate amino acids classified as nonessential—they can be made with much easier (with less restriction) than tyrosine can (tyrosine requires liver hydroxylation).

Sea Vegetables supply iodine and various trace minerals that the thyroid needs [10].

Vitamin B-6 forms have long been used to support the thyroid nutritionally [6].  It is sometimes used in products that are given to people who take synthetic thyroid medicines [6].

Vitamin B-12 deficiencies have been found in those with inadequate production of TSH (thyroid-stimulating hormone) [9].

Zinc deficiency in humans can cause thyroid problems, alopecia, impotence, skin problems, immune deficiencies, increased susceptibility to infection/sore throats, night blindness, impaired taste, delayed wound healing, impaired appetite, photophobia (hypersensitivity to light), difficulty in dark adaptation, growth retardation, male infertility (low sperm counts), liver enlargement, and spleen enlargement [8,22].

Many people simply take Vegetarian Thyro as a Food supplement to help them feel better.  


[1] Robbins J, Rall JE, Gorden P.  The thyroid and iodine metabolism.  In Duncan’s Diseases of Metabolism, 7th ed.  WB Saunders, Phil.:1009-1104, 1974
[2] Many thyroid conditions are underdiagnosed. Med Trib, Jan 25,1996;2
[3] Thiel R.  Suspected hypothyroidism: treat, ignore, or feed? International Journal of Naturopathic Medicine, 2002; 1(1): 12-22
[4] Physician’s Desk Reference, 60th ed. Thompson PDR, Montvale (NJ), 2006
[5] Guyton AG, Hall JE.  Textbook of Medical Physiology, 9th ed.  W.B. Saunders Co., Phil., 1996 [21] Ensminger AH, Ensminger ME, Konlande JE, Robson JRK.  Food & Nutrition Encyclopedia, 2nd ed.  CRC Press, New York, 1993
[6] Thiel R.  Serious Nutrition, 3rd edition.  Center for Natural Health Research, 1997
[7] Michael B. Zimmermann, Rita Wegmüller, Christophe Zeder, Nourredine Chaouki and Toni Torresani. The Effects of Vitamin A Deficiency and Vitamin A Supplementation on Thyroid Function in Goitrous Children.  J Clin Endocrinol Metab. 2004;89(11):5441-5447
[8] Ensminger AH, Ensminger ME, Konlande JE, Robson JRK.  Food & Nutrition Encyclopedia, 2nd ed.  CRC Press, New York, 1993
[9] Agarwal R, Chhillar N, Kushwaha S, Singh NK, Tripathi CB. Role of vitamin B(12), folate, and thyroid stimulating hormone in dementia: A hospital-based study in north Indian population.  Ann Indian Acad Neurol. 2010 Oct;13(4):257-62
[10] Seaweed, kelp, raw.  USDA Nutrient Database for Standard Reference, Release 11-1, August 1997
[11] Wu J, West LJ, Stewart DI..  Effect of humic substances on Cu(II) solubility in kaolin-sand soil. J Hazard Mater. 2002 Oct 14;94(3):223-238
[12] Pedersen M.  Nutritional Herbology.  Whitman Books, Warsaw (IN), 1998
[13] Null G.  The Complete Encyclopedia of Natural Healing.  Kensington Books, 1998
[14] Blomstrand E, Newsholme EA.  Effect of branch-chain amino acid supplementation on exercise-induced change in aromatic amino acid concentration in human muscle.  ACTA Physiol Scand,1992;146:293-298
[15] Specific nutrients aid in high-performance activity.  Nutr Week, June 4, 1994:7
[16] Null G.  The Clinician’s Handbook of Natural Healing.  Kensington Books, NY, 1997
[17] Moller SE.  Tryptophan and Tyrosine Availability and Oral Contraceptives.   Lancet, September 1, 1979:472
[18] Gelenberg AJ, Wojcik JD, Growdon JH, et al. Tyrosine for the Treatment of Depression.  Am J Psychiatry, 1980;137(5):622-623
[19] Goldberg IK. L-Tyrosine in Depression.  Lancet, August 16, 1980:364.
[20] Hemila H.  Vitamin C and Lowering Blood Pressure:  Need For Intervention Trials. Journal of Hypertension, 1991;9(11):1076-1077
[21] Hamiliton K. Clinical Pearls, 1992.  ITServices, Sacramento, 1991
[22] Cunnane SC.  Zinc: Clinical and Biochemical Significance.  CRC Press, Boca Raton (FL),1988

Some of these studies (or citations) may not conform to peer review standards (though most do). Therefore, the results are not conclusive. Professionals can, and often do, come to different conclusions when reviewing scientific data. None of these statements have been reviewed by the FDA. All products distributed by Doctors’ Research, Inc. are nutritional and are not intended for the treatment or prevention of any medical condition.

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Advanced Joint Complex™ for Optimal Joint Health

Advanced Joint Complex™ for Optimal Joint Health

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Many people have joint complaints including various forms of arthritis, rheumatism, lupus, fibromyalgia, multiple sclerosis, and other disorders. There are many products intended to help such people, yet that there is no one formula that is best for everyone. Since most products are not 100% Food, they often do not contain all the nutrient factors needed for optimal joint health. At Doctors” Research we believe that nutritional supplementation should be Food, or as close to Food as possible, which is why we came up with 100% Food Advanced Joint Complex.

Take glucosamine sulfate as an example. In most products, glucosamine sulfate is extracted from marine exoskeletons (shellfish) and is so over refined that other natural factors that can be helpful for joints are missing [1,2]. The same is true for refined chrondroitin sulfate, which can come from pork, sharks, or even whales [1,2]. However, Advanced Joint Complex contains concentrated bovine tracheal cartilage which is naturally high in collagen, proteoglycans, chondrocytes (including, but not limited to, chondroitin sulfates), glucosamine, and other factors which each have specific functions for joints and other connective tissue [1]. “The collagen fibers are arranged in arches so that near the surface they are horizontal in orientation–this allows the cartilage to resist tensile stresses and transmit vertical loads. The proteoglycans…give hyaline cartilage its turgor and elasticity and play an important role in limiting friction. The chondrocytes synthesize the matrix as well as enzymatically digest it…Matrix turnover is carefully controlled as chondrocytes secrete the degradative enzymes in an inactive form and enrich the matrix with enzyme inhibitors.
Diseases that destroy articular cartilage do so by activating catabolic enzymes and decreasing the production of inhibitors, thereby accelerating the matrix breakdown. The chondrocytes react by increasing matrix production” [3]. Chondroitin sulfates (CS) “4&6 are glycosaminoglycans which participate in the matrix structure of cartilage. They are well absorbed after oral intake…Several clinical studies have demonstrated the chondroprotective efficacy of CS 4&6 in osteoarthritis involving the hip, knee and finger joints” [4]; an animal study found that CS-C significantly inhibited “edema, synovitis and destruction of articular cartilage” [5]. Unlike Advanced Joint Complex, typical extracted glucosamine sulfate and chondroitin sulfate formulas are simply to incomplete to work as well as nature intended [2].

Vitamin C helps neutralize free radicals to stop their damage and helps build connective tissues such as collagen [6]. Most other products contain ascorbic acid which is the USP synthesized so-called vitamin C. USP ascorbic acid is made by fermenting corn sugar into sorbitol, then hydrogenating it until it turns into sorbose, then acetone (commonly referred to as nail polish remover) is added to break the molecular bonds which creates ascorbic acid! All the vitamin C in Advanced Joint Complex is from Acerola (it is not a mixture of ascorbic acid with some Acerola thrown in as some do). Acerola is a cherry-like berry that is one of the most naturally concentrated vitamin C Foods known to exist–various cherries have been recommended to help people with arthritis [7]. Vitamin C in Foods such as Acerola exists in at least two forms unlike USP ascorbic acid which does not contain both forms [6]! Acerola is also less acidic than USP ascorbic acid (some feel that increased acidity tends to hurt, rather than help joints [7]).

Food vitamin D has been found to be more effective than at least one USP form for rickets [8]. Food calcium is 7 times as effective in raising serum ionic calcium levels [9]. Food magnesium is better absorbed and retained than magnesium salts [10]. Clinically, magnesium is often used for muscle tightness. Food zinc contains items that have better absorption than the zinc salts [11]. Food phosphorus works with calcium in the body, whereas Food potassium is an important electrolyte [7]. Alfalfa is a Food which is rich in trace minerals [12]. “Aloe veraincreases collagen content…acts as a modulatory system toward wounds with anti-inflammatory effects…exerts anti-inflammatory activity through its inhibitory action on the arachidonic pathway via cyclooxygenase…Aloe vera contains a carboxypeptidase that inactivates bradykinin, salicylates, and a substance that inhibits thromboxane formation”[13]. Bioflavonoids are helpful to strengthen capillary walls [13]; not only can stronger capillary walls reduce bruising, they can improve circulation (and nutrition) to all parts of the body including joints.

Borage seeds contains gamma-linoleic acid and linoleic acid [13]. Borage is used for “rheumatism of the joints; as a pain reliever” [13]. Food boron is an essential mineral; part of its benefit is believed to be in the inhibition of certain enzymes [7] (proper enzyme inhibition is believed to be helpful for those suffering from forms of arthritis [1,3]). Burdock root is a Food traditional used by those with gout and rheumatism [10]. Cayenne contains capsaicin which has been shown to assist with pain modulation–“Long term desensitization of the fibers occurs after repeated exposure to capsaicin, and results in a subsequent loss of pain sensation…Capsicum binds to the C-type vanilliod receptor (VRI) and opens a cationic channel allowing the influx of calcium…Cayenne is used for painful muscle spasms in the areas of shoulder, arm and spine. In folk medicine the herb is used for frostbite, chronic lumbago… Cayenne is used for gout, arthritis, sciatica” [13]. “Chondroitin is a biological polymer that acts as the flexible connecting matrix between the protein ligaments in cartilage…Chondroitin helps attract essential fluid into the proteoglycan molecules, “water magnet”, which not only acts as a shock absorber but “sweeps” nutrients into the cartilage as well. Glucosamine, another of the beneficial substances in this area, stimulates chondrocyte activity. It is also the critical building block of proteoglycans and other matrix components. Both chondroitin and glucosamine play vital roles in joint maintenance” [12]; there have been purification, absorption, and other problems in found in some chondroitin formulas which are not Food [2,12].

Devil”s Claw is primarily used for rheumatism; a double-bind study found it to “lessen the pain of osteoarthritis” [13]. “The major chemical component, which is though to be responsible for the anti-inflammatory activity of devil”s claw, is harpagoside, a monoterpenic glucoside” [12]. The grape seed extract used in Advanced Joint Complex is a minimum of 92% proanthocyanidins. Proanthocyanidins are a type of bioflavonoids which studies have found to significantly decrease “Pain, limb heaviness, and feeling of swelling” [12,14]. Additionally, proantocyanidins have been found to increase the resistance of connective fibers to degradation [13] and “Proanthocyanidins extracted from Grape Seed stabilizes capillary walls and prevents increases in permeability which causes edema” [14]). Silicon in Advanced Joint Complex comes from the herb horsetail (which has long been used for gout and rheumatism [14]); “to keep on regenerating cartilage your body needs one basic element: silicon…However the older you get the more difficult it becomes for your body to assimilate silicon…To remedy the situation, plant therapists prescribe horsetail” [15].

Superoxide dismutase (S.O.D.)…protects intracellular components from oxidative damage” [7]; “superoxide has been successfully used to treat human inflammatory diseases” [12]. S.O.D. has been shown to inhibit articular tissue damage associated with osteoarthritis [16]. Ingestion of an isolated form of S.O.D. is not as effective as Food CuZn S.O.D. [17]; which with Mn S.O.D., exists naturally, in Advanced Joint Complex. Whole yucca seems helpful for people who complain that arthritic complaints increase with weather changes. “One report found that the oral administration of a yucca saponin extract for up to 15 months was well-tolerated for the treatment of various arthritic conditions” [12].

Advanced Joint Complex is a Food and contains many Foods, each of which plays a unique role in joint and connective tissue health (including knees). No other isolated joint product truly compares with it, which is why Advanced Joint Complex is the choice of doctors who prefer to recommend Foods, and not chemical isolates, for optimal joint health.

Advanced Joint Complex™ contains concentrated bovine tracheal cartilage which is naturally high in collagen, proteoglycans, chondrocytes (including, but not limited to, chondroitin sulfates), glucosamine, and other factors which each have specific functions for joints and other connective tissue.


[1] Hendlor SS, Rorvak D, editors. PDR for Nutritional Supplements, 1st ed. Medical Economics, Montvale (NJ), 2001

[2] Williams D. The Truth About Glucosamine and Chondroitin. Mountain Home Nutritionals, Ranson (WV), Fall 2002

[3] Cotran RS, Kumar V, Collins T. Robbins Pathologic Basis of Disease, 6th ed. WB Saunders, Phil., 1999

[4] Conrozier T. Anti-arthrosis treatment: efficacy and tolerance of chondroitin sulfates (CS 4&6). Presse Med, 1998;27(36):1862-1865

[5] Omata T, Itokazu Y, Ionue N, Segawa Y. Effects of chondroitin sulfate-C on articular cartilage destruction in murine collagen-induced arthritis. Arzneimittelforschung, 2000;50(2):148-153

[6] Shils ME, Olson JA, Shike M. Modern Nutrition in Health and Disease, 8th ed. Lea & Febiger, Phil.,1994

[7] Airola P. How to Get Well. Health Plus, Sherwood (OR), 1974

[8] Bland J. Study on renatured vitamin D3. Linus Pauling Institute of Science and Medicine. November 25, 1985

[9] Hamet P, et al. The evaluation of the scientific evidence for a relationship between calcium and hypertension. J Nutr, 1995;125:311S-400S

[10] Rude R.K., Shils M.E. Magnesium. In Modern Nutrition in Health and Disease, 10th ed. Lippincott William & Wilkins, Phil, 2005: 223-247

[11] Andlid TA, Veide J, Sandberg AS. Metabolism of extracellular inositol hexaphosphate (phytate) by Saccharomyces cerevisiae. Int J. Food Microbiology. 2004;97(2):157-169

[12] DerMarerosian A, ed. The Review of Natural Products. Facts and Comparisons, St. Louis, 2001

[13] Williams DG. Instant Pain Relief, Special Report. Phillips Health, Potomac (MD), 2001

[14] Gruenwald J, et al editors. PDR for Herbal Medicine, 2nd ed. Medical Economics, Montvale (NJ), 2000

[15] Robinson A. The natural remedy that can cure arthritis

[16] Null G. Superoxide Dismutase. In The Clinician”s Handbook of Natural Healing. Kensington Books, New York, 1997:137-144

 [17] Haun SE, et al. Polyethylene glycol-conjugated superoxide dismutase fails to augment brain superoxide dismutase activity in piglets. Stroke,1991;22(5):655-659

Some of these studies (or citations) may not conform to peer review standards (though most do). Therefore, the results are not conclusive. Professionals can, and often do, come to different conclusions when reviewing scientific data. None of these statements have been reviewed by the FDA. All products distributed by Doctors” Research, Inc. are nutritional and are not intended for the treatment or prevention of any medical condition.

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Advanced Joint

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